☆ 4.6 Review

Recent progress in nanozymes for the treatment of diabetic wounds

JOURNAL OF MATERIALS CHEMISTRY B (2023)

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Summary: Bacterial biofilm-related infectious diseases have a severe impact on human health. The low permeability and enrichment of therapeutic agents within the biofilm pose a challenge for treatment. This article summarizes the current progress in nanotechnology methods to improve the penetrability of therapeutic agents and discusses the challenges and future implementations of engineered delivery systems to manage biofilm infections.

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Review Chemistry, Multidisciplinary

Detection of Glucose Based on Noble Metal Nanozymes: Mechanism, Activity Regulation, and Enantioselective Recognition

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Summary: Glucose monitoring is crucial for evaluating glucose metabolism disorders. Noble metal nanozymes (NMNZs) are widely used due to their excellent properties. This review summarizes the chemical mechanism of NMNZs with glucose oxidase and peroxidase mimicking activities, and presents detailed strategies for regulating their enzyme-like activities. It also describes the design of NMNZs with enantioselective recognition of D-glucose and L-glucose. The review concludes with discussions on potential solutions to existing challenges and future development possibilities.

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Review Immunology

Targeting matrix metalloproteases in diabetic wound healing

Junren Chen et al.

Summary: Chronic inflammation is involved in the progression of various chronic diseases, including obesity, diabetes mellitus, and its complications. Diabetic ulcer, characterized by chronic non-healing wounds, is a serious complication of diabetes that significantly impacts patients' quality of life and imposes high medical costs. Matrix metalloproteases (MMPs), which play a crucial role in the healing process, have been identified as potential biomarkers for the diagnosis of diabetic ulcer and therapeutic targets for its treatment. This review focuses on natural products derived from herbs, vegetables, and animals that target MMPs and have shown potential in treating diabetic ulcer.

FRONTIERS IN IMMUNOLOGY (2023)

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Article Nanoscience & Nanotechnology

Injectable Tissue-Adhesive Hydrogel for Photothermal/Chemodynamic Synergistic Antibacterial and Wound Healing Promotion

Han Huang et al.

Summary: The development of hydrogel dressings with injectability, adhesion, antibacterial properties, and wound healing promotion is urgently needed. The design of multifunctional injectable hydrogels based on Ag-doped Mo2C-derived polyoxometalate (AgPOM) nanoparticles, urea, gelatin, and tea polyphenols (TPs) has been presented for antibacterial and wound healing acceleration. The hydrogel exhibits excellent tissue adhesion after injection due to the in situ formation triggered by recombination of TPs and gelatin chains. AgPOM in the hydrogel acts as an antimicrobial agent by generating singlet oxygen and sterilizing under near-infrared light. In vitro studies demonstrate high bactericidal ability against drug-resistant Staphylococcus aureus and facilitate wound healing through synergistic photothermal/chemodynamic therapy. Therefore, the injectable hydrogel with AgPOM offers a novel therapeutic agent for drug-resistant bacteria-infected wounds and wound healing promotion.

ACS APPLIED MATERIALS & INTERFACES (2023)

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Article Chemistry, Multidisciplinary

Amorphizing Metal Selenides-Based ROS Biocatalysts at Surface Nanolayer toward Ultrafast Inflammatory Diabetic Wound Healing

Yuting Deng et al.

Summary: This study develops a cobalt selenide-based biocatalyst with an amorphous Ru@CoSe nanolayer for ultrafast and broadspectrum catalytic ROS-elimination. The biocatalyst shows excellent catalase-like kinetics and can efficiently rescue the proliferation of mesenchymal stem cells in an oxidative stress environment. The study offers an effective nanomedicine for catalytic ROS-scavenging and ultrafast healing of inflammatory wounds, and provides a strategy to design biocatalytic metal compounds.

ACS NANO (2023)

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Article Engineering, Biomedical

Glucose metabolism-inspired catalytic patches for NIR-II phototherapy of diabetic wound infection

Jingyang Shan et al.

Summary: This study developed a catalytic microneedle patch using near-infrared-II responsive and dual-nanozyme active Au-Cu2MoS4 nanosheets for treating diabetic wound infection. The patch achieves glucose consumption, oxygen generation, and bacterial elimination, providing an effective treatment for diabetic patients with wound infection.

