☆ 4.4 Article

Removal of senescent cells reduces the viral load and attenuates pulmonary and systemic inflammation in SARS-CoV-2-infected, aged hamsters

NATURE AGING (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Cell Biology

SARS-CoV-2 infection induces persistent adipose tissue damage in aged golden Syrian hamsters

Gemma Bogard et al.

Summary: COVID-19 primarily affects the respiratory system, but it also has extrapulmonary manifestations. It has been found that SARS-CoV-2 can directly affect white adipose tissue (WAT), leading to insulin resistance and dyslipidemia. However, there is limited data on the impact of SARS-CoV-2 on WAT in older individuals. This study revealed that SARS-CoV-2 infection caused changes in adipocyte size and lipid metabolism in WAT, and older hamsters had a more severe response. Additionally, older hamsters showed difficulties in clearing dead adipocytes by macrophages, leading to the persistence of large adipose crown-like structures (CLSs).

CELL DEATH & DISEASE (2023)

添加到收藏夹

Article Immunology

COVID-19 and cellular senescence

Clemens A. Schmitt et al.

Summary: The severity of COVID-19 is determined by host factors, with cellular senescence playing a critical role in the hyperinflammatory response caused by SARS-CoV-2. Elderly individuals have a higher proportion of senescent cells, leading to the spreading of cellular senescence and worsening symptoms such as cytokine storms. Targeted elimination of senescent cells may offer a novel therapeutic approach to attenuate clinical deterioration in COVID-19.

NATURE REVIEWS IMMUNOLOGY (2023)

添加到收藏夹

Review Cell Biology

Triple jeopardy in ageing: COVID-19, co-morbidities and inflamm-ageing

Irene Maeve Rea et al.

Summary: Covid-19 has had a significant impact on human life, with varying degrees of symptoms in different individuals. Older people and those with comorbidities such as diabetes, heart disease, and obesity are more likely to develop severe symptoms. Enhancing the immune function in older and frail individuals to prevent serious Covid-19 infection is a key consideration.

AGEING RESEARCH REVIEWS (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

DNA damage response at telomeres boosts the transcription of SARS-CoV-2 receptor ACE2 during aging

Sara Sepe et al.

Summary: As individuals age, the expression of ACE2 in the lungs increases, making elderly individuals more susceptible to SARS-CoV-2. Telomere damage triggers DDR activation, leading to an upregulation of ACE2 and potentially increasing susceptibility to infection in the elderly.

EMBO REPORTS (2022)

添加到收藏夹

Article Pharmacology & Pharmacy

The therapeutic efficacy of quercetin in combination with antiviral drugs in hospitalized COVID-19 patients: A randomized controlled trial

Mojtaba Shohan et al.

Summary: This study evaluated the therapeutic efficacy of quercetin in combination with remdesivir and favipiravir in severe hospitalized COVID-19 patients. Quercetin was found to prevent disease progression and reduce inflammatory markers related to SARS-Cov-2 pathogenesis. However, the impact on mortality and ICU-admission duration was not significant.

EUROPEAN JOURNAL OF PHARMACOLOGY (2022)

添加到收藏夹

Article Respiratory System

Pulmonary infection by SARS-CoV-2 induces senescence accompanied by an inflammatory phenotype in severe COVID-19: possible implications for viral mutagenesis

Konstantinos Evangelou et al.

Summary: This study found that SARS-CoV-2 infection in severe COVID-19 patients leads to cellular senescence and a proinflammatory phenotype in AT2 cells. In vitro experiments showed that SARS-CoV-2 infection induces cell senescence and inflammation. Infected senescent cells may contribute to SARS-CoV-2 mutagenesis mediated by APOBEC enzymes.

EUROPEAN RESPIRATORY JOURNAL (2022)

添加到收藏夹

Article Gastroenterology & Hepatology

Alteration of the gut microbiota following SARS-CoV-2 infection correlates with disease severity in hamsters

Valentin Sencio et al.

