Adverse effects of sulfamethoxazole on locomotor behavior and lipid metabolism by inhibiting acetylcholinesterase and lipase in Daphnia magna

Article Biochemistry & Molecular Biology

Peptidoglycan recognition protein SC (PGRP-SC) shapes gut microbiota richness, diversity and composition by modulating immunity in the house fly Musca domestica

Yadi Liang et al.

Summary: MdPGRP-SC plays a crucial role in shaping the gut microbial community structure by degrading or neutralizing various PAMPs, selectively suppressing the growth of certain bacteria, and modulating the immune intensity of the gut.

INSECT MOLECULAR BIOLOGY (2023)

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Article Environmental Sciences

Sulfamethoxazole degradation by Aeromonas caviae and co-metabolism by the mixed bacteria

Qiaoning Wang et al.

Summary: Sulfamethoxazole (SMX), a commonly found antibiotic in the environment, is efficiently degraded by a mixed bacteria community including Aeromonas caviae strain GLB-10. In addition to the bioproducts generated by single bacteria, the mixed bacteria produce acetanilide and hydroquinone during SMX degradation. The degradation mechanism of the mixed bacteria is more complex and involves acetylation, sulfur reduction 4S pathway, and ipso-hydrolysis. The molecular mechanism reveals the overexpression of outer membrane proteins and catalase peroxidase, as well as the involvement of 6-hydroxynicotinate 3-monooxygenase.

CHEMOSPHERE (2023)

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Article Environmental Sciences

Synergistic removal of sulfamethoxazole and dimethyl phthalate by five constructed wetland substrates

Guowan Li et al.

Summary: The frequent detection and joint toxicity of sulfonamides (SAs) and phthalate acid esters (PAEs) in the water environment pose serious health and safety problems. Vertical flow constructed wetland (VFCW) provides a solution for reducing these problems. This study investigated the synergistic removal of sulfamethoxazole (SMX) and dimethyl phthalate (DMP) using various substrates in VFCW. Results showed that biochar, zeolite, vermiculite, peat, and sand exhibited excellent synergistic adsorption of SMX and DMP, providing an effective method to remove these substances.

CHEMOSPHERE (2023)

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Article Environmental Sciences

Disturbances in growth, oxidative stress, energy reserves and the expressions of related genes in Daphnia magna after exposure to ZnO under thermal stress

Paweena Sanpradit et al.

Summary: The effects of ZnO concentration under elevated temperature on growth, oxidative stress, and gene expression in exposed Daphnia magna were investigated in this study. The results showed that elevated temperature and increased ZnO concentration induced toxicity in D. magna, affecting their growth and energy reserves, with minimal effects on juveniles. This study highlights the potential use of D. magna as a bioindicator for monitoring environmental change.

SCIENCE OF THE TOTAL ENVIRONMENT (2023)

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Article Environmental Sciences

Short and long-term exposure to the pesticides fipronil and 2,4-D: Effects on behavior and life history of Daphnia magna

Raquel A. Moreira et al.

Summary: The high contamination levels caused by pesticides make aquatic ecosystems vulnerable. Mobile organisms can avoid continuous exposure to contaminants by moving to less disturbed habitats. This study used a system called HeMHAS to evaluate the ability of Daphnia magna to detect and avoid habitats contaminated by specific pesticides. The colonization of habitats and chronic toxicity were also assessed for different parameters. The results showed that D. magna did not prefer less contaminated areas and did not move to highly contaminated zones. Additionally, exposure to a mixture of pesticides significantly prevented colonization, and negative consequences on survival, fecundity, and body length were observed with chronic exposure to a specific pesticide. The study suggests that the risk of local population extinction may be underestimated if only forced exposure endpoints are examined.

CHEMOSPHERE (2023)

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Article Environmental Sciences

Toxic effects and molecular mechanisms of sulfamethoxazole on Scenedesmus obliquus

Dongmei Xu et al.

Summary: The antibiotic sulfamethoxazole (SMX) has been found to have biotoxic effects on Scenedesmus obliquus, an aquatic organism. Exposure to SMX promotes gene expression, leading to changes in algal cell ultrastructure. These changes include blurred cell walls, damaged chloroplast structure, and increased number and volume of mitochondria per cell. The effects of SMX on gene expression are related to inhibition of cell growth, decrease in chlorophyll content, increase in cell membrane permeability, production of reactive oxygen species, increased lipid peroxidation, and higher activities of antioxidant enzymes. The abnormal expression of non-coding RNAs may be an important mechanism underlying the carcinogenic effects of SMX.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2022)

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Review Environmental Sciences

Occurrence and ecotoxicity of sulfonamides in the aquatic environment: A review

Weiyan Duan et al.