ACTA BIOMATERIALIA (2023)

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Article Nanoscience & Nanotechnology

Nanohybrid Double Network Hydrogels Based on a Platinum Nanozyme Composite for Antimicrobial and Diabetic Wound Healing

Ziying Zhou et al.

Summary: In this study, a nanohybrid double network hydrogel based on a platinum nanozyme composite was developed for managing diabetic wound healing. The hydrogel exhibited oxygen supply capacity, enzyme catalytic performance, and pH self-regulation. It showed synergistic antibacterial effects through the production of ROS and reshaped the redox microenvironment to transition the wound from the inflammatory phase to the proliferative phase. The microenvironmentally adaptive hydrogel treatment showed a significant promoting effect in the repair of diabetic infected wounds.

ACS APPLIED MATERIALS & INTERFACES (2023)

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Review Microbiology

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Oana Ciofu et al.

Summary: Chronic infections caused by microbial biofilms pose a significant clinical challenge due to the resistance of biofilms to antimicrobials and the immune system, leading to persistent and recurrent infections. This Review discusses the current understanding of the mechanisms underlying the tolerance of biofilms to the immune system and to antimicrobials, as well as their role in the development of antimicrobial resistance.

NATURE REVIEWS MICROBIOLOGY (2022)

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Article Engineering, Biomedical

Adaptive Hydrogels Based on Nanozyme with Dual-Enhanced Triple Enzyme-Like Activities for Wound Disinfection and Mimicking Antioxidant Defense System

Yang Li et al.

Summary: Bacterial infection and oxidative stress are effectively addressed by a multifunctional hydrogel incorporating molybdenum disulfide nanosheets with triple enzyme-like activities. The nanozyme activities of MoS2 are enhanced through carbon nanotubes and near-infrared irradiation, contributing to significant antibacterial and free radical scavenging abilities. The dynamic boron ester crosslinked hydrogel accelerates skin reconstruction by promoting collagen deposition, angiogenesis, and maximizing the efficiency of the nanozyme in irregular wound cavities.

ADVANCED HEALTHCARE MATERIALS (2022)

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Article Optics

Orthogonal Aza-BODIPY-BODIPY dyad as heavy-atom free photosensitizer for photo-initiated antibacterial therapy

Dongliang Yang et al.

Summary: A novel halogen-free photosensitizer, NDB, was synthesized in this study. The ROS generation capability of NDB under 730 nm laser illumination was found to be 3-fold higher than that of the commercial ICG, suggesting its potential application in photo-initiated antibacterial therapy.

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Article Biotechnology & Applied Microbiology

pH-switchable nanozyme cascade catalysis: a strategy for spatial-temporal modulation of pathological wound microenvironment to rescue stalled healing in diabetic ulcer

Xuancheng Du et al.

Summary: This study introduces a pH-switchable nanozyme cascade catalysis strategy for diabetic ulcer management. By modulating the pH of the pathological wound microenvironment, this strategy accelerates wound healing while minimizing toxicity to normal tissues.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Review Chemistry, Multidisciplinary

Nanophysical Antimicrobial Strategies: A Rational Deployment of Nanomaterials and Physical Stimulations in Combating Bacterial Infections

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Summary: This review provides an overview of nanophysical antimicrobial strategies (NPAS), categorizing them based on the modes of their physical stimulation. The biomedical applications of NPAS in combating bacterial infections are discussed, with a focus on design and antimicrobial mechanisms. Current challenges and future perspectives of NPAS in clinical treatment of bacterial infections are also summarized and discussed, highlighting their potential use in clinical settings.

ADVANCED SCIENCE (2022)

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Article Nanoscience & Nanotechnology

Thermosensitive Hydrogel Incorporating Prussian Blue Nanoparticles Promotes Diabetic Wound Healing via ROS Scavenging and Mitochondrial Function Restoration

Zhao Xu et al.

Summary: Diabetic foot ulcer is a serious complication in diabetes patients, and oxidative stress is thought to be a key driver of the pathogenesis of such ulcers. In this study, researchers synthesized Prussian blue nanoparticles with the ability to efficiently scavenge reactive oxygen species and incorporated them into a hydrogel for the treatment of diabetic foot ulcers.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Chemistry, Multidisciplinary

Artificial Nonenzymatic Antioxidant MXene Nanosheet-Anchored Injectable Hydrogel as a Mild Photothermal-Controlled Oxygen Release Platform for Diabetic Wound Healing

Yang Li et al.