Summary: Mounting evidence suggests that the gut plays a critical role during respiratory viral infections. Using a hamster model, this study found that SARS-CoV-2 infection led to intestinal inflammation, altered intestinal barrier property, liver inflammation, and disrupted lipid metabolism. The changes were accompanied by alterations in the gut microbiota composition, characterized by an increase in harmful bacterial taxa and a decrease in bacteria that produce SCFAs. These alterations in the gut microbiota were correlated with disease severity in hamsters.

GUT MICROBES (2022)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Emerging therapeutic opportunities for integrin inhibitors

R. J. Slack et al.

Summary: Integrins play crucial roles in cell adhesion and signaling, making them potential therapeutic targets. This review discusses the challenges and development of integrin inhibitors, particularly those targeting integrins with an alpha v-subunit. Opportunities exist for learning from previous trials and exploring new modalities in integrin drug design.

NATURE REVIEWS DRUG DISCOVERY (2022)

添加到收藏夹

Review Medical Laboratory Technology

Role of senescence in the chronic health consequences of COVID-19

Erin O. Wissler Gerdes et al.

Summary: COVID-19 can have long-lasting effects on patients, known as Long-Hauler's Syndrome. Older adults are at greater risk for severe outcomes. The aging process may interfere with defenses against viral infection and contribute to increased risk for long-term COVID-19 sequelae. Senolytics and other geroscience interventions may be an option for delaying, preventing, or alleviating Long-Hauler's Syndrome.

TRANSLATIONAL RESEARCH (2022)

添加到收藏夹

Article Cell Biology

SARS-CoV-2 infection in hamsters and humans results in lasting and unique systemic perturbations after recovery

Justin J. Frere et al.

Summary: This study compared the short- and long-term systemic responses after SARS-CoV-2 and influenza A virus (IAV) infection, and found that SARS-CoV-2 caused more severe and lasting lung and kidney damage compared to IAV. It also uniquely affected the olfactory bulb and olfactory epithelium. Despite viral clearance, the olfactory bulb and epithelium showed sustained transcriptional changes and correlated with behavioral changes, providing insights into the persistent symptoms of COVID-19.

SCIENCE TRANSLATIONAL MEDICINE (2022)

添加到收藏夹

Article Cell Biology

A diminished immune response underlies age-related SARS-CoV-2 pathologies

Kohei Oishi et al.

Summary: Older individuals have a higher morbidity and mortality rate in response to SARS-CoV-2 infection. The golden hamster model revealed that older animals have a weaker immune response and reduced tissue repair in the respiratory tract post-infection. Age-related differences in the adaptive immune response include decreased potency of neutralizing antibodies and increased suppressor T cells and neutrophils in the respiratory tract.

CELL REPORTS (2022)

添加到收藏夹

Article Immunology

Impaired immune response drives age-dependent severity of COVID-19

Julius Beer et al.

Summary: The study reveals that advanced age is correlated with severe COVID-19 due to impaired immune response, specifically the diminished IFN-gamma response and excessive virus replication. It suggests that immunotherapy combining IFN-gamma and IFN-lambda could benefit highly vulnerable individuals.

JOURNAL OF EXPERIMENTAL MEDICINE (2022)

添加到收藏夹

Article Medicine, Research & Experimental

Caffeine intake exerts dual genome-wide effects on hippocampal metabolism and learning-dependent transcription

Isabel Paiva et al.

Summary: Chronic caffeine intake in mice has been found to exert various effects in the hippocampus, improving information encoding by fine-tuning metabolic genes and enhancing the salience of information processing.

JOURNAL OF CLINICAL INVESTIGATION (2022)

添加到收藏夹

Article Cell Biology

SARS-CoV-2 infection triggers paracrine senescence and leads to a sustained senescence-associated inflammatory response

Shunya Tsuji et al.

