Hydrolyzable emulsions as a dual release platform for hydrophobic drugs and DNA

Several challenges need to be overcome when applying nucleic acids as therapeutic agents. We developed a new way to control the onset of the release of cholesterol-conjugated oligonucleotides with a simple, versatile, and cheap platform. Moreover, we combine the platform into a dual-release system that can release a hydrophobic drug with zero-order kinetics, followed by a rapid release of cholesterol-conjugated DNA.

Automated summary

Several challenges must be addressed in the application of nucleic acids as therapeutic agents. We have developed a simple, versatile, and cost-effective platform to control the release of cholesterol-conjugated oligonucleotides. Furthermore, we have integrated this platform into a dual-release system that allows for zero-order kinetics release of a hydrophobic drug, followed by rapid release of cholesterol-conjugated DNA.