☆ 4.7 Article

Aminative annulation of cyano-enynyl esters leading to functionalized cyclopentenones

CHEMICAL COMMUNICATIONS (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Chemistry, Multidisciplinary

Pd(0)-Catalyzed Asymmetric 7-Endo Hydroacyloxylative Cyclization of 1,6-Enyne Enabled by an Anion Ligand-Directed Strategy

Ming Dong et al.

Summary: In this study, a Pd(0)-catalyzed hydroacyloxylative cyclization of 1,6-enyne was developed, which proceeds in either a 7-endo-trig or 6-exo-trig fashion when paired with an appropriate dihaloacetic acid reactant. The reaction can produce highly enantiopure seven-membered heterocycles or six-membered rings with moderate enantioselectivity, depending on the substituents on the alkene moiety. Preliminary experimental studies suggest an unusual reaction mechanism involving E-to-Z isomerization of a vinyl-Pd(II) species and alkene trans-oxypalladation, which is governed by the carboxylate selected.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2023)

添加到收藏夹

Article Chemistry, Organic

Palladium-Catalyzed Carbo-Aminative Cyclization of 1,6-Enynes: Access to Napthyridinone Derivatives

Undamatla Suri Babu et al.

Summary: This article presents a general approach to the synthesis of napthyridinones through the Pd-catalyzed annulation of 1,6-enynes with 2-iodoanilines. The protocol involves a rare carbo-aminative cyclization via the 6-endo-trig mode, and overcomes the commonly observed exo-trig/dig cyclizations. The regioselective aryl palladation of alkyne followed by intramolecular Heck-type reaction enables the cascade synthesis.

ORGANIC LETTERS (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

Metal-Catalyst-Free Radical Cyclization of 1,6-Enynes for the Selective and Switchable Synthesis of Lactams in Water

Xuan-Chi Yu et al.

Summary: Three novel radical cyclization reactions of 1,6-enynes with sulfonyl hydrazides have been presented, providing convenient synthetic approaches for accessing different types of lactam derivatives from the same substrate in metal-catalyst-free systems.

ACS SUSTAINABLE CHEMISTRY & ENGINEERING (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

Rhodium-Catalyzed Diastereo- and Enantioselective Divergent Annulations between Cyclobutanones and 1,5-Enynes: Repaid Construction of Complex C(sp3)-Rich Scaffolds

Si-Hua Hou et al.

Summary: This article describes the development of Rh(I)-catalyzed intramolecular annulations for constructing complex C(sp3)-rich scaffolds. Different catalysts exhibit divergent reactivities and achieve excellent diastereo- and enantioselectivity.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

添加到收藏夹

Article Chemistry, Organic

Domino Aza-Annulations of Enynyl-/(Alkynyl)aryl-acetonitriles to Access Nitrogen-Enriched Heterocycles

Chada Raji Reddy et al.

Summary: Unprecedented domino aza-annulations of (E)-2-en-4-ynyl-acetonitriles with sodium azide under metal-and oxidant-free conditions for the assembly of triazolo-pyridines are accomplished. The developed strategy offers broad substrate scope and demonstrated its synthetic utility via denitrogenative coupling of fused triazoles with different nucleophiles.

JOURNAL OF ORGANIC CHEMISTRY (2022)

添加到收藏夹

Review Chemistry, Organic

Recent advances in the tandem annulation of 1,3-enynes to functionalized pyridine and pyrrole derivatives

Yi Liu et al.

Summary: Significant progress has been made in the tandem annulation of enynes in recent years, mainly focusing on the corresponding reactions of 1,3-enyne structural motifs to provide functionalized pyridine and pyrrole derivatives. These functionalization reactions involve various methods of introducing functional groups, facilitating the synthesis of N-heterocycles.

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY (2021)

添加到收藏夹

Article Chemistry, Organic

Synthesis of Cyclopentenones through Rhodium-Catalyzed C-H Annulation of Acrylic Acids with Formaldehyde and Malonates

Shuling Yu et al.

Summary: An efficient rhodium-catalyzed protocol for the synthesis of cyclopentenones based on a three-component reaction of acrylic acids, formaldehyde, and malonates was reported. The treatment of a variety of alkyl halides with a Na2CO3/MeOH solution could smoothly achieve 5-alkylation of the cyclopentenones. Excess formaldehyde and malonate led to a multicomponent reaction that afforded multisubstituted cyclopentenones through a Michael addition.

