☆ 4.6 Review

Functional anti-bone tumor biomaterial scaffold: construction and application

JOURNAL OF MATERIALS CHEMISTRY B (2023)

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Targeted and responsive biomaterials in osteoarthritis

Jiadong Li et al.

Summary: Osteoarthritis (OA) is a degenerative disease characterized by loss of articular cartilage and chronic inflammation, leading to multiple dysfunctions and tissue lesions. However, drug delivery to the affected joints is hindered by non-vascular environment and dense cartilage matrix, resulting in low drug bioavailability. Biomaterials have shown promise in improving drug targeting and achieving precision therapy for OA. This article reviews the understanding of OA's pathological mechanisms, discusses advances in different types of targeted biomaterials, and analyzes limitations and challenges in clinical translation and biosafety, aiming to guide future therapeutic strategies for OA.

THERANOSTICS (2023)

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Review Materials Science, Multidisciplinary

Hydrogels for bone organoid construction: From a materiobiological perspective

Shunli Wu et al.

Summary: Bone organoids offer realistic models for bone regenerative medicine development, and the matrix microenvironment around tissues and cells plays a crucial role. Matrigel, traditionally used as a matrix, faces challenges, making newly developed hydrogels suitable alternatives. This review summarizes the development and limitations of Matrigel and highlights promising hydrogel alternatives for bone organoid cultures.

JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY (2023)

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Article Engineering, Environmental

3D printed hydrogel/bioceramics core/shell scaffold with NIR-II triggered drug release for chemo-photothermal therapy of bone tumors and enhanced bone repair

Xiaonan Zhang et al.

Summary: In this study, 3D printed gelatin/bioceramics core/shell scaffolds were developed for the treatment of bone defects caused by osteosarcoma. The scaffolds exhibited photothermal therapy using NIR-II laser irradiation and achieved on-demand drug release for chemo-photothermal therapy. In vitro and in vivo experiments confirmed the synergistic effect of chemo-photothermal therapy on anti-tumor, as well as the promotion of vascularized bone regeneration.

CHEMICAL ENGINEERING JOURNAL (2023)

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Review Chemistry, Multidisciplinary

Rational Design of Biomaterials to Potentiate Cancer Thermal Therapy

Yujie Zhu et al.

Summary: Cancer thermal therapy, such as radiofrequency ablation, microwave ablation, and high-intensity focused ultrasound, has been effective in tumor ablation. However, it still has limitations in terms of damage to normal tissues and incomplete ablation for large tumors. Biomaterials can enhance local hyperthermia and synergize with other treatment modalities. This review discusses the development of functional biomaterials for improved hyperthermia and their potential applications in clinical settings.

CHEMICAL REVIEWS (2023)

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Article Engineering, Environmental

Lyophilization-inactivated cancer cells composited Janus scaffold for tumor postoperative immuno-chemotherapy

Gaizhen Kuang et al.

Summary: Immunotherapy is important for treating malignant tumors. A sponge-nanofiber Janus scaffold has been developed for tumor postoperative immuno-chemotherapy, containing lyophilization-inactivated cancer cells, immune adjuvant imiquimod, and 5-fluorouracil (5-FU). The scaffold exhibits excellent anti-recurrence and anti-metastasis efficiency in a mouse breast tumor model, making it a promising option for combination therapy after tumor surgery.

CHEMICAL ENGINEERING JOURNAL (2023)

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Article Medicine, Research & Experimental

Photothermal therapeutic potency of plasmonic silver nanoparticles for apoptosis and anti-angiogenesis in testosterone induced benign prostate hyperplasia in rats

Basma H. Marghani et al.

Summary: In this study, the effectiveness of plasmonic AgNPs photothermal therapy in the treatment of benign prostate hyperplasia (BPH) was demonstrated. The use of a near-infrared laser to increase the potency of silver nanoparticles showed promising results in decreasing prostate size, inducing apoptosis, inhibiting angiogenesis, and improving biocompatibility of vital organs in BPH rats.

