☆ 4.7 Review

Neurofilament light chains to assess sepsis-associated encephalopathy: Are we on the track toward clinical implementation?

CRITICAL CARE (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Neurosciences

Elevated sTREM2 and NFL levels in patients with sepsis associated encephalopathy

Gunseli Orhun et al.

Summary: The study investigates whether neurofilament light chain (NFL) and soluble triggering receptor expressed on myeloid cells 2 (sTREM2) could serve as prognostic biomarkers in sepsis-associated encephalopathy (SAE). The results show that serum and cerebrospinal fluid (CSF) levels of sTREM2 and NFL are associated with the severity of cognitive decline in SAE patients.

INTERNATIONAL JOURNAL OF NEUROSCIENCE (2023)

添加到收藏夹

Article Clinical Neurology

Neurofilament light chain levels predict encephalopathy and outcome in community-acquired pneumonia

Ha-Yeun Chung et al.

Summary: The objective of this study was to determine whether sNfL levels are increased in patients with community-acquired pneumonia (CAP) and if increased sNfL levels are associated with disease-associated confusion or disease severity. The study found that sNfL concentrations are specifically associated with confusion and not with pneumonia disease severity, thus reflecting a potential objective marker for encephalopathy in these patients.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2023)

添加到收藏夹

Review Clinical Neurology

The multifaceted role of neurofilament light chain protein in non-primary neurological diseases

Samir Abu-Rumeileh et al.

Summary: Abu-Rumeileh et al. provide an overview of the role of neurofilament light chain protein as a biomarker in various medical fields. Its validation and application have greatly impacted the diagnosis and prognosis of neurological diseases. Recent studies have also explored its potential applications in non-primary neurological conditions.

BRAIN (2023)

添加到收藏夹

Article Medical Laboratory Technology

Neurofilament light chain as neuronal injury marker - what is needed to facilitate implementation in clinical laboratory practice?

Burak Arslan et al.

Summary: Neurobiomarkers, particularly the neurofilament light chain protein (NfL), have received significant attention in the past decade. NfL has been developed as a widely used biomarker for axonal damage in various neurological disorders, including multiple sclerosis, amyotrophic lateral sclerosis, and Alzheimer's disease. Despite the availability of precise assays for NfL quantification, there are still analytical and logistical considerations that need to be addressed for its implementation in clinical practice. This review provides an overview of NfL as a biomarker and highlights the additional work needed to facilitate its clinical use.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2023)

添加到收藏夹

Article Clinical Neurology

Validity and Performance of Blood Biomarkers for Alzheimer Disease to Predict Dementia Risk in a Large Clinic-Based Cohort

Vincent Planche et al.

Summary: Blood biomarkers for Alzheimer's disease can effectively discriminate AD from other neurodegenerative diseases and may serve as hallmarks of underlying pathology, but they add little to 5-year dementia risk prediction models.

NEUROLOGY (2023)

添加到收藏夹

Article Clinical Neurology

Validity and Performance of Blood Biomarkers for Alzheimer Disease to Predict Dementia Risk in a Large Clinic-Based Cohort

Vincent Planche et al.

Summary: In a clinic-based cohort of patients with subjective cognitive complaint or mild cognitive impairment, blood biomarkers may serve as good indicators of underlying pathology but do not contribute significantly to 5-year dementia risk prediction models that include traditional predictors.

NEUROLOGY (2023)

添加到收藏夹

Editorial Material Pharmacology & Pharmacy

Blood-Based Alzheimer's Biomarkers

[Anonymous]

CLINICAL PHARMACOLOGY & THERAPEUTICS (2022)

添加到收藏夹

Article Medical Laboratory Technology

Biological variation of serum neurofilament light chain

Claus Vinter Bodker Hviid et al.

Summary: Serum NfL exhibits tight homeostatic regulation with minimal diurnal and day-to-day variation, but significant between-subject variation. This highlights its suitability as a biomarker for disease monitoring, but caution is advised when interpreting NfL levels in relation to reference intervals in a clinical setting.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2022)

添加到收藏夹

Article Oncology

Prognostic significance of SNCA and its methylation in bladder cancer

Zhengcun Wu et al.

