Functional roles of sphingolipids in immunity and their implication in disease

Review Urology & Nephrology

Trained immunity - basic concepts and contributions to immunopathology

Jordi Ochando et al.

Summary: Trained immunity is a functional state of the innate immune response characterized by long-term epigenetic reprogramming. It enhances immune responses against microbial pathogens and has implications in inflammation and transplantation.

NATURE REVIEWS NEPHROLOGY (2023)

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Article Biochemistry & Molecular Biology

T-Cell-Specific CerS4 Depletion Prolonged Inflammation and Enhanced Tumor Burden in the AOM/DSS-Induced CAC Model

Khadija El-Hindi et al.

Summary: This study reveals the importance of CerS4 in the multifactorial process of inflammatory bowel disease (IBD) and colitis-associated cancer (CAC). Deficiency of CerS4 in T-cells leads to sustained activation and prevents the resolution of inflammation, resulting in a higher tumor burden in a mouse model of CAC. In contrast, CerS4 deficiency in epithelial cells leads to smaller colon tumors and appears to be beneficial.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Endocrinology & Metabolism

Ablation of ORMDL3 impairs adipose tissue thermogenesis and insulin sensitivity by increasing ceramide generation

Yu Song et al.

Summary: The study reveals that ORMDL3 plays an important role in the regulation of brown adipose tissue thermogenesis, white adipose tissue browning, and insulin resistance.

MOLECULAR METABOLISM (2022)

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Article Cell Biology

Multi-Omics Prognostic Signatures Based on Lipid Metabolism for Colorectal Cancer

YuanLin Sun et al.

Summary: This study investigated the role of lipid metabolism in the prognosis of colorectal cancer (CRC) using metabonomics and transcriptomics. The study developed prognostic signatures and a composite nomogram to predict the outcome of CRC patients. The study also explored the potential relationship between tumor microenvironment and immune infiltration.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

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Article Medicine, Research & Experimental

Ceramide kinase knockout ameliorates multiple sclerosis-like behaviors and demyelination in cuprizone-treated mice

Ai Tanaka et al.

Summary: Changes in sphingolipid metabolism in the brain can affect various cellular functions. In this study, we investigated the roles of CerK and C1P in multiple sclerosis. Our results showed that CerK knockout improved motor dysfunction and demyelination in a multiple sclerosis mouse model. Additionally, CerK knockout also had an impact on gender differences in mice.

LIFE SCIENCES (2022)

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Article Immunology

Multi-Platform Omics Analysis Reveals Molecular Signatures for Pathogenesis and Activity of Systemic Lupus Erythematosus

Xiaolan Huang et al.

Summary: This study investigated the molecular characteristics of systemic lupus erythematosus (SLE) patients with different disease activity levels using a comprehensive multi-omics analysis. The results showed that the complement system and inflammatory response were activated in SLE patients and were associated with disease activity. Additionally, the immunoglobulin mediated immune response was activated in patients with low disease activity but slightly suppressed in patients with high disease activity. Imbalance in lipid metabolism, particularly sphingolipid metabolism, and dysregulated apolipoproteins were also observed to contribute to the disease activity of SLE.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Nanoscience & Nanotechnology

Nanoscale fluorescence imaging of biological ultrastructure via molecular anchoring and physical expansion

Wei Wang et al.

Summary: Expansion microscopy (ExM) is a recently developed nanoscale fluorescence imaging method that enhances resolution by physically expanding biological samples. This review focuses on the early conception and development of ExM, discussing various variations and challenges faced, as well as the potential to push the resolution and accuracy beyond current limits.

NANO CONVERGENCE (2022)

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Article Gastroenterology & Hepatology

Hepatocyte-Secreted Autotaxin Exacerbates Nonalcoholic Fatty Liver Disease Through Autocrine Inhibition of the PPARα/FGF21 Axis

Han Qiu et al.

Summary: This study found that serum levels of autotaxin in NAFLD patients were positively correlated with histologic scores and disease severity. In mouse models, reducing hepatic autotaxin or using an anti-autotaxin antibody significantly decreased high-fat diet-induced NAFLD and nonalcoholic steatohepatitis and fibrosis, with increased serum FGF21.

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2022)

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Article Pharmacology & Pharmacy

Effects of ceramide kinase knockout on lipopolysaccharide-treated sepsis-model mice: Changes in serum cytokine/chemokine levels and increased lethality

Ai Tanaka et al.

Summary: This study investigated the effects of CerK/C1P pathway on the onset and progression of sepsis-related events in LPS-treated sepsis-model mice. The results showed that CerK knockout increased the lethality in mice and affected the levels of various immune/inflammation-related molecules.

JOURNAL OF PHARMACOLOGICAL SCIENCES (2022)

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Article Multidisciplinary Sciences

Clinical relevance of CERK and SPHK1 in breast cancer and their association with metastasis and drug resistance

Priyanka Bhadwal et al.

Summary: This study investigated the clinical significance of sphingolipids metabolism in breast cancer. The overexpression of CERK and SPHK1 was found to be associated with nodal metastasis, late tumor stage, high proliferation potency, and poor patient survival. Computational network analysis revealed their association with known metastasis and drug resistance markers. These findings suggest that CERK and SPHK1 could serve as potential biomarkers in breast cancer patients.

SCIENTIFIC REPORTS (2022)

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Article Biochemistry & Molecular Biology

Plasma metabolome predicts trained immunity responses after antituberculosis BCG vaccination

Valerie A. C. M. Koeken et al.

Summary: Circulating metabolites have a significant impact on the trained immunity induced by BCG vaccination, with the tricarboxylic acid (TCA) cycle and glutamine metabolism being particularly important.

PLOS BIOLOGY (2022)

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Review Pharmacology & Pharmacy

How sphingolipids affect T cells in the resolution of inflammation

Jennifer Christina Hartel et al.

Summary: The concept of proper resolution of inflammation has gained attention in recent years. This review focuses on the role of T cells and sphingolipids in the resolution of inflammation, providing insights into potential therapeutic approaches.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Biology

Multi-Omic analyses characterize the ceramide/sphingomyelin pathway as a therapeutic target in Alzheimer's disease

Priyanka Baloni et al.