LIFE SCIENCES (2022)

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Article Materials Science, Biomaterials

Optimizing the strontium content to achieve an ideal osseointegration through balancing apatite-forming ability and osteogenic activity

Zhen Geng et al.

Summary: This study showed that Sr incorporation in titanium implants can improve osseointegration, new bone formation, and mineralization. Implants with high Sr content were found to be more favorable for cell spreading, proliferation, osteogenic differentiation, and extracellular matrix mineralization. The competitive effect of osteogenic activity and apatite-forming ability on bone-implant osseointegration was proposed, providing a new strategy for implant design.

BIOMATERIALS ADVANCES (2022)

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Review Chemistry, Medicinal

Curcumin nanoformulations: Beneficial nanomedicine against cancer

Solmaz Maleki Dizaj et al.

Summary: Curcumin, a phytochemical derived from turmeric, is widely used for cancer treatment. However, its efficacy is limited due to issues like rapid metabolism, low bioavailability, and toxicity. Scientists have explored novel drug delivery systems to overcome these problems.

PHYTOTHERAPY RESEARCH (2022)

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Article Engineering, Biomedical

Three-dimensional (3D) scaffolds as powerful weapons for tumor immunotherapy

Shuyan Han et al.

Summary: This article introduces the current status and challenges in the field of cancer immunotherapy. It focuses on biomaterial-based immunomodulatory strategies, particularly the advantages of macroscale 3D biomaterial scaffolds in local immunotherapy. The design requirements and the relationships between physicochemical and biological properties of these scaffolds are discussed. The article summarizes the recent advances in the development of various 3D scaffolds and explores the opportunities and challenges in this field.

BIOACTIVE MATERIALS (2022)

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Review Pharmacology & Pharmacy

Ultrasound-activated nanomaterials for sonodynamic cancer theranostics

Nan Wu et al.

Summary: Despite the challenges in cancer treatment, sonodynamic therapy (SDT) shows promising potential as a new approach. This review provides an understanding of the mechanisms, efficacy, and future directions of SDT-based applications in tumor therapy.

DRUG DISCOVERY TODAY (2022)

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Article Engineering, Biomedical

Fabrication of physical and chemical crosslinked hydrogels for bone tissue engineering

Xu Xue et al.

Summary: Bone tissue engineering provides promising tools for the treatment of bone-related diseases using biomimetic hydrogels. This article discusses the fabrication of biomimetic hydrogels using thermal sensitive polymers, mineral ions, chemically triggered agents, photo crosslinking initiators, and enzyme triggers. These hydrogels accelerate bone regeneration and the article also highlights key factors influencing therapeutic effects.

BIOACTIVE MATERIALS (2022)

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Article Chemistry, Multidisciplinary

Rational Design of Multifunctional CuS Nanoparticle-PEG Composite Soft Hydrogel-Coated 3D Hard Polycaprolactone Scaffolds for Efficient Bone Regeneration

Xu Xue et al.

Summary: A CuS-PEG-PCL scaffold with excellent photothermal properties and stable elasticity was designed for efficient bone regeneration. The scaffold released dexamethasone sodium phosphate (Dexp) and promoted osteogenic differentiation of bone cells through controlled release and mild heating.

ADVANCED FUNCTIONAL MATERIALS (2022)

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Review Medicine, Research & Experimental

Bacterial extracellular vesicles-based therapeutic strategies for bone and soft tissue tumors therapy

Han Liu et al.

Summary: This review provides an overview of the applications of bacterial extracellular vesicles (BEVs) in cancer therapy. They have low toxicity, strong drug loading capacity, and the ability to stimulate immune responses, showing great potential in the treatment of bone and soft tissue tumors.

THERANOSTICS (2022)

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Review Medicine, Research & Experimental

Silk fibroin-based biomaterials for cartilage/osteochondral repair

Ziyang Zhou et al.