Summary: This study investigates the role of SNCA gene in bladder cancer (BLCA) and its potential as a prognostic diagnostic biomarker. The results show that SNCA is downregulated in BLCA tumor tissues and is negatively correlated with DNA methylation. High SNCA expression is associated with poor overall survival. SNCA is also found to play a role in immune cell infiltration, particularly with T cells. Therefore, SNCA may serve as a promising prognostic biomarker in BLCA patients.

BMC CANCER (2022)

添加到收藏夹

Article Clinical Neurology

Comparison of CSF and serum neurofilament light and heavy chain as differential diagnostic biomarkers for ALS

Steffen Halbgebauer et al.

Summary: The study showed that elevated levels of NfL and NfH in ALS patients compared to other neurological disorders. The correlation between CSF and serum NfL was stronger than that of NfH. CSF NfL had the best diagnostic potential for ALS, followed by CSF NfH, serum NfL, and serum NfH.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2022)

添加到收藏夹

Article Clinical Neurology

Serum neurofilament light chain for individual prognostication of disease activity in people with multiple sclerosis: a retrospective modelling and validation study

Pascal Benkert et al.

Summary: sNfL is a biomarker of neuronal damage used in monitoring disease activity in multiple sclerosis patients. This study established a reference database to correct for age and BMI, showing sNfL's potential in identifying individuals at risk for future disease activity. The results suggest that sNfL Z scores could predict acute and chronic disease activity in multiple sclerosis patients, with higher Z scores indicating increased risk.

LANCET NEUROLOGY (2022)

添加到收藏夹

Article Clinical Neurology

Prognostic value of serum/plasma neurofilament light chain for COVID-19-associated mortality

Ruturaj R. Masvekar et al.

Summary: Elevated levels of circulating neurofilament light chain (NfL) in severe COVID-19 patients may predict mortality. Combining NfL measurements with other prognostic markers could help identify patients at high risk of COVID-19-associated mortality.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2022)

添加到收藏夹

Article Medicine, General & Internal

Plasma neurofilament light chain protein as a predictor of days in delirium and deep sedation, mortality and length of stay in critically ill patients

Valerie J. Page et al.

Summary: This study aims to explore the association between plasma neurofilament light protein (NfL) and delirium in critically ill patients. The findings indicate that critically ill patients have high NfL levels upon admission, and patients with higher plasma NfL levels experience more delirium or deep sedation days. Additionally, measuring plasma NfL levels on the first day can predict mortality within six months.

EBIOMEDICINE (2022)

添加到收藏夹

Article Clinical Neurology

Contributors to Serum NfL Levels in People without Neurologic Disease

Kathryn C. Fitzgerald et al.

Summary: This study aimed to assess the effects of demographics, lifestyle factors, and comorbidities on serum neurofilament light chain (sNfL) levels in individuals without neurologic disease and establish population-specific reference ranges for sNfL. The study analyzed data from the National Health and Nutrition Examination Survey (NHANES) and found that age, creatinine, and glycosylated hemoglobin (HbA1c) were the best predictors of sNfL levels. The results provide guidance for interpreting sNfL levels in relation to neurologic conditions.

ANNALS OF NEUROLOGY (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

The 2022 Lady Estelle Wolfson lectureship on neurofilaments

Axel Petzold

Summary: This review comprehensively discusses the isoforms, mutations, post-translational modifications, and functions of neurofilament proteins in neurodegenerative diseases and oncology. The review highlights the role of neurofilament proteins in cellular function and axonal transport, and evaluates their potential as biomarkers in disease diagnosis and clinical trials.

JOURNAL OF NEUROCHEMISTRY (2022)

添加到收藏夹

Article Anesthesiology

Perioperative Neurofilament Light Plasma Concentrations and Cognition before and after Cardiac Surgery: A Prospective Nested Cohort Study

Charles H. Brown et al.

Summary: Changes in neurofilament light after cardiac surgery are associated with postoperative cognitive function. Higher baseline neurofilament light concentration is associated with worse baseline cognition but can lead to improvements in cognition at 1 year.

ANESTHESIOLOGY (2022)

添加到收藏夹

Article Clinical Neurology

Establishment of reference values for plasma neurofilament light based on healthy individuals aged 5-90 years

Joel Simren et al.