ORGANIC LETTERS (2021)

添加到收藏夹

Review Chemistry, Applied

Recent Advances in the Interrupted Nazarov Reaction

Anton V. Yadykov et al.

ADVANCED SYNTHESIS & CATALYSIS (2020)

添加到收藏夹

Article Chemistry, Organic

Total Syntheses of All Six Chiral Natural Pyrethrins: Accurate Determination of the Physical Properties, Their Insecticidal Activities, and Evaluation of Synthetic Methods

Momoyo Kawamoto et al.

JOURNAL OF ORGANIC CHEMISTRY (2020)

添加到收藏夹

Article Chemistry, Organic

Rh(III)-Catalyzed Domino [4+2] Annulation/Aza-Michael Addition of N-(Pivaloyloxy)benzamides with 1,5-Enynes via C-H Activation: Synthesis of Functionalized Aromathecins

Chada Raji Reddy et al.

JOURNAL OF ORGANIC CHEMISTRY (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Cobalt-Catalyzed Enantioselective Hydroarylation of 1,6-Enynes

Andrew Whyte et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

添加到收藏夹

Review Chemistry, Multidisciplinary

New Twists in Nazarov Cyclization Chemistry

Alison J. Frontier et al.

ACCOUNTS OF CHEMICAL RESEARCH (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Total Synthesis of Cryptotrione

Mao-Yun Lyu et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

添加到收藏夹

Article Chemistry, Organic

Gold-Catalyzed Synthesis of Chiral Cyclopentadienyl Esters via Chirality Transfer

Ke Zhao et al.

ORGANIC LETTERS (2020)

添加到收藏夹

Article Chemistry, Organic

Easy Access to 2,4-Disubstituted Cyclopentenones by a Gold(III)-Catalyzed A3-Coupling/Cyclization Cascade

Jian Li et al.

ORGANIC LETTERS (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Oxa-[3+3] annulation of MBH-carbonates of propiolaldehydes with α-nitro/bromo ketones to access 2H-pyrans

Chada Raji Reddy et al.

CHEMICAL COMMUNICATIONS (2020)

添加到收藏夹

Review Chemistry, Multidisciplinary

Radical-mediated oxidative annulations of 1,n-enynes involving C-H functionalization

Yang Li et al.

CHEMICAL COMMUNICATIONS (2020)

添加到收藏夹

Article Chemistry, Organic

Coupling-Isomerization-Cycloisomerization Reaction (CICIR) - An Unexpected and Efficient Domino Approach to Luminescent 2-(Hydroxymethylene)indenones

Helya Janatian Ghazvini et al.

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2019)

添加到收藏夹

Article Chemistry, Organic

Access to Highly Functionalized Cyclopentenones via Diastereoselective Pauson-Khand Reaction of Siloxy-Tethered 1,7-Enynes

Austin G. Gallagher et al.

ORGANIC LETTERS (2019)

添加到收藏夹

Article Chemistry, Organic

Copper-Catalyzed Intramolecular Chalcogenoamination of Enynyl Azides: Synthesis of 5-Selenyl/Sulfenyl Nicotinates

Chada Raji Reddy et al.

ORGANIC LETTERS (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Photooxygenation of 2-propargylfurans: a path to structurally diverse nitrogen- containing 5-membered rings

Lucile Marin et al.

CHEMICAL COMMUNICATIONS (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Photocatalytic carbanion generation from C-H bonds - reductant free Barbier/Grignard-type reactions

Anna Lucia Berger et al.

CHEMICAL SCIENCE (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Total Syntheses of Crinipellins Enabled by Cobalt-Mediated and Palladium-Catalyzed Intramolecular Pauson-Khand Reactions

Zhihui Huang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)

添加到收藏夹

Article Chemistry, Organic

Cu(I)-Catalyzed Aminative Aza-Annulation of Enynyl Azide using N-Fluorobenzenesulfonimide: Synthesis of 5-Aminonicotinates

Chada Raji Reddy et al.