Summary: Osteoarthritis is a common joint disease that causes physical and psychological harm to patients and burdens the healthcare system. Tissue engineering has been focusing on cartilage repair, with silk fibroin as a promising biomaterial due to its unique properties and capabilities for functional modification.

THERANOSTICS (2022)

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Article Nanoscience & Nanotechnology

3D-Printed Multifunctional Polyetheretherketone Bone Scaffold for Multimodal Treatment of Osteosarcoma and Osteomyelitis

Ce Zhu et al.

Summary: The study developed the first 3D-printed PEEK-based bone scaffold with multiple functions for treating challenging bone diseases. The scaffold, coated with a drug-laden hydroxyapatite layer, utilized graphene nanosheets for on-demand photothermal conversion under laser irradiation. The presence of antibiotics and anti-cancer drugs enhanced treatment efficacy against drug-resistant bacteria and osteosarcoma cells.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Chemistry, Multidisciplinary

Combinatorial Photothermal 3D-Printing Scaffold and Checkpoint Blockade Inhibits Growth/Metastasis of Breast Cancer to Bone and Accelerates Osteogenesis

Chao He et al.

Summary: A BG@NbSiR scaffold has been developed to effectively treat bone metastasis of breast cancer by activating immune response, suppressing metastases, preventing tumor relapses, and promoting osteogenesis. Single-cell sequencing has been used to identify critical factors responding to this scaffold-based therapy, providing insights into underlying therapeutic mechanisms.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Chemistry, Applied

Magnetic bioactive glasses/Cisplatin loaded-chitosan (CS)-grafted- poly (ε-caprolactone) nanofibers against bone cancer treatment

Zahra Amini et al.

Summary: Bioactive glasses and magnetic bioactive glasses doped with Cisplatin were incorporated into chitosan-grafted-poly(epsilon-caprolactone) nanofibers for controlled drug release, resulting in accelerated release at lower pH and higher temperature conditions. The optimal concentration for killing MG-63 osteosarcoma cells was found to be 100 μg/mL of nanofibers. Future research may focus on the application of these nanofibers as implantable devices for bone cancer therapy.

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Article Materials Science, Biomaterials

Systems for local, sustained release of zoledronic acid as a potential treatment for metastatic bone disease

Rohith Jayaram et al.

Summary: This study investigated two biomaterials, PMMA bone cement and PLGA, for local delivery of zoledronic acid (ZA) in the treatment of metastatic bone cancer. Results showed that PLGA had a better drug release effect compared to PMMA, which may be useful in the treatment of metastatic bone cancer.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Nitrogen-containing bisphosphonate-loaded micro-arc oxidation coating for biodegradable magnesium alloy pellets inhibits osteosarcoma through targeting of the mevalonate pathway

Mei Li et al.

Summary: A new BP-loaded MAO coated Mg-Sr alloy pellet was developed to inhibit OS, showing promising potential for repairing defects after tumor removal in OS therapy. The pellet demonstrated multiple desired features for efficient tumor eradication through in vitro and in vivo studies, suggesting a superior inhibitory effect on OS by targeting the mevalonate pathway at the molecular level.

ACTA BIOMATERIALIA (2021)

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Article Chemistry, Multidisciplinary

Photosynthetic oxygen-self-generated 3D-printing microbial scaffold enhances osteosarcoma elimination and prompts bone regeneration

Chao He et al.

Summary: A multifunctional and exquisite photosynthetic oxygen-self-generated therapeutic platform has been engineered for enhanced photodynamic therapy against OS. The study provides insight into the bacteria-enhanced PDT against OS and the following augmented osseous tissue regeneration.

NANO TODAY (2021)

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Article Nanoscience & Nanotechnology

3D Printed Bioceramic Scaffolds as a Universal Therapeutic Platform for Synergistic Therapy of Osteosarcoma

Wentao Dang et al.

