期刊
NEW JOURNAL OF CHEMISTRY
卷 47, 期 24, 页码 11394-11397出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d3nj02065g
关键词
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In this article, we showcase the utilization of continuous flow technology for the synthesis of hydrazine derivatives through deoxygenation of free alcohols using di-tert-butylazodicarboxylate. This straightforward method demonstrates excellent tolerance towards various functional groups and allows for large-scale synthesis and late-stage functionalization. Furthermore, it presents a pathway to access three families of pharmacological compounds.
Herein we demonstrate the application of continuous flow technology to the synthesis of hydrazine derivatives by deoxygenation of free alcohols with di-tert-butylazodicarboxylate. This operationally simple protocol has excellent functional group tolerance and enables large-scale synthesis and late-stage functionalization. It also provides access to three families of pharmacological compounds.
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