4.6 Review

DOAC-associated bleeding, hemostatic strategies, and thrombin generation assays-a review of the literature

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Cardiac & Cardiovascular Systems

Thrombin Generation and other hemostatic parameters in patients with atrial fibrillation in use of warfarin or rivaroxaban

Rita Carolina Figueiredo Duarte et al.

Summary: This study evaluated the hemostasis in patients with non-valvular atrial fibrillation undergoing warfarin or rivaroxaban treatment, showing that warfarin users had lower levels of coagulation while rivaroxaban users exhibited higher levels. Additionally, the use of oral anticoagulants significantly reduced levels of monocyte-platelet aggregates, glycoprotein IIb/IIIa, and platelet and endothelium microparticles.

JOURNAL OF THROMBOSIS AND THROMBOLYSIS (2021)

Article Hematology

Calibrated automated thrombogram II: removing barriers for thrombin generation measurements

P. L. A. Giesen et al.

Summary: The study compared the performance of CAT-I and CAT-II methods in assessing thrombin generation in plasma, showing similar results in control plasma. The CAT-II method demonstrated better performance in the presence of a direct thrombin inhibitor.

THROMBOSIS JOURNAL (2021)

Article Hematology

Ciraparantag, an anticoagulant reversal drug: mechanism of action, pharmacokinetics, and reversal of anticoagulants

Jack Ansell et al.

Summary: Ciraparantag is a small molecule designed to reverse the effects of anticoagulants, showing rapid onset and short half-life. It has the potential to reduce blood loss in animal models and serve as a DOAC reversal agent.
Article Hematology

Study of thrombin generation with St Genesia to evaluate xaban pharmacodynamics: Analytical performances over 18 months

Geoffrey Foulon-Pinto et al.

Summary: ST Genesia system showed reliable measurement of TG parameters in both in vitro and ex vivo xaban plasma samples, with the use of reference plasma improving standardization and inter-laboratory comparisons. The system demonstrated good agreement with the CAT method, despite some observed biases in peak height and endogenous thrombin potential values.

INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY (2021)

Article Surgery

Safety and efficacy of direct oral anticoagulants under long-term immunosuppressive therapy after liver, kidney and pancreas transplantation

Christian Pfrepper et al.

Summary: This study aimed to describe the safety and efficacy of DOACs in patients after solid organ transplantation, showing that DOAC treatment increased immunosuppressive trough levels without significant adverse effects, and reached expected plasma levels in all patients.

TRANSPLANT INTERNATIONAL (2021)

Article Multidisciplinary Sciences

The in vitro addition of idarucizumab to plasma samples from patients increases thrombin generation

Mojca Bozic Mijovski et al.

Summary: The study demonstrates that in vitro addition of idarucizumab to plasma samples from patients increases thrombin generation. Further investigation is needed to explore the use of idarucizumab to neutralize dabigatran in patient plasma samples and the clinical relevance of in vitro increased thrombin generation induced by idarucizumab.

SCIENTIFIC REPORTS (2021)

Letter Medicine, General & Internal

Availability of Specific Direct Oral Anticoagulant Reversal Agents in US Hospitals

Zahir Kanjee et al.

JAMA NETWORK OPEN (2021)

Article Hematology

Plasma levels do not predict thrombin generation in patients taking direct oral anticoagulants

Michael Metze et al.

Summary: This study evaluated the antithrombotic effect of DOAC on thrombin generation (TG) in relation to their plasma level. The results showed that all DOACs significantly prolonged lag time and time to peak, with anti-Xa inhibitors showing a more pronounced effect on thrombin peak. There is a nonlinear dose-response relationship for all DOACs, with the greatest antithrombotic effect observed at lower plasma levels. TG assays may be superior to plasma levels in assessing the intensity of anticoagulation.

INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY (2021)

Review Hematology

Thrombin generation assays are versatile tools in blood coagulation analysis: A review of technical features, and applications from research to laboratory routine

Francois Depasse et al.

Summary: Thrombin generation assay, also known as thrombin generation test, is a global assay that provides a comprehensive view of hemostasis balance by continuously and simultaneously measuring thrombin formation and inhibition. Standardization and automation of this assay have provided researchers, clinical laboratories, and the pharmaceutical industry with a versatile tool for various clinical and non-clinical applications.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2021)

Article Hematology

Investigation of the Optimal Dose aPCC in Reversing the Effect of Factor Xa Inhibitors-An In Vitro Study

Nina Haagenrud Schultz et al.

