期刊
EUROPEAN RADIOLOGY
卷 -, 期 -, 页码 -出版社
SPRINGER
DOI: 10.1007/s00330-023-09812-9
关键词
Carcinoma; renal cell; Machine learning; Deep learning; Decision-making; Nephrectomy
A retrospective study was conducted to determine the accuracy of using 3D-CT multi-level anatomical features in predicting surgical decision-making for renal cell carcinoma. The study found that the combination of multi-level features outperformed single-level features in predicting partial or radical nephrectomy. The automated surgical decision framework based on 3D-CT multi-level anatomical features showed robust performance in guiding surgery for renal cell carcinoma.
Objectives To determine whether 3D-CT multi-level anatomical features can provide a more accurate prediction of surgical decision-making for partial or radical nephrectomy in renal cell carcinoma. Methods This is a retrospective study based on multi-center cohorts. A total of 473 participants with pathologically proved renal cell carcinoma were split into the internal training and the external testing set. The training set contains 412 cases from five open-source cohorts and two local hospitals. The external testing set includes 61 participants from another local hospital. The proposed automatic analytic framework contains the following modules: a 3D kidney and tumor segmentation model constructed by 3D-UNet, a multi-level feature extractor based on the region of interest, and a partial or radical nephrectomy prediction classifier by XGBoost. The fivefold cross-validation strategy was used to get a robust model. A quantitative model interpretation method called the Shapley Additive Explanations was conducted to explore the contribution of each feature. Results In the prediction of partial versus radical nephrectomy, the combination of multi-level features achieved better performance than any single-level feature. For the internal validation, the AUROC was 0.93 +/- 0.1, 0.94 +/- 0.1, 0.93 +/- 0.1, 0.93 +/- 0.1, and 0.93 +/- 0.1, respectively, as determined by the fivefold cross-validation. The AUROC from the optimal model was 0.82 +/- 0.1 in the external testing set. The tumor shape Maximum 3D Diameter plays the most vital role in the model decision. Conclusions The automated surgical decision framework for partial or radical nephrectomy based on 3D-CT multi-level anatomical features exhibits robust performance in renal cell carcinoma. The framework points the way towards guiding surgery through medical images and machine learning.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据