A non-enzymatic glucose sensor based on a mesoporous carbon sphere immobilized Co-MOF-74 nanocomposite

Exploration of credible non-enzymatic glucose sensors with high selectivity and sensitivity is of great significance for early clinical monitoring of glucose concentration and preventing the threat of diabetes to human health. Here, mesoporous carbon (MC) sphere immobilized Co-MOF-74 nanorods (NRs), denoted as Co-MOF-74 NRs/MC, were successfully prepared, in which the nanostructural porous carbon sphere was obtained using cobalt glycolate as the built-in template followed by a subsequent carbonization and acid treatment, and the MC spheres were then in situ deposited on the surface of Co-MOF-74 NRs via a solvothermal method. Benefiting from the good conductivity of the grafted porous carbon spheres and the abundant active sites, as well as the permeability of microporous MOF-74 nanocrystals, the Co-MOF-74 NRs/MC modified glassy carbon electrode (GCE) exhibited effective non-enzymatic glucose sensing performance with a fast response time (less than 3 s) and a glucose sensitivity of 98.0 & mu;A cm(-2) mM(-1). Furthermore, the Co-MOF-74 NRs/MC/GCE showed a favourable anti-interference capability in the presence of various interferents and good long-term reusability. The applicability of Co-MOF-74 NRs/MC/GCE for glucose sensing in real serum samples was also investigated, verifying the applicability of the electrode for targeted glucose monitoring in practical applications.

Automated summary

Exploration of credible non-enzymatic glucose sensors with high selectivity and sensitivity is important for early clinical monitoring of glucose concentration. In this study, mesoporous carbon (MC) sphere immobilized Co-MOF-74 nanorods (NRs) were prepared and showed effective glucose sensing performance. The Co-MOF-74 NRs/MC modified glassy carbon electrode (GCE) exhibited fast response time and high glucose sensitivity, as well as good anti-interference capability and long-term reusability. The applicability of the sensor for glucose sensing in real serum samples was also demonstrated.