4.7 Review

Advances in cutaneous squamous cell carcinoma

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Review Pathology

Cutaneous Squamous Cell Carcinoma: The Frontier of Cancer Immunoprevention

Michael S. Chang et al.

Summary: Cutaneous squamous cell carcinoma (cSCC) is the second most common cancer, and immunosuppression is a significant risk factor. The immune system plays a critical role in regulating cSCC development and progression, and age-related immunosenescence is closely associated with cSCC risk. In addition to immune checkpoint blockade therapy, novel immunotherapy and the development of a preventive cSCC vaccine show promise in cSCC prevention and may have implications for other epithelial cancers, such as mucosal SCCs.

ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2022)

Article Dermatology

A 10-year retrospective cohort study of ruxolitinib and association with nonmelanoma skin cancer in patients with polycythemia vera and myelofibrosis

John Q. Lin et al.

Summary: This study systematically assessed the risk of developing nonmelanoma skin cancers (NMSCs) after ruxolitinib exposure in patients with polycythemia vera (PV) or myelofibrosis (MF). The results showed that ruxolitinib exposure is associated with an increased risk of squamous cell carcinoma (SCC) in PV or MF patients, particularly in non Janus kinase 2-mutated patients.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2022)

Letter Dermatology

Treatment of Cutaneous Squamous Cell Carcinoma With the Topical Histone Deacetylase Inhibitor Remetinostat

James M. Kilgour et al.

Summary: This case series study investigates the use of the histone deacetylase inhibitor remetinostat in the treatment of patients with squamous cell carcinoma.

JAMA DERMATOLOGY (2022)

Article Dermatology

Low-Dose Acitretin for Secondary Prevention of Keratinocyte Carcinomas in Solid-Organ Transplant Recipients

Efrat Solomon-Cohen et al.

Summary: Low-dose acitretin treatment in SOTRs has shown to significantly reduce the number of new keratinocyte carcinomas, including both SCC and basal cell carcinoma, indicating its positive effect as a chemoprevention method in this population.

DERMATOLOGY (2022)

Article Oncology

Enhanced metastatic risk assessment in cutaneous squamous cell carcinoma with the 40-gene expression profile test

Sherrif F. Ibrahim et al.

Summary: This study validates the prognostic value of the 40-GEP test for cutaneous squamous cell carcinoma patients and demonstrates that integrating the test with clinicopathologic risk factor assessment methods can improve risk classification, potentially informing risk-appropriate management strategies for patients.

FUTURE ONCOLOGY (2022)

Article Dermatology

Cohort and nested case-control study of cutaneous squamous cell carcinoma in solid organ transplant recipients, by medication

Jennifer R. Dusendang et al.

Summary: This study aimed to evaluate the risk of cutaneous squamous cell carcinoma (cSCC) in solid organ transplant recipients (SOTRs) using immunosuppressive medications. The results showed that the annual incidence of cSCC was higher in SOTRs compared to persons without transplantation. Lung transplant and the use of voriconazole were associated with an increased risk of cSCC, while belatacept and other immunosuppressive medications were not.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2022)

Review Oncology

The Aryl Hydrocarbon Receptor in the Pathogenesis of Environmentally-Induced Squamous Cell Carcinomas of the Skin

Christian Vogeley et al.

Summary: This article summarizes the role of AHR in skin carcinogenesis, focusing on its impact on defense mechanisms such as DNA repair, apoptosis, and anti-tumor immune responses, as well as the possible consequences of simultaneous exposure to different AHR-stimulating environmental factors on the development of cutaneous SCC.

FRONTIERS IN ONCOLOGY (2022)

Article Biology

Genome-wide association study of actinic keratosis identifies new susceptibility loci implicated in pigmentation and immune regulation pathways

Yuhree Kim et al.

Summary: A study on actinic keratosis identified multiple loci showing significant association with implicated genes within biological pathways related to pigmentation, immune regulation, and tissue homeostasis. The findings provide novel insight into the genetics and pathogenesis of actinic keratosis susceptibility.

