The value of procalcitonin and brain natriuretic peptide in predicting the prognosis of sepsis

Objective: To explore the value of procalcitonin (PCT) and brain natriuretic peptide (BNP) in predicting the prognosis of sepsis. Methods: A total of 65 patients with sepsis received treatment in Deqing County People's Hospital from 2019 January and 2021 January and their data were collected retrospectively. Based on the survival and death of patients, 40 living patients were regarded as survival group, and 25 dead patients were regarded as the death group. PCT, BNP and, Acute Physiology and Chronic Health Evaluation II (APACHE II) scores of sepsis pa-tients in both groups on the first, third, and seventh days of admission were collected and compared respectively. ROC curve was utilized to calculate the relationship between the three indicators and prognosis. Results: Compared with the death group, the PCT, BNP, and APACHE II scores in the survival group were lower on the first, third, and seventh days (P < 0.05). On the first, third, and seventh day, the AUC of PCT were 0.768, 0.829, and 0.831; the AUC of BNP were 0.771, 0.805, and 0.848; the AUC of APACHE II were 0.891, 0.809, and 0.974 (P < 0.05). Conclusion: The level of plasma PCT and BNP in sepsis patients was increased, and they are positively correlated with the sever-ity of the disease, which can be used as an indicator of bad prognosis of sepsis patients.

Automated summary

This study investigated the value of procalcitonin (PCT) and brain natriuretic peptide (BNP) in predicting the prognosis of sepsis. The results showed that plasma levels of PCT and BNP were elevated in sepsis patients and positively correlated with disease severity, suggesting that they can be used as prognostic indicators.