☆ 4.7 Review

Latest advances and perspectives of liquid biopsy for cancer diagnostics driven by microfluidic on-chip assays

LAB ON A CHIP (2023)

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Review Biochemistry & Molecular Biology

Microfluidic-Based Technologies for CTC Isolation: A Review of 10 Years of Intense Efforts towards Liquid Biopsy

Lucie Descamps et al.

Summary: The selection of circulating tumor cells (CTCs) from blood as a real-time liquid biopsy has gained attention for its potential in research and clinical applications. Microfluidic-based isolation technologies have emerged as promising tools to overcome the technical challenges posed by the rarity and heterogeneity of CTCs. This review provides an overview of the latest microfluidic devices implemented for CTC isolation, highlighting the tradeoff between recovery and purity.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Materials Science, Biomaterials

Ultrahigh SERS activity of the TiO2@Ag nanostructure leveraged for accurately detecting CTCs in peripheral blood

Yanping Xu et al.

Summary: In this work, a TiO2@Ag nanostructure-based SERS bioprobe was successfully developed for the accurate detection of circulating tumor cells (CTCs) in peripheral blood. The bioprobe exhibited ultrahigh sensitivity, good specificity, low toxicity, and high accuracy in CTC detection. The results demonstrated the great potential of the TiO2@Ag-based SERS bioprobe in early screening and diagnosis of tumors.

BIOMATERIALS SCIENCE (2022)

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Review Biotechnology & Applied Microbiology

Review on Strategies and Technologies for Exosome Isolation and Purification

Jiaci Chen et al.

Summary: Exosomes, as nano-sized extracellular vesicles, play an important role in cell-specific material transfer and have potential applications in prognosis, diagnosis, and treatment. Existing exosomal separation techniques have limitations in terms of complexity, time consumption, and low purity, highlighting the need for efficient and simple isolation methods. Microfluidic chips have emerged as a promising technology for exosome isolation. A comprehensive review covering exosomal properties, conventional technologies, emerging isolation strategies, and large-scale production of engineered exosomes is essential.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2022)

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Article Nanoscience & Nanotechnology

Ultrasensitive Analysis of Exosomes Using a 3D Self-Assembled Nanostructured SiO2 Microfluidic Chip

Qiaoyu Li et al.

Summary: In this study, a 3D-SiO2 porous chip was developed to greatly improve the sensitivity for biosensing by combining nanoscale porous characteristics and multiple exosome specific markers. The chip was applied for prostate cancer staging in mice and early detection of clinical prostate cancer patients, achieving significant results. The expression of multiple specific markers in clinical serum samples identified disease fingerprints, supporting the potential application of exosomes as a noninvasive surrogate biopsy for prostate cancer.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Chemistry, Analytical

Rapid On-Chip Isolation of Cancer-Associated Exosomes and Combined Analysis of Exosomes and Exosomal Proteins

Lu Zheng et al.

Summary: This study proposes a microfluidic chip for specific exosome isolation and sensitive quantification using a signal switch strategy. The platform enables efficient capture of exosomes and profiling of exosomal surface proteins, making it a potential tool for early cancer screening and diagnosis.

ANALYTICAL CHEMISTRY (2022)

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Article Biophysics

Rapid and efficient capturing of circulating tumor cells from breast cancer Patient's whole blood via the antibody functionalized microfluidic (AFM) chip

Aynur Abdulla et al.

Summary: This study demonstrates a novel antibody functionalized microfluidic chip that can rapidly and accurately capture circulating tumor cells (CTCs) from cancer patients' whole blood. The chip offers a valuable tool for cancer screening, prognosis, and diagnosis.

BIOSENSORS & BIOELECTRONICS (2022)

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Article Biophysics

Integrated microfluidic system for isolating exosome and analyzing protein marker PD-L1

Yunxing Lu et al.

Summary: This study presents an integrated microfluidic system for the isolation and detection of exosomes, specifically analyzing the abundance of the PD-L1 protein marker. The system is able to complete the analysis within two hours and has a limit of detection of 10.76 exosomes per microliter. Significant variations in PD-L1 abundance among different cancer cell lines were observed, highlighting the importance of personalized treatments. Additionally, clinical samples showed differences in sensitivity towards immune response, providing valuable insights for the design of immunotherapy strategies for different types of tumors.

BIOSENSORS & BIOELECTRONICS (2022)

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Article Biology

Octahedral silver oxide nanoparticles enabling remarkable SERS activity for detecting circulating tumor cells

Meng He et al.