COMMUNICATIONS BIOLOGY (2022)

Article Dermatology

Defining the Molecular Landscape of Cancer-Associated Stroma in Cutaneous Squamous Cell Carcinoma

Erin Beebe et al.

Summary: This study analyzes the molecular landscape of cancer-associated stroma (CAS) in cutaneous squamous cell carcinoma (cSCC) and identifies changes in immune cells and the influence of perineural infiltration (PNI) on CAS. The results demonstrate immune exhaustion markers in CAS of cSCC and an increase in IL-17A with PNI. These findings support further research on immunotherapy and anti-IL-17A in cSCC, particularly for cases with PNI.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2022)

Editorial Material Biochemistry & Molecular Biology

A new phase of the Cancer Moonshot to end cancer as we know it

Dinah S. Singer

NATURE MEDICINE (2022)

Article Medicine, General & Internal

Neoadjuvant Cemiplimab for Stage II to IV Cutaneous Squamous-Cell Carcinoma

N. D. Gross et al.

Summary: This study evaluated the efficacy of cemiplimab as neoadjuvant therapy for resectable cutaneous squamous-cell carcinoma. The results showed a high percentage of patients achieved a pathological complete response with this treatment approach.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

Article Dermatology

Validation of a 40-gene expression profile test to predict metastatic risk in localized high-risk cutaneous squamous cell carcinoma

Ashley Wysong et al.

Summary: A gene expression profile (GEP) test was developed and validated to predict metastasis risk in high-risk cutaneous squamous cell carcinoma (cSCC) patients, improving risk-directed patient management.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2021)

Article Multidisciplinary Sciences

Fat1 deletion promotes hybrid EMT state, tumour stemness and metastasis

Ievgenia Pastushenko et al.

Summary: This study reveals that mutation of the FAT1 gene promotes tumor initiation, progression, invasiveness, stemness, and metastasis. Loss of function of FAT1 activates a CAMK2-CD44-SRC axis while inactivates EZH2, playing important roles in the expression of YAP1 and ZEB1.

NATURE (2021)

Article Biochemistry & Molecular Biology

Mutant collagen COL11A1 enhances cancerous invasion

Carolyn S. Lee et al.

Summary: The study revealed mutations in COL11A1 gene in common cutaneous squamous cell carcinomas, which accelerate the process of cancer cell invasion, suggesting that mutant collagens may play a crucial role in cancer development.

ONCOGENE (2021)

Letter Dermatology

Field cancerization in the skin: Past errors repeated

Sarah Morton et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2021)

Article Dermatology

Epigenetic and metabolic interplay in cutaneous squamous cell carcinoma

Gina Pacella et al.

Summary: With the ageing population and increased recreational sun exposure and immunosuppression, cutaneous squamous cell carcinoma is a significant clinical and economic issue. Despite advances in therapy, new research suggests that epigenetic and metabolic dysregulation may be critical contributors to cSCC pathogenesis and potential therapeutic approaches.

EXPERIMENTAL DERMATOLOGY (2021)

Article Medicine, Research & Experimental

HSD17B7 gene in self-renewal and oncogenicity of keratinocytes from Black versus White populations

Xiaoying Xu et al.

Summary: The study found that human populations of Black African ancestry have a higher risk of aggressive cancer types, with their keratinocytes showing higher oncogenic potential and lower mitochondrial activity. The gene HSD17B7 is significantly differentially expressed in Black African individuals with SCCs, with ancestry-specific genetic variants linked to its expression. These findings suggest a targetable determinant of cancer susceptibility among different human populations.

EMBO MOLECULAR MEDICINE (2021)

Article Multidisciplinary Sciences

Chronic UV radiation-induced RORγt+ IL-22-producing lymphoid cells are associated with mutant KC clonal expansion

Julia M. Lewis et al.