Summary: This study investigates the role of sphingomyelin and ceramide metabolism in Alzheimer's disease through multi-omics analyses and imaging features. The findings suggest potential therapeutic targets in the sphingomyelin pathway and demonstrate the efficacy of modulators of S1P metabolism in treating Alzheimer's disease, as validated in mouse models.

COMMUNICATIONS BIOLOGY (2022)

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Review Biochemistry & Molecular Biology

Emerging roles of neutrophils in immune homeostasis

Mingyu Lee et al.

Summary: Neutrophils, as the most abundant innate immune cells, play crucial roles in the immune response, including detecting pathogens, initiating immune cascades, and regulating adaptive immunity.

BMB REPORTS (2022)

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Article Immunology

Sphingosine kinase 1 promotes tumor immune evasion by regulating the MTA3-PD-L1 axis

Poyee Lau et al.

Summary: This study reveals the important role of SPHK1 in tumor immunity and shows that its inhibition can suppress tumor growth and promote antitumor immunity. Additionally, SPHK1 and MTA3 are identified as biological markers for predicting the efficacy of anti-PD-1 mAb therapy in melanoma patients.

CELLULAR & MOLECULAR IMMUNOLOGY (2022)

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Article Biochemistry & Molecular Biology

Upregulation of the serine palmitoyltransferase subunit SPTLC2 by endoplasmic reticulum stress inhibits the hepatic insulin response

Goon-Tae Kim et al.

Summary: The study found that ER stress can regulate the de novo biosynthesis of sphingolipids through the activation of serine palmitoyltransferase, leading to negative effects on hepatic insulin response. Understanding the mechanisms underlying insulin resistance is crucial for new treatments for metabolic diseases such as diabetes.

EXPERIMENTAL AND MOLECULAR MEDICINE (2022)

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Article Biochemistry & Molecular Biology

Mapping Sphingolipid Metabolism Pathways during Phagosomal Maturation

Neelay Mehendale et al.

Summary: This study elucidates the accumulation of ceramides during phagosomal maturation, highlighting the role of ceramide synthase 2 and the involvement of ceramidase activity. The findings indicate that lipid metabolism, especially the synthesis and metabolism of ceramides, plays a significant role in the process of phagocytosis and cellular detoxification.

ACS CHEMICAL BIOLOGY (2021)

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Article Oncology

Ceramide kinase mediates intrinsic resistance and inferior response to chemotherapy in triple-negative breast cancer by upregulating Ras/ERK and PI3K/Akt pathways

Shan Zhu et al.

Summary: The upregulation of ceramide kinase (CERK) has been identified as a biomarker for chemotherapeutic response in triple-negative breast cancer (TNBC), with overexpression promoting TNBC growth and migration, as well as conferring chemo-resistance. However, this resistance could be overcome through CERK inhibition.

CANCER CELL INTERNATIONAL (2021)

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Article Cell Biology

Neutrophil recruitment mediated by sphingosine 1-phosphate (S1P)/S1P receptors during chronic liver injury

Xinhao Zhao et al.

Summary: This study identified that in chronic liver inflammation, the S1P/S1PRs system plays a crucial role in the recruitment of neutrophils. S1P enhances the migration and cytoskeletal remodeling of bone marrow (BM) neutrophils through S1PR(1) and S1PR(2), while the migration and cytoskeletal remodeling of dHL60 cells are mainly mediated by S1PR(2) and S1PR(3). Blocking S1PR(2) significantly reduces neutrophil infiltration in bile duct ligation (BDL)-induced mouse liver injury.

CELLULAR IMMUNOLOGY (2021)

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Article Microbiology

Sphingomyelin Biosynthesis Is Essential for Phagocytic Signaling during Mycobacterium tuberculosis Host Cell Entry

Patrick Niekamp et al.

Summary: Phagocytosis by alveolar macrophages is the initial step in Mycobacterium tuberculosis (Mtb) infection. The process relies on an intact sphingolipid biosynthetic pathway, where disruption leads to reduced pathogen uptake. This pathway is crucial for the segregation of regulatory molecules and downstream activation of signaling molecules, highlighting a potential target for antimycobacterial therapeutics.

MBIO (2021)

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Article Biochemistry & Molecular Biology

Ceramide Synthase 2 Null Mice Are Protected from Ovalbumin-Induced Asthma with Higher T Cell Receptor Signal Strength in CD4+T Cells

Sun-Hye Shin et al.

Summary: This study revealed that CerS2 null mice showed milder symptoms and lower Th2 responses after OVA exposure. CerS2 null CD4+ T cells exhibited impaired Th2 and increased Th17 responses along with higher TCR signal strength post TCR stimulation, suggesting that CerS2 and very-long chain SLs could be therapeutic targets for Th2-related diseases like asthma.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Multidisciplinary Sciences

Monocyte-derived S1P in the lymph node regulates immune responses

Audrey Baeyens et al.

Summary: S1P regulates immune cell residence time in lymph nodes, affecting T cell differentiation and disease severity by modulating S1P receptor signaling.

NATURE (2021)

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Article Immunology

ORMDL3 Functions as a Negative Regulator of Antigen-Mediated Mast Cell Activation via an ATF6-UPR-Autophagy-Dependent Pathway

Jia Li et al.

Summary: ORMDL3 inhibits antigen-induced mast cell activation through regulating the ERS/UPR/autophagy pathway, providing a potential therapeutic target for allergic diseases.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Cell Biology

Autotaxin impedes anti-tumor immunity by suppressing chemotaxis and tumor infiltration of CD8+ T cells

Elisa Matas-Rico et al.

Summary: The study reveals that ATX secreted by melanoma cells repels tumor-infiltrating lymphocytes and circulating CD8(+) T cells, acting as a chaperone for LPA. Mechanistically, T cell repulsion is mainly involved G alpha(12/13)-coupled LPAR6, suppressing CD8(+) T cell infiltration and affecting tumor regression.

CELL REPORTS (2021)

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Review Oncology

Targeting Sphingolipids for Cancer Therapy

Osmel Companioni et al.

Summary: Sphingolipids play diverse roles in cell function, including in cancer progression. While targeting sphingolipids with drugs shows promise in preclinical studies, the results in clinical trials vary. Some drugs like fenretinide and alpha-GalCer are considered more effective, while others have limitations or adverse effects. Further research is needed to fully understand the therapeutic potential of sphingolipid modulation in cancer treatment.