Summary: The study introduces a highly sensitive platform for detecting circulating tumor cells (CTCs) using octahedral Ag2O nanoparticles as a surface-enhanced Raman scattering (SERS) platform. The Ag2O-based SERS bioprobe demonstrates excellent detection specificity for different cancer cells in rabbit blood, satisfying the requirement for rare CTC detection in the peripheral blood of cancer patients.

SCIENCE CHINA-LIFE SCIENCES (2022)

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Article Oncology

Precision medicine in pediatric solid cancers

Mirjam Blattner-Johnson et al.

Summary: Despite advances in diagnosing and treating pediatric cancers, it remains a leading cause of childhood death in developed countries. The heterogeneity of tumor types in children, which differ from adult carcinomas, has made understanding the underlying biology and developing targeted treatments difficult. Additionally, the pharmaceutical industry has been reluctant to develop products for this population due to market size. However, recent changes in science and regulation are addressing these challenges.

SEMINARS IN CANCER BIOLOGY (2022)

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Article Oncology

The potential of liquid biopsy in the management of cancer patients

A. Markou et al.

Summary: Liquid biopsy, through the analysis of CTCs, ctDNA, cfmiRNAs, and EVs, has gained attention as a powerful tool in personalized medicine for monitoring cancer evolution and follow-up of cancer patients in real time. It has significant impacts on prognosis, detection of MRD, treatment selection, and monitoring of cancer patients, and shows potential for early cancer diagnosis.

SEMINARS IN CANCER BIOLOGY (2022)

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Article Chemistry, Multidisciplinary

Detection of VEGF165 in Whole Blood by Differential Pulse Voltammetry Based on a Centrifugal Microfluidic Chip

Xinyu He et al.

Summary: A microfluidic sensing chip that integrates a centrifugal separation pretreatment unit and a composite nanosensing film was proposed for the rapid and sensitive detection of vascular endothelial growth factor 165 (VEGF165) in clinical blood samples. The method achieved a low detection limit and a wide linear range, meeting the needs of clinical VEGF165 detection.

ACS SENSORS (2022)

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Review Multidisciplinary Sciences

Effective Separation of Cancer-Derived Exosomes in Biological Samples for Liquid Biopsy: Classic Strategies and Innovative Development

Yujiao Xie et al.

Summary: Liquid biopsy enables non-invasive detection of cancer-derived components, facilitating clinical diagnosis and surveillance of cancer. The investigation of cancer-derived exosomes, nano-sized vesicles secreted by cancer cells, in liquid biopsy has revealed their important roles in intracellular communication and disease development. This review analyzes classic strategies for exosome separation, discusses their advantages and limitations, presents innovative multi-strategy methods for efficient isolation, and discusses future development trends.

GLOBAL CHALLENGES (2022)

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Article Biophysics

Immunofluorescence analysis of breast cancer biomarkers using antibody-conjugated microbeads embedded in a microfluidic-based liquid biopsy chip

Na Li et al.

Summary: In this study, a continuous, fast, and efficient liquid biopsy chip was developed using immunofluorescence analysis in a microfluidic chip. By disrupting the laminar flow and improving mass transfer efficiency using antibody-conjugated microbeads, the sensitivity and efficiency of cancer detection were significantly improved.

BIOSENSORS & BIOELECTRONICS (2022)

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Article Biophysics

TiO2-based Surface-Enhanced Raman Scattering bio-probe for efficient circulating tumor cell detection on microfilter

Xiawei Xu et al.

Summary: This study presents a novel method for in situ isolating and directly detecting circulating tumor cells (CTCs) from peripheral blood using black TiO2-based Surface-Enhanced Raman Scattering (SERS) bio-probe. The strategy showed high efficiency, reliability, and specificity in distinguishing CTCs from peripheral blood cells. It significantly reduced the detection time and improved the detection sensitivity, making it a potential tool for liquid biopsy.

BIOSENSORS & BIOELECTRONICS (2022)

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Article Biophysics

An integrated lab-on-a-chip platform for pre-concentration and detection of colorectal cancer exosomes using anti-CD63 aptamer as a recognition element

Raja Chinnappan et al.

BIOSENSORS & BIOELECTRONICS (2022)

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Article Biophysics

Microfluidic-based exosome isolation and highly sensitive aptamer exosome membrane protein detection for lung cancer diagnosis

Liang Zhao et al.

Summary: The study introduces an automated centrifugal microfluidic disc system combined with a novel aptamer fluorescence system to efficiently isolate and purify exosomes for detecting cancer with high accuracy in clinical samples. Compared to traditional techniques, this method is cost-effective, rapid, high in purity, sensitivity, and specificity.

