☆ 4.7 Article

Enzymatic degradation of ochratoxin A in the gastrointestinal tract of piglets

JOURNAL OF ANIMAL SCIENCE (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Microbiology

Ochratoxin A degrading enzymes of Stenotrophomonas sp. 043-1a

Christoph Gonaus et al.

Summary: Ochratoxin A, a mycotoxin produced by certain fungi, poses a threat to animal and human health due to its nephrotoxic, carcinogenic, and genotoxic properties. Stenotrophomonas sp. 043-1a, a bacterium isolated from soil, has been previously shown to degrade ochratoxin A into non-toxic compounds. In this study, the enzymes responsible for this degradation were identified as the metallo-dependent hydrolase Chr1_3858681_3267 and a member of the peptidase S9 family, Chr1_3858681_771. This is the first report of an ochratoxin A degrading enzyme from the peptidase S9 family.

FEMS MICROBIOLOGY LETTERS (2023)

添加到收藏夹

Review Biochemistry & Molecular Biology

Biological Detoxification of Mycotoxins: Current Status and Future Advances

Lu Liu et al.

Summary: Mycotoxins, highly toxic metabolites produced by fungi, pose a significant threat to human and animal health. Worldwide contamination of food and feed with mycotoxins leads to substantial financial losses annually. Biological methods for mycotoxin degradation have shown great potential and advantages. This review highlights the important advances in the biological removal of mycotoxins over the past decade, including discussions on the chemical structures, toxicity, and innovative strategies such as using novel probiotics. Prospects for the development of multifunctional approaches using recombinant enzymes and microbial consortia for simultaneous mycotoxin removal are also discussed.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

添加到收藏夹

Review Food Science & Technology

Ochratoxin A in Slaughtered Pigs and Pork Products

Mikela Vlachou et al.

Summary: Ochratoxin A (OTA) is a mycotoxin that is produced by fungi in feeds or foods, and it has been proven to have nephrotoxic, hepatotoxic, teratogenic, neurotoxic, genotoxic, carcinogenic, and immunotoxic effects on animals and humans. Pork meat and pork meat products are important sources of chronic dietary exposure to OTA, and establishing maximum limits for OTA in pork meat and meat by-products is necessary to protect human health.

TOXINS (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Trichoderma Enzymes for Degradation of Aflatoxin B1 and Ochratoxin A

Irene Dini et al.

Summary: The contamination of agricultural products with mycotoxins poses risks to animal and human health and economic losses, which can be reduced by using biological control methods. The exoenzymes produced by Trichoderma afroharzianum strain T22 may play a role in degrading mycotoxins, particularly Aflatoxin B1 and Ochratoxin A. This study suggests that T. afroharzianum T22 or its peroxidase supplementation could be a sustainable strategy for reducing mycotoxins in feed and food products.

MOLECULES (2022)

添加到收藏夹

Article Food Science & Technology

Toolbox for the Extraction and Quantification of Ochratoxin A and Ochratoxin Alpha Applicable for Different Pig and Poultry Matrices

Barbara Streit et al.

Summary: This article presents a method for the extraction and quantification of OTA and OT alpha in pig and poultry matrices. The samples are extracted using either ethyl acetate/sodium hydrogencarbonate/ethyl acetate or an acetonitrile/water mixture, and quantitative analysis is performed using LC-MS/MS. The method validation demonstrates good linearity, accuracy, and precision.

TOXINS (2022)

添加到收藏夹

Review Agriculture, Dairy & Animal Science

Nutritional impact of mycotoxins in food animal production and strategies for mitigation

Ran Xu et al.

Summary: Mycotoxins, toxic metabolites produced by filamentous fungi, are commonly found as natural contaminants in agricultural commodities worldwide. Their presence can lead to health issues in both animals and humans, affecting their performance and physiology. Mitigation strategies are necessary to reduce the risk of mycotoxicity.

JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY (2022)

添加到收藏夹

Article Food Science & Technology

A Newly Isolated Alcaligenes faecalis ANSA176 with the Capability of Alleviating Immune Injury and Inflammation through Efficiently Degrading Ochratoxin A

Rui Zheng et al.

Summary: In this study, a strain of Alcaligenes faecalis, named ANSA176, was isolated and characterized for its strong ability to detoxify Ochratoxin A (OTA). The results showed that ANSA176 could effectively degrade OTA and alleviate immune injury and inflammation induced by OTA.

TOXINS (2022)

添加到收藏夹

Article Mycology

Ochratoxin A affects oocyte maturation and subsequent embryo developmental dynamics in the juvenile sheep model

Maria Elena Dell'Aquila et al.

Summary: In this study, the effects of low levels of OTA exposure on oocyte maturation, fertilization, and embryo development were evaluated using a juvenile sheep model. It was found that OTA induced cytotoxic effects at micromolar concentrations, while impairing oocyte ability to prevent polyspermy and increasing blastocyst apoptosis at nanomolar concentrations.