FRONTIERS IN ONCOLOGY (2021)

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Article Dentistry, Oral Surgery & Medicine

Downregulation of ceramide synthase 1 promotes oral cancer through endoplasmic reticulum stress

Wen Chen et al.

Summary: The study found that the expression of ceramide synthase 1 is downregulated in oral cancer tissues and cell lines. Knockout of ceramide synthase 1 is associated with the severity of oral malignant transformation in a mouse model. Knockdown of ceramide synthase 1 promotes cell proliferation, migration, and invasion in vitro, possibly through inducing VEGFA upregulation via endoplasmic reticulum stress, leading to chemotherapeutic drug resistance.

INTERNATIONAL JOURNAL OF ORAL SCIENCE (2021)

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Article Multidisciplinary Sciences

Ceramide kinase regulates TNF-α-induced immune responses in human monocytic cells

Fatema Al-Rashed et al.

Summary: The study revealed that CERK plays a critical role in regulating inflammatory responses in human monocytes during TNF-alpha stimulation. Inhibition of CERK affected the expression of inflammatory markers and secretion of inflammatory factors, as well as reduced phosphorylation of JNK, p38, and NF-kappa B. Furthermore, NF-kappa B/AP-1 activity was suppressed by inhibition of CERK, suggesting CERK as a potential target for developing novel therapies for chronic inflammatory diseases.

SCIENTIFIC REPORTS (2021)

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Article Oncology

Neutral Sphingomyelinase 2 Heightens Anti-Melanoma Immune Responses and Anti-PD-1 Therapy Efficacy

Anne Montfort et al.

Summary: Dysregulation of lipid metabolism affects cancer cell behavior, and increasing SMPD3 expression can reduce melanoma growth and enhance Th1 polarization and CD8(+) T-cell-dependent immune responses.

CANCER IMMUNOLOGY RESEARCH (2021)

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Review Immunology

The Impact of Dietary Sphingolipids on Intestinal Microbiota and Gastrointestinal Immune Homeostasis

Johanna Rohrhofer et al.

Summary: The large surfaces of gastrointestinal organs are adapted to their tasks of nutritional uptake and defense, with immune cells within the mucosa regulating a balance to prevent inflammation. An increase in GI disorders in Western societies is linked to dietary changes and gut microbiome imbalance, leading to chronic inflammation. Understanding the mechanisms of immuno-nutrition and the impact of dietary compounds on gut immune homeostasis is essential for disease prevention and treatment.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Cell Biology

The Anti-Infectious Role of Sphingosine in Microbial Diseases

Yuqing Wu et al.

Summary: Sphingolipids play crucial roles in regulating pathobiological processes such as cancer, inflammation, and infectious diseases. Unlike ceramide which promotes microbial infections, sphingosine has bactericidal effects and is an important natural defense component against bacterial pathogens in the respiratory tract. Recent studies suggest that the bactericidal effect of sphingosine may be due to bacterial membrane permeabilization and subsequent bacterial death.

CELLS (2021)

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Review Biochemistry & Molecular Biology

The Functional Role of Sphingosine Kinase 2

Rocio Diaz Escarcega et al.

Summary: S1P, a bioactive lipid molecule synthesized by SPHK1 and SPHK2, plays key roles in various signaling pathways, with SPHK2 regulating processes in the nucleus and mitochondria. Investigation into SPHK2 as a target for age-associated conditions is ongoing.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

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Review Immunology

Dendritic cell migration in inflammation and immunity

Juan Liu et al.

Summary: Dendritic cells play crucial roles in immune defense and tolerance, but dysregulation of their migration can lead to immune imbalance and diseases. Researchers are exploring new strategies targeting the migration of distinct dendritic cell subsets for the treatment of related diseases.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

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Article Immunology

Regulatory T cells reduce endothelial neutral sphingomyelinase 2 to prevent T-cell migration into tumors

Paulina Akeus et al.

Summary: The study identified nSMase2 as a crucial mediator in endothelial cells that supports transendothelial migration, which can be targeted by Tregs to reduce T-cell migration into tumors.

EUROPEAN JOURNAL OF IMMUNOLOGY (2021)

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Article Multidisciplinary Sciences

Wild-type GBA1 increases the α-synuclein tetramer-monomer ratio, reduces lipid-rich aggregates, and attenuates motor and cognitive deficits in mice

Kelly E. Glajch et al.

Summary: Loss-of-function mutations in GBA1 are strong genetic risk factors for Lewy body disorders, enhancing GCase activity can improve αS dyshomeostasis and reduce lipid-rich aggregates, ameliorating PD-like phenotypes.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Article Cell Biology

A reference map of sphingolipids in murine tissues

Sneha Muralidharan et al.

Summary: This study utilized liquid chromatography coupled with mass spectrometry to compile a murine sphingolipid atlas, revealing the distribution of 114 SP species in different tissues and discovering tissue-specific and sex-specific differences. This comprehensive research provides insights into the role of sphingolipids in mammalian health and disease.

CELL REPORTS (2021)

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Article Microbiology

Staphylococcus aureus a-Toxin Induces Acid Sphingomyelinase Release From a Human Endothelial Cell Line

David Krones et al.

Summary: Staphylococcal alpha-toxin induces an increase in cytosolic Ca2+ and p38 MAPK phosphorylation in endothelial cells, accompanied by the release of lysosomal protein acid sphingomyelinase. This suggests that the toxin may trigger membrane repair mechanisms in endothelial cells similar to those observed in other cell types after damage by different toxins.

FRONTIERS IN MICROBIOLOGY (2021)

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Review Microbiology

Functions of Sphingolipids in Pathogenesis During Host-Pathogen Interactions

Jian Wang et al.

Summary: Sphingolipids are important signaling molecules in microbial pathogens' development and pathogenicity, regulating the balance between microbes and hosts. Bacteria and viruses can utilize host sphingolipids to promote infection, while sphingolipids are also involved in fungus-host interactions.

FRONTIERS IN MICROBIOLOGY (2021)

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Review Biochemistry & Molecular Biology

Metabolomics: A Scoping Review of Its Role as a Tool for Disease Biomarker Discovery in Selected Non-Communicable Diseases

Adewale Victor Aderemi et al.

