Phosphatase Ssu72 Is Essential for Homeostatic Balance Between CD4+T Cell Lineages

Ssu72, a dual-specificity protein phosphatase, not only participates in transcription biogenesis, but also affects pathophysiological functions in a tissue-specific manner. Recently, it has been shown that Ssu72 is required for T cell differentiation and function by controlling multiple immune receptor-mediated signals, including TCR and several cytokine receptor signaling pathways. Ssu72 deficiency in T cells is associated with impaired fine-tuning of receptor -mediated signaling and a defect in CD4+ T cell homeostasis, resulting in immune-mediated diseases. However, the mechanism by which Ssu72 in T cells integrates the pathophysiology of multiple immune-mediated diseases is still poorly elucidated. In this review, we will focus on the immunoregulatory mechanism of Ssu72 phosphatase in CD4+ T cell differentiation, activation, and phenotypic function. We will also discuss the current understanding of the correlation between Ssu72 in T cells and pathological functions which suggests that Ssu72 might be a therapeutic target in autoimmune disorders and other diseases.

Automated summary

Ssu72 is a dual-specificity protein phosphatase that participates in transcription biogenesis and affects pathophysiological functions in a tissue-specific manner. It has been shown that Ssu72 is required for T cell differentiation and function by controlling multiple immune receptor-mediated signals. The mechanism by which Ssu72 integrates the pathophysiology of multiple immune-mediated diseases is still poorly understood.