Summary: Chronic UV exposure leads to a shift in the immune response towards ROR gamma t+ IL-22/IL-17A-producing cells, which are associated with mutant KC growth, and targeting these immune components may represent potential strategies for skin cancer prevention.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Article Multidisciplinary Sciences

Gene expression profiling of perineural invasion in head and neck cutaneous squamous cell carcinoma

Timothy J. Eviston et al.

Summary: Perineural invasion in head and neck cutaneous squamous cell carcinoma is associated with aggressive clinical behaviors leading to local recurrence and treatment failure. Gene expression analysis found significant up- and down-regulation of 144 genes in HNcSCC with extensive PNI, while focal and non PNI cohorts showed indistinguishable gene expression. A tailored panel of 10 genes was able to identify extensive PNI with high sensitivity and specificity.

SCIENTIFIC REPORTS (2021)

Review Oncology

Immunotherapy for the Treatment of Cutaneous Squamous Cell Carcinoma

Andrea Boutros et al.

Summary: Cutaneous squamous cell carcinoma (CSCC) constitutes 20% of all keratinocytic tumors, with most cases being small and low-risk lesions, but 5% may progress to locally advanced or metastatic. The introduction of immunotherapy has provided new treatment options for advanced CSCC, showing encouraging results.

FRONTIERS IN ONCOLOGY (2021)

Article Genetics & Heredity

The landscape of driver mutations in cutaneous squamous cell carcinoma

Darwin Chang et al.

Summary: Cutaneous squamous cell carcinoma originates from keratinocytes in the skin and is characterized by high mutation burden primarily caused by UV-induced DNA damage. Through meta-analysis of sequencing data, multiple driver genes were identified, offering potential therapeutic targets and insights into the biology of this type of skin cancer.

NPJ GENOMIC MEDICINE (2021)

Review Dermatology

Molecular genetics of cutaneous squamous cell carcinoma: perspective for treatment strategies

L. Di Nardo et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2020)

Article Multidisciplinary Sciences

Genome-wide meta-analysis identifies eight new susceptibility loci for cutaneous squamous cell carcinoma

Kavita Y. Sarin et al.

NATURE COMMUNICATIONS (2020)

Article Dermatology

Field cancerization: Definition, epidemiology, risk factors, and outcomes

Tyler J. Willenbrink et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2020)

Article Multidisciplinary Sciences

NOTCH1 gene amplification promotes expansion of Cancer Associated Fibroblast populations in human skin

Atul Katarkar et al.

NATURE COMMUNICATIONS (2020)

Article Dermatology

Intralesional 5-fluorouracil for the treatment of squamous cell carcinomas

Luke Maxfield. et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2020)

Article Oncology

A framework for advancing our understanding of cancer-associated fibroblasts

Erik Sahai et al.

NATURE REVIEWS CANCER (2020)

Article Oncology

Cutaneous Squamous Cell Carcinoma

Abigail Waldman et al.

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA (2019)

Article Dermatology

Risk factors for keratinocyte carcinoma skin cancer in nonwhite individuals: A retrospective analysis

Kumar S. Nadhan et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2019)

Article Biochemistry & Molecular Biology

Adaptive Immune Resistance Emerges from Tumor-Initiating Stem Cells

Yuxuan Miao et al.

Review Biochemistry & Molecular Biology

The Role of the Immune System in Cutaneous Squamous Cell Carcinoma

Matthew J. Bottomley et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Biochemistry & Molecular Biology

Targeted Therapy Against the Cell of Origin in Cutaneous Squamous Cell Carcinoma

Stephen J. Goldie et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Biochemistry & Molecular Biology

Clonal replacement of tumor-specific T cells following PD-1 blockade

Kathryn E. Yost et al.

NATURE MEDICINE (2019)

Review Oncology

Cancer-associated fibroblasts: an emerging target of anti-cancer immunotherapy

Tongyan Liu et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)

Review Dermatology

Actinic keratoses: review of clinical, dermoscopic, and therapeutic aspects

Clarissa Prieto Herman Reinehr et al.