Summary: Metabolomics is a branch of omics sciences that aims to identify and assess small molecules in samples for their diagnostic and therapeutic potentials. It has been utilized in various aspects of life and has shown potential in biomarker discovery for disease diagnosis and management. However, challenges remain in translating laboratory discoveries to clinical applications.

METABOLITES (2021)

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Article Chemistry, Organic

Azidosphinganine enables metabolic labeling and detection of sphingolipid de novo synthesis

Julian Fink et al.

Summary: This study demonstrates the use of biocompatible click chemistry, fluorescence microscopy, and mass spectrometry to investigate sphingolipid metabolism. By synthesizing an azide probe and conducting live-cell fluorescence imaging, the researchers identified the subcellular localization of synthetic analogues and analyzed metabolic breakdown products, providing insights into sphingolipid biosynthetic pathways.

ORGANIC & BIOMOLECULAR CHEMISTRY (2021)

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Article Immunology

Acid Ceramidase Rescues Cystic Fibrosis Mice from Pulmonary Infections

Katrin Anne Becker et al.

Summary: Genetic overexpression of acid ceramidase in cystic fibrosis mice increases immunity and protects against pulmonary infections with P. aeruginosa. Sphingosine has been shown to effectively kill pathogenic bacteria. Normalizing sphingosine levels in airway epithelial cells can prevent infections in cystic fibrosis patients.

INFECTION AND IMMUNITY (2021)

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Article Immunology

Rethinking peripheral T cell tolerance: checkpoints across a T cell's journey

Mohamed A. ElTanbouly et al.

Summary: The fate of T cells is controlled by a series of checkpoints, including quiescence, ignorance, anergy, exhaustion, senescence, and death, which regulate their immune quality and intensity. These checkpoints play important roles in maintaining T cell tolerance and preventing excessive inflammation.

NATURE REVIEWS IMMUNOLOGY (2021)

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Review Cell Biology

Mechanisms and regulation of cholesterol homeostasis

Jie Luo et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

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Review Oncology

Autotaxin Implication in Cancer Metastasis and Autoimunne Disorders: Functional Implication of Binding Autotaxin to the Cell Surface

Olivier Peyruchaud et al.

CANCERS (2020)

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Review Immunology

Finding a Way Out: S1P Signaling and Immune Cell Migration

Audrey A. L. Baeyens et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 38 (2020)

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Article Biochemistry & Molecular Biology

Sphingosine kills bacteria by binding to cardiolipin

Rabea Verhaegh et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2020)

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Article Multidisciplinary Sciences

Genetic deletion of Autotaxin from CD11b+ cells decreases the severity of experimental autoimmune encephalomyelitis

Ioanna Ninou et al.

PLOS ONE (2020)

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Article Multidisciplinary Sciences

Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease

Judith Lang et al.

NATURE COMMUNICATIONS (2020)

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Article Multidisciplinary Sciences

Sphingolipids produced by gut bacteria enter host metabolic pathways impacting ceramide levels

Elizabeth L. Johnson et al.

NATURE COMMUNICATIONS (2020)

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Review Immunology

Phagocytosis: Our Current Understanding of a Universal Biological Process

Eileen Uribe-Querol et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Immunology

Defensins: A Double-Edged Sword in Host Immunity

Dan Xu et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Cell Biology

Acid Sphingomyelinase Downregulation Enhances Mitochondrial Fusion and Promotes Oxidative Metabolism in a Mouse Model of Melanoma

Marco Coazzoli et al.

CELLS (2020)

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Article Biochemistry & Molecular Biology

CCR5 deficiency impairsCD4+T-cell memory responses and antigenic sensitivity through increased ceramide synthesis

Ana Martin-Leal et al.

EMBO JOURNAL (2020)

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Article Biochemistry & Molecular Biology

Sphingosine Kinases are Involved in Macrophage NLRP3 Inflammasome Transcriptional Induction

Shahzad Nawaz Syed et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Immunology

Macrophage Sphingosine 1-Phosphate Receptor 2 Blockade Attenuates Liver Inflammation and Fibrogenesis Triggered by NLRP3 Inflammasome

Lei Hou et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Cell Biology

Neurodegeneration Caused by S1P-Lyase Deficiency Involves Calcium-Dependent Tau Pathology and Abnormal Histone Acetylation

Shah Alam et al.

CELLS (2020)

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Article Multidisciplinary Sciences

Nanoscale imaging of bacterial infections by sphingolipid expansion microscopy

Ralph Goetz et al.

NATURE COMMUNICATIONS (2020)

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Review Pharmacology & Pharmacy

Ozanimod for Treatment of Relapsing-Remitting Multiple Sclerosis in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Yue Sun et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Article Medicine, Research & Experimental

Sphingosine kinase 2 restricts T cell immunopathology but permits viral persistence

Caleb J. Studstill et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

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Article Biochemistry & Molecular Biology

Inhibition of acid ceramidase regulates MHC class II antigen presentation and suppression of autoimmune arthritis

Dan Zhao et al.

CYTOKINE (2020)

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Review Immunology

Rethinking mucosal antibody responses: IgM, IgG and IgD join IgA

Kang Chen et al.

NATURE REVIEWS IMMUNOLOGY (2020)

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Review Immunology

Efferocytosis in health and disease

Amanda C. Doran et al.

NATURE REVIEWS IMMUNOLOGY (2020)

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Article Cell Biology

Mitochondrial dysfunction and mitophagy defect triggered by heterozygous GBA mutations

Hongyu Li et al.

AUTOPHAGY (2019)

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Article Cell Biology

Autotaxin-Lysophosphatidic Acid Axis Blockade Improves Inflammation by Regulating Th17 Cell Differentiation in DSS-Induced Chronic Colitis Mice

Ya-Lan Dong et al.

INFLAMMATION (2019)

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Review Nutrition & Dietetics

Circulating Saturated Fatty Acids and Incident Type 2 Diabetes: A Systematic Review and Meta-Analysis

Lihua Huang et al.

NUTRIENTS (2019)

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Article Neurosciences

Stimulation of Sphingosine Kinase 1 (SPHK1) Is Beneficial in a Huntington's Disease Pre-clinical Model

Alba Di Pardo et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2019)

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Article Cell Biology

Preclinical evidence of sphingosine kinase 1 inhibition in alleviation of intestinal epithelial injury in polymicrobial sepsis

Felix Nnaemeka Ugwu et al.

