☆ 4.5 Article

Long-Term Kidney and Maternal Outcomes After Pregnancy in Living Kidney Donors

TRANSPLANT INTERNATIONAL (2023)

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Pregnancy after living kidney donation, a systematic review of the available evidence, and a review of the current guidance

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Summary: Understanding and communicating the risk of pregnancy complications after living kidney donation is crucial, especially for women of childbearing age who make up the majority of living kidney donors. This research examined various studies and guidelines to compare the quality and consistency of information about post-donation pregnancy complications. The absolute risk of pre-eclampsia was found to increase after donation, while the risks of adverse fetal and neonatal outcomes remained similar. Guidelines and consensus statements agreed on the importance of informing donors about the risks, but the depth and scope of this guidance varied. It is necessary to better identify and personalize the risk for these women in order to ensure informed consent for donation.

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Summary: The study found that obese kidney donors were more likely to develop diabetes, hypertension, and proteinuria compared to nonobese donors. Obese donors had a higher increase in eGFR in the first 10 years post-donation, but this trend became comparable to nonobese donors thereafter. The absolute risk of developing ESKD was small for obese donors, and their risk of death was similar to that of nonobese donors.

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