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Article
Chemistry, Analytical
Yunyan Xie et al.
Summary: In this study, a sensitive turn-on fluorescent biosensor based on a three-dimensional DNA walker was developed for the detection of HER2 and miRNA-21. The biosensor demonstrated high sensitivity and specificity, enabling accurate multiplex detection of biomarkers.
Review
Cell Biology
Abdul Fatah A. Samad et al.
Summary: MicroRNA has the potential to regulate genetic pathways and has been explored as a therapeutic tool. However, there are challenges such as off-target effects, immunogenicity, and delivery platforms. Recently, innovative approaches have been developed to address these issues. Nevertheless, dosage remains an uncertainty for miRNA administration.
WILEY INTERDISCIPLINARY REVIEWS-RNA
(2023)
Article
Chemistry, Analytical
Chang Song et al.
Summary: In this work, a one-pot process was developed to self-generate distinguishable fluorescent probes for multiple microRNA (miRNA) detection. The generated G-quadruplex fluorescent dye-free probes could be separated and detected by a high-performance liquid chromatography-fluorescence platform. The detection of multiple miRNAs could be realized in one run, and it was successfully applied to multiplex detection of miRNAs in serum samples from breast cancer patients within 30 minutes.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Futing Wang et al.
Summary: A dual-biomarker, self-powered biosensor was developed using enzymatic biofuel cells, catalytic hairpin assembly, and DNA hybridization chain reaction. It can detect microRNA-21 (miRNA-21) and microRNA-155 (miRNA-155) with high sensitivity. The biosensor operates by generating a double-helix chain in the presence of miRNA-21, while miRNA-155 inhibits the completion of the reaction. The self-powered biosensor allows for simultaneous ultrasensitive detection of miRNA-21 and miRNA-155, with detection limits of 0.15 and 0.66 fM, respectively. It also demonstrates highly sensitive detection in human serum samples.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Leo K. B. Tam et al.
Summary: An advanced photodynamic molecular beacon (PMB) was synthesized, consisting of a photosensitizer and a quencher connected by two peptide segments. The PMB could only be activated by the coexistence of two tumor-associated enzymes, enhancing tumor specificity in photodynamic therapy (PDT) without causing skin photosensitivity.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Engineering, Biomedical
Xinyue Song et al.
Summary: Researchers developed an upconversion nanoparticle-based optogenetic nanosystem for enhanced photodynamic therapy and cascade gene therapy. Genetically-encoded photosensitizers were localized in mitochondria and activated by upconversion nanoprobe to generate reactive oxygen species, controlling the release of siRNA and inducing cancer cell apoptosis.
ACTA BIOMATERIALIA
(2023)
Article
Chemistry, Analytical
Chan Yang et al.
Summary: A new theranostic platform, hairpin probe-photosensitizing MOFs (HPMOF), was developed for precise diagnosis and efficient treatment. The HPMOF could recognize tumor-related miRNA, enabling high DNA loading capacity and intracellular delivery. It also exhibited high efficiency in generating reactive oxygen species for inducing cell apoptosis, thus achieving effective photodynamic therapy. The specific recognition ability of HPMOF based on miRNA imaging provided a promising nanoplatform for accurate cancer treatment.
ANALYTICA CHIMICA ACTA
(2023)
Review
Chemistry, Multidisciplinary
Bo Wang et al.
Summary: The development of stimuli-responsive nanodevices with high efficiency and specificity is crucial in biosensing and drug delivery. DNAzymes, a class of DNA molecules with specific catalytic activity, have drawn much attention due to their unique properties and easy design. This review provides an introduction to DNAzyme classification and properties, and systematically summarizes the construction of various DNAzyme-based nanodevices such as motors, amplifiers, and logic gates. The application of DNAzyme-based nanodevices in sensing and therapeutics is also discussed, along with current limitations and future directions.
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
(2023)
Article
Chemistry, Multidisciplinary
Pu Zhang et al.
Summary: This article introduces an analytical platform that uses miRNA-guided imaging for selective detection of breast cancer cells and ovarian cancer cells, as well as selective photodynamic therapy to kill these cancer cells using visible light.
Article
Engineering, Biomedical
Jing Jing Wang et al.