INFLAMMATION RESEARCH (2019)

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Article Immunology

T Cell-Specific Overexpression of Acid Sphingomyelinase Results in Elevated T Cell Activation and Reduced Parasitemia During Plasmodium yoelii Infection

Matthias Hose et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Review Immunology

Sphingosine-1-Phosphate and Macrophage Biology-How the Sphinx Tames the Big Eater

Andreas Weigert et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Medicine, General & Internal

Sphingomyelin synthase 1 enhances BCR signaling to promote lupus-like autoimmune response

Chenqiong Wang et al.

EBIOMEDICINE (2019)

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Review Neurosciences

Glucocerebrosidase and its relevance to Parkinson disease

Jenny Do et al.

MOLECULAR NEURODEGENERATION (2019)

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Article Cell Biology

Pro-Survival Lipid Sphingosine-1-Phosphate Metabolically Programs T Cells to Limit Anti-tumor Activity

Paramita Chakraborty et al.

CELL REPORTS (2019)

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Review Immunology

In vivo Differentiation of Human Monocytes

Alice Coillard et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Cell Biology

Monitoring the Sphingolipid de novo Synthesis by Stable-Isotope Labeling and Liquid Chromatography-Mass Spectrometry

Dominik Wigger et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2019)

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Article Biochemistry & Molecular Biology

Sphingolipid-mediated inflammatory signaling leading to autophagy inhibition converts erythropoiesis to myelopoiesis in human hematopoietic stem/progenitor cells

Marion Orsini et al.

CELL DEATH AND DIFFERENTIATION (2019)

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Article Neurosciences

Inhibition of sphingomyelin synthase 1 ameliorates alzheimer-like pathology in APP/PS1 transgenic mice through promoting lysosomal degradation of BACE1

Mei-Hong Lu et al.

EXPERIMENTAL NEUROLOGY (2019)

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Article Biochemistry & Molecular Biology

Autotaxin determines colitis severity in mice and is secreted by B cells in the colon

Songbai Lin et al.

FASEB JOURNAL (2019)

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Article Neurosciences

Lipid transporter Spns2 promotes microglia pro-inflammatory activation in response to amyloid-beta peptide

Liansheng Zhong et al.

GLIA (2019)

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Review Clinical Neurology

Fingolimod Rebound: A Review of the Clinical Experience and Management Considerations

Brian Barry et al.

NEUROLOGY AND THERAPY (2019)

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Article Medicine, Research & Experimental

PP2A enables IL-2 signaling by preserving IL-2Rβ chain expression during Treg development

Amir Sharabi et al.

JCI INSIGHT (2019)

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Article Immunology

CD4 T cell sphingosine 1-phosphate receptor (S1PR)1 and S1PR4 and endothelial S1PR2 regulate afferent lymphatic migration

Yanbao Xiong et al.

SCIENCE IMMUNOLOGY (2019)

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Review Cell Biology

Sphingolipids and their metabolism in physiology and disease

Yusuf A. Hannun et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

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Article Physiology

Neutrophil elastase increases airway ceramide levels via upregulation of serine palmitoyltransferase

Sophia Karandashova et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2018)

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Article Hematology

Novel Role of IL (Interleukin)-1β in Neutrophil Extracellular Trap Formation and Abdominal Aortic Aneurysms

Akshaya K. Meher et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2018)

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Article Pharmacology & Pharmacy

Knockout of Ceramide Kinase Aggravates Pathological and Lethal Responses in Mice with Experimental Colitis

Satomi Suzuki et al.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2018)

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Article Oncology

The Autotaxin-Lysophosphatidic Acid Axis Promotes Lung Carcinogenesis

Christiana Magkrioti et al.

CANCER RESEARCH (2018)

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Article Endocrinology & Metabolism

Ceramide Transporter CERT Is Involved in Muscle Insulin Signaling Defects Under Lipotoxic Conditions

Cecile L. Bandet et al.

DIABETES (2018)

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Article Biochemistry & Molecular Biology

Loss of acid ceramidase in myeloid cells suppresses intestinal neutrophil recruitment

Mel Pilar Espaillat et al.

FASEB JOURNAL (2018)

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Article Biochemistry & Molecular Biology

Hepatocyte-specific deletion of LASS2 protects against diet-induced hepatic steatosis and insulin resistance

Shaohua Fan et al.

FREE RADICAL BIOLOGY AND MEDICINE (2018)

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Article Gastroenterology & Hepatology

Sphingosine kinase 1 promotes liver fibrosis by preventing miR-19b-3p-mediated inhibition of CCR2

Tian Lan et al.

HEPATOLOGY (2018)

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Article Endocrinology & Metabolism

SPHK1-S1PR1-RANKL Axis Regulates the Interactions Between Macrophages and BMSCs in Inflammatory Bone Loss

Lan Xiao et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2018)

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Review Medicine, Research & Experimental

Role of sphingolipids in senescence: implication in aging and age-related diseases

Magali Trayssac et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

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Article Cell Biology

Sphingolipids role in the regulation of inflammatory response: From leukocyte biology to bacterial infection

Elena Chiricozzi et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2018)

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Article Multidisciplinary Sciences

Reactive astrocytic S1P3 signaling modulates the blood-tumor barrier in brain metastases

Brunilde Gril et al.

NATURE COMMUNICATIONS (2018)

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Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer's Disease

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NATURE COMMUNICATIONS (2018)

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Ceramide Synthase 6 Deficiency Enhances Inflammation in the DSS model of Colitis

Kristi Helke et al.

SCIENTIFIC REPORTS (2018)

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Triple Negative Breast Cancer Depends on Sphingosine Kinase 1 (SphK1)/Sphingosine-1-Phosphate (S1P)/Sphingosine 1-Phosphate Receptor 3 (S1PR3)/Notch Signaling for Metastasis

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MEDICAL SCIENCE MONITOR (2018)

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Article Cell Biology

Sphingosine 1-Phosphate (S1P)/S1P Receptor2/3 Axis Promotes Inflammatory M1 Polarization of Bone Marrow-Derived Monocyte/Macrophage via G(α)i/o/PI3K/JNK Pathway

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CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2018)

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Article Biochemistry & Molecular Biology

Deficiency of alkaline SMase enhances dextran sulfate sodium-induced colitis in mice with upregulation of autotaxin

Ping Zhang et al.