BIOSENSORS & BIOELECTRONICS (2022)

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Review Engineering, Electrical & Electronic

A review of microfluidic-based mixing methods

Zhenghua Li et al.

Summary: Microfluidic-based mixing methods have great potential in biorelated and materials science fields. They offer advantages such as compact size, ease of operation, and precise control of mixing process. This review summarizes various microfluidic-based mixing methods and discusses their applications in improving fluid mixing performance.

SENSORS AND ACTUATORS A-PHYSICAL (2022)

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Review Medicine, General & Internal

Circulating tumor cell isolation for cancer diagnosis and prognosis

Zicheng Deng et al.

Summary: Circulating tumor cells (CTCs) play a crucial role in cancer diagnosis and prognosis. Current detection technologies have limitations due to tumor heterogeneity, but a new technique using superparamagnetic nanoprobe shows higher sensitivity and biomarker independence.

EBIOMEDICINE (2022)

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Article Biophysics

Recent advances in integrated microfluidics for liquid biopsies and future directions

Jianjian Zhuang et al.

Summary: Liquid biopsies have attracted the interest of researchers as a new tumor diagnosis technique due to their unique benefits of non-invasiveness, sensitivity, and convenience. Recent advances in microfluidic technology have enabled high-throughput, high-sensitivity, and high-controllability detection of specific biomarkers in liquid biopsies. Challenges and future directions include further improvements in microfluidic technology to meet the increasing demand for tumor detection and individualized treatment.

BIOSENSORS & BIOELECTRONICS (2022)

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Review Biochemistry & Molecular Biology

Recent Advances in Detection for Breast-Cancer-Derived Exosomes

Qin Tang et al.

Summary: Breast cancer is a common malignant tumor in women, with a high incidence and late-stage diagnosis. It is important to develop simple and efficient detection methods for early diagnosis to improve the survival rate and quality of life. Exosomes, as biomarkers, play a critical role in breast cancer diagnosis and treatment. This review summarizes several traditional exosome detection methods and focuses on the latest research progress in breast cancer exosome detection.

MOLECULES (2022)

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Article Materials Science, Biomaterials

Highly sensitive and simultaneous detection of ctDNAs related to non-small cell lung cancer in serum using a catalytic hairpin assembly strategy in a SERS microfluidic chip

Xiaowei Cao et al.

Summary: A novel detection method combining surface-enhanced Raman scattering (SERS) and catalytic hairpin assembly (CHA) was proposed to rapidly and sensitively detect circulating tumor DNA (ctDNA) related to non-small cell lung cancer (NSCLC). The method demonstrated high specificity, reproducibility, and stability, and its clinical feasibility was verified by analyzing serum samples. The constructed micro-platform has great potential in dynamic monitoring of cancer staging and early cancer screening.

JOURNAL OF MATERIALS CHEMISTRY B (2022)

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Review Nanoscience & Nanotechnology

Advances in Organ-on-a-Chip Materials and Devices

Bishal Kumar Nahak et al.

Summary: The organ-on-a-chip (OoC) technology provides an accurate pathway for biomedical applications from preclinical to clinical translational precision. It accurately represents human physiology in vitro and allows noninvasive real-time monitoring and treatment. The technology combines emerging approaches such as advanced materials, artificial intelligence, machine learning, three-dimensional bioprinting, and genomics, and has broad application prospects.

ACS APPLIED BIO MATERIALS (2022)

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Review Oncology

Cancer diagnostics based on plasma protein biomarkers: hard times but great expectations

Ulf Landegren et al.

Summary: Current protein biomarkers and detection methods fall short of meeting the needs for accurate cancer diagnosis, highlighting the importance of exploring biomarkers deep within the proteome. The molecular detection sensitivity of protein assays lags behind nucleic acid detection reactions, necessitating improvements to ensure early detection of malignant growth through liquid biopsy.

MOLECULAR ONCOLOGY (2021)

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Review Chemistry, Multidisciplinary

Label-Free Isolation of Exosomes Using Microfluidic Technologies

Sara Hassanpour Tamrin et al.

Summary: Exosomes are cell-derived structures containing lipids, proteins, and nucleic acids, playing roles in physiological and pathological processes. Microfluidic technology offers simple, cost-effective, precise, and fast processing for exosome isolation, yet faces challenges hindering their clinical utility.