Summary: The recent development of a new method to accurately measure neurofilament light in plasma has revealed its potential as a sensitive and robust biomarker for neuroaxonal damage. Efforts are now being made to incorporate plasma neurofilament light into clinical practice and establish reference values to aid interpretation of test results.

BRAIN COMMUNICATIONS (2022)

添加到收藏夹

Review Clinical Neurology

Blood-based biomarkers for Alzheimer's disease: towards clinical implementation

Charlotte E. Teunissen et al.

Summary: Recent research suggests that blood-based biomarkers for Alzheimer's disease may become a reality, with consistent results across different cohorts. Additionally, other blood-based biomarkers can provide information about disease progression and treatment effects.

LANCET NEUROLOGY (2022)

添加到收藏夹

Article Critical Care Medicine

Postseptic Cognitive Impairment and Expression of APOE in Peripheral Blood: The Cognition After SepsiS (CASS) Observational Pilot Study

Samuel M. Brown et al.

Summary: Through deep sequencing RNA analysis to investigate the possible influence factors of cognitive impairment after sepsis, it was found that 1 in 5 sepsis survivors experienced executive dysfunction and the APOE gene had a low expression level in relation to cognitive impairment. Future research directions were suggested based on potential findings.

JOURNAL OF INTENSIVE CARE MEDICINE (2021)

添加到收藏夹

Article Critical Care Medicine

Inflammation and Coagulation during Critical Illness and Long-Term Cognitive Impairment and Disability

Nathan E. Brummel et al.

Summary: This study found that markers of systemic inflammation and coagulation measured early during critical illness are not associated with long-term cognitive outcomes, but CRP and MMP-9 were significantly associated with disability at 3 and 12 months. No consistent associations were found between other markers and disability outcomes. More research is needed to understand the relationship between inflammation markers and long-term outcomes in critical illness.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2021)

添加到收藏夹

Article Anesthesiology

Sepsis-associated encephalopathy A nationwide survey on diagnostic procedures and neuromonitoring in German intensive care units

F. Klawitter et al.

Summary: The study evaluated the clinical practice of diagnostics and neuro monitoring of SAE in intensive care units in Germany and found a great heterogeneity in current practices, with a majority of participants desiring the establishment of uniform concepts. Innovative biomarkers of neuroaxonal injury in blood and cerebrospinal fluid, as well as electrophysiological and brain imaging techniques, could provide valuable prognostic information for the neurocognitive outcome of patients with SAE.

ANAESTHESIST (2021)

添加到收藏夹

Article Cell Biology

Factors influencing serum neurofilament light chain levels in normal aging

Marisa Koini et al.

Aging-US (2021)

添加到收藏夹

Article Clinical Neurology

Serum Neurofilament Light Chain Levels in the Intensive Care Unit: Comparison between Severely Ill Patients with and without Coronavirus Disease 2019

Raoul Sutter et al.

Summary: There is increasing evidence for various neurological manifestations of COVID-19, with higher sNfL concentrations observed in critically ill patients with COVID-19 compared to healthy controls and critically ill non-COVID-19 patients. Elevated sNfL levels were associated with unfavorable short-term outcomes, indicating common and pronounced neuronal injury in critically ill patients.

ANNALS OF NEUROLOGY (2021)

添加到收藏夹

Review Clinical Neurology

Current advances in plasma and cerebrospinal fluid biomarkers in Alzheimer's disease

Antoine Leuzy et al.

Summary: Recent advances in CSF and blood-based biomarkers of Alzheimer's disease lesions include the introduction of fully automated assays, certified reference materials for CSF A beta 42, and a unified protocol for sample handling. These developments support the reliability and availability of biomarkers, such as A beta, P-tau, and NfL, in both CSF and blood, with potential applications in clinical practice and trials.

CURRENT OPINION IN NEUROLOGY (2021)

添加到收藏夹

Article Geriatrics & Gerontology

Interleukin-1β Modulates Synaptic Transmission and Synaptic Plasticity During the Acute Phase of Sepsis in the Senescence-Accelerated Mouse Hippocampus

Koji Hoshino et al.

Summary: Aging and pre-existing cognitive impairment are independent risk factors for sepsis-associated encephalopathy. This study in mice showed that SAMR1 and SAMP8 had different responses in synaptic transmission and neuroinflammation during the acute phase of sepsis. The modulation of synaptic transmission was found to be related to centrally derived IL-1 receptor-mediated signaling and microglial activation.