JOURNAL OF LIPID RESEARCH (2018)

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S1PR1 predicts patient survival and promotes chemotherapy drug resistance in gastric cancer cells through STAT3 constitutive activation

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EBIOMEDICINE (2018)

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Immune checkpoint inhibitors: recent progress and potential biomarkers

Pramod Darvin et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2018)

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ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY (2018)

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Sphingolipid metabolism in cancer signalling and therapy

Besim Ogretmen

NATURE REVIEWS CANCER (2018)

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Sphingosine kinase 1 expression enhances colon tumor growth

Hideki Furuya et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2017)

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The Role of Sphingosine-1-Phosphate and Ceramide-1-Phosphate in Inflammation and Cancer

Nitai C. Hait et al.

MEDIATORS OF INFLAMMATION (2017)

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Complement drives glucosylceramide accumulation and tissue inflammation in Gaucher disease

Manoj K. Pandey et al.

NATURE (2017)

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Lymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells

Alejandra Mendoza et al.

NATURE (2017)

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Blockade of Experimental Multiple Sclerosis by Inhibition of the Acid Sphingomyelinase/Ceramide System

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NEUROSIGNALS (2017)

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TLR-Induced SMPD3 Defects Enhance Inflammatory Response of B Cell and Macrophage in the Pathogenesis of SLE

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SCANDINAVIAN JOURNAL OF IMMUNOLOGY (2017)

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Comprehensive identification of sphingolipid species by in silico retention time and tandem mass spectral library

Hiroshi Tsugawa et al.

JOURNAL OF CHEMINFORMATICS (2017)

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Article Cell Biology

Plasma Dihydroceramides Are Diabetes Susceptibility Biomarker Candidates in Mice and Humans

Leonore Wigger et al.

CELL REPORTS (2017)

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Disrupting ceramide-CD300f interaction prevents septic peritonitis by stimulating neutrophil recruitment

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SCIENTIFIC REPORTS (2017)

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Defective Sphingosine-1-phosphate metabolism is a druggable target in Huntington's disease

Alba Di Pardo et al.

SCIENTIFIC REPORTS (2017)

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Regulation of Arthritis Severity by the Acid Sphingomyelinase

Nadine Beckmann et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2017)

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Enhanced Acid Sphingomyelinase Activity Drives Immune Evasion and Tumor Growth in Non-Small Cell Lung Carcinoma

Katerina Kachler et al.

CANCER RESEARCH (2017)

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Ceramide synthesis regulates T cell activity and GVHD development

M. Hanief Sofi et al.

JCI INSIGHT (2017)

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Acid Ceramidase Deficiency in Mice Results in a Broad Range of Central Nervous System Abnormalities

Jakub Sikora et al.

AMERICAN JOURNAL OF PATHOLOGY (2017)

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Targeting acid sphingomyelinase with anti-angiogenic chemotherapy

Jeanna Jacobi et al.

CELLULAR SIGNALLING (2017)

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Negative regulatory roles of ORMDL3 in the FcεRI-triggered expression of proinflammatory mediators and chemotactic response in murine mast cells

Viktor Bugajev et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2016)

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Article Immunology

Inhibition of Acid Sphingomyelinase Allows for Selective Targeting of CD4+ Conventional versus Foxp3+ Regulatory T Cells

Claudia Hollmann et al.

JOURNAL OF IMMUNOLOGY (2016)

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Article Surgery

High levels of sphingolipids in human breast cancer

Masayuki Nagahashi et al.

JOURNAL OF SURGICAL RESEARCH (2016)

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Phosphatase PP2A is requisite for the function of regulatory T cells

Sokratis A. Apostolidis et al.

NATURE IMMUNOLOGY (2016)

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Review Cell Biology

Metabolomics: beyond biomarkers and towards mechanisms

Caroline H. Johnson et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2016)

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Activation-Induced Cell Death of Dendritic Cells Is Dependent on Sphingosine Kinase 1

Anja Schwiebs et al.

FRONTIERS IN PHARMACOLOGY (2016)

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Article Anesthesiology

Sphingosine 1-phosphate Receptor 2 Signaling Suppresses Macrophage Phagocytosis and Impairs Host Defense against Sepsis

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ANESTHESIOLOGY (2015)

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Article Biochemistry & Molecular Biology

Pseudomonas aeruginosa Pyocyanin Induces Neutrophil Death via Mitochondrial Reactive Oxygen Species and Mitochondrial Acid Sphingomyelinase

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ANTIOXIDANTS & REDOX SIGNALING (2015)

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Review Biochemistry & Molecular Biology

Preclinical development of a C6-ceramide NanoLiposome, a novel sphingolipid therapeutic

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BIOLOGICAL CHEMISTRY (2015)

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Article Oncology

Regulation of cellular sphingosine-1-phosphate by sphingosine kinase 1 and sphingosine-1-phopshate lyase determines chemotherapy resistance in gastroesophageal cancer

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BMC CANCER (2015)

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Article Immunology

Lack of ceramide synthase 2 suppresses the development of experimental autoimmune encephalomyelitis by impairing the migratory capacity of neutrophils

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BRAIN BEHAVIOR AND IMMUNITY (2015)

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Article Biochemistry & Molecular Biology

Azide-Tagged Sphingolipids: New Tools for Metabolic Flux Analysis

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CHEMBIOCHEM (2015)

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Editorial Material Endocrinology & Metabolism

Therapeutic Window of Interleukin-2 for Autoimmune Diseases

Qizhi Tang

DIABETES (2015)

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Article Biochemistry & Molecular Biology

Tumor-induced inflammation in mammary adipose tissue stimulates a vicious cycle of autotaxin expression and breast cancer progression

Matthew G. K. Benesch et al.

FASEB JOURNAL (2015)

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Article Biochemistry & Molecular Biology

LPS-mediated septic shock is augmented in ceramide synthase 2 null mice due to elevated activity of TNFα-converting enzyme

Mohammad Ali et al.

FEBS LETTERS (2015)

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Article Cell Biology

Exacerbation of experimental autoimmune encephalomyelitis in ceramide synthase 6 knockout mice is associated with enhanced activation/migration of neutrophils

Max Eberle et al.

