Expedient (3+3)-annulation of in situ generated azaoxyallyl cations with diaziridines

Efficient annulation of in situ formed azaoxyallyl cations using a base has been accomplished with diaziridines to provide 1,2,4-triazines at room temperature. The substrate scope, scale up, functional group tolerance and transition-metal free reaction conditions are the important practical features.

Automated summary

Efficient annulation of in situ formed azaoxyallyl cations using diaziridines has been achieved at room temperature with the aid of a base, leading to the formation of 1,2,4-triazines. The practical advantages of this reaction include its broad substrate scope, scalability, high tolerance towards functional groups, and the absence of transition-metal catalysts.