Summary: In this study, quantum dot-molecular beacon functionalized MoS2 fluorescent probes were designed for the dual detection of multiple myeloma (MM)-related miRNA-155 and miRNA-150. The results indicate that this method is the most sensitive detection reported so far and can detect miRNA-155 and miRNA-150 at low concentrations in human serum.
BIOACTIVE MATERIALS
(2022)
Review
Chemistry, Inorganic & Nuclear
Chen Chen et al.
Summary: Photodynamic therapy (PDT) has proved its significance in cancer treatment, but its therapeutic effect is limited by the low penetration of light source, tumor microenvironment (TME) hypoxia, and tumor cell metastasis and recurrence. This review presents the design of PDT platforms and discusses the latest studies on combinatorial cancer therapy strategies using PDT, aiming to evaluate its potential in future clinical cancer treatments. The latest progress mainly focuses on three aspects: combining with drugs or gases to overcome TME hypoxia, employing advanced light sources to increase penetration depth, and combining with immunotherapy to inhibit tumor metastasis. The integration of diagnosis and treatment using an imaging-guided therapeutic nanoplatform has brought more optimized treatment effects to PDT.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Chemistry, Analytical
Chan Yang et al.
Summary: A new two-photon nanoprobe (TP-CHA-MOFs) was developed using MOF as nanocarrier and hairpins as a two-photon fluorescence signal amplifier for intracellular miRNA imaging. The nanoprobe showed high loading capacity, stability, and biocompatibility. It achieved sensitive imaging of intracellular miRNA in tumor cells with different levels and deep tumor tissues.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Review
Genetics & Heredity
Caroline Diener et al.
Summary: In this review, the main challenges and strategies for the therapeutic application of miRNAs are discussed, with particular emphasis on approaches that have already been studied clinically.
TRENDS IN GENETICS
(2022)
Article
Biophysics
Simin Cheng et al.
Summary: In this study, a MnO2 nanosheet-mediated generalist probe (MNSGP) was designed for intracellular dual-miRNAs imaging and enhanced synergistic therapy of chemodynamic therapy (CDT) and photodynamic therapy (PDT). The prepared generalist probe was fully characterized and its accuracy of dual-miRNAs detection and the high curative effect of enhanced CDT/PDT synergistic therapy were verified through in vitro and in vivo experiments.
BIOSENSORS & BIOELECTRONICS
(2022)
Review
Chemistry, Inorganic & Nuclear
Miriam Daniel et al.
Summary: Biomolecules play a crucial role in regulating homeostasis, and their accurate detection as biomarkers is of great importance in clinical diagnosis. Electrochemical sensing, a simple and cost-effective method, shows potential for the miniaturization of healthcare devices. Metal-organic frameworks (MOFs), with their unique properties, have emerged as promising candidates for electrochemical sensors to detect biomolecules.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Sabrin Mohamed Mohamed Abd Elhamed ElKashef et al.
Summary: The study found that asthma patients had significantly higher serum expression levels of miRNA-21 and miRNA-155, with a positive correlation between miRNA-21 and IL-4 levels. miRNA-21 and miRNA-155 show potential as non-invasive biomarkers for the diagnosis of eosinophilic asthma and treatment response assessment.
Article
Chemistry, Multidisciplinary
Zhiheng Cai et al.
Summary: Accurate diagnosis and precise treatment are crucial in dealing with cancer. The constructed Au/Pd octopus nanoparticle-DNA nanomachine serves as an automatic diagnosis and treatment logic system, showing promising results in accurately identifying tumor cells and providing therapeutic effects.
Article
Chemistry, Analytical
Juan Zhang et al.
Summary: In this study, DNAzyme logic circuits were constructed for the analysis and imaging of multiple microRNAs in living cells using Cu/ZIF-8 NPs as a nanocarrier. The logic gate modules of the system were efficiently released by pH-responsive Cu/ZIF-8 NPs, allowing for multiple logic computations initiated by endogenous miRNA. This research provides a new method for the application of DNA biocomputing circuits in living cells.
ANALYTICAL CHEMISTRY
(2021)
Article
Engineering, Biomedical
Yaser Hadadian et al.
