4.7 Article

TRIM28 promotes the escape of gastric cancer cells from immune surveillance by increasing PD-L1 abundance

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Oncology

Dual PD-1 and CTLA-4 Checkpoint Blockade Using Balstilimab and Zalifrelimab Combination as Second-Line Treatment for Advanced Cervical Cancer: An Open-Label Phase II Study

David M. O'Malley et al.

Summary: This phase II trial evaluated the efficacy of dual treatment with balstilimab and zalifrelimab in patients with recurrent and/or metastatic cervical cancer. The results showed promising and durable clinical activity, with favorable tolerability, in these patients.

JOURNAL OF CLINICAL ONCOLOGY (2022)

Review Pharmacology & Pharmacy

The generation of PD-L1 and PD-L2 in cancer cells: From nuclear chromatin reorganization to extracellular presentation

Zhiwei Fan et al.

Summary: This article provides a systematic and comprehensive overview of the regulation of PD-L1, from nuclear chromatin reorganization to extracellular presentation. Understanding the regulation of PD-L1/PD-L2 and their regulatory networks can shed light on the development and application of immune checkpoint blockade therapy and combination therapies.

ACTA PHARMACEUTICA SINICA B (2022)

Article Biochemistry & Molecular Biology

Sequential ubiquitination of p53 by TRIM28, RLIM, and MDM2 in lung tumorigenesis

Jun-O Jin et al.

Summary: TRIM28 is often overexpressed in lung cancer patients and regulates the levels of p53 by targeting ubiquitin ligases RLIM and MDM2, affecting proliferation, migration, and invasiveness of lung cancer cells.

CELL DEATH AND DIFFERENTIATION (2021)

Article Biochemistry & Molecular Biology

Deubiquitinating enzyme OTUB1 promotes cancer cell immunosuppression via preventing ER-associated degradation of immune checkpoint protein PD-L1

Dan Zhu et al.

Summary: OTUB1 positively regulates PD-L1 stability, mediates cancer immune responses through the PD-1/PD-L1 axis, and may be a potential therapeutic target for cancer immunotherapy by influencing tumor growth and cytotoxicity mediated by immune cells.

CELL DEATH AND DIFFERENTIATION (2021)

Article Biochemistry & Molecular Biology

In vivo CRISPR screens identify the E3 ligase Cop1 as a modulator of macrophage infiltration and cancer immunotherapy target

Xiaoqing Wang et al.

Summary: This study suggests that Cop1 may be a potential target for improving cancer immunotherapy efficacy in TNBC by regulating chemokine secretion and macrophage infiltration in the tumor microenvironment, as demonstrated through experiments in mouse models. This finding highlights the importance of understanding the role of Cop1 in TNBC treatment and its potential implications for enhancing anti-tumor immunity.
Article Oncology

Design and Efficacy of a Monovalent Bispecific PD-1/CTLA4 Antibody That Enhances CTLA4 Blockade on PD-1+ Activated T Cells

Simon J. Dovedi et al.

Summary: MEDI5752 is a novel monovalent bispecific antibody that enhances the clinical benefits of PD-1 blockade while reducing immune-related adverse events, leading to improved therapeutic outcomes. It represents a significant advancement in the rational design of cancer immunotherapy and shows promising potential in targeting PD-1(+) T cells with enhanced activity compared to conventional mAb combination strategies.

CANCER DISCOVERY (2021)

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Review Pathology

Immunotherapy of gastric cancer: Past, future perspective and challenges

Jun Xie et al.

Summary: Gastric cancer is the third leading cause of deaths and the fifth most common cancers worldwide. Traditional treatment approaches include chemotherapy, radiation, surgery, and targeted therapy. Immunotherapy has shown promising results, but the prognosis remains poor.

PATHOLOGY RESEARCH AND PRACTICE (2021)

Article Oncology

The SETDB1-TRIM28 Complex Suppresses Antitumor Immunity

Jianhuang Lin et al.

Summary: The SETDB1-TRIM28 complex acts as a critical suppressor of antitumor immunity by negatively regulating PD-L1 expression and activating the cGAS-STING innate immune response pathway to increase infiltration of CD8(+) T cells. Inhibition of SETDB1-TRIM28 bridges innate and adaptive immunity, leading to enhanced antitumor effects of immune checkpoint blockade.

