ViscY nuclear magnetic resonance experiments for in situ chemical reaction monitoring under spin diffusion conditions

Article Chemistry, Analytical

Use of Diethanolamine as a Viscous Solvent for Mixture Analysis by Multidimensional Heteronuclear ViscY NMR Experiments

Ritchy Leroy et al.

Summary: Diethanolamine/DMSO-d(6) is reported as a viscous binary solvent for the individualization of low-polarity mixture components by multidimensional heteronuclear ViscY NMR experiments. Solvent viscosity slows down molecular tumbling, promoting magnetization transfer by dipolar longitudinal cross-relaxation. Analysis of mixtures is achieved through 3D heteronuclear single-quantum coherence-NOESY (HSQC-NOESY) experiments under viscous conditions.

ANALYTICAL CHEMISTRY (2022)

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Review Chemistry, Physical

Tailoring the nuclear Overhauser effect for the study of small and medium-sized molecules by solvent viscosity manipulation

Pedro Lameiras et al.

Summary: The nuclear Overhauser effect (NOE) is a result of cross-relaxation between nuclear spins mediated by dipolar coupling, becoming increasingly important in determining through-space atom proximity relationships within molecules. The efficiency of NOE depends on the molecular rotational correlation time, and increasing solution viscosity can reveal otherwise unobservable NOEs.

PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY (2021)

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Article Chemistry, Analytical

ViscY NMR experiments in phosphoric acid as a viscous solvent for individualization of small molecules within mixtures by spin diffusion

Francois Pedinielli et al.

Summary: The ViscY NMR approach utilizes spin diffusion in highly viscous solvents or solvent blends to individualize the NMR spectra of small molecule mixture components, providing a new solution for the analysis of small molecules within complex mixtures.

ANALYST (2021)

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Article Chemistry, Analytical