FRONTIERS IN AGING NEUROSCIENCE (2021)

添加到收藏夹

Article Clinical Neurology

Blood neurofilament light concentration at admittance: a potential prognostic marker in COVID-19

Anne Hege Aamodt et al.

Summary: Elevated concentrations of NfL and GFAp in COVID-19 patients upon admission may indicate increased mortality risk, and these biomarker concentrations are associated with clinical outcomes.

JOURNAL OF NEUROLOGY (2021)

添加到收藏夹

Article Clinical Neurology

Blood neurofilament light chain and total tau levels at admission predict death in COVID-19 patients

Rebecca De Lorenzo et al.

Summary: The study investigated the clinical prognostic value of markers of neural tissue damage in predicting survival or transfer to ICU in patients infected with COVID-19. Results showed that certain markers were significantly increased in patients with fatal outcomes or needing ICU transfer, with total tau levels accurately predicting mortality. Blood neural markers may offer additional prognostic value for predicting COVID-19 outcomes.

JOURNAL OF NEUROLOGY (2021)

添加到收藏夹

Article Medicine, General & Internal

Mid-German Sepsis Cohort (MSC): a prospective observational study of sepsis survivorship

Carolin Fleischmann-Struzek et al.

Summary: The Mid-German Sepsis Cohort (MSC) aims to investigate mid-term and long-term functional disabilities in sepsis survivors, as well as post-acute mortality, health-related quality of life, and healthcare utilization. To date, recruitment and baseline data collection have been completed, providing a unique resource for research on the long-term sequelae of sepsis survivors. The future plans include follow-up assessments at 3, 6, and 12 months after ICU discharge, with additional yearly follow-ups up to 5 years post-discharge. Several cooperation and satellite projects have been initiated to further explore the outcomes of sepsis survivors.

BMJ OPEN (2021)

添加到收藏夹

Letter Clinical Neurology

Neurofilament Light Chain in Patients with COVID-19 and Bacterial Pneumonia

Ha-Yeun Chung et al.

ANNALS OF NEUROLOGY (2021)

添加到收藏夹

Review Critical Care Medicine

Delirium in critical illness: clinical manifestations, outcomes, and management

Joanna L. Stollings et al.

Summary: Delirium is a common manifestation of brain dysfunction in critically ill patients, with its duration predicting various negative outcomes. The absence of validated tools may lead to misdiagnosis, while ICU bedside instruments can provide valuable information. Screening for predisposing and precipitating factors and implementing strategies like the ABCDEF bundle can improve patient outcomes.

INTENSIVE CARE MEDICINE (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Systemic inflammation induced the delayed reduction of excitatory synapses in the CA3 during ageing

Tatsuya Manabe et al.

Summary: Sepsis-associated encephalopathy (SAE) involves diverse cerebral dysfunctions in response to pathogen-induced systemic inflammation. Injection of LPS from different bacterial strains in aged mice resulted in short-term neuroinflammation with subsequent normalization, showing more pronounced inflammatory responses with E. coli LPS compared to Salmonella LPS. Reduction in excitatory synaptic puncta in the hippocampus was observed at a later time point, possibly attributed to microglia-mediated elimination of C3-tagged synapses.

JOURNAL OF NEUROCHEMISTRY (2021)

添加到收藏夹

Article Immunology

Plasma neurofilament light chain level predicts outcomes in stroke patients receiving endovascular thrombectomy

Chih-Hao Chen et al.

Summary: Among patients with AIS who received EVT, significant increases in plasma GFAP and UCHL1 levels over time were observed in those with hemorrhagic transformation. Higher plasma NfL levels were predictive of unfavorable functional outcomes.

JOURNAL OF NEUROINFLAMMATION (2021)

添加到收藏夹

Article Cell Biology

Serum neurofilament light protein correlates with unfavorable clinical outcomes in hospitalized patients with COVID-19

Mercedes Prudencio et al.

