期刊
CELL REPORTS
卷 15, 期 5, 页码 1062-1075出版社
CELL PRESS
DOI: 10.1016/j.celrep.2016.04.001
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资金
- Deutsche Forschungsgemeinschaft [DFG-SFB620, DFG-GRK1660, DFG-SFB643, DFG-SFB1181]
- Interdisciplinary Center for Clinical Research of the FAU
- Emerging Field Initiative of the FAU
- Dr. Robert Pfleger-Stiftung
- Bavarian Genome Network (BayGene)
- NIH [CA189990, P30 CA21765]
- American Lebanese Syrian Associated Charities of St. Jude Children's Research Hospital
- National Health and Medical Research Council of Australia [NHMRC 485807]
Neutralization or deletion of tumor necrosis factor (TNF) causes loss of control of intracellular pathogens in mice and humans, but the underlying mechanisms are incompletely understood. Here, we found that TNF antagonized alternative activation of macrophages and dendritic cells by IL-4. TNF inhibited IL-4-induced arginase 1 (Arg1) expression by decreasing histone acetylation, without affecting STAT6 phosphorylation and nuclear translocation. In Leishmania major-infected C57BL/6 wild-type mice, type 2 nitric oxide (NO) synthase (NOS2) was detected in inflammatory dendritic cells or macrophages, some of which co-expressed Arg1. In TNF-deficient mice, Arg1 was hyperexpressed, causing an impaired production of NO in situ. A similar phenotype was seen in L. major-infected BALB/c mice. Arg1 deletion in hematopoietic cells protected these mice from an otherwise lethal disease, although their disease-mediating T cell response (Th2, Treg) was maintained. Thus, deletion or TNF-mediated restriction of Arg1 unleashes the production of NO by NOS2, which is critical for pathogen control.
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