Summary: This study reveals that SARS-CoV-2 infection can induce senescence-like cell-cycle arrest in neighboring uninfected cells through virus-induced cytokine production. The infected cells continue to express inflammatory factors known as senescence-associated secretory phenotypes even after the virus is no longer detectable. The expression of senescence markers and inflammatory genes is increased in the pulmonary cells of severe post-acute COVID-19 syndrome patients. Senolytic drugs can effectively reduce cellular senescence and inflammation in the lung after SARS-CoV-2 infection.

NATURE AGING (2022)

添加到收藏夹

Article Cell Biology

Single-cell transcriptomic atlas of primate cardiopulmonary aging

Shuai Ma et al.

Summary: The research indicates that aging is associated with increased systemic inflammation and compromised virus defense in the cardiopulmonary system. With age, expression of the SARS-CoV-2 receptor ACE2 increases, while the accumulation of the cytokine IL7 induces ACE2 expression. Treatment with vitamin C can block IL7-induced ACE2 expression, suggesting that geroprotective strategies may reduce the severity of COVID-19 in the elderly.

CELL RESEARCH (2021)

添加到收藏夹

Article Medicine, General & Internal

Potential Clinical Benefits of Quercetin in the Early Stage of COVID-19: Results of a Second, Pilot, Randomized, Controlled and Open-Label Clinical Trial

Francesco Di Pierro et al.

Summary: Treatment with QP in COVID-19 patients can lead to faster virus clearance, reduced symptoms severity, and improved blood parameters, showing promising potential as a therapeutic intervention for the disease.

INTERNATIONAL JOURNAL OF GENERAL MEDICINE (2021)

添加到收藏夹

Article Medicine, General & Internal

Possible Therapeutic Effects of Adjuvant Quercetin Supplementation Against Early-Stage COVID-19 Infection: A Prospective, Randomized, Controlled, and Open-Label Study

Francesco Di Pierro et al.

Summary: The study indicates that Quercetin Phytosome may have potential therapeutic effects for COVID-19 patients, reducing hospitalization and mortality rates. It is also shown to be safe and may have anti-fatigue and appetite-enhancing properties.

INTERNATIONAL JOURNAL OF GENERAL MEDICINE (2021)

添加到收藏夹

Review Cell Biology

Cellular senescence in ageing: from mechanisms to therapeutic opportunities

Raffaella Di Micco et al.

Summary: Cellular senescence is characterized by permanent proliferation arrest and can occur in response to various stresses like telomere dysfunction. Apart from stress-induced senescence, it can also be part of controlled programs in biological processes like embryonic development. Senescent cells contribute to impaired tissue regeneration, chronic diseases, and organismal aging, but also present an opportunity for intervention in aging and associated diseases.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

The aging transcriptome and cellular landscape of the human lung in relation to SARS-CoV-2

Ryan D. Chow et al.

Summary: Age is a major risk factor for severe illness from COVID-19, and the heightened severity of COVID-19 in older populations may be related to age-associated changes in the transcriptome and cellular landscape of the aging lung. Specific age-associated cells and genes interact with the SARS-CoV-2 proteome and are dysregulated by SARS-CoV-2 infection in vitro and in patients with severe COVID-19.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Article Cell Biology

A single-cell transcriptomic landscape of the lungs of patients with COVID-19

Si Wang et al.

Summary: This study provides insights into the molecular basis of lung pathology in COVID-19 patients through multi-omics and single-nucleus transcriptomic analysis, identifying pathological features associated with SARS-CoV-2 infection such as hyperinflammation, alveolar epithelial cell exhaustion, vascular changes, and fibrosis. It also highlights lung senescence as a molecular state of COVID-19 pathology and suggests FOXO3A suppression as a potential mechanism for COVID-19 pulmonary fibrosis.

NATURE CELL BIOLOGY (2021)

添加到收藏夹

Article Biology

SARS-CoV-2 infection induces protective immunity and limits transmission in Syrian hamsters

Prabhuanand Selvaraj et al.

Summary: The study found that SARS-CoV-2 infection induces protective immunity in hamsters, preventing re-exposure and limiting transmission, which may help guide public health policies and vaccine development.

LIFE SCIENCE ALLIANCE (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

The aging lung: Physiology, disease, and immunity

Jaime L. Schneider et al.

