☆ 4.4 Article

An efficient feeder-free and chemically-defined expansion strategy for highly purified natural killer cells derived from human cord blood

REGENERATIVE THERAPY (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Cell & Tissue Engineering

The Role of NK Cells and Their Exosomes in Graft Versus Host Disease and Graft Versus Leukemia

Alireza Zafarani et al.

Summary: NK cells play an important role in preventing and controlling tumors and viral diseases, but their role in hematopoietic stem cell transplantation is not fully understood. Some research suggests that NK cells can prevent infections and tumor relapse without causing graft versus host disease. NK cell-derived exosomes also have anti-leukemia effects in graft-versus-leukemia. Furthermore, NK cells have antiviral effects in post-HCT cytomegalovirus infection.

STEM CELL REVIEWS AND REPORTS (2023)

添加到收藏夹

Review Immunology

Advances in NK cell production

Fang Fang et al.

Summary: Immunotherapy based on natural killer (NK) cells is a promising approach for treating a variety of cancers. Strategies for obtaining large quantities of NK cells with high purity and cytotoxicity have been developed, including using different cellular sources and genetic modification technologies. Closed, automated, and GMP-controlled large-scale expansion systems are also being studied.

CELLULAR & MOLECULAR IMMUNOLOGY (2022)

添加到收藏夹

Review Immunology

NK-cell exhaustion, B-cell exhaustion and T-cell exhaustion-the differences and similarities

Kevin Roe

Summary: T-cell exhaustion has been extensively studied, while less attention has been given to NK-cell exhaustion and B-cell exhaustion. There are differences and similarities between lymphocyte exhaustion, including NK-cell exhaustion, B-cell exhaustion, and T-cell exhaustion. Lymphocyte exhaustion is often confused with anergy, cellular senescence, and suppression, and it is not a binary state but rather a continuum caused by different levels and duration of continuous antigenic stimulation.

IMMUNOLOGY (2022)

添加到收藏夹

Review Medicine, Research & Experimental

Natural killer cells: a promising immunotherapy for cancer

Junfeng Chu et al.

Summary: This article summarizes the recent advances and clinical applications of natural killer (NK) cell immunotherapy, focusing on the biology and function of NK cells, different types of NK cell therapy, and clinical trials and future perspectives of NK cell therapy.

JOURNAL OF TRANSLATIONAL MEDICINE (2022)

添加到收藏夹

Review Oncology

Natural killer cells in clinical development as non-engineered, engineered, and combination therapies

Nina Lamers-Kok et al.

Summary: This review summarizes the clinical status of allogeneic NK cell-based therapies for hematological and solid tumors, discusses different cell sources, engineering methods, and combination therapies. It also reviews regulatory challenges and the competitive landscape, providing a comprehensive overview.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2022)

添加到收藏夹

Article Cell & Tissue Engineering

Establishment of an efficient ex vivo expansion strategy for human natural killer cells stimulated by defined cytokine cocktail and antibodies against natural killer cell activating receptors

Tsutomu Nakazawa et al.

Summary: This study showed that a robust expansion system for highly purified human NK cells using a defined cytokine cocktail and anti-NK cell activating receptor antibodies was established. The system could be feasible for autologous or allogeneic NK cell-based immunotherapy of GBM and easily controlled under Japanese law on regenerative medicine. The expansion process can enhance NK cell purity and activity for potential cancer treatment.

REGENERATIVE THERAPY (2022)

添加到收藏夹

Review Oncology

Exploring the NK cell platform for cancer immunotherapy

Jacob A. Myers et al.

Summary: NK cells have innate potential to kill cancer cells, leading to the development of various NK cell-based therapies for cancer treatment. The main focus of NK cell therapy research is on optimizing sources of therapeutic NK cells and enhancing their cytotoxicity and persistence in the body.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

添加到收藏夹

Review Oncology

Temozolomide-induced aplastic anaemia: Case report and review of the literature

Peter J. Gilbar et al.

Summary: The case report describes a 68-year-old female with GBM who developed very severe aplastic anemia (AA) likely due to temozolomide (TMZ) treatment, requiring platelet transfusions, antibiotics, antiviral and antifungal prophylaxis, and G-CSF. The patient's blood counts returned to normal after 38 days, highlighting the importance of monitoring for rare but potentially fatal toxicities associated with TMZ.

JOURNAL OF ONCOLOGY PHARMACY PRACTICE (2021)

添加到收藏夹

Review Oncology

NK cell-based cancer immunotherapy: from basic biology to clinical development

Sizhe Liu et al.

Summary: NK cells, as a specialized immune effector cell type, play a critical role in immune activation against abnormal cells. Unlike T cell activation, NK cell activation is governed by interactions between NK receptors and target cells, leading to significant attention in cancer immunotherapy. Many efforts are focused on developing and engineering NK cell-based cancer immunotherapy.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

CRISPR-Cas9-Mediated TIM3 Knockout in Human Natural Killer Cells Enhances Growth Inhibitory Effects on Human Glioma Cells

Takayuki Morimoto et al.