CANCER IMMUNOLOGY RESEARCH (2021)

Article Biochemistry & Molecular Biology

Expansion of tumor-associated Treg cells upon disruption of a CTLA-4-dependent feedback loop

Francesco Marangoni et al.

Summary: The study reveals that T regulatory cells interact with tumor-associated conventional dendritic cells to receive activation signals and self-regulate their function through a CTLA-4- and CD28-dependent feedback loop. CTLA-4 blockade may lead to Treg cell hyper-proliferation and impact therapeutic benefits in cancer patients.
Review Oncology

Regulatory mechanisms of immune checkpoints PD-L1 and CTLA-4 in cancer

Hao Zhang et al.

Summary: The regulatory mechanisms of PD-L1 and CTLA-4 play a crucial role in immunotherapy, and understanding their interactions can help improve patients' treatment responses and clinical care.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

Article Multidisciplinary Sciences

TRIM28 SUMOylates and stabilizes NLRP3 to facilitate inflammasome activation

Ying Qin et al.

Summary: The E3 ligase TRIM28 can SUMOylate NLRP3, thereby limiting its proteasomal degradation and increasing NLRP3 inflammasome activity.

NATURE COMMUNICATIONS (2021)

Article Biochemistry & Molecular Biology

The E3 ubiquitin ligase TRIM7 suppressed hepatocellular carcinoma progression by directly targeting Src protein

Lihui Zhu et al.

CELL DEATH AND DIFFERENTIATION (2020)

Review Oncology

Gastric cancer: Epidemiology, risk factors and prevention strategies

Lei Yang et al.

CHINESE JOURNAL OF CANCER RESEARCH (2020)

Article Gastroenterology & Hepatology

MET Inhibitors Promote Liver Tumor Evasion of the Immune Response by Stabilizing PDL1

Hui Li et al.

GASTROENTEROLOGY (2019)

Review Oncology

Combination of CTLA-4 and PD-1 blockers for treatment of cancer

Anand Rotte

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)

Review Biochemistry & Molecular Biology

Biochemical Aspects of PD-L1 Regulation in Cancer Immunotherapy

Jinfang Zhang et al.

TRENDS IN BIOCHEMICAL SCIENCES (2018)

Article Multidisciplinary Sciences

TRIM28 protects TRIM24 from SPOP-mediated degradation and promotes prostate cancer progression

Ka-wing Fong et al.

NATURE COMMUNICATIONS (2018)

Article Multidisciplinary Sciences

Identification of CMTM6 and CMTM4 as PD-L1 protein regulators

Riccardo Mezzadra et al.

NATURE (2017)

Article Multidisciplinary Sciences

CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity

Marian L. Burr et al.

NATURE (2017)

Article Multidisciplinary Sciences

Identification of essential genes for cancer immunotherapy

Shashank J. Patel et al.

NATURE (2017)

Article Cell Biology

Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression

Angel Garcia-Diaz et al.

CELL REPORTS (2017)

Review Cell Biology

The complexity of TRIM28 contribution to cancer

Patrycja Czerwinska et al.

JOURNAL OF BIOMEDICAL SCIENCE (2017)

Article Oncology

Deubiquitination and Stabilization of PD-L1 by CSN5

Seung-Oe Lim et al.

CANCER CELL (2016)

Review Medicine, General & Internal

Molecular and Biochemical Aspects of the PD-1 Checkpoint Pathway

Vassiliki A. Boussiotis

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Review Oncology

PD-L1 Expression as a Predictive Biomarker in Cancer Immunotherapy

Sandip Pravin Patel et al.

MOLECULAR CANCER THERAPEUTICS (2015)

Article Biotechnology & Applied Microbiology

Quality control, modeling, and visualization of CRISPR screens with MAGeCK-VISPR

Wei Li et al.

GENOME BIOLOGY (2015)

Article Multidisciplinary Sciences

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

Ophir Shalem et al.

SCIENCE (2014)

Article Biotechnology & Applied Microbiology

MAGeCK enables robust identification of essential genes from genome-scale CRISPR/Cas9 knockout screens

Wei Li et al.

GENOME BIOLOGY (2014)