Summary: Human population is aging faster than ever before in history, requiring a deeper understanding of aging biology and its connection to diseases. Aging lungs face various stresses, increasing the risk of lung diseases, respiratory infections, and lung cancer.

CELL (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

The struggle of a good friend getting old: cellular senescence in viral responses and therapy

Jaskaren Kohli et al.

Summary: Cellular senescence is a stable cell cycle arrest associated with macromolecular alterations and inflammation, which play important roles in controlling viral spread and activating immune responses. However, excessive and aberrant senescent cells can lead to pathology and dysfunction. Pharmacological interventions, including antiviral therapies, can induce premature senescence and have detrimental effects if not controlled properly.

EMBO REPORTS (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Host parameters and mode of infection influence outcome in SARS-CoV-2-infected hamsters

Bryan D. Griffin et al.

Summary: The study investigated the impact of exposure route, sex, and age on SARS-CoV-2 pathogenesis in golden hamsters. It found that different exposure routes can affect weight changes, while male and older hamsters have more difficulty recovering and clearing the virus.

ISCIENCE (2021)

添加到收藏夹

Article Geriatrics & Gerontology

Fisetin for COVID-19 in skilled nursing facilities: Senolytic trials in the COVID era

Brandon P. Verdoorn et al.

Summary: Senescent cells (SnCs), which are metabolically active and resistant to apoptosis, increase with age and chronic diseases, making individuals more susceptible to SARS-CoV-2 complications. Senolytic agents, like Fisetin, selectively target and eliminate SnCs, showing promise in delaying or preventing multiple disorders. Clinical trials are underway to investigate the impact of senolytics on decreasing SARS-CoV-2 progression and morbidity in older adults, with logistical challenges considered for conducting trials in long-term care settings.

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY (2021)

添加到收藏夹

Article Virology

SARS-CoV-2 Spike Protein Induces Paracrine Senescence and Leukocyte Adhesion in Endothelial Cells

Keith Meyer et al.

Summary: Increased mortality in COVID-19 cases is often associated with microvascular complications. The spike protein of SARS-CoV-2 can induce cellular senescence and inflammatory responses in human epithelial cells, leading to enhanced leukocyte adhesion. Various inhibitors have shown potential in reversing the senescence effects and reducing inflammatory responses.

JOURNAL OF VIROLOGY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Virus-induced senescence is a driver and therapeutic target in COVID-19

Soyoung Lee et al.

Summary: Virus-induced senescence is a key pathogenic feature in COVID-19, and senolytic drugs, which induce apoptosis of senescent cells, can alleviate disease severity in COVID-19 patients, as demonstrated in hamsters and mice infected with SARS-CoV-2.

NATURE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Senolytics reduce coronavirus-related mortality in old mice

Christina D. Camell et al.

Summary: The research demonstrates that cellular senescence plays a critical role in pathogen infections, with aging mice experiencing increased senescence and inflammation after exposure to pathogens. Targeting cellular senescence can significantly reduce mortality and inflammatory markers.

SCIENCE (2021)

添加到收藏夹

Review Cell Biology

SARS-CoV-2, COVID-19 and the aging immune system

Juliet M. Bartleson et al.

Summary: The COVID-19 pandemic poses a greater risk for severe disease and death in older adults and individuals with age-related metabolic and cardiovascular diseases. Interventions targeting immunosenescence may be crucial in reducing mortality and disability caused by the pandemic, ultimately improving complications associated with severe COVID-19 in individuals of all ages.

NATURE AGING (2021)

添加到收藏夹

Article Geriatrics & Gerontology

Prediction of SARS-CoV Interaction with Host Proteins during Lung Aging Reveals a Potential Role for TRIB3 in COVID-19

Diogo de Moraes et al.

Summary: Old individuals are more susceptible to pneumonia and respiratory failure, with decreased TRIB3 expression in aged male individuals potentially leading to more severe cases of COVID-19. Therefore, drugs that stimulate TRIB3 expression may be evaluated as a potential therapy.