Summary: Brain imaging studies of COVID-19 patients have shown evidence of neuroaxonal injury, and serum levels of neurofilament light chain (NFL) may predict the extent of neuronal damage and are associated with clinical outcomes. Lower NFL serum concentrations were observed in COVID-19 patients treated with remdesivir, suggesting that neuroaxonal injury should be considered as an outcome in acute pharmacotherapeutic trials for COVID-19.

SCIENCE TRANSLATIONAL MEDICINE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Seven day pre-analytical stability of serum and plasma neurofilament light chain

Patrick Altmann et al.

Summary: The study found that the soluble serum and plasma NfL concentration remains stable when unprocessed blood samples are stored up to 7 days at room temperature, which is crucial for ensuring reliable study protocols.

SCIENTIFIC REPORTS (2021)

添加到收藏夹

Article Critical Care Medicine

Long-term outcomes after critical illness: recent insights

Anne-Francoise Rousseau et al.

Summary: Survivors of intensive care often suffer from post-intensive care sequelae, collectively known as post-intensive care syndrome (PICS). The impact of PICS on quality of life, health-related costs, and hospital readmissions is a significant public health issue. This Viewpoint summarizes current knowledge and gaps in understanding PICS and its management approaches.

CRITICAL CARE (2021)

添加到收藏夹

Article Critical Care Medicine

Biomarkers of Delirium Duration and Delirium Severity in the ICU*

Babar A. Khan et al.

CRITICAL CARE MEDICINE (2020)

添加到收藏夹

Article Medicine, General & Internal

Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the Global Burden of Disease Study

Kristina E. Rudd et al.

LANCET (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Serum neurofilament light levels in normal aging and their association with morphologic brain changes

Michael Khalil et al.

NATURE COMMUNICATIONS (2020)

添加到收藏夹

Review Medicine, General & Internal

Sepsis-Associated Encephalopathy: From Delirium to Dementia?

Ha-Yeun Chung et al.

JOURNAL OF CLINICAL MEDICINE (2020)

添加到收藏夹

Review Clinical Neurology

Neurofilaments: neurobiological foundations for biomarker applications

Arie R. Gafson et al.

BRAIN (2020)

添加到收藏夹

Letter Critical Care Medicine

Biomarker Panel to Differentiate Brain Injury From Brain Dysfunction in Patients With Sepsis-Associated Encephalopathy

Johannes Ehler et al.

CRITICAL CARE MEDICINE (2020)

添加到收藏夹

Article Multidisciplinary Sciences

The dynamic change of serum S100B levels from day 1 to day 3 is more associated with sepsis-associated encephalopathy

Long Wu et al.

SCIENTIFIC REPORTS (2020)

添加到收藏夹

Article Immunology

Downregulation of synapse-associated protein expression and loss of homeostatic microglial control in cerebrospinal fluid of infectious patients with delirium and patients with Alzheimer's disease

A. M. Peters van Ton et al.

BRAIN BEHAVIOR AND IMMUNITY (2020)

添加到收藏夹

Article Medicine, General & Internal

Delirium

Jo Ellen Wilson et al.

NATURE REVIEWS DISEASE PRIMERS (2020)

添加到收藏夹

Review Critical Care Medicine

Mortality in sepsis and septic shock in Europe, North America and Australia between 2009 and 2019-results from a systematic review and meta-analysis

Michael Bauer et al.

CRITICAL CARE (2020)

添加到收藏夹

Article Critical Care Medicine

Association between delirium in the intensive care unit and subsequent neuropsychiatric disorders

Kyla N. Brown et al.

CRITICAL CARE (2020)

添加到收藏夹

Article Clinical Neurology

Pro-inflammatory activation of microglia in the brain of patients with sepsis

T. Zrzavy et al.

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2019)

添加到收藏夹

Article Anesthesiology

Elevated serum S-100β in patients with septic shock is associated with delirium

Kristo Erikson et al.

ACTA ANAESTHESIOLOGICA SCANDINAVICA (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

The S100B story: from biomarker to active factor in neural injury

Fabrizio Michetti et al.

JOURNAL OF NEUROCHEMISTRY (2019)

添加到收藏夹

Article Multidisciplinary Sciences

The prognostic value of neurofilament levels in patients with sepsis-associated encephalopathy - A prospective, pilot observational study

Johannes Ehler et al.

