☆ 4.6 Article

Multiple organelle-targeted 1,8-naphthyridine derivatives for detecting the polarity of organelles

JOURNAL OF MATERIALS CHEMISTRY B (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Chemistry, Analytical

Near-infrared mitochondria-targeted fluorescent probe with a large Stokes shift for rapid and sensitive detection of cysteine/homocysteine and its bioimaging application

Shixuan An et al.

Summary: In this study, a novel near-infrared fluorescent probe was designed and developed for the detection and fluorescence imaging of cysteine/homocysteine. The probe exhibited rapid response and high sensitivity, with a detection limit of 46 nM for cysteine. Additionally, the probe could be employed for imaging and detection in living cells and in vivo.

SENSORS AND ACTUATORS B-CHEMICAL (2023)

添加到收藏夹

Review Chemistry, Multidisciplinary

Fluorescent Probes for Biological Species and Microenvironments: from Rational Design to Bioimaging Applications

Hongbao Fang et al.

Summary: The complex balance of biological species and microenvironments is crucial for the healthy development of living organisms. Disruption of this balance can lead to diseases and even death, making real-time monitoring of these changes significant.

ACCOUNTS OF CHEMICAL RESEARCH (2023)

添加到收藏夹

Article Engineering, Environmental

Development of near-infrared mitochondrial polarity fluorescent probe for evaluating mitophagy in mice heart and potential cancer diagnosis

Tao Zhang et al.

Summary: Mitophagy is a process that removes excess or damaged mitochondria and affects cell polarity. A polarity-sensitive fluorescent probe, NIR-BT-P, can monitor mitophagy and distinguish normal cells from cancer cells. The probe was also able to visualize mitophagy in cardiomyocytes during starvation.

CHEMICAL ENGINEERING JOURNAL (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

The Function, Structure, and Origins of the ER Membrane Protein Complex

Ramanujan S. Hegde

Summary: The endoplasmic reticulum (ER) is essential for the insertion, folding, and assembly of membrane proteins in eukaryotes. The ER membrane protein complex (EMC), consisting of nine proteins, has been implicated in multiple aspects of membrane protein biogenesis. Recent studies have shed light on the role of EMC in transmembrane domain insertion and revealed its range of substrates.

ANNUAL REVIEW OF BIOCHEMISTRY (2022)

添加到收藏夹

Article Chemistry, Analytical

Dicyanoisophorone derivatives with self-targeting abilities towards multiple organelles for fluorescent markers and viscosity detection

Jing-Yang Ni et al.

Summary: Four fluorescent dyes with self-targeting abilities towards organelles were designed and proved to be able to locate lysosomes, endoplasmic reticulum, mitochondria and lipid droplets. They can also detect viscosity changes within corresponding organelles.

SENSORS AND ACTUATORS B-CHEMICAL (2022)

添加到收藏夹

Article Chemistry, Analytical

High-fidelity imaging probe for lysosomes and selective visualization of cancer cells and tissues

Xiaogang Guan et al.

Summary: In this study, we developed a versatile high-performance fluorescent probe, DCMP, to monitor the dynamic changes and viscosity of lysosomes. DCMP showed high sensitivity to viscosity changes and could target lysosomes for imaging at a low dose. Furthermore, it could track lysosomal motility and viscosity changes, and effectively monitor the interaction between lysosomes and damaged organelles.

SENSORS AND ACTUATORS B-CHEMICAL (2022)

添加到收藏夹

Article Chemistry, Analytical

Fluorescent probes based on acridine derivatives and their application in dynamic monitoring of cell polarity variation

Hai-Yan Peng et al.

Summary: Polarity and viscosity, two important microenvironment parameters, were studied using polarity-sensitive and viscosity-sensitive probes. These probes demonstrated changes in fluorescence emission and intensity in response to solvent polarity and viscosity, respectively, providing a tool for localization of specific components within cells.

ANALYST (2022)

添加到收藏夹

Article Chemistry, Organic

Near-infrared fluorescent probes based on a quinoxaline skeleton for imaging nucleic acids in mitochondria

Hai-Yan Peng et al.

Summary: In this paper, cationic probes 1a and 1b and a neutral dye 1c were designed and synthesized for the detection of nucleic acids. The probes showed excellent selectivity and an ON-OFF fluorescence response to DNA and RNA with linear correlation between fluorescence intensity and concentration. The probes also demonstrated potential for staining nucleic acids in mitochondria, highlighting their usefulness in low toxicity mitochondrial nucleic acid probes.