ACS NANO (2021)

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Review Nanoscience & Nanotechnology

Progress in Nanomaterials-Based Optical and Electrochemical Methods for the Assays of Exosomes

Xiaohua Ma et al.

Summary: Exosomes, small membrane-bound vesicles secreted by cells, have been considered as emerging and noninvasive biomarkers for cancer diagnosis. Integration of nanomaterials with various techniques significantly improves the analytical performances of exosome biosensors.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

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Review Biochemistry & Molecular Biology

Fabrication and Applications of Microfluidic Devices: A Review

Adelina-Gabriela Niculescu et al.

Summary: Microfluidics is an emerging field that combines principles from various disciplines to fabricate miniaturized chips with channels and chambers. These chips, made using diverse methods, can be utilized in nanoparticle preparation, cell analysis, and diagnosis, among other biomedical applications.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Chemistry, Analytical

A cost-effective serpentine micromixer utilizing ellipse curve

Xin Wang et al.

Summary: The serpentine micromixer with ellipse curve design shows improved mixing performance and reduced pressure drop compared to traditional zigzag and square-wave designs. By utilizing Dean vortices induced by the continuous change in flow direction through ellipse curves, this novel micromixer is more cost-effective for rapid mixing in complex microfluidic systems.

ANALYTICA CHIMICA ACTA (2021)

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Article Chemistry, Analytical

A herringbone mixer based microfluidic device HBEXO-chip for purifying tumor-derived exosomes and establishing miRNA signature in pancreatic cancer

Yong Zhang et al.

Summary: The study developed a novel microfluidic device HBEXO-Chip for efficient isolation of exosomes from plasma using membrane lipid markers. It was found that GPC1+ exosomes can distinguish pancreatic cancer from Pancreatitis group and healthy control group. Additionally, a miRNA signature for pancreatic cancer was identified through RNA sequencing.

SENSORS AND ACTUATORS B-CHEMICAL (2021)

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Review Chemistry, Analytical

Fabrication Methods for Microfluidic Devices: An Overview

Simon Scott et al.

Summary: Microfluidic devices have the potential to automate a wide variety of chemical and biological operations with higher efficiency and repeatability. Polymer-based devices offer advantages in terms of cost and biocompatibility. Different manufacturing approaches, including direct and replication methods, are described in this study.

MICROMACHINES (2021)

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Review Engineering, Biomedical

Progress in the research of nanomaterial-based exosome bioanalysis and exosome-based nanomaterials tumor therapy

Zhiwei Sun et al.

Summary: Exosomes and nanomaterials have shown great potential in overcoming challenges in bioanalysis. The research progress in utilizing nanomaterials for exosome analysis has advanced significantly, offering promising clinical applications. The future development of this field holds great potential for innovative methods in biomedical research.

BIOMATERIALS (2021)

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Article Chemistry, Multidisciplinary

A nanostructured microfluidic device for plasmon-assisted electrochemical detection of hydrogen peroxide released from cancer cells

Carolina del Real Mata et al.

Summary: A new nanostructured microfluidic device was proposed for ultrasensitive, quantitative detection of H2O2 released from cancer cells, featuring self-organized gold nanocavities enhanced with graphene nanosheets. The device successfully measured released H2O2 from breast cancer and prostate cancer cells in human plasma with a superb LOD. The proposed electrode combining gold plasmonic nanocavities and graphene sheets paves the way for non-invasive plasmon-assisted electrochemical sensors that can effectively detect low concentrations of H2O2 released from cancer cells.

NANOSCALE (2021)

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Article Biochemical Research Methods

Direct isolation of circulating extracellular vesicles from blood for vascular risk profiling in type 2 diabetes mellitus

Hui Min Tay et al.

Summary: A novel microfluidic platform has been developed for efficient isolation of EVs of different sizes directly from blood, with clinical studies showing higher levels of EVs in high-risk T2DM patients and abnormal levels of platelet or leukocyte-derived EVs, which induce vascular inflammation and reflect a pro-inflammatory phenotype.

LAB ON A CHIP (2021)

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Article Biochemical Research Methods

Simple and fast isolation of circulating exosomes with a chitosan modified shuttle flow microchip for breast cancer diagnosis

Wenwen Chen et al.

Summary: The study proposes a simple, quick, and label-free method for isolating circulating exosomes from patient serum. Further validation through miRNA sequencing and RT-PCR reveals a potential new biomarker.

LAB ON A CHIP (2021)

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Article Nanoscience & Nanotechnology

Ultrafast Detection of Exosomal RNAs via Cationic Lipoplex Nanoparticles in a Micromixer Biochip for Cancer Diagnosis

Yunchen Yang et al.

