期刊
CELL REPORTS
卷 15, 期 10, 页码 2136-2146出版社
CELL PRESS
DOI: 10.1016/j.celrep.2016.05.009
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资金
- Fondazione Italiana Sclerosi Multipla (FISM) [2014/R/15]
- Office of the Assistant Secretary of Defense for Health Affairs, through the Multiple Sclerosis Research Program [W81XWH-14-1-0156]
- National Institutes of Health (NIH)/National Institute on Aging (NIA) grant [AG034906]
- Meylin Projekt e.V.
- Familie Ernst Wendt Stiftung Stadt Koeln
- Deutsche Forschungsgemeinschaft [DFG Exc 257]
- L-Nutra
Dietary interventions have not been effective in the treatment of multiple sclerosis (MS). Here, we show that periodic 3-day cycles of a fasting mimicking diet (FMD) are effective in ameliorating demyelination and symptoms in a murine experimental autoimmune encephalomyelitis (EAE) model. The FMD reduced clinical severity in all mice and completely reversed symptoms in 20% of animals. These improvements were associated with increased corticosterone levels and regulatory T (T-reg) cell numbers and reduced levels of pro-inflammatory cytokines, T(H)1 and T(H)17 cells, and antigen-presenting cells (APCs). Moreover, the FMD promoted oligodendrocyte precursor cell regeneration and remyelination in axons in both EAE and cuprizone MS models, supporting its effects on both suppression of autoimmunity and remyelination. We also report preliminary data suggesting that an FMD or a chronic ketogenic diet are safe, feasible, and potentially effective in the treatment of relapsing-remitting multiple sclerosis (RRMS) patients.
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