Summary: A multifunctional local implantation platform was developed for synergistic photothermal therapy and chemotherapy treatment of osteosarcoma. The content of TiN and DOX in the scaffolds can be flexibly adjusted, providing both therapeutic effects and mechanical support for bone tissue. The scaffolds have the potential to be a universal platform for loading different therapeutic agents.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Review Pharmacology & Pharmacy

Curcumin encapsulation in nanostructures for cancer therapy: A 10-year overview

Natalia A. D'Angelo et al.

Summary: This study reviews the literature from the past 10 years on the encapsulation of curcumin (CUR) in nanostructured systems, highlighting its use and ability in cancer therapy. The findings show that these nanoformulations achieved higher solubility, improved tumor cytotoxicity, prolonged CUR release, and reduced side effects, among other interesting advantages.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Review Pharmacology & Pharmacy

Biomedical Applications and Bioavailability of Curcumin-An Updated Overview

Soo-In Sohn et al.

Summary: Curcumin, the bioactive compound in turmeric, has various pharmacological activities; however, its low bioavailability limits clinical applications. Advancements in research have shown methods to enhance curcumin's bioavailability and expand its biomedical applications.

PHARMACEUTICS (2021)

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Review Dentistry, Oral Surgery & Medicine

Biomaterial-based strategies for maxillofacial tumour therapy and bone defect regeneration

Bowen Tan et al.

Summary: Maxillofacial tumours not only involve dealing with the tumours themselves, but also repairing jaw bone defects. Utilizing biomaterials can enhance tumour treatment efficiency, reduce recurrence and metastasis, and provide new promising anti-tumour therapies for patients.

INTERNATIONAL JOURNAL OF ORAL SCIENCE (2021)

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Review Oncology

Update on Osteosarcoma

Rebekah Belayneh et al.

Summary: In recent years, new surgical techniques and novel forms of chemotherapy are being explored to improve the treatment outcomes of osteosarcoma. Researchers are focusing on precision surgery, inhaled chemotherapy, and novel immunomodulators to block molecular pathways associated with OSA proliferation and metastasis. The goal is to exceed the current plateau in treatment efficacy and improve overall survival rates in the near future.

CURRENT ONCOLOGY REPORTS (2021)

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Article Nanoscience & Nanotechnology

Curcumin-Microsphere/IR820 Hybrid Bifunctional Hydrogels for In Situ Osteosarcoma Chemo-co-Thermal Therapy and Bone Reconstruction

Bowen Tan et al.

Summary: The study presents a hybrid hydrogel platform for the treatment of osteosarcoma and bone regeneration, using hyperthermia and curcumin to eradicate tumor cells and promote activation of bone mesenchymal stem cells. The gel turns into a gel through heat sensitivity for therapy, utilizing laser-induced hyperthermia and drug release to effectively kill tumor cells, ultimately achieving therapeutic and bone reconstruction outcomes.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Nanoscience & Nanotechnology

W-Doped TiO2 Nanorods for Multimode Tumor Eradication in Osteosarcoma Models under Single Ultrasound Irradiation

Bijiang Geng et al.

Summary: The study introduces a facile synthesis method for ultrafine nanorod sonosensitizers, using tungsten-doped titanium dioxide nanorods for tumor therapy. The doped nanorods show effectiveness in eradicating tumors with no significant systemic toxicity.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Chemistry, Multidisciplinary

Antiangiogenesis Combined with Inhibition of the Hypoxia Pathway Facilitates Low-Dose, X-ray-Induced Photodynamic Therapy

Zhao Jiang et al.

Summary: The study achieved highly efficient, low-dose X-ray-induced photodynamic therapy through optimization of scintillation efficiency, nanoplatform structure, and therapeutic methods. The developed nanoplatform system could simultaneously attack tumors and exhibited high biosafety.

ACS NANO (2021)

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Article Engineering, Biomedical

Sustained and controlled delivery of doxorubicin from an in-situ setting biphasic hydroxyapatite carrier for local treatment of a highly proliferative human osteosarcoma

Yang Liu et al.

