4.6 Article

Synthesis and anticancer properties of dendritic glycoconjugates containing multiple o-carborane clusters

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Summary: The recruitment of natural antibodies present in human blood stream to the surface of cancer cells has shown promise in immunotherapy against cancer. A new approach combining cell metabolism of azido-sugar and bio-orthogonal click chemistry to conjugate structurally defined glycodendrimers as antibody binding modules has been demonstrated to recruit antibodies to target cells and activate a cytotoxic response.

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