ANAIS BRASILEIROS DE DERMATOLOGIA (2019)

Article Multidisciplinary Sciences

Immunity to commensal papillomaviruses protects against skin cancer

John D. Strickley et al.

NATURE (2019)

Article Dermatology

Nationwide Incidence of Metastatic Cutaneous Squamous Cell Carcinoma in England

Zoe C. Venables et al.

JAMA DERMATOLOGY (2019)

Article Biochemistry & Molecular Biology

The AHR represses nucleotide excision repair and apoptosis and contributes to UV-induced skin carcinogenesis

Marius Pollet et al.

CELL DEATH AND DIFFERENTIATION (2018)

Review Medicine, General & Internal

Behavioral Counseling to Prevent Skin Cancer US Preventive Services Task Force Recommendation Statement

David C. Grossman et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2018)

Review Medicine, Research & Experimental

Fibroblast heterogeneity: implications for human disease

Magnus D. Lynch et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

Article Dermatology

Subclonal Evolution of Cancer-Related Gene Mutations in p53 Immunopositive Patches in Human Skin

Amel A. Albibas et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2018)

Article Dermatology

Cutaneous squamous cell carcinoma Incidence, risk factors, diagnosis, and staging

Syril Keena T. Que et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2018)

Article Dermatology

Guidelines of care for the management of cutaneous squamous cell carcinoma

Murad Alam et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2018)

Article Biochemistry & Molecular Biology

Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing

Xinyi Guo et al.

NATURE MEDICINE (2018)

Article Medicine, General & Internal

PD-1 Blockade with Cemiplimab in Advanced Cutaneous Squamous-Cell Carcinoma

M. R. Migden et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Multidisciplinary Sciences

Methylation profiling identifies two subclasses of squamous cell carcinoma related to distinct cells of origin

Manuel Rodriguez-Paredes et al.

NATURE COMMUNICATIONS (2018)

Article Immunology

The human CIB1-EVER1-EVER2 complex governs keratinocyte-intrinsic immunity to β-papillomaviruses

Sarah Jill de Jong et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2018)

Review Medicine, General & Internal

Update on Keratinocyte Carcinomas

Kishwer S. Nehal et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Multidisciplinary Sciences

The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature

Gareth J. Inman et al.

NATURE COMMUNICATIONS (2018)

Article Multidisciplinary Sciences

Lineage tracking reveals dynamic relationships of T cells in colorectal cancer

Lei Zhang et al.

NATURE (2018)

Review Oncology

Deciphering the cells of origin of squamous cell carcinomas

Adriana Sanchez-Danes et al.

NATURE REVIEWS CANCER (2018)

Article Surgery

Voriconazole and squamous cell carcinoma after lung transplantation: A multicenter study

B. Hamandi et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2018)

Review Dermatology

Reflectance confocal microscopy of skin in vivo: From bench to bedside

Milind Rajadhyaksha et al.

LASERS IN SURGERY AND MEDICINE (2017)

Article Biochemistry & Molecular Biology

Kindlin-1 protects cells from oxidative damage through activation of ERK signalling

Hila Emmert et al.

FREE RADICAL BIOLOGY AND MEDICINE (2017)

Article Dermatology

Survival of Patients with Cutaneous Squamous Cell Carcinoma: Results of a Prospective Cohort Study

Thomas K. Eigentler et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2017)

Article Dermatology

Gefitinib for patients with incurable cutaneous squamous cell carcinoma: A single-arm phase II clinical trial

William N. William et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2017)

Article Medicine, General & Internal

The incidence and multiplicity rates of keratinocyte cancers in Australia

Nirmala Pandeya et al.

MEDICAL JOURNAL OF AUSTRALIA (2017)

Article Multidisciplinary Sciences

Dermatologist-level classification of skin cancer with deep neural networks

Andre Esteva et al.

NATURE (2017)

Article Multidisciplinary Sciences

Inflammatory memory sensitizes skin epithelial stem cells to tissue damage

Shruti Naik et al.