Summary: Doxorubicin is a cornerstone drug in osteosarcoma treatment, but achieving sufficient concentration in tumor tissue after systemic administration remains a challenge. A study evaluated the use of a clinically approved CaS/HA carrier for local, sustained, and controlled delivery of DOX in-vitro and in-vivo, showing promising results for improving treatment outcomes.

ACTA BIOMATERIALIA (2021)

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Review Endocrinology & Metabolism

A concise review on the role of selenium for bone cancer applications

Yanhao Hou et al.

Summary: Cancer, especially bone cancer, presents a significant health challenge worldwide with limited new clinical treatment strategies. Selenium has shown specific targeting inhibition effects on bone cancer, indicating potential for the development of novel treatment approaches. Further research on the combination of selenium with various materials for bone cancer applications is needed for future advancements.

BONE (2021)

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Review Materials Science, Multidisciplinary

Interplay of reactive oxygen species (ROS) and tissue engineering: a review on clinical aspects of ROS-responsive biomaterials

Nishant Tyagi et al.

Summary: Reactive oxygen species (ROS) are by-products of oxygen that can act as secondary messengers in signal transduction and cell cycle. Tissue engineering utilizes these ROS properties for effective regeneration, with hypoxic conditions being a limitation. New biomaterials can sense and respond to stresses, overcoming limitations and holding potential for tissue regeneration and drug delivery.

JOURNAL OF MATERIALS SCIENCE (2021)

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Article Chemistry, Multidisciplinary

Bioinspired adhesive and tumor microenvironment responsive nanoMOFs assembled 3D-printed scaffold for anti-tumor therapy and bone regeneration

Yanan Jiang et al.

Summary: Tumor-induced bone loss is a major reason for the failure of bone tumor therapy. A 3D-printed implant was developed to release anti-cancer drugs and growth factors for anti-tumor therapy and osteogenesis. This new approach offers a smart and responsive therapeutic ability for diverse biomedical applications.

NANO TODAY (2021)

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3D-printed bioceramic scaffolds with Fe3S4 microflowers for magnetothermal and chemodynamic therapy of bone tumor and regeneration of bone defects

Hui Zhuang et al.

Summary: The development of an intelligent therapeutic platform with Fe3S4 layers on 3D-printed bioceramic scaffolds enables efficient tumor therapy and enhanced bone defect repair, showcasing potential for osteosarcoma treatment and multifunctional biomaterial design.

BIOFABRICATION (2021)

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Article Biotechnology & Applied Microbiology

3D-printing magnesium-polycaprolactone loaded with melatonin inhibits the development of osteosarcoma by regulating cell-in-cell structures

Weilin Zhang et al.

Summary: Melatonin-loaded Mg-PCL scaffolds inhibited the proliferation, invasion, and metastasis of osteosarcoma cells by interfering with the mitochondrial physiology and key CIC pathway, showing potential as a therapeutic approach for osteosarcoma.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Article Materials Science, Multidisciplinary

Cancer immunotherapy: Classification, therapeutic mechanisms, and nanomaterial-based synergistic therapy

Xiangyu Meng et al.

Summary: Cancer immunotherapy is a growing field in the fight against cancer, with various effective ways such as cancer vaccines, immune checkpoint inhibitors, and adoptive cell therapy. Nanomaterials hold promise in enhancing treatment efficiency, especially when combined with conventional therapies in integrated nanoplatforms. Challenges like low response rates and immune-related adverse effects persist in cancer immunotherapy.

APPLIED MATERIALS TODAY (2021)

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Article Nanoscience & Nanotechnology

Fabrication of Micro-Nano Bioactive Glass Scaffold Incorporated with Siglec-15 for Bone Repair and Postoperative Treatment of Osteosarcoma

Xiao Li et al.

Summary: This study aimed to fabricate micro-nano bioactive glass scaffolds loaded with chemotherapeutics and siglec-15 monoclonal antibody for postoperative treatment of osteosarcoma. The results showed that the MNBG scaffold decreased PTEN expression, up-regulated DJ-1 expression, and enhanced adhesion strength and phosphorylation activity, indicating potential for bone regeneration and tumor suppression.