Summary: Rapid population growth and increasing demand for animal protein food have led to a continuous increase in global utilization of antibiotic, specifically sulfonamides (SAs), which are found to be ubiquitous in aquatic environments and pose a potential ecological risk. Research on different trophic level organisms shows that algae are the most susceptible to selected sulfonamide antibiotics, and some of these antibiotics pose a great risk to the aquatic system.

SCIENCE OF THE TOTAL ENVIRONMENT (2022)

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Article Engineering, Environmental

Combined toxicity of polystyrene microplastics and ammonium perfluorooctanoate to Daphnia magna: Mediation of intestinal blockage

Ciara Chun Chen et al.

Summary: This study evaluates the combined toxicity of microplastics (MPs) and perfluorinated compounds (PFCs) to aquatic organisms and reveals the underlying mechanisms. The results show that the combined toxicity varies with the concentration ratios of MPs and PFCs, highlighting the importance of assessing the risks of long-term exposure in aquatic environments.

WATER RESEARCH (2022)

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Article Biochemistry & Molecular Biology

Toxicity Assessment of an Anti-Cancer Drug of p-Toluene Sulfonamide in Zebrafish Larvae Based on Cardiovascular and Locomotion Activities

Andrew Yau Wah Young et al.

Summary: This study investigated the potential cardio and neural toxicity of p-Toluene sulfonamide (p-TSA) in sublethal concentrations using zebrafish as an in vivo animal model. The results showed that the overall toxicity of p-TSA was relatively low in zebrafish larvae, with minor alterations observed in the cardiac rhythm and physiology. However, acute exposure to p-TSA significantly increased locomotion activity, while prolonged exposure reduced the locomotor startle reflex activities in zebrafish. The study also revealed higher respiratory rate and blood flow velocity in acutely treated fish groups. Molecular docking analysis provided insights into the potential molecular mechanism of p-TSA on observed altered responses and minor altered vascular performance in zebrafish larvae.

BIOMOLECULES (2022)

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Article Biochemistry & Molecular Biology

Molecular mechanism of two functional protein structure changes under 2,3-butanedione-induced oxidative stress and apoptosis effects in the hepatocytes

Xinyu Ni et al.

Summary: Food security has become a major concern due to recent food safety incidents. The widespread use of 2,3-butanedione as a food additive poses significant risk to food security. This study found that 2,3-butanedione has adverse effects at the cellular and molecular levels, disrupting the redox balance of cells, causing mitochondrial dysfunction, and resulting in cell apoptosis and death.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

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Article Engineering, Environmental

Integrating transcriptome and physiological analysis to reveal the essential responses of Daphnia magna to antimony trioxide nanoparticle

Jihai Gu et al.

Summary: This study investigated the toxicity mechanisms of nano-size antimony trioxide (nATO) and soluble Sb(III) compounds on Daphnia magna. The results showed that both nATO and soluble Sb(III) induced oxidative stress, altered metabolism, and caused damage to the nervous system of D. magna, indicating their toxicity to aquatic organisms.

JOURNAL OF HAZARDOUS MATERIALS (2022)

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Article Environmental Sciences

Protective effects of small heat shock proteins in Daphnia magna against heavy metal exposure

Muyi Li et al.

Summary: This study revealed the important role of the sHSP family in Daphnia magna under heavy metal exposure, demonstrating the predominant role of DmsHSP1 in stress response and providing important insights into the survival mechanisms of D. magna in adverse environments.

SCIENCE OF THE TOTAL ENVIRONMENT (2022)

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Review Chemistry, Medicinal

Zebrafish as a Screening Model to Study the Single and Joint Effects of Antibiotics

Roxana Jijie et al.

Summary: The excessive use of antibiotics and the limit of wastewater treatment facilities have resulted in drug residue accumulation in the natural environment, raising concerns over potential harmful effects on ecosystems and human health. Zebrafish has emerged as a promising animal model for studying the toxic effects of drugs and their therapeutic efficacy due to limitations of traditional vertebrate model systems. Despite significant literature on the impact of single antibiotic exposure, there is little information on the effects of antibiotic mixtures using zebrafish as an animal model.

