Mechanism of p53 Action

P53 is a 393 residue protein in human made up of five proposed domains, with which the central DNA binding domain with 100-300 sequences very important for the direct binding of p53 in the promoters of its target genes to specific response elements. P53 is a tumor suppressor gene with cellular stress like oxygen deficiency, oxidative stress, radiation and carcinogens substances, and its stimulated has major roles in translational regulation and feedback processes. A wide assortment of harm signals that relate a stability, post-translational alteration and recruitment of p53 to binding sites in chromatin which activate the p53 pathway. As a transcriptional activation, p53 mediates transcriptional changes which facilitate cell death, senescence or reversing and protective arrest of the cell cycle. P53 is a protein under intense investigation because it is necessary to prevent tumor, in human tumors have been found to deregulation of p53 activity. On this article study focuses on the mechanism of suppressive p53 effects in the response to any stress and correlation of the mutation p53 with different tumours.

Automated summary

P53 is a human protein consisting of five proposed domains, with a central DNA binding domain crucial for the direct binding of p53 to specific elements in the promoters of its target genes. Stimulated by cellular stressors, P53 acts as a tumor suppressor gene and plays significant roles in translational regulation and feedback processes. Various damage signals can activate the p53 pathway by affecting p53 stability, post-translational modifications, and recruitment to binding sites in chromatin. P53 functions as a transcriptional activator, mediating transcriptional changes that promote cell death, senescence, or cell cycle arrest. Due to its importance in tumor prevention, deregulation of p53 activity has been observed in human tumors. This article focuses on the mechanism of p53's suppressive effects in response to stress and the correlation between mutant p53 and different types of tumors.