Summary: This study demonstrates that lower concentrations of aPCC can effectively reverse the effects of FXa inhibitors in vitro, suggesting that this method may be a safe and viable reversal strategy.

CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS (2021)

Article Hematology

Anticoagulated patients exhibit intact endogenous thrombin potential using ST Genesia unlike the Calibrated Automated Thrombogram

Tuukka A. Helin et al.

Summary: The study found that the data from ST Genesia did not correlate with CAT when observing coagulation in anticoagulated patients, but it was independently associated with INR, anti-Xa, and DOAC concentrations. ST Genesia showed no ETP effect of DOACs and failed to give readout at high INR or anti-Xa activity, unlike CAT.

RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS (2021)

Article Cardiac & Cardiovascular Systems

Elderly people are inherently sensitive to the pharmacological activity of rivaroxaban: implications for DOAC prescribing

Emmanouela Kampouraki et al.

Summary: Elderly patients have been shown to have a higher sensitivity to the direct oral anticoagulant rivaroxaban compared to young patients, potentially requiring lower doses for therapeutic anticoagulation.

JOURNAL OF THROMBOSIS AND THROMBOLYSIS (2021)

Article Cardiac & Cardiovascular Systems

Rivaroxaban and Dabigatran for Suppression of Mechanical Heart Valve-Induced Thrombin Generation

Iqbal H. Jaffer et al.

ANNALS OF THORACIC SURGERY (2020)

Article Hematology

Effects of rivaroxaban and dabigatran on global hemostasis in patients with atrial fibrillation

Anica Petkovic et al.

BLOOD COAGULATION & FIBRINOLYSIS (2020)

Article Hematology

Rivaroxaban in patients with mechanical heart valves: A pilot study

Eva Roost et al.

THROMBOSIS RESEARCH (2020)

Article Hematology

Efficacy of pro- and anticoagulant strategies in plasma of patients undergoing hepatobiliary surgery

Sarah Bos et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2020)

Article Hematology

Emergencies on direct oral anticoagulants: Management, outcomes, and laboratory effects of prothrombin complex concentrate

Roisin Bavalia et al.

RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS (2020)

Article Hematology

Inhibition of thrombin generation 12 hours after intake of direct oral anticoagulants

Michael Metze et al.

RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS (2020)

Article Hematology

Direct oral anticoagulant plasma levels and thrombin generation on ST Genesia system

Christian Pfrepper et al.

RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS (2020)

Article Medicine, General & Internal

Full Study Report of Andexanet Alfa for Bleeding Associated with Factor Xa Inhibitors

S. J. Connolly et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Medicine, General & Internal

Rivaroxaban Versus Vitamin K Antagonist in Antiphospholipid Syndrome A Randomized Noninferiority Trial

Josep Ordi-Ros et al.

ANNALS OF INTERNAL MEDICINE (2019)

Article Education, Scientific Disciplines

What we have learned about direct oral anticoagulant reversal

Deborah M. Siegal

Hematology-American Society of Hematology Education Program (2019)

Article Hematology

Reversal of Factor Xa Inhibitors by Andexanet Alfa May Increase Thrombogenesis Compared to Pretreatment Values

Fakiha Siddiqui et al.

CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS (2019)

Article Hematology

Rivaroxaban reversal with prothrombin complex concentrate or tranexamic acid in healthy volunteers

J. H. Levy et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2018)

Review Hematology

Laboratory testing in patients treated with direct oral anticoagulants: a practical guide for clinicians

J. Douxfils et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2018)

Article Hematology

Betrixaban: Impact on Routine and Specific Coagulation Assays-A Practical Laboratory Guide

Romain Siriez et al.

THROMBOSIS AND HAEMOSTASIS (2018)

Article Hematology

Laboratory Assessment of the Anticoagulant Activity of Apixaban in Patients With Nonvalvular Atrial Fibrillation

Elias Kyriakou et al.

CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS (2018)

Review Hematology

Andexanet alfa for the treatment of hemorrhage

Andrea Cervi et al.

EXPERT REVIEW OF HEMATOLOGY (2018)

Review Hematology

Pharmacological reversal of the direct oral anticoagulants-A comprehensive review of the literature

Joseph R. Shaw et al.

RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS (2018)

Review Emergency Medicine

The impact of prothrombin complex concentrates when treating DOAC-associated bleeding: a review

Maureane Hoffman et al.

INTERNATIONAL JOURNAL OF EMERGENCY MEDICINE (2018)

Review Hematology

A review of commercially available thrombin generation assays

Jeremy Kintigh et al.

RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS (2018)

Article Cardiac & Cardiovascular Systems

Effects of thromboprophylactic doses of apixaban and rivaroxaban on coagulation and thrombin generation in association with total hip replacement

Tuukka A. Helin et al.

JOURNAL OF THROMBOSIS AND THROMBOLYSIS (2017)

Article Medicine, General & Internal

Idarucizumab for Dabigatran Reversal - Full Cohort Analysis

Charles V. Pollack et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Article Critical Care Medicine

Laboratory Assessment of the Anticoagulant Activity of Direct Oral Anticoagulants

Bethany T. Samuelson et al.

Article Medicine, Research & Experimental

Reversibility of Apixaban Anticoagulation with a Four-Factor Prothrombin Complex Concentrate in Healthy Volunteers

S. Nagalla et al.

CTS-CLINICAL AND TRANSLATIONAL SCIENCE (2016)

Article Hematology

Edoxaban: Impact on routine and specific coagulation assays A practical laboratory guide

Jonathan Douxfils et al.

THROMBOSIS AND HAEMOSTASIS (2016)

Article Cardiac & Cardiovascular Systems

Effects of Rivaroxaban on Platelet Activation and Platelet-Coagulation Pathway Interaction: In Vitro and In Vivo Studies

Elisabeth Perzborn et al.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS (2015)

Article Clinical Neurology

Impact of dabigatran on platelet function and fibrinolysis

Argirios E. Tsantes et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2015)

Article Hematology

Multimodal assessment of non-specific hemostatic agents for apixaban reversal

A. -C. Martin et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2015)

Article Medicine, General & Internal

Andexanet Alfa for the Reversal of Factor Xa Inhibitor Activity

Deborah M. Siegal et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Article Hematology

Association rate constants rationalise the pharmacodynamics of apixaban and rivaroxaban

Georges Jourdi et al.

THROMBOSIS AND HAEMOSTASIS (2015)

Article Hematology

How the Direct Oral Anticoagulant Apixaban Affects Thrombin Generation Parameters

Armando Tripodi et al.

THROMBOSIS RESEARCH (2015)

Article Hematology

Comparison of Methods to Determine Rivaroxaban anti-factor Xa activity

Suman Rathbun et al.

THROMBOSIS RESEARCH (2015)

Article Hematology

Laboratory Assessment of the Anticoagulant Activity of Dabigatran

Elias Kyriakou et al.

CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS (2015)

Article Hematology

The use of FEIBA® in the correction of coagulation abnormalities induced by dabigatran

T. -L. Khoo et al.

INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY (2013)

Article Medicine, General & Internal

Dabigatran versus Warfarin in Patients with Mechanical Heart Valves

John W. Eikelboom et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Article Hematology

Impact of apixaban on routine and specific coagulation assays: a practical laboratory guide

Jonathan Douxfils et al.

THROMBOSIS AND HAEMOSTASIS (2013)

Article Medical Laboratory Technology

Measuring Rivaroxaban in a clinical laboratory setting, using common coagulation assays, Xa inhibition and thrombin generation

Pascal J. Molenaar et al.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2012)

Article Hematology

Preanalytic variables of thrombin generation: towards a standard procedure and validation of the method

R. Loeffen et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2012)

Article Cardiac & Cardiovascular Systems

Effects of dabigatran in vitro on thrombin biomarkers by Calibrated Automated Thrombography in patients after ischemic stroke

Victor Serebruany et al.

JOURNAL OF THROMBOSIS AND THROMBOLYSIS (2012)

Article Hematology

Thrombin generation in patients after acute deep-vein thrombosis

Arina J. ten Cate-Hoek et al.

THROMBOSIS AND HAEMOSTASIS (2008)

Letter Hematology

Three different patterns of calibrated automated thrombogram obtained with six different anticoagulants

M. M. Samama et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2007)

Article Medicine, General & Internal

Identification of patients at low risk for recurrent venous thromboembolism by measuring thrombin generation

Gregor Hron et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2006)

Review Hematology

The measurement and application of thrombin generation

T Baglin

BRITISH JOURNAL OF HAEMATOLOGY (2005)