Summary: This study develops an injectable hydrogel based on MXene nanosheets for diabetic wound healing. The hydrogel utilizes oxyhemoglobin to release oxygen controllably and MXene to scavenge reactive oxygen species and bacteria. The hydrogel also benefits from the regulation of macrophage polarization. Overall, it effectively promotes the healing of infected diabetic wounds.

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An injectable and biodegradable hydrogel incorporated with photoregulated NO generators to heal MRSA-infected wounds

Xinyi Lv et al.

Summary: An injectable, degradable, and photoactivated antibacterial hydrogel (MPDA-BNN6@Gel) was developed for the treatment of infected wounds. The hydrogel could generate local hyperthermia and release large quantities of NO gas to treat the infection under laser irradiation. It was found that the hydrogel eradicated bacteria by damaging the cell membrane, genetic metabolism, and material energy. Additionally, the hydrogel promoted wound healing in vivo in the absence of laser irradiation.

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Zhaoyuan Lyu et al.

Summary: This review highlights the significance of 2D nanomaterials with enzyme-like properties, particularly peroxidase (POD)-like activity, in biomedical applications. The classification of different types of 2D POD-like nanomaterials is presented, along with various strategies to impart POD-like properties to these materials. The review focuses on representative examples of biomedical applications, including antibacterial, biosensing, and cancer therapy. The future challenges and prospects of 2D POD-like nanomaterials are also discussed.

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Injectable Hydrogel Based on Defect-Rich Multi-Nanozymes for Diabetic Wound Healing via an Oxygen Self-Supplying Cascade Reaction

Yang Li et al.

Summary: Defect-rich molybdenum disulfide nanosheets loaded with BSA-modified gold nanoparticles (MoS2@Au@BSA NSs) are designed to promote diabetic wound healing through an oxygen self-supplying cascade reaction. This novel material can consume glucose, eradicate bacteria, reduce oxidative stress, alleviate hypoxia, and facilitate glucose oxidation, thereby accelerating the healing of diabetic wounds.

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Article Materials Science, Biomaterials

Application of a Cascaded Nanozyme in Infected Wound Recovery of Diabetic Mice

Yanfang Zhang et al.

Summary: The emergence of peroxidase (POD)-like nano-zyme-derived catalytic therapy has provided a promising choice for reactive oxygen species (ROS)-mediated broad-spectrum anti-bacterials to replace antibiotics. By coating glucose oxidase (GOx) onto POD-like Fe2(MoO4)3, a cascade nanoenzymatic active material was developed, which achieved the synergistic effect of starvation and ROS-mediated therapy, showing high antibacterial efficacy.

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Article Engineering, Biomedical

Construction of multifunctional hydrogel based on the tannic acid-metal coating decorated MoS2 dual nanozyme for bacteria-infected wound healing

Yang Li et al.

Summary: A hydrogel with antibacterial and antioxidant properties is developed to treat bacterial-infected wounds. The hydrogel can alleviate the inflammatory response and tissue hypoxia of infected wounds. Additionally, the hydrogel exhibits fast self-healing and shape adaptability.

BIOACTIVE MATERIALS (2022)

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Article Engineering, Biomedical

Glucose/ROS cascade-responsive ceria nanozymes for diabetic wound healing

Xiaojuan Yu et al.

Summary: This study developed a glucose/ROS cascade-responsive nanozyme for diabetic wound treatment, which effectively regulates the microenvironment and promotes wound healing. In vitro and in vivo experiments demonstrated its potential in diabetic wound repair.

MATERIALS TODAY BIO (2022)

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Article Chemistry, Multidisciplinary

Specific Nanodrug for Diabetic Chronic Wounds Based on Antioxidase-Mimicking MOF-818 Nanozymes

Daiyong Chao et al.