Summary: Exosomes are nanosized extracellular vesicles that play a role in intercellular communication, with exosomal RNAs being promising cancer liquid biopsy biomarkers. Conventional methods for characterizing exosomal RNAs have limitations, but a new microfluidic cationic lipoplex nanoparticles assay has been developed to enable rapid and sensitive detection of exosomal RNAs, showing higher diagnostic accuracy and efficiency in lung cancer compared to traditional qRT-PCR assays.

ACS APPLIED NANO MATERIALS (2021)

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Article Biochemical Research Methods

Gear-shaped micromixer for synthesis of silica particles utilizing inertio-elastic flow instability

Sun Ok Hong et al.

Summary: The study discusses the challenge of mixing in microscale flows and proposes an efficient mixing scheme by combining inertio-elastic flow instability with a modified serpentine channel design. Results show that this new scheme achieves highly efficient mixing over a wider range of flow rates and is successfully applied to the continuous synthesis of silica nanoparticles, resulting in nanoparticles with more uniform size distribution.

LAB ON A CHIP (2021)

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Article Biochemical Research Methods

Microfluidic-based capture and release of cancer-derived exosomes via peptide-nanowire hybrid interface

Thanawat Suwatthanarak et al.

Summary: Peptide-functionalized nanowires have been developed as an effective means to capture and release cancer-derived exosomes within a microfluidic channel. This approach significantly enhances the exosome-capturing ability of ZnO nanowires, providing a new avenue for developing microfluidic platforms for exosome-based diagnostics and therapeutics.

LAB ON A CHIP (2021)

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Article Biochemical Research Methods

An Integrated Microfluidic Chip and Its Clinical Application for Circulating Tumor Cell Isolation and Single-Cell Analysis

Mingxin Xu et al.

CYTOMETRY PART A (2020)

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Review Chemistry, Multidisciplinary

Progress in Microfluidics-Based Exosome Separation and Detection Technologies for Diagnostic Applications

Shujing Lin et al.

SMALL (2020)

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Article Nanoscience & Nanotechnology

Rapid Label-Free Isolation of Circulating Tumor Cells from Patients' Peripheral Blood Using Electrically Charged Fe3O4 Nanoparticles

Shengming Wu et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Chemistry, Analytical

Integrated Microfluidic Device for Accurate Extracellular Vesicle Quantification and Protein Markers Analysis Directly from Human Whole Blood

Sisi Zhou et al.

ANALYTICAL CHEMISTRY (2020)

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Article Biophysics

Isolation and analysis of extracellular vesicles in a Morpho butterfly wing-integrated microvortex biochip

Shanying Han et al.

BIOSENSORS & BIOELECTRONICS (2020)

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Article Nanoscience & Nanotechnology

AFM-compatible microfluidic platform for affinity-based capture and nanomechanical characterization of circulating tumor cells

Muhammedin Deliorman et al.

MICROSYSTEMS & NANOENGINEERING (2020)

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Review Biophysics

Optical, electrochemical and electrical (nano)biosensors for detection of exosomes: A comprehensive overview

Lizhou Xu et al.

BIOSENSORS & BIOELECTRONICS (2020)

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Review Biophysics

Recent advances of aptasensors for exosomes detection

Chao Zhu et al.

BIOSENSORS & BIOELECTRONICS (2020)

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Review Biochemical Research Methods

Microfluidic systems for cancer diagnostics

Jose L. Garcia-Cordero et al.

CURRENT OPINION IN BIOTECHNOLOGY (2020)

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Article Chemistry, Analytical

Nonenzymatic chemiluminescence detection of circulating tumor cells in blood based on Au@luminol nanoparticles, hybridization chain reaction and magnetic isolation

Hai-Xia Cao et al.

SENSORS AND ACTUATORS B-CHEMICAL (2020)

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Review Oncology

Precision Prevention and Cancer Interception: The New Challenges of Liquid Biopsy

Maria Jose Serrano et al.

CANCER DISCOVERY (2020)

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Article Dentistry, Oral Surgery & Medicine

Effect of etching with low concentration hydrofluoric acid on the bond strength of CAD/CAM resin block

Yuiko Niizuma et al.

DENTAL MATERIALS JOURNAL (2020)

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Article Chemistry, Analytical

Efficient Isolation and Phenotypic Profiling of Circulating Hepatocellular Carcinoma Cells via a Combinatorial-Antibody-Functionalized Microfluidic Synergetic-Chip

Lin Zhu et al.