NATURE (2017)

Article Genetics & Heredity

Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden

Zachary R. Chalmers et al.

GENOME MEDICINE (2017)

Review Dermatology

Cutaneous squamous cell carcinoma: an epidemiological review

A. C. Green et al.

BRITISH JOURNAL OF DERMATOLOGY (2017)

Article Biochemistry & Molecular Biology

HPV16 E7 Genetic Conservation Is Critical to Carcinogenesis

Lisa Mirabello et al.

Article Biochemistry & Molecular Biology

Landscape of Infiltrating T Cells in Liver Cancer Revealed by Single-Cell Sequencing

Chunhong Zheng et al.

Article Dermatology

Neoadjuvant intralesional methotrexate in cutaneous squamous cell carcinoma: a comparative cohort study

R. Salido-Vallejo et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2016)

Review Dermatology

The Promise of Genomics and the Development of Targeted Therapies for Cutaneous Squamous Cell Carcinoma

Catherine A. Harwood et al.

ACTA DERMATO-VENEREOLOGICA (2016)

Review Genetics & Heredity

Protein oxidation, UVA and human DNA repair

Peter Karran et al.

DNA REPAIR (2016)

Review Medicine, General & Internal

Screening for Skin Cancer US Preventive Services Task Force Recommendation Statement

Kirsten Bibbins-Domingo et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2016)

Article Dermatology

PD-L1 expression in cutaneous squamous cell carcinoma correlates with risk of metastasis

Nathaniel A. Slater et al.

JOURNAL OF CUTANEOUS PATHOLOGY (2016)

Review Dermatology

Intralesional 5-fluorouracil (FU) as a treatment for nonmelanoma skin cancer (NMSC): A review

Lauren Metterle et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2016)

Article Dermatology

Occupation and relative risk of cutaneous squamous cell carcinoma (cSCC): A 45-year follow-up study in 4 Nordic countries

Jose Hernan Alfonso et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2016)

Review Dermatology

Keratoacanthoma (KA): An update and review

Bartlomiej Kwiek et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2016)

Article Multidisciplinary Sciences

Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma

Patrizia Cammareri et al.

NATURE COMMUNICATIONS (2016)

Article Multidisciplinary Sciences

Genome-wide association study identifies novel susceptibility loci for cutaneous squamous cell carcinoma

Harvind S. Chahal et al.

NATURE COMMUNICATIONS (2016)

Article Otorhinolaryngology

Sentinel Lymph Node Biopsy for Cutaneous Squamous Cell Carcinoma on the Head and Neck

Alison B. Durham et al.

JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY (2016)

Review Oncology

The biology and function of fibroblasts in cancer

Raghu Kalluri

NATURE REVIEWS CANCER (2016)

Article Public, Environmental & Occupational Health

Prevalence and Costs of Skin Cancer Treatment in the US, 2002-2006 and 2007-2011

Gery P. Guy et al.

AMERICAN JOURNAL OF PREVENTIVE MEDICINE (2015)

Article Oncology

Genomic Analysis of Metastatic Cutaneous Squamous Cell Carcinoma

Yvonne Y. Li et al.

CLINICAL CANCER RESEARCH (2015)

Review Dermatology

High-risk cutaneous squamous cell carcinoma and the emerging role of sentinel lymph node biopsy: A literature review

Cristian Navarrete-Dechent et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2015)

Article Dermatology

Tanning lamps: Health effects and reclassification by the Food and Drug Administration

Alexander Ernst et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2015)

Article Biochemistry & Molecular Biology

Genomic landscape of carcinogen-induced and genetically induced mouse skin squamous cell carcinoma

Dany Nassar et al.

NATURE MEDICINE (2015)

Article Medicine, General & Internal

Improved Overall Survival in Melanoma with Combined Dabrafenib and Trametinib

Caroline Robert et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Article Medicine, General & Internal

A Phase 3 Randomized Trial of Nicotinamide for Skin-Cancer Chemoprevention

Andrew C. Chen et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Article Multidisciplinary Sciences

High burden and pervasive positive selection of somatic mutations in normal human skin

Inigo Martincorena et al.

