ANALYSIS OF AN EXTENDED GENE REGULATORY NETWORK MODEL WITH TIME DELAY

This paper is concerned with the analysis of an extended gene regulatory network model with time delayed negative feedback. An extended model amounts to considering the unmodeled dynamics in the earlier Gene regulatory network (GRN) designs. Stability analysis of the extended model is further investigated with different design parameters. A local stability condition is derived for a model of extended GRN with time delay. Several numerical examples are given to illustrate the stability characteristics of the delayed extended GRN model and the results are compared with the benchmark homogeneous gene regulatory network.

Automated summary

This paper explores the analysis of an extended gene regulatory network model with time delayed negative feedback. The stability of the extended model is investigated using different design parameters, and a local stability condition is derived. Numerical examples are provided to illustrate the stability characteristics of the delayed extended GRN model, and the results are compared with a benchmark homogeneous gene regulatory network.