SCIENCE OF ADVANCED MATERIALS (2021)

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Biofunctional magnesium-coated Ti6Al4V scaffolds promote autophagy-dependent apoptosis in osteosarcoma by activating the AMPK/mTOR/ULK1 signaling pathway

X. Wei et al.

Summary: The study determined the importance of the proper concentration of released magnesium ions for inhibiting osteosarcoma and ensuring biosafety, demonstrating the anti-osteosarcoma effects of magnesium-coated Ti6Al4V scaffolds, which may contribute to further clinical application.

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Nahyun Kwon et al.

Summary: Photodynamic therapy (PDT) shows promise in treating various cancers, but its therapeutic benefits are limited by oxygen dependence and inadequate light permeability. Recent advancements in supramolecular approaches have led to the development of multifunctional supramolecular photosensitizer assemblies that combine PDT with other therapies to achieve synergistic effects and maximize treatment outcomes.

CHEMICAL SCIENCE (2021)

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Review Chemistry, Multidisciplinary

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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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CHEMICAL ENGINEERING JOURNAL (2020)

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2D MXene-Integrated 3D-Printing Scaffolds for Augmented Osteosarcoma Phototherapy and Accelerated Tissue Reconstruction

Shanshan Pan et al.

ADVANCED SCIENCE (2020)

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Article Nanoscience & Nanotechnology

Controlled Delivery of Curcumin and Vitamin K2 from Hydroxyapatite-Coated Titanium Implant for Enhanced in Vitro Chemoprevention, Osteogenesis, and in Vivo Osseointegration

Naboneeta Sarkar et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Carbon dot/WS2 heterojunctions for NIR-II enhanced photothermal therapy of osteosarcoma and bone regeneration

Bijiang Geng et al.

CHEMICAL ENGINEERING JOURNAL (2020)

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Multifunctional bone cement for synergistic magnetic hyperthermia ablation and chemotherapy of osteosarcoma

Bing Liang et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2020)

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A novel photothermally controlled multifunctional scaffold for clinical treatment of osteosarcoma and tissue regeneration

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MATERIALS TODAY (2020)

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Cryogenic 3D printing of porous scaffolds for in situ delivery of 2D black phosphorus nanosheets, doxorubicin hydrochloride and osteogenic peptide for treating tumor resection-induced bone defects

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BIOFABRICATION (2020)

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Zehao Jing et al.

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Review Orthopedics

The efficacy and safety comparison of first-line chemotherapeutic agents (high-dose methotrexate, doxorubicin, cisplatin, and ifosfamide) for osteosarcoma: a network meta-analysis

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JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH (2020)

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INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

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Applications of Inorganic Nanomaterials in Photothermal Therapy Based on Combinational Cancer Treatment

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INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

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3D printed biodegradable implants as an individualized drug delivery system for local chemotherapy of osteosarcoma

Yonghui Wang et al.

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Controlled release of soy isoflavones from multifunctional 3D printed bone tissue engineering scaffolds

Naboneeta Sarkar et al.

ACTA BIOMATERIALIA (2020)

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Piezocatalytic Tumor Therapy by Ultrasound-Triggered and BaTiO3-Mediated Piezoelectricity

Piao Zhu et al.

ADVANCED MATERIALS (2020)

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Article Engineering, Biomedical

In vitro evaluation of bone cements impregnated with selenium nanoparticles stabilized by phosphatidylcholine (PC) for application in bone

Zeynep Karahaliloglu et al.

JOURNAL OF BIOMATERIALS APPLICATIONS (2020)

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Integrative treatment of anti-tumor/bone repair by combination of MoS2 nanosheets with 3D printed bioactive borosilicate glass scaffolds

Hui Wang et al.