PLOS ONE (2019)

添加到收藏夹

Article Clinical Neurology

Serum and CSF neurofilament light chain levels in antibody-mediated encephalitis

Sara Mariotto et al.

JOURNAL OF NEUROLOGY (2019)

添加到收藏夹

Review Clinical Neurology

Neurofilament light chain as a biomarker in neurological disorders

Lorenzo Gaetani et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2019)

添加到收藏夹

Article Infectious Diseases

Association between Elevated Serum Tau Protein Level and Sepsis-Associated Encephalopathy in Patients with Severe Sepsis

Teng Zhao et al.

CANADIAN JOURNAL OF INFECTIOUS DISEASES & MEDICAL MICROBIOLOGY (2019)

添加到收藏夹

Article Critical Care Medicine

Association Between Sepsis and Microvascular Brain Injury*

William Ehlenbach et al.

CRITICAL CARE MEDICINE (2019)

添加到收藏夹

Article Critical Care Medicine

Serum glial fibrillary acidic protein and ubiquitin C-terminal hydrolase-L1 for diagnosis of sepsis-associated encephalopathy and outcome prognostication

Long Wu et al.

JOURNAL OF CRITICAL CARE (2019)

添加到收藏夹

Article Neurosciences

Diagnostic value of NT-proCNP compared to NSE and S100B in cerebrospinal fluid and plasma of patients with sepsis-associated encephalopathy

Johannes Ehler et al.

NEUROSCIENCE LETTERS (2019)

添加到收藏夹

Article Clinical Neurology

Association of Cerebrospinal Fluid Neurofilament Light Protein With Risk of Mild Cognitive Impairment Among Individuals Without Cognitive Impairment

Silke Kern et al.

JAMA NEUROLOGY (2019)

添加到收藏夹

Review Medicine, General & Internal

Enhancing Recovery From Sepsis A Review

Hallie C. Prescott et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2018)

添加到收藏夹

Article Neurosciences

Long-Term Neuroinflammation Induced by Influenza A Virus Infection and the Impact on Hippocampal Neuron Morphology and Function

Shirin Hosseini et al.

JOURNAL OF NEUROSCIENCE (2018)

添加到收藏夹

Review Medicine, General & Internal

Sepsis and septic shock

Maurizio Cecconi et al.

LANCET (2018)

添加到收藏夹

Article Critical Care Medicine

Long-term cognitive impairment and delirium in intensive care: A prospective cohort study

Marion L. Mitchell et al.

AUSTRALIAN CRITICAL CARE (2018)

添加到收藏夹

Article Critical Care Medicine

Clinical phenotypes of delirium during critical illness and severity of subsequent long-term cognitive impairment: a prospective cohort study

Timothy D. Girard et al.

LANCET RESPIRATORY MEDICINE (2018)

添加到收藏夹

Review Clinical Neurology

Neurofilaments as biomarkers in neurological disorders

Michael Khalil et al.

NATURE REVIEWS NEUROLOGY (2018)

添加到收藏夹

Letter Pediatrics

Association of Bacteremic Sepsis With Long-term Neurocognitive Dysfunction in Pediatric Patients With Acute Lymphoblastic Leukemia

Yin Ting Cheung et al.

JAMA PEDIATRICS (2018)

添加到收藏夹

Article Medicine, Research & Experimental

Targeting inflammatory monocytes in sepsis-associated encephalopathy and long-term cognitive impairment

Graciela Andonegui et al.

JCI INSIGHT (2018)

添加到收藏夹

Article Critical Care Medicine

Potentially modifiable factors contributing to sepsis-associated encephalopathy

Romain Sonneville et al.

INTENSIVE CARE MEDICINE (2017)

添加到收藏夹

Letter Medicine, General & Internal

Proportion and Cost of Unplanned 30-Day Readmissions After Sepsis Compared With Other Medical Conditions

Florian B. Mayr et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2017)

添加到收藏夹

Review Immunology

Polarization of microglia and its role in bacterial sepsis

Monique Michels et al.

JOURNAL OF NEUROIMMUNOLOGY (2017)

添加到收藏夹

Review Clinical Neurology

Strategic roadmap for an early diagnosis of Alzheimer's disease based on biomarkers

Giovanni B. Frisoni et al.

