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Expectant Management or Early Ibuprofen for Patent Ductus Arteriosus

NEW ENGLAND JOURNAL OF MEDICINE (2023)

Oral Ibuprofen Is More Effective than Intravenous Ibuprofen for Closure of a Patent Ductus Arteriosus: Can Pharmacokinetic Modeling Help Us to Understand Why?

Cornelis Smit et al.

Summary: This study explores the mechanism behind the greater effectiveness of oral ibuprofen compared to intravenous ibuprofen in closing a patent ductus arteriosus. The results show that after oral dosing, the concentration of the biologically active S-enantiomer is lower for a significant portion of the dosing interval. The study also indicates that R- to S-conversion does not exceed 45%.

NEONATOLOGY (2023)

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Article Medicine, General & Internal

Expectant Management or Early Ibuprofen for Patent Ductus Arteriosus

Tim Hundscheid et al.

Summary: This trial showed that in the treatment of PDA in extremely preterm infants, expectant management was noninferior to early ibuprofen treatment in terms of necrotizing enterocolitis, bronchopulmonary dysplasia, or death at 36 weeks' postmenstrual age.

NEW ENGLAND JOURNAL OF MEDICINE (2023)

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Editorial Material Pediatrics

Acetaminophen and the Developing Lung: Could There Be Lifelong Consequences? COMMENT

Clyde J. Wright

JOURNAL OF PEDIATRICS (2021)

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Article Pediatrics

Understanding the pathobiology in patent ductus arteriosus in prematurity-beyond prostaglandins and oxygen

Tim Hundscheid et al.

PEDIATRIC RESEARCH (2019)

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Article Pediatrics

Early treatment versus expectative management of patent ductus arteriosus in preterm infants: a multicentre, randomised, non-inferiority trial in Europe (BeNeDuctus trial)

Tim Hundscheid et al.

BMC PEDIATRICS (2018)

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Expectant Management or Early Ibuprofen for Patent Ductus Arteriosus

相关参考文献

Oral Ibuprofen Is More Effective than Intravenous Ibuprofen for Closure of a Patent Ductus Arteriosus: Can Pharmacokinetic Modeling Help Us to Understand Why?

Expectant Management or Early Ibuprofen for Patent Ductus Arteriosus

Acetaminophen and the Developing Lung: Could There Be Lifelong Consequences? COMMENT

Understanding the pathobiology in patent ductus arteriosus in prematurity-beyond prostaglandins and oxygen

Early treatment versus expectative management of patent ductus arteriosus in preterm infants: a multicentre, randomised, non-inferiority trial in Europe (BeNeDuctus trial)

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