IMMUNOLOGY AND CELL BIOLOGY (2015)

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Review Biochemistry & Molecular Biology

Ceramide-Induced Apoptosis in Renal Tubular Cells: A Role of Mitochondria and Sphingosine-1-Phoshate

Norishi Ueda

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2015)

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Article Allergy

Aberrant ORM (yeast)-like protein isoform 3 (ORMDL3) expression dysregulates ceramide homeostasis in cells and ceramide exacerbates allergic asthma in mice

Clement Oyeniran et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2015)

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Macrophage-specific de Novo Synthesis of Ceramide Is Dispensable for Inflammasome-driven Inflammation and Insulin Resistance in Obesity

Christina D. Camell et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

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Review Cell Biology

Role of Sphingolipids in the Pathobiology of Lung Inflammation

Riccardo Ghidoni et al.

MEDIATORS OF INFLAMMATION (2015)

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Role of acid sphingomyelinase bioactivity in human CD4+ T-cell activation and immune responses

A. Bai et al.

CELL DEATH & DISEASE (2015)

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Disruption of Sphingolipid Biosynthesis Blocks Phagocytosis of Candida albicans

Fikadu G. Tafesse et al.

PLOS PATHOGENS (2015)

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Increased Dihydroceramide/Ceramide Ratio Mediated by Defective Expression of degs1 Impairs Adipocyte Differentiation and Function

Nuria Barbarroja et al.

DIABETES (2015)

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Gene: a gene-centered information resource at NCBI

Garth R. Brown et al.

NUCLEIC ACIDS RESEARCH (2015)

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Aggravation of Alzheimer's disease due to the COX-2-mediated reciprocal regulation of IL-1β and Aβ between glial and neuron cells

Pu Wang et al.

AGING CELL (2014)

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Article Endocrinology & Metabolism

ENPP2 Contributes to Adipose Tissue Expansion and Insulin Resistance in Diet-Induced Obesity

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DIABETES (2014)

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Article Allergy

Sphingosine-1-phosphate receptors control B-cell migration through signaling components associated with primary immunodeficiencies, chronic lymphocytic leukemia, and multiple sclerosis

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JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2014)

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Article Immunology

Acid sphingomyelinase modulates the autophagic process by controlling lysosomal biogenesis in Alzheimer's disease

Jong Kil Lee et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2014)

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Article Gastroenterology & Hepatology

ASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic steatohepatitis

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JOURNAL OF HEPATOLOGY (2014)

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CD39 and CD161 Modulate Th17 Responses in Crohn's Disease

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JOURNAL OF IMMUNOLOGY (2014)

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Review Biochemistry & Molecular Biology

An update on the biology of sphingosine 1-phosphate receptors

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JOURNAL OF LIPID RESEARCH (2014)

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Sphingolipid metabolites in inflammatory disease

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NATURE (2014)

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Immunohistochemical detection of sphingosine-1-phosphate receptor 1 and 5 in human multiple sclerosis lesions

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NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2014)

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Article Endocrinology & Metabolism

Acid sphingomyelinase plays a key role in palmitic acid-amplified inflammatory signaling triggered by lipopolysaccharide at low concentrations in macrophages

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AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2013)

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Sphingomyelin Synthase 2 Activity and Liver Steatosis: An Effect of Ceramide-Mediated Peroxisome Proliferator-Activated Receptor γ2 Suppression

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ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2013)

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Article Biochemistry & Molecular Biology

Ceramide mediates lung fibrosis in cystic fibrosis

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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2013)

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Article Biochemistry & Molecular Biology

PPARγ agonists upregulate sphingosine 1-phosphate (S1P) receptor 1 expression, which in turn reduces SIP-induced [Ca2+]i increases in renal mesangial cells

Alexander Koch et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2013)

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Macrophage PPAR gamma Co-activator-1 alpha participates in repressing foam cell formation and atherosclerosis in response to conjugated linoleic acid

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EMBO MOLECULAR MEDICINE (2013)

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Article Immunology

Apoptotic cells enhance sphingosine-1-phosphate receptor 1 dependent macrophage migration

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EUROPEAN JOURNAL OF IMMUNOLOGY (2013)

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Article Immunology

Defective sphingosine 1-phosphate receptor 1 (S1P1) phosphorylation exacerbates TH17-mediated autoimmune neuroinflammation

Christopher S. Garris et al.

NATURE IMMUNOLOGY (2013)

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Article Cell Biology

Impaired Sphingolipid Synthesis in the Respiratory Tract Induces Airway Hyperreactivity

Tilla S. Worgall et al.

SCIENCE TRANSLATIONAL MEDICINE (2013)

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Article Biochemistry & Molecular Biology

Neuronal Expression of Glucosylceramide Synthase in Central Nervous System Regulates Body Weight and Energy Homeostasis

Viola Nordstroem et al.

PLOS BIOLOGY (2013)

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Article Endocrinology & Metabolism

Ceramide Mediates Vascular Dysfunction in Diet-Induced Obesity by PP2A-Mediated Dephosphorylation of the eNOS-Akt Complex

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DIABETES (2012)

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Article Biochemistry & Molecular Biology

Ceramide kinase deficiency improves diet-induced obesity and insulin resistance

Susumu Mitsutake et al.

FEBS LETTERS (2012)

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Review Immunology

S1PR2 links germinal center confinement and growth regulation

Jesse A. Green et al.

IMMUNOLOGICAL REVIEWS (2012)

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Article Immunology

Autotaxin expression from synovial fibroblasts is essential for the pathogenesis of modeled arthritis

Ioanna Nikitopoulou et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2012)

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Article Endocrinology & Metabolism

Autotaxin and Its Product Lysophosphatidic Acid Suppress Brown Adipose Differentiation and Promote Diet-Induced Obesity in Mice

Lorenzo Federico et al.

MOLECULAR ENDOCRINOLOGY (2012)

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Article Endocrinology & Metabolism

Immunological cell type characterization and Th1-Th17 cytokine production in a mouse model of Gaucher disease

Manoj Kumar Pandey et al.

MOLECULAR GENETICS AND METABOLISM (2012)

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Review Pharmacology & Pharmacy

Drug targeting of sphingolipid metabolism: sphingomyelinases and ceramidases

Daniel Canals et al.

