4.5 Article

Dupuytren's contracture-associated SNPs increase SFRP4 expression in non-immune cells including fibroblasts to enhance inflammation development

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Evaluation of WNT Signaling Pathway Gene Variants WNT7B rs6519955, SFRP4 rs17171229 and RSPO2 rs611744 in Patients with Dupuytren's Contracture

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Summary: The study found that the WNT7B rs6519955 genotype TT increases the likelihood of developing Dupuytren's contracture, while the RSPO2 rs611744 genotype GG may decrease the likelihood of disease manifestation. The SFRP4 rs17171229 genotype appears to not be significantly associated with the development of Dupuytren's contracture.
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