CHEMICAL ENGINEERING JOURNAL (2020)

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Article Nanoscience & Nanotechnology

Magnesium-doped Nanostructured Titanium Surface Modulates Macrophage-mediated Inflammatory Response for Ameliorative Osseointegration

Xinrui Qiao et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

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Article Engineering, Environmental

Borocarbonitrides nanosheets engineered 3D-printed scaffolds for integrated strategy of osteosarcoma therapy and bone regeneration

Cancan Zhao et al.

CHEMICAL ENGINEERING JOURNAL (2020)

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Article Physics, Applied

V-TiO2 nanospindles with regulating tumor microenvironment performance for enhanced sonodynamic cancer therapy

Xianwen Wang et al.

APPLIED PHYSICS REVIEWS (2020)

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Article Chemistry, Multidisciplinary

Ultrasmall Iron-Doped Titanium Oxide Nanodots for Enhanced Sonodynamic and Chemodynamic Cancer Therapy

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ACS NANO (2020)

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Article Pharmacology & Pharmacy

3D Printed Calcium Phosphate Cement (CPC) Scaffolds for Anti-Cancer Drug Delivery

Yan Wu et al.

PHARMACEUTICS (2020)

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Design and evaluation a kind of functional biomaterial for bone tissue engineering: Selenium/mesoporous bioactive glass nanospheres

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Wamidh H. Talib et al.

MOLECULES (2020)

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Article Medicine, Research & Experimental

Tumor Microenvironment-triggered Nanosystems as dual-relief Tumor Hypoxia Immunomodulators for enhanced Phototherapy

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THERANOSTICS (2020)

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Bio-evaluation of doxorubicin (DOX)-incorporated hydroxyapatite (HAp)-chitosan (CS) nanocomposite triggered on osteosarcoma cells

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Baicalein Nanofiber Scaffold Containing Hyaluronic Acid and Polyvinyl Alcohol: Preparation and Evaluation

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TURKISH JOURNAL OF MEDICAL SCIENCES (2020)

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Liposome-Encapsulated Curcumin-Loaded 3D Printed Scaffold for Bone Tissue Engineering

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Tuning the biomimetic behavior of scaffolds for regenerative medicine through surface modifications

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Multifunctional mesoporous magnetic Mg2SiO4-CuFe2O4 core-shell nanocomposite for simultaneous bone cancer therapy and regeneration

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3D Printed Composite Scaffolds Incorporating Ruthenium Complex-Loaded Liposomes as a Delivery System to Prevent the Proliferation of MG-63 Cells

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Article Oncology

Catechins-Modified Selenium-Doped Hydroxyapatite Nanomaterials for Improved Osteosarcoma Therapy Through Generation of Reactive Oxygen Species

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Implantable Synthetic Immune Niche for Spatiotemporal Modulation of Tumor-Derived Immunosuppression and Systemic Antitumor Immunity: Postoperative Immunotherapy

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All-Trans Retinoic Acid Prevents Osteosarcoma Metastasis by Inhibiting M2 Polarization of Tumor-Associated Macrophages

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Magnetic nanoparticle heating and heat transfer on a microscale: Basic principles, realities and physical limitations of hyperthermia for tumour therapy

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Chemical and biological properties of the world's most expensive spice Saffron

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Hematoporphyrin Monomethyl Ether Enhances the Killing of Ultrasound on Osteosarcoma Cells Involving Intracellular Reactive Oxygen Species and Calcium Ion Elevation

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Hematoporphyrin Monomethyl Ether Enhances the Killing Action of Ultrasound on Osteosarcoma In Vivo

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Soybean-based biornaterials: preparation, properties and tissue regeneration potential

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TLR7 and TLR8 as targets in cancer therapy

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Sonodynamic therapy of cancer using a novel porphyrin derivative, DCPH-P-Na(I), which is devoid of photosensitivity

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Expression of the melatonin receptor (MT) 1 in benign and malignant human bone tumors

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Novel hyperthermia for metastatic bone tumors with magnetic materials by generating an alternating electromagnetic field

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Timeline - Chemotherapy and the war on cancer

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ROS stress in cancer cells and therapeutic implications

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Molecular emission from single-bubble sonoluminescence

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