PHARMACEUTICALS (2021)

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Review Environmental Sciences

Daphnia magna model in the toxicity assessment of pharmaceuticals: A review

Angelika Tkaczyk et al.

Summary: Daphnia magna is commonly used to assess the toxicity of pharmaceuticals, with tests based on immobilisation and lethality standardised by OECD. Analysis of behavioral and physiological parameters can reveal sublethal effects induced by lower concentrations of pharmaceuticals.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

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Article Environmental Sciences

Environmentally relevant concentration of cypermethrin or/and sulfamethoxazole induce neurotoxicity of grass carp: Involvement of blood-brain barrier, oxidative stress and apoptosis

Hongjing Zhao et al.

Summary: The study found that exposure to cypermethrin and sulfamethoxazole, as well as their mixture in water environment, significantly affects the brain function, oxidative stress, and apoptosis of grass carp. The results showed that these two chemicals induce similar biological responses and may enhance each other's toxic effects.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

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Article Engineering, Environmental

Uptake of microalgae as sublethal biomarker reveals phototoxicity of oxytetracycline to the crustacean Daphnia magna

Luis Peroti et al.

Summary: This study assessed the toxicity and photosensitivity of oxytetracycline (OTC) in aquatic organisms, finding that UV exposure exacerbated its toxicity and affected the physiological health of Daphnia magna and microalgae.

WATER RESEARCH (2021)

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Article Environmental Sciences

Effects of environmental norfloxacin concentrations on the intestinal health and function of juvenile common carp and potential risk to humans

Xue-Li Zhao et al.

Summary: The study demonstrated that chronic exposure to antibiotics can induce oxidative stress, damage intestinal barrier function, and alter the expression of immune-related genes in fish. Additionally, antibiotics may also affect the regulation of the NF-kappa B signaling pathway, impacting the intestinal health of fish.

ENVIRONMENTAL POLLUTION (2021)

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Review Environmental Sciences

Occurrence, fate, and risk assessment of typical tetracycline antibiotics in the aquatic environment: A review

Longyao Xu et al.

Summary: Tetracyclines, widely used as antibiotics, are excreted in large quantities into the environment, causing adverse effects on both ecological systems and human health. This article summarizes the environmental occurrence and behaviors of tetracyclines in aquatic environments, as well as their toxicities and potential risks.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

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Article Ecology

Sulfonamide antibiotics in groundwater and their migration in the vadose zone: A case in a drinking water resource

Rui Zuo et al.

Summary: This study focused on the migration of three sulfonamide antibiotics in groundwater, showing that sulfamethoxypyridazine has higher concentration and adsorption capacity. Coexisting ions and water pH have significant impacts on the adsorption and migration of sulfonamides.

ECOLOGICAL ENGINEERING (2021)

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Article Environmental Sciences

Combined effects of polyethylene and organic contaminant on zebrafish (Danio rerio): Accumulation of 9-Nitroanthracene, biomarkers and intestinal microbiota

Jinghua Zhang et al.

Summary: Microplastics are predicted to act as carriers for organic pollutants, but their carrier role and bio-toxic effects with other pollutants in environments are poorly acknowledged. This study investigated the effects of polyethylene (PE) and 9-Nitroanthracene (9-NAnt) on zebrafish, showing that PE could carry 9-NAnt into fish causing bioaccumulation, but in the case of coexisting exposures, PE reduced 9-NAnt bioaccumulation. The study suggests that microplastics with other emerging pollutants in chronic toxicity are probably next objects in future works.

ENVIRONMENTAL POLLUTION (2021)

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Article Environmental Sciences

Neurotoxicity of chlorpyrifos and chlorpyrifos-oxon to Daphnia magna

Stephanie A. Maggio et al.

Summary: Chlorpyrifos (CPF) and its metabolic product chlorpyrifos-oxon (CPFO) both exhibit neurotoxic effects, with CPFO being more acutely toxic to Daphnia magna. However, neither compound showed effects on reproduction or growth in chronic exposures to D. magna.

