Dinuclear-gold-catalyzed cyclization of 1,7-enynes with alkyl bromides

Dinuclear-gold-catalyzed radical difunctionalization of alkyl bromides with 1,7-enynes has been established via dehalogenation and 1,5-HAT processes. This protocol was used to construct, in a facile and efficient manner, a wide range of cyclopenta[c]quinolines bearing two quaternary carbon centers with good yields (28 examples, up to 84% yield). The good functional group compatibility and gram-scale preparation ability of the reaction proved its synthetic robustness.

Automated summary

A dinuclear gold-catalyzed radical difunctionalization of alkyl bromides with 1,7-enynes has been developed via dehalogenation and 1,5-HAT processes. This protocol efficiently constructs cyclopenta[c]quinolines bearing two quaternary carbon centers with good yields (28 examples, up to 84% yield). The reaction exhibits excellent functional group compatibility and scalability, demonstrating its synthetic robustness.