ANALYTICAL CHEMISTRY (2020)

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Article Biochemical Research Methods

Microfluidic Raman biochip detection of exosomes: a promising tool for prostate cancer diagnosis

Yanlin Wang et al.

LAB ON A CHIP (2020)

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Review Biochemistry & Molecular Biology

Applications of genome editing technology in the targeted therapy of human diseases: mechanisms, advances and prospects

Hongyi Li et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

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Review Materials Science, Biomaterials

An efficient strategy for circulating tumor cell detection: surface-enhanced Raman spectroscopy

Jie Lin et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

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Article Chemistry, Multidisciplinary

ZnO nanowire-integrated bio-microchips for specific capture and non-destructive release of circulating tumor cells

Heng Cui et al.

NANOSCALE (2020)

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Review Chemistry, Analytical

Engineering microfluidic chip for circulating tumor cells: From enrichment, release to single cell analysis

Xu Yu et al.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2019)

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Review Chemistry, Analytical

Recent advances in microfluidic platforms for single-cell analysis in cancer biology, diagnosis and therapy

Hamed Tavakoli et al.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2019)

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Review Biotechnology & Applied Microbiology

Recent Advances in Biosensors for Detecting Cancer-Derived Exosomes

Nan Cheng et al.

TRENDS IN BIOTECHNOLOGY (2019)

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Article Biophysics

Direct quantification of cancerous exosomes via surface plasmon resonance with dual gold nanoparticle-assisted signal amplification

Qing Wang et al.

BIOSENSORS & BIOELECTRONICS (2019)

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Review Chemistry, Analytical

Microfluidics-based approaches for separation and analysis of circulating tumor cells

Jiaxiang Yin et al.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2019)

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Review Chemistry, Analytical

DEP-on-a-Chip: Dielectrophoresis Applied to Microfluidic Platforms

Haoqing Zhang et al.

MICROMACHINES (2019)

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Article Chemistry, Analytical

Single-Cell Phenotypic Profiling of CTCs in Whole Blood Using an Integrated Microfluidic Device

Haimeng Pei et al.

ANALYTICAL CHEMISTRY (2019)

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Article Chemistry, Multidisciplinary

Isolation and Profiling of Circulating Tumor-Associated Exosomes Using Extracellular Vesicular Lipid-Protein Binding Affinity Based Microfluidic Device

Yoon-Tae Kang et al.

SMALL (2019)

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Article Biochemical Research Methods

Arrayed microfluidic chip for detection of circulating tumor cells and evaluation of drug potency

Xuejia Huang et al.

ANALYTICAL BIOCHEMISTRY (2019)

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Article Chemistry, Multidisciplinary

Bioinspired Engineering of a Multivalent Aptamer-Functionalized Nanointerface to Enhance the Capture and Release of Circulating Tumor Cells

Yanling Song et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

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Article Chemistry, Multidisciplinary

A Novel Multifunctional Nanowire Platform for Highly Efficient Isolation and Analysis of Circulating Tumor-Specific Markers

Jiyun Lim et al.

FRONTIERS IN CHEMISTRY (2019)

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Review Chemistry, Applied

Microfluidic Screening of Circulating Tumor Biomarkers toward Liquid Biopsy

Nanjing Hao et al.

SEPARATION AND PURIFICATION REVIEWS (2018)

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Article Chemistry, Multidisciplinary

Multiplexed Profiling of Single Extracellular Vesicles

Kyungheon Lee et al.

ACS NANO (2018)

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Article Chemistry, Multidisciplinary

Integrated Analysis of Exosomal Protein Biomarkers on Alternating Current Electrokinetic Chips Enables Rapid Detection of Pancreatic Cancer in Patient Blood

Jean M. Lewis et al.

ACS NANO (2018)

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Article Biochemical Research Methods

Fully automated, on-site isolation of cfDNA from whole blood for cancer therapy monitoring

Chi-Ju Kim et al.

LAB ON A CHIP (2018)

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Review Biochemical Research Methods

Circulating tumor DNA and liquid biopsy: opportunities, challenges, and recent advances in detection technologies

Lena Gorgannezhad et al.

LAB ON A CHIP (2018)

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Review Biochemical Research Methods

Capillary microfluidics in microchannels: from microfluidic networks to capillaric circuits

Ayokunle Olanrewaju et al.

LAB ON A CHIP (2018)

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Recent Progress in Isolation and Detection of Extracellular Vesicles for Cancer Diagnostics

Wenshuo Wang et al.

