Multisystemic Inflammatory Syndrome Temporally Associated with COVID-19 in a Regional Pediatric Hospital from Mexico

Multisystemic inflammatory syndrome (MIS-C) is an inflammatory condition temporally associated with COVID-19 in children; nevertheless, the clinical and immunologic spectrum of MIS-C is heterogeneous, and its long-term effects are unknown. During the period of August 2020 to December 2021, a total of 52 MIS-C cases were confirmed in pediatric patients from the Hospital del Nino DIF Hidalgo, diagnosed using criteria from the World Health Organization. All patients had serologic IgG confirmation of SARS-CoV2, the mean age of the patients was 7 years, and 94% of the patients did not have a previous underlying disease. In addition to the presentation of lymphopenia, neutropenia, and thrombocytopenia, elevations in D-dimer and ferritin levels were observed in all patients. There was clinical improvement with intravenous gamma globulin and corticosteroid treatment.

Automated summary

During August 2020 to December 2021, 52 cases of multisystemic inflammatory syndrome (MIS-C) in pediatric patients were confirmed using World Health Organization criteria. All patients had serologic IgG confirmation of SARS-CoV-2, with a mean age of 7 years and 94% without underlying diseases. In addition to lymphopenia, neutropenia, and thrombocytopenia, elevated D-dimer and ferritin levels were observed in all patients. Clinical improvement was achieved with intravenous gamma globulin and corticosteroid treatment.