Summary: This study proposed and examined a theranostic platform integrating magnetomotive and thermal ultrasound imaging for preclinical magnetic hyperthermia. It was found that magnetic nanoparticles can be effectively used as contrast agents and heat generators during MH, while ultrasound thermometry can successfully monitor temperature in real time.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
H. M. Schouw et al.
Summary: Targeted optical fluorescence imaging is progressing towards clinical implementation, particularly in oncology. However, challenges such as the need for pivotal trial data remain before it can become a standard part of clinical practice. Collaboration across disciplines is essential to overcome these challenges and advance the clinical implementation of this imaging modality.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Review
Chemistry, Physical
Rui-Qin Yang et al.
Summary: NIR-II fluorescence imaging has shown unique advantages in guiding tumor resection surgery, with improved penetration depths and signal-to-noise ratios. Its application in cancer surgery has demonstrated significant prospects for improving surgical outcomes.
Article
Biochemical Research Methods
Yanjie Zheng et al.
Summary: This study developed a method for simultaneous detection of miRNA-21 and miRNA-155 using T7 exonuclease-assisted target recycling amplification and graphene oxide fluorescence quenching, showing high sensitivity and excellent analytical performance. The method has the potential to effectively warn drug resistance in lung cancer through monitoring abnormal miRNA expression.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Review
Chemistry, Inorganic & Nuclear
Miriam de J. Velasquez-Hernandez et al.
Summary: Metal-organic frameworks (MOFs) combined with biomacromolecules, viruses, and cells have emerged as novel biocomposites for various applications. The integration of biological entities into MOF matrices generates biocomposites with enhanced stability, resistance, selectivity, and controlled release. The post functionalization of MOF-based drug carriers with lipids is a potential approach to improve dispersion, stability, and circulation time in biological fluids.
COORDINATION CHEMISTRY REVIEWS
(2021)
Review
Materials Science, Biomaterials
Samara Rodrigues Alves et al.
Summary: Photodynamic therapy (PDT) combined with immunotherapy has become a promising option for treating metastatic cancer, and the use of metal-organic frameworks as fourth generation photosensitizers has shown outstanding outcomes in pre-clinical studies. These new PSs can help alleviate skin photosensitivity, improve treatment efficacy, and play a crucial role in cancer therapy.
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Peng Miao et al.
Summary: The research developed an amplified electrochemical method for miRNA detection based on DNA logic gates, enabling the analysis of multiple miRNAs. Signal amplification was achieved through target-triggered strand displacement polymerization and catalytic hairpin assembly, successfully establishing various logic gates.
ACS CENTRAL SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Pei-Hong Tong et al.
Summary: This article reviews the progress of using metal-organic frameworks (MOFs) as delivery materials for various biomacromolecules. It introduces the use of biomacromolecular drugs for disease therapy and common clinical delivery systems, and describes the advantages of using MOFs as delivery materials. It summarizes the application of MOFs in delivering different types of biomacromolecules for the treatment of human diseases.
CHEMICAL COMMUNICATIONS
(2021)
Review
Chemistry, Physical
Shuang Zhao et al.
Summary: DNA computers are a prominent type of next-generation molecular computers capable of performing Boolean logic. SDLG logic gates have shown great potential in biosensing by analyzing multiple targets simultaneously. The unique YES/NO output generated by SDLG biosensors contrasts with the quantitative measurement used in traditional biosensors.
NANOSCALE HORIZONS
(2021)
Review
Chemistry, Analytical
Fen Wu et al.
Review
Biotechnology & Applied Microbiology
Tingting Li et al.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2020)
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ANALYTICAL CHEMISTRY
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ANALYTICAL CHEMISTRY
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Jia Liu et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
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Tim A. Ahles et al.
Annual Review of Clinical Psychology
(2018)
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Yu Cao et al.
ACS APPLIED MATERIALS & INTERFACES
(2017)
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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
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Review
Pharmacology & Pharmacy
Jing Zhao et al.
DRUG DISCOVERY TODAY
(2017)
Review
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Wenpei Fan et al.
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Ming-Xue Wu et al.
ADVANCED MATERIALS
(2017)
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Jihye Park et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2014)