ADVANCED HEALTHCARE MATERIALS (2018)

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Highly sensitive detection of exosomes by SERS using gold nanostar@ Raman reporter@ nanoshell structures modified with a bivalent cholesterollabeled DNA anchor

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ANALYST (2018)

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Article Chemistry, Analytical

Magnetic-Based Microfluidic Device for On-Chip Isolation and Detection of Tumor-Derived Exosomes

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Detection of exosomes by ZnO nanowires coated three-dimensional scaffold chip device

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ClearCell® FX, a label-free microfluidics technology for enrichment of viable circulating tumor cells

Yifang Lee et al.

CYTOMETRY PART A (2018)

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Review Biochemistry & Molecular Biology

Blood-Based Cancer Biomarkers in Liquid Biopsy: A Promising Non-Invasive Alternative to Tissue Biopsy

Jose Marrugo-Ramirez et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Article Multidisciplinary Sciences

Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response

Gang Chen et al.

NATURE (2018)

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Review Chemistry, Analytical

The Use of Microfluidic Technology for Cancer Applications and Liquid Biopsy

Arutha Kulasinghe et al.

MICROMACHINES (2018)

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Article Biochemical Research Methods

Integrated nanoscale deterministic lateral displacement arrays for separation of extracellular vesicles from clinically-relevant volumes of biological samples

Joshua T. Smith et al.

LAB ON A CHIP (2018)

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Article Chemistry, Analytical

Novel microfluidic device for the continuous separation of cancer cells using dielectrophoresis

Anas Alazzam et al.

JOURNAL OF SEPARATION SCIENCE (2017)

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Article Biochemical Research Methods

3D printed conformal microfluidics for isolation and profiling of biomarkers from whole organs

Manjot Singh et al.

LAB ON A CHIP (2017)

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Article Multidisciplinary Sciences

Isolation of exosomes from whole blood by integrating acoustics and microfluidics

Mengxi Wu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

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Article Chemistry, Analytical

An integrated microfluidic chip for one-step isolation of circulating tumor cells

Tae Yoon Lee et al.

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Article Medicine, Research & Experimental

Precisely Enumerating Circulating Tumor Cells Utilizing a Multi-Functional Microfluidic Chip and Unique Image Interpretation Algorithm

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THERANOSTICS (2017)

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Article Multidisciplinary Sciences

An integrated double-filtration microfluidic device for isolation, enrichment and quantification of urinary extracellular vesicles for detection of bladder cancer

Li-Guo Liang et al.

SCIENTIFIC REPORTS (2017)

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Article Chemistry, Multidisciplinary

Aptamer/AuNP Biosensor for Colorimetric Profiling of Exosomal Proteins

Ying Jiang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)

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Article Chemistry, Multidisciplinary

Field-Free Isolation of Exosomes from Extracellular Vesicles by Microfluidic Viscoelastic Flows

Chao Liu et al.

ACS NANO (2017)

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Review Biophysics

Microfluidic approaches for isolation, detection, and characterization of extracellular vesicles: Current status and future directions

Shima Gholizadeh et al.

BIOSENSORS & BIOELECTRONICS (2017)

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Article Chemistry, Multidisciplinary

Integrated Magneto-Electrochemical Sensor for Exosome Analysis

Sangmoo Jeong et al.

ACS NANO (2016)

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Review Engineering, Environmental

Passive mixers in microfluidic systems: A review

Chia -Yen Lee et al.

CHEMICAL ENGINEERING JOURNAL (2016)

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Article Biochemical Research Methods

Development of an aptasensor for electrochemical detection of exosomes

Qing Zhou et al.

METHODS (2016)

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Article Nanoscience & Nanotechnology

Nanoscale lateral displacement arrays for the separation of exosomes and colloids down to 20 nm

Benjamin H. Wunsch et al.

NATURE NANOTECHNOLOGY (2016)

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Review Chemistry, Analytical

Polymer Microfluidics: Simple, Low-Cost Fabrication Process Bridging Academic Lab Research to Commercialized Production

Chia-Wen Tsao

MICROMACHINES (2016)

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Article Oncology

Prospective Validation of Rapid Plasma Genotyping for the Detection of EGFR and KRAS Mutations in Advanced Lung Cancer

Adrian G. Sacher et al.

JAMA ONCOLOGY (2016)

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Article Chemistry, Multidisciplinary

Acoustic Purification of Extracellular Microvesicles

Kyungheon Lee et al.

