4.7 Article

Construction of three contiguous stereocenters through amine-catalyzed asymmetric aldol reactions

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CHEMICAL COMMUNICATIONS
卷 59, 期 54, 页码 8424-8427

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ROYAL SOC CHEMISTRY
DOI: 10.1039/d3cc01606d

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Three contiguous stereocenters were formed through an amino acid-catalyzed asymmetric aldol reaction between alpha-siloxyketones and racemizable alpha-haloaldehydes via dynamic kinetic resolution. The highly functionalized products can also be synthesized in a one-pot catalytic asymmetric manner by alpha-bromination of simple aldehydes followed by the asymmetric aldol reaction.
Three contiguous stereocenters were constructed by an amino acid-catalyzed asymmetric aldol reaction of alpha-siloxyketones with racemizable alpha-haloaldehydes via dynamic kinetic resolution. One-pot catalytic asymmetric synthesis of the highly functionalized products could also be accomplished by the alpha-bromination of simple aldehydes and the subsequent asymmetric aldol reaction.

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