期刊
NAR GENOMICS AND BIOINFORMATICS
卷 5, 期 1, 页码 -出版社
OXFORD UNIV PRESS
DOI: 10.1093/nargab/lqad025
关键词
-
The nuclear pore complex exhibits different manifestations across eukaryotes, with certain components being restricted to specific clades. Using extensive data collection, we create a robust library of nucleoporin protein sequences and their respective family-specific position-specific scoring matrices that can be used to detect nucleoporins in proteomes with high sensitivity and specificity compared to existing methods.
The nuclear pore complex exhibits different manifestations across eukaryotes, with certain components being restricted to specific clades. Several studies have been conducted to delineate the nuclear pore complex composition in various model organisms. Due to its pivotal role in cell viability, traditional lab experiments, such as gene knockdowns, can prove inconclusive and need to be complemented by a high-quality computational process. Here, using an extensive data collection, we create a robust library of nucleoporin protein sequences and their respective family-specific position-specific scoring matrices. By extensively validating each profile in different settings, we propose that the created profiles can be used to detect nucleoporins in proteomes with high sensitivity and specificity compared to existing methods. This library of profiles and the underlying sequence data can be used for the detection of nucleoporins in target proteomes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据