CHEMOSPHERE (2021)

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Article Environmental Sciences

Antibiotic accumulation, growth performance, intestinal diversification, and function of Nile tilapia (Oreochromis niloticus) feed by diets supplemented with different doses of sulfamethoxazole

Longxiang Fang et al.

Summary: This study comprehensively investigated the effects of exposure to different doses of sulfamethoxazole (SMZ) on Nile tilapia. The results showed that high doses of SMZ negatively impacted the growth and intestinal function of fish, highlighting the importance of rational and regulated use of SMZ in aquaculture.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2021)

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Review Biophysics

Sulfonamide drugs: structure, antibacterial property, toxicity, and biophysical interactions

Aben Ovung et al.

Summary: Sulfonamide drugs have various pharmacological activities and can be used to treat a variety of diseases, such as sulfamethazine for bacterial infections in veterinary medicine and sulfadiazine for treating toxoplasmosis in livestock.

BIOPHYSICAL REVIEWS (2021)

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Review Biotechnology & Applied Microbiology

Antibiotics: An overview on the environmental occurrence, toxicity, degradation, and removal methods

Qiulian Yang et al.

Summary: This paper provides an overview of the presence of antibiotics in the environment, their toxicity to non-target organisms, and current treatment technologies. Studies have shown that antibiotics are most frequently detected in wastewater, exhibiting toxicity to aquatic organisms. Fluoroquinolones, tetracyclines, and sulfonamides are the most common antibiotics in the environment and can be removed through biotic or abiotic processes.

BIOENGINEERED (2021)

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Article Environmental Sciences

Early exposure to environmental levels of sulfamethoxazole triggers immune and inflammatory response of healthy zebrafish larvae

Jingyu Liu et al.

SCIENCE OF THE TOTAL ENVIRONMENT (2020)

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Article Environmental Sciences

Ecological and human health risk of sulfonamides in surface water and groundwater of Huixian karst wetland in Guilin, China

Li-Tang Qin et al.

SCIENCE OF THE TOTAL ENVIRONMENT (2020)

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Review Environmental Sciences

Occurrence and toxicity of antibiotics in the aquatic environment: A review

Pavla Kovalakova et al.

CHEMOSPHERE (2020)

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Article Engineering, Environmental

Individual and combined mechanistic toxicity of sulfonamides and their implications for ecological risk assessment in the Three Gorges Reservoir Area (TGRA), China

Naima Hamid et al.

JOURNAL OF HAZARDOUS MATERIALS (2020)

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Article Engineering, Environmental

Cisplatin affects locomotor activity and physiological endpoints of Daphnia magna

Adam Bownik et al.

JOURNAL OF HAZARDOUS MATERIALS (2020)

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Article Engineering, Environmental

Obesogenic Effect of Sulfamethoxazole on Drosophila melanogaster with Simultaneous Disturbances on Eclosion Rhythm, Glucolipid Metabolism, and Microbiota

Zhenyang Yu et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2020)

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Article Environmental Sciences

Effects of azithromycin on feeding behavior and nutrition accumulation of Daphnia magna under the different exposure pathways

Yang Li et al.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2020)

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Article Engineering, Environmental

Reproduction stage specific dysregulation of Daphnia magna metabolites as an early indicator of reproductive endocrine disruption

Tae-Yong Jeong et al.

WATER RESEARCH (2020)

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Article Marine & Freshwater Biology

Interactions between dietary lipid levels and chronic exposure of legal aquaculture dose of sulfamethoxazole in juvenile largemouth bass Micropterus salmoides

Shiwei Xie et al.

AQUATIC TOXICOLOGY (2020)

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Article Environmental Sciences

Lambda-cyhalothrin affects swimming activity and physiological responses of Daphnia magna

Adam Bownik et al.

CHEMOSPHERE (2019)

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Article Chemistry, Analytical

Spectroscopic characterization, calorimetric study and molecular docking to evaluate the bioconjugation of maltol with hemoglobin

Lining Zhao et al.

LUMINESCENCE (2019)

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Article Environmental Sciences

Comprehensive study of sulfamethoxazole effects in marine mussels: Bioconcentration, enzymatic activities and metabolomics

Albert Serra-Compte et al.