SCIENCE (2015)

Article Otorhinolaryngology

Epigenetic alterations in metastatic cutaneous carcinoma

Owen A. Darr et al.

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK (2015)

Article Biochemistry & Molecular Biology

Effect of Immunosuppressants Tacrolimus and Mycophenolate Mofetil on the Keratinocyte UVB Response

Mei Ming et al.

PHOTOCHEMISTRY AND PHOTOBIOLOGY (2015)

Article Oncology

Mutational Landscape of Aggressive Cutaneous Squamous Cell Carcinoma

Curtis R. Pickering et al.

CLINICAL CANCER RESEARCH (2014)

Review Biochemistry & Molecular Biology

Tumour-stroma crosstalk in the development of squamous cell carcinoma

Yok Zuan Lim et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2014)

Review Medicine, Research & Experimental

Multifocal epithelial tumors and field cancerization: stroma as a primary determinant

G. Paolo Dotto

JOURNAL OF CLINICAL INVESTIGATION (2014)

Article Dermatology

NOTCH1 Mutations Occur Early during Cutaneous Squamous Cell Carcinogenesis

Andrew P. South et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2014)

Review Dermatology

Skin cancer and photoprotection in people of color: A review and recommendations for physicians and the public

Oma N. Agbai et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2014)

Article Dermatology

Role of human papillomavirus in cutaneous squamous cell carcinoma: A meta-analysis

Jennifer Wang et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2014)

Article Biochemistry & Molecular Biology

Kindlin-1 controls Wnt and TGF-β availability to regulate cutaneous stem cell proliferation

Emanuel Rognoni et al.

NATURE MEDICINE (2014)

Article Medicine, Research & Experimental

Modeling Cutaneous Squamous Carcinoma Development in the Mouse

Phillips Y. Huang et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2014)

Review Biochemistry & Molecular Biology

Ultraviolet radiation-induced non-melanoma skin cancer: Regulation of DNA damage repair and inflammation

InYoung Kim et al.

GENES & DISEASES (2014)

Review Biochemistry & Molecular Biology

UV Radiation and the Skin

John D'Orazio et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2013)

Letter Dermatology

Intralesional interferon alfa-2b for refractory, recurrent squamous cell carcinoma of the face

Allison Hanlon et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2013)

Article Oncology

HIV Infection Status, Immunodeficiency, and the Incidence of Non-Melanoma Skin Cancer

Michael J. Silverberg et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2013)

Article Biochemistry & Molecular Biology

IQGAP1 scaffold-kinase interaction blockade selectively targets RAS-MAP kinase-driven tumors

Katherine L. Jameson et al.

NATURE MEDICINE (2013)

Article Biochemistry & Molecular Biology

RECQL4, the Protein Mutated in Rothmund-Thomson Syndrome, Functions in Telomere Maintenance

Avik K. Ghosh et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Review Medicine, Research & Experimental

From keratinocyte to cancer: the pathogenesis and modeling of cutaneous squamous cell carcinoma

Vladimir Ratushny et al.

JOURNAL OF CLINICAL INVESTIGATION (2012)

Article Dermatology

IL-12 and IL-23 Affect Photocarcinogenesis Differently

Christian Jantschitsch et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2012)

Article Multidisciplinary Sciences

Defining the mode of tumour growth by clonal analysis

Gregory Driessens et al.

NATURE (2012)

Article Medicine, General & Internal

Sirolimus and Secondary Skin-Cancer Prevention in Kidney Transplantation

Sylvie Euvrard et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

Article Medicine, General & Internal

Combined BRAF and MEK Inhibition in Melanoma with BRAF V600 Mutations

Keith T. Flaherty et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

Article Dermatology

Hereditary Nonmelanoma Skin Cancer

Vasiliki Nikolaou et al.