ORGANIC LETTERS (2018)

添加到收藏夹

Article Chemistry, Organic

One-Pot Consecutive Sulfonamidation/ipso-Cyclization Strategy for the Construction of Azaspirocyclohexadienones

Chada Raji Reddy et al.

JOURNAL OF ORGANIC CHEMISTRY (2017)

添加到收藏夹

Article Chemistry, Multidisciplinary

Copper-Catalyzed Synthesis and Applications of Yndiamides

Steven J. Mansfield et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)

添加到收藏夹

Article Chemistry, Multidisciplinary

Markovnikov-Selective Palladium Catalyst for Carbonylation of Alkynes with Heteroarenes

Jie Liu et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)

添加到收藏夹

Review Chemistry, Multidisciplinary

Synthesis of Chiral Cyclopentenones

Svilen P. Simeonov et al.

CHEMICAL REVIEWS (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Nineteen-step total synthesis of (+)-phorbol

Shuhei Kawamura et al.

NATURE (2016)

添加到收藏夹

Article Chemistry, Organic

Construction of Cyclopenta[b]indol-1-ones by a Tandem Gold(I)-Catalyzed Rearrangement/Nazarov Reaction and Application to the Synthesis of Bruceolline H

Dina Scarpi et al.

ORGANIC LETTERS (2016)

添加到收藏夹

Review Chemistry, Multidisciplinary

Tigliane Diterpenoids from the Euphorbiaceae and Thymelaeaceae Families

Hong-Bing Wang et al.

CHEMICAL REVIEWS (2015)

添加到收藏夹

Article Chemistry, Organic

Aza-Annulation of Enynyl Azides: A New Approach to Substituted Pyridines

Chada Raji Reddy et al.

ORGANIC LETTERS (2015)

添加到收藏夹

Article Multidisciplinary Sciences

Synthesis of tetrasubstituted 1-silyloxy-3-aminobutadienes and chemistry beyond Diels-Alder reactions

Xijian Li et al.

NATURE COMMUNICATIONS (2015)

添加到收藏夹

Article Chemistry, Organic

A Metal-Free Tandem C-C/C-O Bond Formation Approach to Diversely Functionalized Tetrasubstituted Furans

Chada Raji Reddy et al.

JOURNAL OF ORGANIC CHEMISTRY (2014)

添加到收藏夹

Article Chemistry, Organic

Sequential Allylic Substitution/Pauson-Khand Reaction: A Strategy to Bicyclic Fused Cyclopentenones from MBH-Acetates of Acetylenic Aldehydes

Chada Raji Reddy et al.

JOURNAL OF ORGANIC CHEMISTRY (2014)

添加到收藏夹

Article Chemistry, Organic

Novel [4+2]-Benzannulation To Access Substituted Benzenes and Polycyclic Aromatic and Benzene-Fused Heteroaromatic Compounds

Chada Raji Reddy et al.

ORGANIC LETTERS (2014)

添加到收藏夹

Review Chemistry, Organic

Recent Progress in the Synthetic Assembly of 2-Cyclopentenones

David J. Aitken et al.

SYNTHESIS-STUTTGART (2014)

添加到收藏夹

Article Chemistry, Multidisciplinary

Synthesis of Spiroheterocycles by Palladium-Catalyzed Domino Cycloisomerization/Cross-Coupling of α-Allenols and Baylis-Hillman Acetates

Benito Alcaide et al.

CHEMISTRY-A EUROPEAN JOURNAL (2009)

添加到收藏夹

Article Chemistry, Medicinal

Synthesis and evaluation of 4/5-hydroxy-2,3-diaryl(substituted)-cyclopent-2-en-1-ones as cis-restricted analogues of combretastatin A-4 as novel anticancer agents

Mukund K. Gurjar et al.

JOURNAL OF MEDICINAL CHEMISTRY (2007)

添加到收藏夹

Review Oncology

Cyclopentenone: a special moiety for anticancer drug design

Matteo Conti

ANTI-CANCER DRUGS (2006)

添加到收藏夹

Article Chemistry, Medicinal

Microwave assisted synthesis of fragrant jasmone heterocyclic analogues

Anna Pawelczyk et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2006)

添加到收藏夹

Article Multidisciplinary Sciences

Lessons from natural molecules

J Clardy et al.

NATURE (2004)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.