期刊
ORGANIC CHEMISTRY FRONTIERS
卷 10, 期 15, 页码 3786-3791出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d3qo00662j
关键词
-
Here, a novel and sustainable electrochemically driven oxidative 5-exo-dig radical cyclization of N-propargylbenzamides with alcohols is described, providing a convenient method for the synthesis of structurally diverse oxazole ketals in moderate to good yields. This protocol is achieved under mild conditions in an undivided cell without the need for external transition-metal catalysts, chemical oxidants, and ketalization acids, and exhibits scalability, broad substrate scope, and excellent functional group compatibility. Mechanistic studies reveal that the reaction proceeds via a nucleophilic substitution process rather than ketalization.
Here, an unprecedented and sustainable electrochemically driven oxidative 5-exo-dig radical cyclization of N-propargylbenzamides with alcohols is described, which provides a straightforward method to quickly deliver structurally diverse oxazole ketals in moderate to good yields. Achieved under mild conditions in an operationally simple undivided cell without the use of any external transition-metal catalysts, chemical oxidants, and acids required for ketalization, this protocol is scalable and features broad substrate scope and functional group compatibility. Mechanistic studies prove that there is no ketalization process, rather a nucleophilic substitution process is involved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据