期刊
PATHOPHYSIOLOGY
卷 30, 期 1, 页码 37-47出版社
MDPI
DOI: 10.3390/pathophysiology30010005
关键词
resveratrol; high-fructose high-lipid diet; light-dark cycle; melatonin; pro-inflammatory activity; oxidative stress; metabolic disorder; rats
类别
This study investigates the impact of resveratrol on systemic inflammation and metabolic disorders in rats exposed to a high-fructose high-lipid diet (HFHLD) and round-the-clock lighting (RCL). The combined effect of HFHLD and RCL leads to decreased levels of melatonin and increased pro-inflammatory activities, oxidative stress, and metabolic disorder. Resveratrol mitigates these effects, leading to increased melatonin levels and reduced inflammation and metabolic disorder.
This study aims to investigate the effect of resveratrol on systemic inflammatory response and metabolic disorder in rats fed a high-fructose high-lipid diet (HFHLD) and exposed to round-the-clock lighting (RCL). 21 adult male Wistar rats were randomly divided into 3 groups: control (group 1, n = 7); HFHLD for 8 weeks + round-the-clock lighting (RCL) (group 2, n = 7); HFHLD + RCL + Resveratrol (in a daily dose of 5 mg/kg intragastrically (group 3, n = 7). Results show that the combined effect of HFHLD and RCL reduces the serum melatonin (p < 0.001) and accelerates pro-inflammatory activities, oxidative stress, and metabolic disorder. There is a significant increase in the serum tumour necrosis factor-alpha (TNF-a) and C-reactive protein (CRP) (both p < 0.001), blood malondialdehyde-thiobarbituric acid adducts (MDA-TBA(2)) (p < 0.001), serum glucose (p < 0.01), insulin concentration, and the homeostatic model assessment insulin resistance (HOMA-IR) index (both p < 0.001), serum with very low-density lipoprotein (VLDL), and triacylglycerol (TAG) (both p < 0.001). At the same time, the decrease in the serum high-density lipoprotein (HDL) level (p < 0.001) is observed in the HFHLD + RCL group compared to the control. In the HFHLD + RCL + Resveratrol group, hypomelatonaemia (p < 0.001), pro-inflammatory actions, oxidative stress, and metabolic disorder were mitigated. Resveratrol can cause a significant rise in the serum melatonin and reduce serum TNF-a and CRP levels (both p < 0.001), blood MDA-TBA(2) (p < 0.001), serum glucose (both p < 0.01), insulin concentration, and HOMA-IR (both p < 0.001), serum VLDL and TAG (both p < 0.001) compared to the group 2, while serum HDL level increases (p < 0.01). Resveratrol attenuates pro-inflammatory responses and prevents considerable metabolic disorder in rats fed HFHLD under RCL.
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