SEMINARS IN CUTANEOUS MEDICINE AND SURGERY (2012)

Review Biotechnology & Applied Microbiology

Surgical Approaches to Create Murine Models of Human Wound Healing

VictorW. Wong et al.

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY (2011)

Review Dermatology

Ungual and periungual human papillomavirus-associated squamous cell carcinoma: A review

Catherine Riddel et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2011)

Review Biochemistry & Molecular Biology

Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression

Mina J. Bissell et al.

NATURE MEDICINE (2011)

Article Biochemistry & Molecular Biology

Differential Roles of T-cell Subsets in Regulation of Ultraviolet Radiation Induced Cutaneous Photocarcinogenesis

Tahseen H. Nasti et al.

PHOTOCHEMISTRY AND PHOTOBIOLOGY (2011)

Article Multidisciplinary Sciences

Identifying the cellular origin of squamous skin tumors

Gaelle Lapouge et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Multidisciplinary Sciences

Defining the origins of Ras/p53-mediated squamous cell carcinoma

Andrew C. White et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Multidisciplinary Sciences

Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma

Nicholas J. Wang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Review Medicine, General & Internal

Molecular pathways and targets in cancer-related inflammation

Alberto Mantovani et al.

ANNALS OF MEDICINE (2010)

Article Biochemistry & Molecular Biology

Autocrine VEGF Signaling Synergizes with EGFR in Tumor Cells to Promote Epithelial Cancer Development

Beate M. Lichtenberger et al.

Article Chemistry, Applied

Monitoring of mercury, arsenic, and lead in traditional Asian herbal preparations on the Dutch market and estimation of associated risks

M. J. Martena et al.

FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT (2010)

Article Multidisciplinary Sciences

DNMT1 maintains progenitor function in self-renewing somatic tissue

George L. Sen et al.

NATURE (2010)

Article Multidisciplinary Sciences

Opposing roles for calcineurin and ATF3 in squamous skin cancer

Xunwei Wu et al.

NATURE (2010)

Article Biochemistry & Molecular Biology

Invasive three-dimensional organotypic neoplasia from multiple normal human epithelia

Todd W. Ridky et al.

NATURE MEDICINE (2010)

Article Multidisciplinary Sciences

Tumor formation initiated by nondividing epidermal cells via an inflammatory infiltrate

Esther N. Arwert et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Hematology

Cancer in dyskeratosis congenita

Blanche P. Alter et al.

Article Dermatology

Epidermolysis bullosa and the risk of life-threatening cancers: The National EB Registry experience, 1986-2006

Jo-David Fine et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2009)

Article Cell Biology

Involvement of Members of the Cadherin Superfamily in Cancer

Geert Berx et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2009)

Article Environmental Sciences

An evaluation of the mode of action framework for mutagenic carcinogens case study: Cyclophosphamide

Nancy McCarroll et al.

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS (2008)

Article Dermatology

Detection of human papillomavirus DNA in cutaneous squamous cell carcinoma among immunocompetent individuals

Maryam M. Asgari et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2008)

Review Cell Biology

Cancer as an overhealing wound:: an old hypothesis revisited

Matthias Schaefer et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)

Review Genetics & Heredity

Oculocutaneous albinism

Karen Gronskov et al.

ORPHANET JOURNAL OF RARE DISEASES (2007)

Article Immunology

IL-10 controls ultraviolet-induced carcinogenesis in mice

Karin Loser et al.

JOURNAL OF IMMUNOLOGY (2007)

Article Dermatology

Cutaneous human papillomaviruses persist on healthy skin

Kristina Hazard et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2007)

Review Oncology

Modelling cancer in human skin tissue

PA Khavari

NATURE REVIEWS CANCER (2006)

Article Oncology

Enhanced photocarcinogenesis in interleukin-12-deficient mice

A Maeda et al.

CANCER RESEARCH (2006)

Review Cell Biology

Arsenic carcinogenesis in the skin

Hsin-Su Yu et al.

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