ACS NANO (2015)

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Article Chemistry, Analytical

Size-Based Separation of Particles and Cells Utilizing Viscoelastic Effects in Straight Microchannels

Chao Liu et al.

ANALYTICAL CHEMISTRY (2015)

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Article Biophysics

Label-free impedance detection of cancer cells from whole blood on an integrated centrifugal microfluidic platform

Charles E. Nwankire et al.

BIOSENSORS & BIOELECTRONICS (2015)

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Article Biochemical Research Methods

Circulating tumor cell detection using a parallel flow micro-aperture chip system

Chun-Li Chang et al.

LAB ON A CHIP (2015)

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Article Multidisciplinary Sciences

Acoustic separation of circulating tumor cells

Peng Li et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

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Review Chemistry, Analytical

Proteomics analysis of the mode of antibacterial action of nanoparticles and their interactions with proteins

Hani Nasser Abdelhamid et al.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2015)

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Article Multidisciplinary Sciences

Chip-based analysis of exosomal mRNA mediating drug resistance in glioblastoma

Huilin Shao et al.

NATURE COMMUNICATIONS (2015)

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Article Chemistry, Analytical

Detecting Exosomes Specifically: A Multiplexed Device Based on Alternating Current Electrohydrodynamic Induced Nanoshearing

Ramanathan Vaidyanathan et al.

ANALYTICAL CHEMISTRY (2014)

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Article Chemistry, Analytical

All-in-One Centrifugal Microfluidic Device for Size-Selective Circulating Tumor Cell Isolation with High Purity

Ada Lee et al.

ANALYTICAL CHEMISTRY (2014)

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Review Pharmacology & Pharmacy

Diagnostic and Prognostic Potential of Extracellular Vesicles in Peripheral Blood

Anne Louise Schacht Revenfeld et al.

CLINICAL THERAPEUTICS (2014)

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Review Chemistry, Analytical

Droplet microfluidics for single-molecule and single-cell analysis in cancer research, diagnosis and therapy

Dong-Ku Kang et al.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2014)

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Article Biochemical Research Methods

Separation of tumor cells with dielectrophoresis-based microfluidic chip

Mohammed Alshareef et al.

BIOMICROFLUIDICS (2013)

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Article Biophysics

Continuous labeling of circulating tumor cells with microbeads using a vortex micromixer for highly selective isolation

Ming Xian Lin et al.

BIOSENSORS & BIOELECTRONICS (2013)

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Article Chemistry, Multidisciplinary

A chemiluminescence imaging array for the detection of cancer cells by dual-aptamer recognition and bio-bar-code nanoprobe-based rolling circle amplification

Sai Bi et al.

CHEMICAL COMMUNICATIONS (2013)

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Article Engineering, Environmental

Simulation and experimental investigation of planar micromixers with short-mixing-length

Mohammad Sadegh Cheri et al.

CHEMICAL ENGINEERING JOURNAL (2013)

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Article Biochemical Research Methods

Ciliated micropillars for the microfluidic-based isolation of nanoscale lipid vesicles

Zongxing Wang et al.

LAB ON A CHIP (2013)

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Review Oncology

Liquid biopsy: monitoring cancer-genetics in the blood

Emily Crowley et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2013)

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Article Multidisciplinary Sciences

Isolation and retrieval of circulating tumor cells using centrifugal forces

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SCIENTIFIC REPORTS (2013)

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ATOMIC FORCE MICROSCOPY A tip for diagnosing cancer

Malgorzata Lekka

NATURE NANOTECHNOLOGY (2012)

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Review Chemistry, Multidisciplinary

Colorimetric Biosensing Using Smart Materials

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ADVANCED MATERIALS (2011)

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Article Chemistry, Analytical

Interfacing Cell-Based Assays in Environmental Scanning Electron Microscopy Using Dielectrophoresis

Khashayar Khoshmanesh et al.

ANALYTICAL CHEMISTRY (2011)

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Review Radiology, Nuclear Medicine & Medical Imaging

Seeding of tumour cells following breast biopsy: a literature review

C. F. Loughran et al.

BRITISH JOURNAL OF RADIOLOGY (2011)

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Article Biochemical Research Methods

Interdigitated comb-like electrodes for continuous separation of malignant cells from blood using dielectrophoresis

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ELECTROPHORESIS (2011)

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Review Chemistry, Multidisciplinary

Microfluidic lab-on-a-chip platforms: requirements, characteristics and applications

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CHEMICAL SOCIETY REVIEWS (2010)

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Soft lithography for micro- and nanoscale patterning

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