MYCOTOXIN RESEARCH (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Bacillus subtilis ANSB168 Producing d-alanyl-d-alanine Carboxypeptidase Could Alleviate the Immune Injury and Inflammation Induced by Ochratoxin A

Hanrui Qing et al.

Summary: The study demonstrated that Bacillus subtilis ANSB168 could degrade OTA and its bioproduct could alleviate damages induced by OTA in laying hens, including reducing inflammation and oxidative stress.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Article Agriculture, Dairy & Animal Science

Ochratoxin A: its impact on poultry gut health and microbiota, an overview

Shuangshuang Zhai et al.

Summary: OTA is a widespread mycotoxin that is nephrotoxic, hepatotoxic, teratogenic, immunotoxic, and enterotoxic to various animal species. Poultry are more sensitive to OTA with a lower absorption rate, making the gut an important target tissue. OTA can lead to gut dysbiosis, increased gut permeability, immunity, and bacterial translocation, ultimately causing gut and other organ injury.

POULTRY SCIENCE (2021)

添加到收藏夹

Article Food Science & Technology

Mycotoxin Removal by Lactobacillus spp. and Their Application in Animal Liquid Feed

Chaima Ragoubi et al.

Summary: The use of lactic acid bacteria for removing mycotoxins from contaminated feed has been proposed as a cost-effective, safe, and promising strategy. The study found that viable LAB cells were effective at removing ZEA and DON, with heat-inactivated cells showing lower efficiency.

TOXINS (2021)

添加到收藏夹

Article Food Science & Technology

Biomarkers of Deoxynivalenol, Citrinin, Ochratoxin A and Zearalenone in Pigs after Exposure to Naturally Contaminated Feed Close to Guidance Values

Agnieszka Tkaczyk et al.

Summary: This study successfully utilized LC-MS/MS methods to determine mycotoxin biomarkers of exposure in pigs. The levels of biomarkers in urine and serum correlated well with toxin intake, demonstrating their suitability for exposure monitoring. Urine is suitable for monitoring multiple mycotoxin exposures, while serum may be used to monitor specific mycotoxin exposures. Additionally, both matrices are suitable candidates to monitor prolonged OTA exposure in pigs.

TOXINS (2021)

添加到收藏夹

Review Food Science & Technology

Mycotoxin Biomarkers in Pigs-Current State of Knowledge and Analytics

Agnieszka Tkaczyk et al.

Summary: Farm animals, especially pigs, are susceptible to mycotoxin exposure which poses a significant food safety issue. Biomarkers have become a popular method for evaluating mycotoxin exposure in pigs, with tandem mass spectrometry commonly used for quantification. Sample preparation for multi-mycotoxin methods remains a challenge, but various strategies are being explored to address this issue.

TOXINS (2021)

添加到收藏夹

Review Food Science & Technology

Worldwide contamination of food-crops with mycotoxins: Validity of the widely cited 'FAO estimate' of 25%

Mari Eskola et al.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2020)

添加到收藏夹

Article Environmental Sciences

Detoxification of ochratoxin A by Lysobacter sp. CW239 and characteristics of a novel degrading gene carboxypeptidase cp4

Wei Wei et al.

ENVIRONMENTAL POLLUTION (2020)

添加到收藏夹

Article Food Science & Technology

An In Silico Target Fishing Approach to Identify Novel Ochratoxin A Hydrolyzing Enzyme

Luca Dellafiora et al.

TOXINS (2020)

添加到收藏夹

Review Food Science & Technology

Toxin Degradation by Rumen Microorganisms: A Review

Zhi Hung Loh et al.

TOXINS (2020)

添加到收藏夹

Article Food Science & Technology

Truncated Expression of a Carboxypeptidase A from Bovine Improves Its Enzymatic Properties and Detoxification Efficiency of Ochratoxin A

Lu Xiong et al.

TOXINS (2020)

添加到收藏夹

Article Chemistry, Applied

Carboxypeptidase A immobilization with zeolitic imidazolate framework for enhancement of ochratoxin A degradation ability

Lei Ma et al.

FOOD AND AGRICULTURAL IMMUNOLOGY (2020)

添加到收藏夹

Article Food Science & Technology

Degrading Ochratoxin A and Zearalenone Mycotoxins Using a Multifunctional Recombinant Enzyme

Md Shofiul Azam et al.

TOXINS (2019)

添加到收藏夹

Article Food Science & Technology

Heterologous Expression and Characterization of A Novel Ochratoxin A Degrading Enzyme, N-acyl-L-amino Acid Amidohydrolase, from Alcaligenes faecalis

Honghai Zhang et al.

TOXINS (2019)

添加到收藏夹

Article Food Science & Technology

In-Vitro Application of a Qatari Burkholderia cepacia strain (QBC03) in the Biocontrol of Mycotoxigenic Fungi and in the Reduction of Ochratoxin A biosynthesis by Aspergillus carbonarius

Randa Zeidan et al.

TOXINS (2019)

添加到收藏夹

Article Biochemical Research Methods

Ochratoxin A determination in swine muscle and liver from French conventional or organic farming production systems

Vincent Hort et al.