Summary: This study presents an effective antioxidative system for diabetic chronic wound healing by integrating a metal organic framework (MOF) nanozyme with antioxidant enzyme-like activity with a hydrogel (Gel), which can modulate the oxidative stress microenvironment and transition from the inflammation phase to the proliferation phase, comparable to a widely used clinical drug.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

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Article Chemistry, Multidisciplinary

Photothermal-Amplified Single Atom Nanozyme for Biofouling Control in Seawater

Wei Wang et al.

Summary: This study introduces a photothermal nanozyme with haloperoxidase-like activity, which generates heat to greatly accelerate the reaction kinetics. It exhibits superior antibacterial activity and can be used for biofouling prevention in real marine conditions.

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Article Engineering, Biomedical

A biomimetic nanocomposite with enzyme-like activities and CXCR4 antagonism efficiently enhances the therapeutic efficacy of acute myeloid leukemia

Fei Kong et al.

Summary: This study developed a novel biomimetic nanocomposite that efficiently kills leukemia cells in the bone marrow while preventing their homing, and also blocks the infiltration of leukemia cells to other organs.

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Review Chemistry, Multidisciplinary

Catalase-Like Nanozymes: Classification, Catalytic Mechanisms, and Their Applications

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Summary: The field of nanozymes has witnessed rapid development, and CAT-like nanozymes in particular, as crucial regulators of reactive oxygen species, have attracted extensive research interest. Compared to other nanozymes, CAT-like nanozymes possess unique properties and find wide applications in fields such as tumor therapy and disease treatment. Therefore, a systematic discussion on CAT-like nanozymes is of great significance.

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Article Engineering, Environmental

Acidity-responsive cascade nanoreactor based on metal-nanozyme and glucose oxidase combination for starving and photothermal-enhanced chemodynamic antibacterial therapy

Tongyao Wang et al.

Summary: This study developed a novel nanoreactor that utilizes glucose oxidation to generate highly active radicals for starvation therapy and chemodynamic therapy. It also incorporates photothermal enhancement and release of copper ions for enhanced angiogenesis, thereby combating persistent inflammation and bacterial infection during wound healing.

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Article Chemistry, Applied

Triphenylamine flanked boron difluoride formazanate for NIR-II fluorescence imaging-guided photothermal therapy

Hui Li et al.

Summary: In this study, a small molecular fluorescent dye based on boron difluoride formazanate and encapsulated into nanoparticles was successfully synthesized. The nanoparticles showed high fluorescence quantum yield and photothermal conversion efficiency in the NIR-II region, making them promising for cancer therapy.

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Review Chemistry, Multidisciplinary

Biofilm microenvironment-responsive nanoparticles for the treatment of bacterial infection

Yanling Hu et al.

Summary: Biofilm infectious diseases have become a growing global health issue, and conventional antibiotic therapy is ineffective due to poor biofilm penetration and antibiotic tolerance. The development of biofilm microenvironment-responsive nanoparticles offers a promising strategy for combating biofilm infection.

NANO TODAY (2022)

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Review Chemistry, Multidisciplinary

Plasmonic Nanozymes: Leveraging Localized Surface Plasmon Resonance to Boost the Enzyme-Mimicking Activity of Nanomaterials

Guopeng Xu et al.

Summary: This review discusses the physical mechanisms and applications of plasmonic nanozymes (PNzymes), which utilize localized surface plasmon resonance (LSPR) to enhance the enzyme-mimicking activity of nanomaterials. The article introduces the near-field enhancement, hot carriers, and photothermal effect involved in PNzymes. It also highlights the potential applications in biosensing, cancer therapy, and bacterial infections elimination, while addressing current challenges and future perspectives for clinical translation.

SMALL (2022)

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Article Optics

Cerium-based nanoparticles for cancer photodynamic therapy

Hui Li et al.

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JOURNAL OF INNOVATIVE OPTICAL HEALTH SCIENCES (2022)

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Suryanarayana Polaka et al.

ACS OMEGA (2022)

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Nanozymes for Regenerative Medicine

Xiaozhou Mou et al.

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Review Chemistry, Multidisciplinary

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Yanling Hu et al.

Summary: Diabetic wound infection is a common disease that poses challenges due to the diabetic wound environment and bacterial resistance. Nanobiomaterial-based therapeutic systems with stimuli-responsive performance can address these challenges by delivering therapeutic agents on demand.