AGING AND DISEASE (2021)

添加到收藏夹

Article Cell Biology

Chronic WNT/β-catenin signaling induces cellular senescence in lung epithelial cells

Mareike Lehmann et al.

CELLULAR SIGNALLING (2020)

添加到收藏夹

Letter Critical Care Medicine

Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China

Qiurong Ruan et al.

INTENSIVE CARE MEDICINE (2020)

添加到收藏夹

Article Cell Biology

COVID-19 and chronological aging: senolytics and other anti-aging drugs for the treatment or prevention of corona virus infection?

Camillo Sargiacomo et al.

AGING-US (2020)

添加到收藏夹

Article Microbiology

A Mouse Model of SARS-CoV-2 Infection and Pathogenesis

Shi-Hui Sun et al.

CELL HOST & MICROBE (2020)

添加到收藏夹

Article Cell Biology

Elimination of senescent cells by β-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice

Yusheng Cai et al.

CELL RESEARCH (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Pathogenesis and transmission of SARS-CoV-2 in golden hamsters

Sin Fun Sia et al.

NATURE (2020)

添加到收藏夹

Article Hematology

COVID-19 and coagulation: bleeding and thrombotic manifestations of SARS-CoV-2 infection

Hanny Al-Samkari et al.

BLOOD (2020)

添加到收藏夹

Article Immunology

Senescence in Monocytes Facilitates Dengue Virus Infection by Increasing Infectivity

Tzu-Han Hsieh et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2020)

添加到收藏夹

Article Cell Biology

Endoplasmic reticulum stress mediates resistance to BCL-2 inhibitor in uveal melanoma cells

Lara Bellini et al.

CELL DEATH DISCOVERY (2020)

添加到收藏夹

Review Cell Biology

Cellular senescence as a potential mediator of COVID-19 severity in the elderly

Jamil Nehme et al.

AGING CELL (2020)

添加到收藏夹

Review Hematology

Coagulopathy in COVID-19

Toshiaki Iba et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Factors associated with COVID-19-related death using OpenSAFELY

Elizabeth J. Williamson et al.

NATURE (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Syrian hamsters as a small animal model for SARS-CoV-2 infection and countermeasure development

Masaki Imai et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

添加到收藏夹

Article Respiratory System

Cellular senescence: friend or foe to respiratory viral infections?

William J. Kelley et al.

EUROPEAN RESPIRATORY JOURNAL (2020)

添加到收藏夹

Article Virology

Age-Dependent Progression of SARS-CoV-2 Infection in Syrian Hamsters

Nikolaus Osterrieder et al.

VIRUSES-BASEL (2020)

添加到收藏夹

Article Multidisciplinary Sciences

A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures

Kenneth H. Dinnon et al.

NATURE (2020)

添加到收藏夹

Article Pharmacology & Pharmacy

Age-Dependent Assessment of Genes Involved in Cellular Senescence, Telomere, and Mitochondrial Pathways in Human Lung Tissue of Smokers, COPD, and IPF: Associations With SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-DPP4 Axis

Krishna P. Maremanda et al.

FRONTIERS IN PHARMACOLOGY (2020)

添加到收藏夹

Review Biology

The Interaction of Viruses with the Cellular Senescence Response

Rocio Seoane et al.

BIOLOGY-BASEL (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Age-specific mortality and immunity patterns of SARS-CoV-2

Megan O'Driscoll et al.

NATURE (2020)

添加到收藏夹

Article Respiratory System

Pulmonary infection by SARS-CoV-2 induces senescence accompanied by an inflammatory phenotype in severe COVID-19: possible implications for viral mutagenesis

Konstantinos Evangelou et al.

EUROPEAN RESPIRATORY JOURNAL (2020)

添加到收藏夹

Article Immunology

Senescent cell clearance by the immune system: Emerging therapeutic opportunities

Larissa G.P. Langhi Prata et al.

