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Article
Medicine, General & Internal
J. Sadoff et al.
Summary: The Ad26.COV2.S vaccine was found to be 52.9% effective against moderate to severe-critical Covid-19 after a single dose, with protection lasting for at least 6 months. Efficacy varied depending on the Covid-19 variant, but higher protection was observed against severe cases, medical intervention, and death compared to other outcomes.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jong Eun Lee et al.
Summary: This study evaluated the clinical and imaging characteristics of patients with COVID-19 breakthrough infections and found that compared with unvaccinated patients, breakthrough infection patients had a lower proportion of pneumonia on chest CT scans, as well as a lower risk of requiring supplemental oxygen and intensive care unit admission. This suggests that vaccines still play an important role in preventing severe illness and hospitalization.
Article
Medicine, General & Internal
Tal Patalon et al.
Summary: This study demonstrated that receiving a booster dose of the BNT162b2 vaccine can reduce the odds of testing positive for SARS-CoV-2 in the short term, potentially counteracting waning immunity. Further monitoring is needed to determine the duration of immunity following the booster dose.
JAMA INTERNAL MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Simone Vicini et al.
Summary: This study aimed to compare the frequency and severity of pneumonia on chest CT scans in COVID-19 patients who were unvaccinated versus those who were fully vaccinated with mRNA or adenovirus vector vaccines. The results showed that fully vaccinated patients had lower rates and severity of pneumonia. This provides additional evidence for the clinical benefit of vaccination.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2022)
Article
Medicine, General & Internal
Edson D. Moreira et al.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Allergy
Ya-dong Gao et al.
Summary: The severity factors of COVID-19 include age, gender, underlying health conditions such as hypertension, diabetes, obesity, and immunodeficiency, which may lead to complications like acute kidney injury. Various laboratory indicators and parameters can help monitor disease progression, while socioeconomic factors, lifestyle, and quality of healthcare also play a role in individual outcomes.
Article
Medicine, General & Internal
Merryn Voysey et al.
Summary: The ChAdOx1 nCoV-19 vaccine has been shown to have an acceptable safety profile and effectiveness against symptomatic COVID-19, with higher efficacy observed in the group that received a low dose followed by a standard dose.
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiaoyu Han et al.
Summary: The study found that over one-third of severe COVID-19 patients showed fibrotic-like changes in the lung at 6-month follow-up CT, which were associated with older age, acute respiratory distress syndrome, longer hospital stays, tachycardia, noninvasive mechanical ventilation, and higher initial chest CT score.
Article
Medicine, General & Internal
Sara Y. Tartof et al.
Summary: This study aimed to assess the overall and variant-specific effectiveness of the BNT162b2 vaccine against SARS-CoV-2 infections and COVID-19-related hospital admissions among members of a healthcare system in California. The effectiveness of the vaccine remained high against hospital admissions even up to 6 months after full vaccination, despite a decline in effectiveness against SARS-CoV-2 infections over time, which was likely due to waning immunity rather than the delta variant escaping vaccine protection.
Article
Medicine, General & Internal
Noam Barda et al.
Summary: A study using data from Israel's largest health-care organization showed that a third dose of the BNT162b2 mRNA vaccine is effective in preventing individuals from severe COVID-19-related outcomes, compared to receiving only two doses at least 5 months ago. The effectiveness of the third dose in preventing hospital admission was 93%, severe disease 92%, and COVID-19-related death 81%.
Article
Medicine, General & Internal
Ann R. Falsey et al.
Summary: The clinical trial in the United States, Chile, and Peru showed that the AZD1222 vaccine was both safe and effective in preventing symptomatic and severe Covid-19 cases, with an overall estimated efficacy of 74% and a higher efficacy of 83.5% in participants 65 years of age or older. The high vaccine efficacy was consistent across various demographic subgroups, and antibodies increased significantly after each dose.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Medicine, General & Internal
Merryn Voysey et al.
Summary: The AZD1222 vaccine has been approved for emergency use in the UK with an interval of 4-12 weeks between doses. Analysis shows that the vaccine is efficacious with two doses and provides immunoprotection after the first dose before the second dose is administered.
Article
Medicine, General & Internal
Jamie Lopez Bernal et al.
Summary: This study estimated the real-world effectiveness of Pfizer-BioNTech BNT162b2 and Oxford-AstraZeneca ChAdOx1-S vaccines against confirmed COVID-19 symptoms, hospital admissions, and deaths. The vaccines showed significant reduction in symptomatic COVID-19 among older adults and further protection against severe disease. Both vaccines demonstrated similar effects and protection was maintained for over 6 weeks.
BMJ-BRITISH MEDICAL JOURNAL
(2021)
Article
Medicine, General & Internal
Yinon M. Bar-On et al.
Summary: After receiving a third dose of the BNT162b2 mRNA vaccine, Israeli residents aged 60 and above who had previously received two doses of the vaccine saw significantly lower rates of confirmed Covid-19 infection and severe illness compared to those who did not receive a booster shot, indicating the effectiveness of the booster dose in reducing infection and severe illness.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Feng Pan et al.
Article
Critical Care Medicine
Geoffrey D. Rubin et al.
Article
Medicine, General & Internal
Fei Zhou et al.
Article
Infectious Diseases
J. Zhang et al.
CLINICAL MICROBIOLOGY AND INFECTION
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Marco Francone et al.
EUROPEAN RADIOLOGY
(2020)
Review
Radiology, Nuclear Medicine & Medical Imaging
David M. Hansell et al.