NANOSCALE (2022)

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Review Chemistry, Multidisciplinary

Recent advances in nanozymes for combating bacterial infection

Yanqing Su et al.

Summary: Bacterial infection poses a significant threat to global public health. The overuse and misuse of antibiotics have led to the emergence of antibiotic-resistant strains, exacerbated by the COVID-19 pandemic. Thus, there is an urgent need for alternative antibacterial treatments. Nanozymes, with their broad-spectrum antibacterial activity, low drug resistance, and high stability, have emerged as promising new antibacterial agents.

MATERIALS CHEMISTRY FRONTIERS (2022)

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Article Materials Science, Biomaterials

Au-Pt nanozyme-based multifunctional hydrogel dressing for diabetic wound healing

Bo Zhang et al.

Summary: A multifunctional self-healing hydrogel dressing has been developed to regulate the complex microenvironment of diabetic wounds and accelerate the healing process.

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POD Nanozyme optimized by charge separation engineering for light/pH activated bacteria catalytic/photodynamic therapy

Changyu Gao et al.

Summary: This article introduces a novel Ag/Bi2MoO6 (Ag/BMO) nanozyme optimized by charge separation engineering with photoactivated sustainable peroxidase-mimicking activities and NIR-II photodynamic performance, which exhibits satisfactory bactericidal performance against MRSA.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

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Enhanced Potassium-Ion Storage of the 3D Carbon Superstructure by Manipulating the Nitrogen-Doped Species and Morphology

Yanhua Li et al.

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NANO-MICRO LETTERS (2021)

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Review Nanoscience & Nanotechnology

Gold Nanozymes: From Concept to Biomedical Applications

Javier Lou-Franco et al.

Summary: Gold nanoparticles with enzyme-mimicking activities show great potential for applications in biomedicine, but the challenge lies in controlling their physicochemical properties and minimizing side effects for in vivo applications. Specific biorecognition elements may need to be immobilized onto nanozymes to enhance their activity, requiring further research on external parameters and toxicity studies for in vivo applicability.

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Hui Wei et al.

NANO TODAY (2021)

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Yu Chong et al.

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NANO TODAY (2021)

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Review Chemistry, Multidisciplinary

Functional Hydrogels as Wound Dressing to Enhance Wound Healing

Yongping Liang et al.

Summary: Hydrogels have shown promising advantages as wound dressings due to their excellent biochemical and mechanical properties. This review summarizes the advanced functions of hydrogel dressings, such as antimicrobial, adhesion, hemostasis, anti-inflammatory, substance delivery, self-healing, stimulus response, and conductivity, as well as the emerging wound monitoring feature. The potential applications for different types of wounds, including chronic wounds and focus on infected, burn, and diabetic wounds, are discussed, along with proposed future directions for hydrogel wound dressings in wound healing.

ACS NANO (2021)

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Yifei Lu et al.

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Zhuolong Tu et al.

Summary: A conductive hydrogel scaffold with M2 phenotype-enabled properties has been developed to enhance diabetic wound repair by promoting anti-inflammation and antioxidant activities.

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Linqiang Mei et al.

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Platinum-Copper Bimetallic Colloid Nanoparticle Cluster Nanozymes with Multiple Enzyme-like Activities for Scavenging Reactive Oxygen Species

Yan Liu et al.

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Summary: By designing metal-organic framework-based nanoreactors loaded with glucose oxidase and peroxidase-like bovine hemoglobin, an effective cascaded catalytic antibacterial system has been constructed. This system can both starve and kill multidrug-resistant bacteria, and accelerate diabetic wound healing.

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Qianwen Liu et al.

Summary: Nanozymes, as promising alternatives to natural enzymes, have been extensively researched and developed, showing applications in clinical medicine, food safety, environmental monitoring, and chemical production. Metal- and metal oxide-based nanozymes have gained attention due to their remarkable properties and low cost, with in-depth study of their catalytic mechanism being crucial for future applications.

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Summary: Superoxide dismutases (SODs) play a crucial role in combating damage from reactive oxygen species in oxidative stress-related diseases. Nanozymes, as substitutes for SODs, offer better stability and cost-effectiveness.

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ADVANCED FUNCTIONAL MATERIALS (2020)

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Chaoxiu Ren et al.

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