Summary: Studies have shown that enhancing NK cell-mediated cytotoxicity on GBM cells through TIM3 knockout using CRISPR-Cas9 technology may be a promising immunotherapeutic alternative.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Article Oncology

Evaluation of Comprehensive Gene Expression and NK Cell-Mediated Killing in Glioblastoma Cell Line-Derived Spheroids

Takayuki Morimoto et al.

Summary: Glioblastoma (GBM) is the most aggressive primary malignant brain tumor in adults with poor survival rates. Immunotherapy utilizing Natural killer (NK) cells shows promise in treating GBM by exerting a cytotoxic effect on tumor cells. Preclinical evaluation using an ex vivo 3D spheroid model derived from GBM cell lines showed that NK cells had an anti-tumor effect by inducing tumor cell death through apoptosis, providing valuable information for future NK cell-based immunotherapy for GBM patients.

CANCERS (2021)

添加到收藏夹

Article Cell & Tissue Engineering

Harnessing features of adaptive NK cells to generate iPSC-derived NK cells for enhanced immunotherapy

Karrune Woan et al.

Summary: Researchers have successfully generated a NK cell subset called iADAPT by editing induced pluripotent stem cells, which exhibited persistence in vivo and superior antitumor activity. This finding suggests that unique subsets of the immune system can be modeled through iPSC technology, providing a new approach for treating patients with advanced cancer.

CELL STEM CELL (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Ex Vivo Expanded and Activated Natural Killer Cells Prolong the Overall Survival of Mice with Glioblastoma-like Cell-Derived Tumors

Yoichi Shida et al.

Summary: GiNKs, as a promising cell-based immunotherapy, show potential in treating GBM by prolonging the survival of NOG mice carrying U87MG-derived tumors. Although PD-L1 is expressed on U87MG and T98G cells, the expression levels vary significantly. PD-1 blocking antibodies did not have an additional effect on prolonging survival.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Review Oncology

Mitochondria as Playmakers of CAR T-cell Fate and Longevity

Hosein Rostamian et al.

Summary: The development of CAR-T cell therapy has changed the paradigm of cancer treatment, but patients often do not benefit due to poor cell persistence. Strategies based on long-lasting memory T cells may enhance the therapeutic effects of CAR-T cells. Mitochondrial metabolic pathways play a crucial role in determining the fate, function, and longevity of T cells.

CANCER IMMUNOLOGY RESEARCH (2021)

添加到收藏夹

Review Immunology

NK Cells in a Tug-of-War With Cancer: The Roles of Transcription Factors and Cytoskeleton

E. Hui Clarissa Lee et al.

Summary: NK cells play a key role in shaping the immune response against cancer, but their functions are hindered by the immunosuppressive tumor microenvironment. While checkpoint inhibition shows promise in early-stage studies, further exploration is needed in the context of the TME. Surface receptors and T-box transcription factors may play crucial roles in identifying and characterizing NK cell dysfunction.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

MicroRNA-130a enhances the killing ability of natural killer cells against non-small cell lung cancer cells by targeting signal transducers and activators of transcription

Xiaohu Zhou et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

添加到收藏夹

Review Biotechnology & Applied Microbiology

NK cells for cancer immunotherapy

Noriko Shimasaki et al.

NATURE REVIEWS DRUG DISCOVERY (2020)

添加到收藏夹

Article Cell Biology

Effect of CRISPR/Cas9-Mediated PD-1-Disrupted Primary Human Third-Generation CAR-T Cells Targeting EGFRvIII on In Vitro Human Glioblastoma Cell Growth

Tsutomu Nakazawa et al.

CELLS (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Ex vivo-expanded highly purified natural killer cells in combination with temozolomide induce antitumor effects in human glioblastoma cells in vitro

Yoshitaka Tanaka et al.

PLOS ONE (2019)

添加到收藏夹

Review Immunology

Killer Ig-Like Receptors (KIRs): Their Role in NK Cell Modulation and Developments Leading to Their Clinical Exploitation

Daniela Pende et al.

FRONTIERS IN IMMUNOLOGY (2019)

添加到收藏夹

Review Medicine, Research & Experimental

Killers 2.0: NK cell therapies at the forefront of cancer control

Jonathan J. Hodgins et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

添加到收藏夹

Article Biotechnology & Applied Microbiology

A simple method for in vitro preparation of natural killer cells from cord blood

Yong Xu Mu et al.

BMC BIOTECHNOLOGY (2019)

添加到收藏夹

Review Oncology

Technical advances in NK cell-based cellular immunotherapy

Fang Fang et al.

CANCER BIOLOGY & MEDICINE (2019)

添加到收藏夹

Review Immunology

Activating and inhibitory receptors expressed on innate lymphoid cells

Sophie Guia et al.