LANCET NEUROLOGY (2017)

添加到收藏夹

Article Clinical Neurology

Monitoring disease activity in multiple sclerosis using serum neurofilament light protein

Lenka Novakova et al.

NEUROLOGY (2017)

添加到收藏夹

Article Cell Biology

Neurofilaments and Neurofilament Proteins in Health and Disease

Aidong Yuan et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2017)

添加到收藏夹

Article Critical Care Medicine

Translational evidence for two distinct patterns of neuroaxonal injury in sepsis: a longitudinal, prospective translational study

Johannes Ehler et al.

CRITICAL CARE (2017)

添加到收藏夹

Article Critical Care Medicine

Assessment of Global Incidence and Mortality of Hospital-treated Sepsis

Carolin Fleischmann et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2016)

添加到收藏夹

Review Medicine, Research & Experimental

Critical Illness Brain Injury

Timothy D. Girard et al.

ANNUAL REVIEW OF MEDICINE, VOL 67 (2016)

添加到收藏夹

Article Medical Laboratory Technology

Comparison of three analytical platforms for quantification of the neurofilament light chain in blood samples: ELISA, electrochemiluminescence immunoassay and Simoa

Jens Kuhle et al.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2016)

添加到收藏夹

Article Medicine, General & Internal

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

Mervyn Singer et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2016)

添加到收藏夹

Article Critical Care Medicine

Admission plasma levels of the neuronal injury marker neuron-specific enolase are associated with mortality and delirium in sepsis

Brian J. Anderson et al.

JOURNAL OF CRITICAL CARE (2016)

添加到收藏夹

Article Clinical Neurology

Association of Cerebrospinal Fluid Neurofilament Light Concentration With Alzheimer Disease Progression

Henrik Zetterberg et al.

JAMA NEUROLOGY (2016)

添加到收藏夹

Review Cell Biology

Neurofilament assembly and function during neuronal development

Adi Laser-Azogui et al.

CURRENT OPINION IN CELL BIOLOGY (2015)

添加到收藏夹

Review Economics

The Economic and Humanistic Burden of Severe Sepsis

Bogdan Tiru et al.

PHARMACOECONOMICS (2015)

添加到收藏夹

Article Critical Care Medicine

Increased 1-Year Healthcare Use in Survivors of Severe Sepsis

Hallie C. Prescott et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2014)

添加到收藏夹

Article Critical Care Medicine

Risk of Cardiovascular Events in Survivors of Severe Sepsis

Sachin Yende et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2014)

添加到收藏夹

Article Biochemistry & Molecular Biology

Serum S100β is a Better Biomarker than Neuron-Specific Enolase for Sepsis-Associated Encephalopathy and Determining Its Prognosis: A Prospective and Observational Study

Bo Yao et al.

NEUROCHEMICAL RESEARCH (2014)

添加到收藏夹

Article Critical Care Medicine

Depression, post-traumatic stress disorder, and functional disability in survivors of critical illness in the BRAIN-ICU study: a longitudinal cohort study

James C. Jackson et al.

LANCET RESPIRATORY MEDICINE (2014)

添加到收藏夹

Article Critical Care Medicine

Neurofilaments as a plasma biomarker for ICU-acquired weakness: an observational pilot study

Luuk Wieske et al.

CRITICAL CARE (2014)

添加到收藏夹

Article Critical Care Medicine

Inflammation biomarkers and delirium in critically ill patients

Cristiane Ritter et al.

CRITICAL CARE (2014)

添加到收藏夹

Article Immunology

PPARγ activation prevents impairments in spatial memory and neurogenesis following transient illness

Brandi K. Ormerod et al.

BRAIN BEHAVIOR AND IMMUNITY (2013)

添加到收藏夹

Article Clinical Neurology

Persistent cognitive impairment, hippocampal atrophy and EEG changes in sepsis survivors

Alexander Semmler et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2013)

添加到收藏夹

Article Medicine, General & Internal

Long-Term Cognitive Impairment after Critical Illness

P. P. Pandharipande et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

添加到收藏夹

Article Critical Care Medicine

The association between brain volumes, delirium duration, and cognitive outcomes in intensive care unit survivors: The VISIONS cohort magnetic resonance imaging study

Max L. Gunther et al.