ENVIRONMENTAL RESEARCH (2019)

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Article Biochemistry & Molecular Biology

Benzonitriles as tyrosinase inhibitors with hyperbolic inhibition manner

Ken-ichi Nihei et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

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Article Environmental Sciences

Responses of catalase and superoxide dismutase to low-dose quantum dots on molecular and cellular levels

Lining Zhao et al.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2019)

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Article Environmental Sciences

Polystyrene nanoplastic exposure induces immobilization, reproduction, and stress defense in the freshwater cladoceran Daphnia pulex

Zhiquan Liu et al.

CHEMOSPHERE (2019)

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Article Toxicology

Kidney Toxicity and Response of Selenium Containing Protein-glutathione Peroxidase (Gpx3) to CdTe QDs on Different Levels

Lining Zhao et al.

TOXICOLOGICAL SCIENCES (2019)

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Article Environmental Sciences

Chronic exposure to low environmental concentrations and legal aquaculture doses of antibiotics cause systemic adverse effects in Nile tilapia and provoke differential human health risk

Samwel M. Limbu et al.

ENVIRONMENT INTERNATIONAL (2018)

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Article Environmental Sciences

Environmental concentrations of antibiotics impair zebrafish gut health

Li Zhou et al.

ENVIRONMENTAL POLLUTION (2018)

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Review Environmental Sciences

Antibiotics in the aquatic environments: A review of lakes, China

Xiaohui Liu et al.

SCIENCE OF THE TOTAL ENVIRONMENT (2018)

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Article Environmental Sciences

Interaction of a digestive protease, Candida rugosa lipase, with three surfactants investigated by spectroscopy, molecular docking and enzyme activity assay

Rui Zhang et al.

SCIENCE OF THE TOTAL ENVIRONMENT (2018)

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Article Environmental Sciences

Synergistic toxicity of some sulfonamide mixtures on Daphnia magna

Marco De Liguoro et al.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2018)

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Article Chemistry, Medicinal

Non-specific binding sites help to explain mixed inhibition in mushroom tyrosinase activities

Sorour Hassani et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2016)

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Article Gastroenterology & Hepatology

Administration of Antibiotics to Children Before Age 2 Years Increases Risk for Childhood Obesity

Frank I. Scott et al.

GASTROENTEROLOGY (2016)

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Article Environmental Sciences

Exposure of Daphnia magna to trichloroethylene (TCE) and vinyl chloride (VC): Evaluation of gene transcription, cellular activity, and life-history parameters

Magali Houde et al.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2015)

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Article Environmental Sciences

Obesogens beyond Vertebrates: Lipid Perturbation by Tributyltin in the Crustacean Daphnia magna

Rita Jordao et al.

ENVIRONMENTAL HEALTH PERSPECTIVES (2015)

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Article Environmental Sciences

The sensitivity of Daphnia magna and Daphnia curvirostris to 10 veterinary antibacterials and to some of their binary mixtures

Mirco Dalla Bona et al.

CHEMOSPHERE (2014)

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Article Environmental Sciences

Integrated biomarker responses in zebrafish exposed to sulfonamides

Tao Lin et al.

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2014)

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Article Biochemistry & Molecular Biology

Dioxin and Dioxin-Like Compounds Suppress Acetylcholinesterase Activity via Transcriptional Downregulations In Vitro

Hai-Ming Xu et al.

JOURNAL OF MOLECULAR NEUROSCIENCE (2014)

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Article Pediatrics

Association of Antibiotics in Infancy With Early Childhood Obesity

L. Charles Bailey et al.

JAMA PEDIATRICS (2014)

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Article Environmental Sciences

Ubiquitous occurrence of sulfonamides in tropical Asian waters

Akiko Shimizu et al.

SCIENCE OF THE TOTAL ENVIRONMENT (2013)

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Article Multidisciplinary Sciences

Heritability of reproductive fitness traits in a human population

Gueluem Kosova et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

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Article Environmental Sciences

The toxicity of sulfamethazine to Daphnia magna and its additivity to other veterinary sulfonamides and trimethoprim

Marco De Liguoro et al.

CHEMOSPHERE (2009)

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Article Environmental Sciences

In vitro and in vivo inhibition of Daphnia magna acetylcholinesterase by surfactant agents:: possible implications for contamination biomonitoring

L Guilhermino et al.

SCIENCE OF THE TOTAL ENVIRONMENT (2000)

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Adverse effects of sulfamethoxazole on locomotor behavior and lipid metabolism by inhibiting acetylcholinesterase and lipase in Daphnia magna

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