SEMINARS IN IMMUNOLOGY (2019)

添加到收藏夹

Article Medicine, General & Internal

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease

LaTonya J. Hickson et al.

EBIOMEDICINE (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Cellular Senescence: Defining a Path Forward

Vassilis Gorgoulis et al.

CELL (2019)

添加到收藏夹

Article Cell Biology

Fine-tuning the ubiquitin-proteasome system to treat pulmonary fibrosis

Willy Roque et al.

CONNECTIVE TISSUE RESEARCH (2019)

添加到收藏夹

Article Medicine, General & Internal

Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study

Jamie N. Justice et al.

EBIOMEDICINE (2019)

添加到收藏夹

Review Physiology

Cellular senescence in the lung across the age spectrum

Pavan Parikh et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2019)

添加到收藏夹

Review Critical Care Medicine

Cellular Senescence as a Mechanism and Target in Chronic Lung Diseases

Peter J. Barnes et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2019)

添加到收藏夹

Article Cell Biology

Cellular senescence: Immunosurveillance and future immunotherapy

Dominick G. A. Burton et al.

AGEING RESEARCH REVIEWS (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

Tyler J. Bussian et al.

NATURE (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

The Impacts of Cellular Senescence in Elderly Pneumonia and in Age-Related Lung Diseases That Increase the Risk of Respiratory Infections

Shigehisa Yanagi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Targeting cellular senescence prevents age-related bone loss in mice

Joshua N. Farr et al.

NATURE MEDICINE (2017)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Senescent cells: an emerging target for diseases of ageing

Bennett G. Childs et al.

NATURE REVIEWS DRUG DISCOVERY (2017)

添加到收藏夹

Review Medicine, General & Internal

Cellular Senescence: A Translational Perspective

James L. Kirkland et al.

EBIOMEDICINE (2017)

添加到收藏夹

Review Biochemistry & Molecular Biology

Senescence in Health and Disease

Shenghui He et al.

CELL (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

Jianhui Chang et al.

NATURE MEDICINE (2016)

添加到收藏夹

Article Cell Biology

Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors

Yi Zhu et al.

AGING CELL (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

Darren J. Baker et al.

NATURE (2016)

添加到收藏夹

Article Oncology

Is senescence-associated β-galactosidase a marker of neuronal senescence?

Malgorzata Piechota et al.

ONCOTARGET (2016)

添加到收藏夹

Article Immunology

Enhanced Viral Replication by Cellular Replicative Senescence

Ji-Ae Kim et al.

IMMUNE NETWORK (2016)

添加到收藏夹

Article Cell Biology

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

Marco Demaria et al.

DEVELOPMENTAL CELL (2014)

添加到收藏夹

Article Medicine, General & Internal

Senescence Affects Endothelial Cells Susceptibility to Dengue Virus Infection

Sazaly AbuBakar et al.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2014)

添加到收藏夹

Review Cell Biology

Cellular senescence: from physiology to pathology

Daniel Munoz-Espin et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)

添加到收藏夹

Review Medicine, Research & Experimental

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

Tamara Tchkonia et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

添加到收藏夹

Article Multidisciplinary Sciences

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

Darren J. Baker et al.

NATURE (2011)

添加到收藏夹

Article Biochemical Research Methods

Protocols to detect senescence-associated beta-galactosidase (SA-beta gal) activity, a biomarker of senescent cells in culture and in vivo

Florence Debacq-Chainiaux et al.

NATURE PROTOCOLS (2009)

添加到收藏夹

Review Oncology

Cell adhesion antagonists - Therapeutic potential in asthma and chronic obstructive pulmonary disease

Darren G. Woodside et al.

BIODRUGS (2008)

添加到收藏夹

Article Biochemistry & Molecular Biology

Senescence of activated stellate cells limits liver fibrosis

Valery Krizhanovsky et al.

CELL (2008)

添加到收藏夹

Article Critical Care Medicine

Activation of the ubiquitin-proteasome pathway in the diaphragm in chronic obstructive pulmonary disease

Coen A. C. Ottenheijm et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2006)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.