期刊
ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS
卷 15, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s12941-016-0159-8
关键词
Antimicrobial activity; Membrane disruption; Atomic force and scanning electron microscopy
类别
资金
- SYM-BIOTICS Advanced Grant of the European Research Council [269067]
- OTKA grant from the Hungarian National Research Fund [NN110979]
- Hungarian National Research Fund [PD112509]
- European Research Council (ERC) [269067] Funding Source: European Research Council (ERC)
Background: Certain legume plants produce a plethora of AMP-like peptides in their symbiotic cells. The cationic subgroup of the nodule-specific cysteine-rich (NCR) peptides has potent antimicrobial activity against gram-negative and gram-positive bacteria as well as unicellular and filamentous fungi. Findings: It was shown by scanning and atomic force microscopies that the cationic peptides NCR335, NCR247 and Polymyxin B(PMB) affect differentially on the surfaces of Sinorhizobium meliloti bacteria. Similarly to PMB, both NCR peptides caused damages of the outer and inner membranes but at different extent and resulted in the loss of membrane potential that could be the primary reason of their antimicrobial activity. Conclusions: The primary reason for bacterial cell death upon treatment with cationic NCR peptides is the loss of membrane potential.
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