CRITICAL CARE MEDICINE (2012)

添加到收藏夹

Article Critical Care Medicine

Improving long-term outcomes after discharge from intensive care unit: Report from a stakeholders' conference

Dale M. Needham et al.

CRITICAL CARE MEDICINE (2012)

添加到收藏夹

Editorial Material Cell Biology

Neurofilaments at a glance

Aidong Yuan et al.

JOURNAL OF CELL SCIENCE (2012)

添加到收藏夹

Article Biochemistry & Molecular Biology

HMGB1 Mediates Cognitive Impairment in Sepsis Survivors

Sangeeta S. Chavan et al.

MOLECULAR MEDICINE (2012)

添加到收藏夹

Review Clinical Neurology

Sepsis-associated encephalopathy

Teneille E. Gofton et al.

NATURE REVIEWS NEUROLOGY (2012)

添加到收藏夹

Review Critical Care Medicine

The confusion assessment method for the intensive care unit (CAM-ICU) and intensive care delirium screening checklist (ICDSC) for the diagnosis of delirium: a systematic review and meta-analysis of clinical studies

Dimitri Gusmao-Flores et al.

CRITICAL CARE (2012)

添加到收藏夹

Article Surgery

Motor Subtypes of Postoperative Delirium in Older Adults

Thomas N. Robinson et al.

ARCHIVES OF SURGERY (2011)

添加到收藏夹

Article Critical Care Medicine

Sepsis-associated encephalopathy and its differential diagnosis

Emanuele Iacobone et al.

CRITICAL CARE MEDICINE (2010)

添加到收藏夹

Article Critical Care Medicine

Delirium as a predictor of long-term cognitive impairment in survivors of critical illness

Timothy D. Girard et al.

CRITICAL CARE MEDICINE (2010)

添加到收藏夹

Article Medicine, General & Internal

Long-term Cognitive Impairment and Functional Disability Among Survivors of Severe Sepsis

Theodore J. Iwashyna et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2010)

添加到收藏夹

Review Neurosciences

UCHL1 (PGP 9.5): Neuronal biomarker and ubiquitin system protein

Ian N. M. Day et al.

PROGRESS IN NEUROBIOLOGY (2010)

添加到收藏夹

Article Critical Care Medicine

Endotoxemia-induced inflammation and the effect on the human brain

Mark van den Boogaard et al.

CRITICAL CARE (2010)

添加到收藏夹

Article Immunology

Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of beta-amyloid generation

Jae Woong Lee et al.

JOURNAL OF NEUROINFLAMMATION (2008)

添加到收藏夹

Article Anesthesiology

Elevated S100B levels do not correlate with the severity of encephalopathy during sepsis

O. Piazza et al.

BRITISH JOURNAL OF ANAESTHESIA (2007)

添加到收藏夹

Review Critical Care Medicine

Sepsis-associated delirium

Marion Ebersoldt et al.

INTENSIVE CARE MEDICINE (2007)

添加到收藏夹

Article Critical Care Medicine

Elevated serum levels of S-1000 protein and neuron-specific enolase are associated with brain injury in patients with severe sepsis and septic shock

Dug Nam Nguyen et al.

CRITICAL CARE MEDICINE (2006)

添加到收藏夹

Article Health Care Sciences & Services

Fast, systematic, and continuous delirium assessment in hospitalized patients: The Nursing Delirium Screening Scale

JD Gaudreau et al.

JOURNAL OF PAIN AND SYMPTOM MANAGEMENT (2005)

添加到收藏夹

Article Clinical Neurology

The neuropathology of septic shock

T Sharshar et al.

BRAIN PATHOLOGY (2004)

添加到收藏夹

Article Medicine, General & Internal

Apoptosis of neurons in cardiovascular autonomic centres triggered by inducible nitric oxide synthase after death from septic shock

T Sharshar et al.

LANCET (2003)

添加到收藏夹

Article Medicine, General & Internal

Delirium in mechanically ventilated patients - Validity and reliability of the Confusion Assessment Method for the intensive care unit (CAM-ICU)

EW Ely et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2001)

添加到收藏夹

Article Critical Care Medicine

Intensive Care Delirium Screening Checklist: evaluation of a new screening tool

N Bergeron et al.

INTENSIVE CARE MEDICINE (2001)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.