期刊
ALZHEIMERS RESEARCH & THERAPY
卷 8, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s13195-016-0182-1
关键词
Aging; Alzheimer's disease; Amyloid beta; Microgliosis; Mild cognitive impairment; Neuroinflammation; Soluble TREM2; Tau
资金
- University of Oslo
- Anders Jahres stiftelse
- Helse Sor-Ost
- Civitan Foundation
- JPND grant (APGeM)
- Norwegian Research Council (NASATS, DDI)
- Vetenskapsradet [2013-2923]
Background: Alzheimer's disease (AD) neuropathology is associated with neuroinflammation, but there are few useful biomarkers. Mutant variants of triggering receptor expressed on myeloid cells 2 (TREM2) have recently been linked to late-onset AD and other neurodegenerative disorders. TREM2, a microglial receptor, is involved in innate immunity. A cleaved fragment, soluble TREM2 (sTREM2), is present in the cerebrospinal fluid (CSF). Methods: We developed and used a novel enzyme-linked immunosorbent assay to investigate the potential value of CSF sTREM2 as an AD biomarker in two independent cohorts: an AD/mild cognitive impairment (MCI)/control cohort (n = 100) and an AD/control cohort (n = 50). Results: We found no significant difference in sTREM2 levels between groups of controls and patients with AD or MCI. However, among all controls there was a positive correlation between sTREM2 and age (Spearman rho = 0.50; p < 0.001; n = 75). In the AD/MCI/control cohort, CSF sTREM2 correlated positively with total Tau (T-tau) (Spearman rho 0.57; p < 0.001; n = 50), phosphorylated Tau (P-tau) (Spearman rho 0.63; p < 0.001; n = 50) and amyloid-beta 1-42 (A beta 42) (Spearman rho 0.35; p = 0.01; n = 50) in control subjects. Among controls with a CSF A beta 42 above a cut-off value (700 pg/ml) in this cohort, the positive correlation between sTREM2 and A beta 42 was stronger (Spearman rho = 0.44; p = 0.002; n = 46). Conclusions: sTREM2 in CSF correlates with aging in controls, and with the neurodegenerative markers CSF T-tau/P-tau among controls who are negative for AD CSF core biomarkers A beta 42, T-tau or P-tau.
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