Comprehensive behavioral study of C57BL/6.KOR-ApoEshl mice

Background. Apolipoprotein E (ApoE) is associated with Alzheimer's disease (AD) and cognitive dysfunction in elderly individuals. There have been extensive studies on behavioral abnormalities in ApoE-deficient (Apoe(shl)) mice, which have been described as AD mouse models. Spontaneously hyper-lipidemic mice were discovered in 1999 as ApoE-deficient mice due to ApoE gene mutations. However, behavioral abnormalities in commercially available Apoeshl mice remain unclear. Accordingly, we aimed to investigate the behavioral abnormalities of Apoeshl mice. Results. Apoeshl mice showed decreased motor skill learning and increased anxiety-like behavior toward heights. Apoeshl mice did not show abnormal behavior in the Y-maze test, open-field test, light/dark transition test, and passive avoidance test. Conclusion. Our findings suggest the utility of Apoeshl mice in investigating the function of ApoE in the central nervous system.

Automated summary

The study aimed to investigate the behavioral abnormalities of Apoeshl mice. The results showed that Apoeshl mice exhibited decreased motor skill learning and increased anxiety-like behavior towards heights. However, they did not show abnormal behavior in the Y-maze test, open-field test, light/dark transition test, and passive avoidance test. The findings suggest the utility of Apoeshl mice in investigating the function of ApoE in the central nervous system.