SEMINARS IN IMMUNOPATHOLOGY (2018)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Comparison of autogeneic and allogeneic natural killer cells immunotherapy on the clinical outcome of recurrent breast cancer

Shuzhen Liang et al.

ONCOTARGETS AND THERAPY (2017)

添加到收藏夹

Review Immunology

The Rise of Allogeneic Natural Killer Cells As a Platform for Cancer immunotherapy: Recent innovations and Future Developments

John P. Veluchamy et al.

FRONTIERS IN IMMUNOLOGY (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Entire CD3ε, δ, and γ humanized mouse to evaluate human CD3-mediated therapeutics

Otoya Ueda et al.

SCIENTIFIC REPORTS (2017)

添加到收藏夹

Article Hematology

Phase I study of cord blood-derived natural killer cells combined with autologous stem cell transplantation in multiple myeloma

Nina Shah et al.

BRITISH JOURNAL OF HAEMATOLOGY (2017)

添加到收藏夹

Article Hematology

Donor Killer Immunoglobulin-Like Receptor Haplotype B/x Induces Severe Acute Graft-versus-Host Disease in the Presence of Human Leukocyte Antigen Mismatch in T Cell-Replete Hematopoietic Cell Transplantation

Ryosuke Hosokai et al.

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION (2017)

添加到收藏夹

Review Clinical Neurology

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

David N. Louis et al.

ACTA NEUROPATHOLOGICA (2016)

添加到收藏夹

Article Oncology

Selection and expansion of natural killer cells for NK cell-based immunotherapy

Petra S. A. Becker et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2016)

添加到收藏夹

Article Cell Biology

Cytokine-induced memory-like natural killer cells exhibit enhanced responses against myeloid leukemia

Rizwan Romee et al.

SCIENCE TRANSLATIONAL MEDICINE (2016)

添加到收藏夹

Review Hematology

CD19-targeted chimeric antigen receptor T-cell therapy for acute lymphoblastic leukemia

Shannon L. Maude et al.

BLOOD (2015)

添加到收藏夹

Article Medicine, Research & Experimental

Phase I clinical trial of autologous NK cell therapy using novel expansion method in patients with advanced digestive cancer

Naoyuki Sakamoto et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2015)

添加到收藏夹

Article Hematology

Acute GVHD in patients receiving IL-15/4-1BBL activated NK cells following T-cell-depleted stem cell transplantation

Nirali N. Shah et al.

BLOOD (2015)

添加到收藏夹

Article Multidisciplinary Sciences

Antigen Presenting Cell-Mediated Expansion of Human Umbilical Cord Blood Yields Log-Scale Expansion of Natural Killer Cells with Anti-Myeloma Activity

Nina Shah et al.

PLOS ONE (2013)

添加到收藏夹

Article Cell & Tissue Engineering

Clinical-Scale Derivation of Natural Killer Cells From Human Pluripotent Stem Cells for Cancer Therapy

David A. Knorr et al.

STEM CELLS TRANSLATIONAL MEDICINE (2013)

添加到收藏夹

Review Immunology

NK cell MHC class I specific receptors (KIR): from biology to clinical intervention

Ariane Thielens et al.

CURRENT OPINION IN IMMUNOLOGY (2012)

添加到收藏夹

Article Immunology

The unique profile of cord blood natural killer cells balances incomplete maturation and effective killing function upon activation

Martha Luevano et al.

HUMAN IMMUNOLOGY (2012)

添加到收藏夹

Article Oncology

Adoptive Transfer of Autologous Natural Killer Cells Leads to High Levels of Circulating Natural Killer Cells but Does Not Mediate Tumor Regression

Maria R. Parkhurst et al.

CLINICAL CANCER RESEARCH (2011)

添加到收藏夹

Review Immunology

Up on the tightrope: natural killer cell activation and inhibition

Lewis L. Lanier

NATURE IMMUNOLOGY (2008)

添加到收藏夹

Article Pediatrics

Characterization of cord blood natural killer cells:: Implications for transplantation and neonatal infections

JH Dalle et al.

PEDIATRIC RESEARCH (2005)

添加到收藏夹

Article Medicine, General & Internal

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

R Stupp et al.

NEW ENGLAND JOURNAL OF MEDICINE (2005)

添加到收藏夹

Article Oncology

Treatment of colon and lung cancer patients with ex vivo heat shock protein 70-peptide-activated, autologous natural killer cells:: a clinical phase I trial

SW Krause et al.

CLINICAL CANCER RESEARCH (2004)

添加到收藏夹

Article Biophysics

IL-2-based immunotherapy after autologous transplantation for lymphoma and breast cancer induces immune activation and cytokine release: a phase I/II trial

LJ Burns et al.

BONE MARROW TRANSPLANTATION (2003)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.