BRITISH JOURNAL OF PHARMACOLOGY (2011)

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Review Cell Biology

Ceramide kinase: The first decade

Frederic Bornancin

CELLULAR SIGNALLING (2011)

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Review Chemistry, Multidisciplinary

Sphingolipid and Glycosphingolipid Metabolic Pathways in the Era of Sphingolipidomics

Alfred H. Merrill

CHEMICAL REVIEWS (2011)

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Article Biochemistry & Molecular Biology

Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression

Yosuke Osawa et al.

FASEB JOURNAL (2011)

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Article Biochemistry & Molecular Biology

Sphingosine-1-phosphate Lyase Deficiency Produces a Pro-inflammatory Response While Impairing Neutrophil Trafficking

Maria L. Allende et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

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Article Biochemistry & Molecular Biology

Ceramide Kinase Regulates the Production of Tumor Necrosis Factor α (TNFα) via Inhibition of TNFα-converting Enzyme

Nadia F. Lamour et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

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Article Microbiology

DC-SIGN Mediated Sphingomyelinase-Activation and Ceramide Generation Is Essential for Enhancement of Viral Uptake in Dendritic Cells

Elita Avota et al.

PLOS PATHOGENS (2011)

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Article Cell Biology

Acid Sphingomyelinase Deficiency Attenuates Bleomycin-Induced Lung Inflammation and Fibrosis in Mice

Rajwinder Dhami et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2010)

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Review Biochemistry & Molecular Biology

Sphingomyelin metabolism at the plasma membrane: Implications for bioactive sphingolipids

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FEBS LETTERS (2010)

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Article Biochemistry & Molecular Biology

Sphingolipid-mediated Inhibition of Apoptotic Cell Clearance by Alveolar Macrophages

Daniela N. Petrusca et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

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Article Immunology

Ceramide and Ceramide 1-Phosphate Are Negative Regulators of TNF-α Production Induced by Lipopolysaccharide

Szczepan Jozefowski et al.

JOURNAL OF IMMUNOLOGY (2010)

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Article Biochemistry & Molecular Biology

A rapid and quantitative LC-MS/MS method to profile sphingolipids

Max Scherer et al.

JOURNAL OF LIPID RESEARCH (2010)

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Article Immunology

The S1P1-mTOR axis directs the reciprocal differentiation of TH1 and Treg cells

Guangwei Liu et al.

NATURE IMMUNOLOGY (2010)

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Review Biotechnology & Applied Microbiology

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

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NATURE REVIEWS DRUG DISCOVERY (2010)

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Article Multidisciplinary Sciences

Role of Sphingomyelin Synthase in Controlling the Antimicrobial Activity of Neutrophils against Cryptococcus neoformans

Asfia Qureshi et al.

PLOS ONE (2010)

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Article Biochemistry & Molecular Biology

Defective Acid Sphingomyelinase Pathway with Pseudomonas aeruginosa Infection in Cystic Fibrosis

Hong Yu et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2009)

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Article Biochemistry & Molecular Biology

Ceramide 1-phosphate inhibits serine palmitoyltransferase and blocks apoptosis in alveolar macrophages

Maria H. Granado et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2009)

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Article Oncology

Disruption of Sphingosine 1-Phosphate Lyase Confers Resistance to Chemotherapy and Promotes Oncogenesis through Bcl-2/Bcl-xL Upregulation

Sandra Colie et al.

CANCER RESEARCH (2009)

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Article Immunology

The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR

Guangwei Liu et al.

NATURE IMMUNOLOGY (2009)

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Article Immunology

Acid sphingomyelinase is a key regulator of cytotoxic granule secretion by primary T lymphocytes

Jasmin Herz et al.

NATURE IMMUNOLOGY (2009)

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Article Hematology

Ceramide induces p38 MAPK and JNK activation through a mechanism involving a thioredoxin-interacting protein-mediated pathway

Chia-Ling Chen et al.

BLOOD (2008)

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Article Immunology

Neutropenia with impaired immune response to Streptococcus pneumoniae in ceramide kinase-deficient mice

Christine Graf et al.

JOURNAL OF IMMUNOLOGY (2008)

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Article Immunology

Acid sphingomyelinase amplifies redox signaling in Pseudomonas aeruginosa-induced macrophage apoptosis

Yang Zhang et al.

JOURNAL OF IMMUNOLOGY (2008)

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Review Immunology

Mucins in the mucosal barrier to infection

S. K. Linden et al.

MUCOSAL IMMUNOLOGY (2008)

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Article Biochemistry & Molecular Biology

Acidic extracellular pH increases calcium influx-triggered phospholipase D activity along with acidic sphingomyelinase activation to induce matrix metalloproteinase-9 expression in mouse metastatic melanoma

Yasumasa Kato et al.

FEBS JOURNAL (2007)

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Article Cell Biology

De novo C16- and C24-ceramide generation contributes to spontaneous neutrophil apoptosis

Gregory Seumois et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2007)

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Article Cell Biology

Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance

William L. Holland et al.

CELL METABOLISM (2007)

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Article Biochemistry & Molecular Biology

Sphingosine 1-phosphate as a regulator of osteoclast differentiation and osteoclast-osteoblast coupling

Jiyoon Ryu et al.

EMBO JOURNAL (2006)

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Article Multidisciplinary Sciences

Sphingosine-1-phosphate lyase potentiates apoptosis via p53-and p38-dependent pathways and is down-regulated in colon cancer

Babak Oskouian et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

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Article Biochemistry & Molecular Biology

Ceramides reduce CD36 cell surface expression and oxidised LDL uptake by monocytes and macrophages

Yingjun Luan et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2006)

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Article Immunology

Sphingosine kinase and sphingosine-1-phosphate regulate migration, endocytosis and apoptosis of dendritic cells

S Eigenbrod et al.

IMMUNOLOGICAL INVESTIGATIONS (2006)

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Article Cell Biology

Ceramide catabolism critically controls survival of human dendritic cells

L Franchi et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2006)

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Article Biochemistry & Molecular Biology

Ceramide 1-phosphate, a mediator of phagocytosis

V Hinkovska-Galcheva et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

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Article Biochemistry & Molecular Biology

Role of increased sphingomyelinase activity in apoptosis and organ failure of patients with severe sepsis

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