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Comparison of the toxic effects of different mycotoxins on porcine and mouse oocyte meiosis

Yujie Lu et al.

PEERJ (2018)

添加到收藏夹

Article Veterinary Sciences

Experimental ochratoxicosis A in Nile tilapia and its amelioration by some feed additives

Amany M. Diab et al.

INTERNATIONAL JOURNAL OF VETERINARY SCIENCE AND MEDICINE (2018)

添加到收藏夹

Article Food Science & Technology

Tissue distribution of ochratoxin A in pigs after administration of two-levels contaminated diets

A. Altafini et al.

WORLD MYCOTOXIN JOURNAL (2017)

添加到收藏夹

Article Food Science & Technology

Teratogenicity of Ochratoxin A and the Degradation Product, Ochratoxin a, in the Zebrafish (Danio rerio) Embryo Model of Vertebrate Development

Mehreen Haq et al.

TOXINS (2016)

添加到收藏夹

Article Mycology

Comparison of ochratoxin A levels in edible pig tissues and in biological fluids after exposure to a contaminated diet

Jelka Pleadin et al.

MYCOTOXIN RESEARCH (2016)

添加到收藏夹

Article Biochemistry & Molecular Biology

Ochratoxin A promotes porcine circovirus type 2 replication in vitro and in vivo

Fang Gan et al.

FREE RADICAL BIOLOGY AND MEDICINE (2015)

添加到收藏夹

Review Food Science & Technology

Comparative Ochratoxin Toxicity: A Review of the Available Data

Alexandra H. Heussner et al.

TOXINS (2015)

添加到收藏夹

Article Veterinary Sciences

Cellular stress marker alteration and inflammatory response in pigs fed with an ochratoxin contaminated diet

Chiara Bernardini et al.

RESEARCH IN VETERINARY SCIENCE (2014)

添加到收藏夹

Article Food Science & Technology

First Evidence of Placental Transfer of Ochratoxin A in Horses

Fiorenza Minervini et al.

TOXINS (2013)

添加到收藏夹

Article Agriculture, Dairy & Animal Science

Isolation, Screening and Identification of Swine Gut Microbiota with Ochratoxin A Biodegradation Ability

Santi Devi Upadhaya et al.

ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES (2012)

添加到收藏夹

Review Food Science & Technology

Current Situation of Mycotoxin Contamination and Co-occurrence in Animal Feed-Focus on Europe

Elisabeth Streit et al.

TOXINS (2012)

添加到收藏夹

Review Food Science & Technology

Effects of Ochratoxin A on Livestock Production

Gianni Battacone et al.

TOXINS (2010)

添加到收藏夹

Review Food Science & Technology

Biodegradation of Ochratoxin A for Food and Feed Decontamination

Luis Abrunhosa et al.

TOXINS (2010)

添加到收藏夹

Article Environmental Sciences

Acute toxicity of ochratoxin-A in marine water-reared sea bass (Dicentrarchus labrax L.)

Yasser Said El-Sayed et al.

CHEMOSPHERE (2009)

添加到收藏夹

Article Food Science & Technology

Effectiveness of mycotoxin sequestration activity of micronized wheat fibres on distribution of ochratoxin A in plasma, liver and kidney of piglets fed a naturally contaminated diet

N. Aoudia et al.

FOOD AND CHEMICAL TOXICOLOGY (2009)

添加到收藏夹

Review Food Science & Technology

Ochratoxin A: An overview on toxicity and carcinogenicity in animals and humans

Annie Pfohl-Leszkowicz et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2007)

添加到收藏夹

Article Mycology

Ochratoxins: A global perspective

Paul Bayman et al.

MYCOPATHOLOGIA (2006)

添加到收藏夹

Article Food Science & Technology

OPINION OF THE SCIENTIFIC PANEL ON CONTAMINANTS IN THE FOOD CHAIN ON A REQUEST FROM THE COMMISSION RELATED TO OCHRATOXIN A IN FOOD

Jan Alexander et al.

EFSA JOURNAL (2006)

添加到收藏夹

Article Food Science & Technology

Balkan endemic nephropathy: Role of ochratoxins A through biomarkers

Marcel Castegnaro et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2006)

添加到收藏夹

Review Biochemistry & Molecular Biology

Toxicokinetics and toxicodynamics of ochratoxin A, an update

D Ringot et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2006)

添加到收藏夹

Article Neurosciences

Acute neurotoxic effects of the fungal metabolite ochratoxin-A

V Sava et al.

NEUROTOXICOLOGY (2006)

添加到收藏夹

Article Agriculture, Dairy & Animal Science

Effects of Ochratoxin A on heavy pig production

L Malagutti et al.

ANIMAL RESEARCH (2005)

添加到收藏夹

Article Fisheries

Ochratoxin A fed to channel catfish (Ictalurus punctatus) causes reduced growth and lesions of hepatopancreatic tissue

BB Manning et al.

AQUACULTURE (2003)

添加到收藏夹

Article Pathology

Experimental one year ochratoxin A toxicosis in pigs

SD Stoev et al.

EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY (2002)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.