4.5 Article

Crosstalk between diacylglycerol kinase and protein kinase A in the regulation of airway smooth muscle cell proliferation

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Cell Biology

Autocrine regulation of airway smooth muscle contraction by diacylglycerol kinase

Santosh K. Yadav et al.

Summary: Inhibition of DGK activates PKA signaling pathway and induces COX expression and PGE(2) production in ASM cells, leading to attenuation of ASM contraction. This novel mechanism suggests DGK as a potential therapeutic target for effective bronchoprotection in asthma.

JOURNAL OF CELLULAR PHYSIOLOGY (2022)

Article Multidisciplinary Sciences

Structural anatomy of Protein Kinase C C1 domain interactions with diacylglycerol and other agonists

Sachin S. Katti et al.

Summary: This study reveals the structures of C1 domain complexes with DAG and agonists, providing insights into the mechanisms of DAG recognition and capture by C1 domains in the complex environment of a biological membrane. The findings offer guidance for the design of agents that modulate the activities of DAG effector proteins.

NATURE COMMUNICATIONS (2022)

Article Biochemistry & Molecular Biology

Regulation of Airway Smooth Muscle Cell Proliferation by Diacylglycerol Kinase: Relevance to Airway Remodeling in Asthma

Miguel Angel Hernandez-Lara et al.

Summary: Airway remodeling in asthma involves the hyperproliferation of airway smooth muscle (ASM) cells. The inhibition of diacylglycerol kinase (DGK) reduces the conversion of diacylglycerol (DAG) into phosphatidic acid (PA) and inhibits ASM cell proliferation. These findings suggest that DGK may serve as a potential drug target for mitigating airway remodeling in asthma.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Biochemistry & Molecular Biology

Diacylglycerol Kinase Inhibition Reduces Airway Contraction by Negative Feedback Regulation of Gq-Signaling

Pawan Sharma et al.

Summary: This study demonstrated that inhibition of DGK disrupted the DAG:PA ratio, resulting in the inhibition of Gq-PLC activation in a negative feedback manner, thus protecting against ASM contraction.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2021)

Article Multidisciplinary Sciences

Live-cell lipid biochemistry reveals a role of diacylglycerol side-chain composition for cellular lipid dynamics and protein affinities

Milena Schuhmacher et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Review Cell Biology

Cyclooxygenase 2: protein-protein interactions and posttranslational modifications

Anna Alexanian et al.

PHYSIOLOGICAL GENOMICS (2017)

Article Physiology

Antimitogenic effect of bitter taste receptor agonists on airway smooth muscle cells

Pawan Sharma et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2016)

Article Biochemistry & Molecular Biology

Dynamics and Membrane Interactions of Protein Kinase C

Tatyana I. Igumenova

BIOCHEMISTRY (2015)

Article Biochemistry & Molecular Biology

β-Agonist-mediated Relaxation of Airway Smooth Muscle Is Protein Kinase A-dependent

Sarah J. Morgan et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Article Biochemistry & Molecular Biology

beta(2)-Adrenergic Receptor Agonists Modulate Human Airway Smooth Muscle Cell Migration via Vasodilator-Stimulated Phosphoprotein

Elena A. Goncharova et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2012)

Review Chemistry, Multidisciplinary

Regulation and Functions of Diacylglycerol Kinases

Yulia V. Shulga et al.

CHEMICAL REVIEWS (2011)

Article Biochemistry & Molecular Biology

Anti-mitogenic effects of beta-agonists and PGE(2) on airway smooth muscle are PKA dependent

Huandong Yan et al.

FASEB JOURNAL (2011)

Article Biochemistry & Molecular Biology

Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction

Deepak A. Deshpande et al.

NATURE MEDICINE (2010)

Article Multidisciplinary Sciences

Diacylglycerol kinase α mediates HGF-induced Rac activation and membrane ruffling by regulating atypical PKC and RhoGDI

Federica Chianale et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Review Biochemistry & Molecular Biology

Mammalian diacylglycerol kinases: Molecular interactions and biological functions of selected isoforms

Matthew K. Topham et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2009)

Review Cell Biology

Targeting G protein-coupled receptor signaling in asthma

Deepak A. Deshpande et al.

CELLULAR SIGNALLING (2006)

Article Physiology

Role of caveolin-1 in p42/p44 MAP kinase activation and proliferation of human airway smooth muscle

Reinoud Gosens et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2006)

Article Biochemistry & Molecular Biology

Cooperative mitogenic signaling by G protein-coupled receptors and growth factors is dependent on Gq/11

Kok Choi Kong et al.

FASEB JOURNAL (2006)

Article Biochemistry & Molecular Biology

Epileptogenesis in diacylglycerol kinase epsilon deficiency up-regulates COX-2 and tyrosine hydroxylase in hippocampus

WJ Lukiw et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)

Article Biochemistry & Molecular Biology

Interplay between calcium, diacylglycerol, and phosphorylation in the spatial and temporal regulation of PKCα-GFP

A Tanimura et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Physiology

Mechanisms of cytokine effects on G protein-coupled receptor-mediated signaling in airway smooth muscle

RM Pascual et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2001)

Article Critical Care Medicine

Mechanisms of airway remodeling - Airway smooth muscle

JL Black et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2001)

Article Critical Care Medicine

Airway smooth muscle cell proliferation is increased in asthma

PRA Johnson et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2001)

Review Cell Biology

Properties and functions of diacylglycerol kinases

WJ van Blitterswijk et al.

CELLULAR SIGNALLING (2000)

Article Biochemistry & Molecular Biology

Mechanisms of proliferation synergy by receptor tyrosine kinase and G protein-coupled receptor activation in human airway smooth muscle

VP Krymskaya et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2000)