ORGANIC & BIOMOLECULAR CHEMISTRY (2022)

添加到收藏夹

Review Chemistry, Medicinal

1,8-Naphthyridine Derivatives: A Privileged Scaffold for Versatile Biological Activities

Madhwi Ojha et al.

Summary: The 1,8-naphthyridine nucleus is a significant nitrogen-containing heterocyclic compound with versatile biological activities. Different research groups worldwide have developed synthesized 1,8-naphthyridine derivatives with a wide range of biological properties.

MINI-REVIEWS IN MEDICINAL CHEMISTRY (2021)

添加到收藏夹

Article Chemistry, Analytical

Real-Time and High-Fidelity Tracking of Lysosomal Dynamics with a Dicyanoisophorone-Based Fluorescent Probe

Jiaxin Hong et al.

Summary: DCIP, a dicyanoisophorone-based probe, shows great potential for high-fidelity imaging and tracking of lysosomes, with strong fluorescence, good cell permeability, and high photostability. It can achieve long-term and high spatiotemporal resolution imaging of lysosomes, as well as track lysosomal dynamics at extremely low concentrations.

ANALYTICAL CHEMISTRY (2021)

添加到收藏夹

Review Chemistry, Inorganic & Nuclear

Recent progresses in fluorescent probes for detection of polarity

Haibin Xiao et al.

Summary: Polarity is crucial in chemistry and biology, and its deviant changes in subcellular compartments are associated with diseases. Fluorescent probes are commonly used to detect polarity changes, offering simplicity, selectivity, sensitivity, real-time monitoring, non-invasion, and high temporal-spatial resolution. Design strategies, response mechanisms, and imaging applications of organic fluorescent probes have played a significant role in the detection of polarity changes.

COORDINATION CHEMISTRY REVIEWS (2021)

添加到收藏夹

Article Chemistry, Medicinal

Reactive Oxygen Species (ROS)-Responsive Prodrugs, Probes, and Theranostic Prodrugs: Applications in the ROS-Related Diseases

Pengfei Wang et al.

Summary: The study focuses on the role of reactive oxygen species in various diseases and the development of drugs for the targeted treatment and precise diagnosis of ROS-related diseases, also discussed are the activation mechanisms of ROS-responsive prodrugs.

JOURNAL OF MEDICINAL CHEMISTRY (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Targeted Solvatochromic Fluorescent Probes for Imaging Lipid Order in Organelles under Oxidative and Mechanical Stress

Dmytro Danylchuk et al.

Summary: A series of solvatochromic probes have been designed for specific targeting of different organelles in live cells, allowing the detection of variations in lipid order and quantitative description of lipid order in each organelle. These probes revealed the characteristics of organelles under stress conditions, with mitochondria and lysosomes particularly sensitive to stress. The new probes provide a powerful toolbox for monitoring cellular response to physical and chemical stimuli at the level of individual organelle membranes.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

添加到收藏夹

Article Chemistry, Analytical

Near-infrared ratiometric fluorescence imaging of lysosomal polarity in live cells and in vivo

Xijuan Chao et al.

Summary: Changes in lysosomal polarity are important indicators of cell status in physiological and pathological processes, and can be used as markers for cancer detection. The DCM-ML probe is highly sensitive to polarity, making it a potential tool for cancer cell diagnosis and real-time monitoring of cell and zebrafish processes. Its development could contribute to research on lysosome-related physiological and pathological processes.

SENSORS AND ACTUATORS B-CHEMICAL (2021)

添加到收藏夹

Article Chemistry, Analytical

Tracking the polarity changes of asthmatic mice by fluorescence imaging

Cong Liu et al.

Summary: A polarity-sensitive fluorescent probe LW-1 targeting lipid droplets was synthesized for monitoring polarity changes in the lungs of asthma patients. The probe successfully tracked polarity changes in asthma mice and showed potential for medical applications. This study provides a new perspective for asthma research and inspires more strategies for clinical diagnosis and the development of new asthma drugs.

SENSORS AND ACTUATORS B-CHEMICAL (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

A Polarity-Sensitive Ratiometric Fluorescence Probe for Monitoring Changes in Lipid Droplets and Nucleus during Ferroptosis

Kang-Nan Wang et al.

Summary: This study introduces the first LD/nucleus dual-targeted ratiometric fluorescent probe, CQPP, to monitor polarity changes in the cellular microenvironment. Through the application of CQPP, it was found that LD polarity increased in the ferroptosis model, while the polarity between LDs and cytoplasm homogenized.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

添加到收藏夹

Article Chemistry, Analytical

A novel selective probe for detecting glutathione from other biothiols based on the concept of Fluorescence Fusion

Wei Wang et al.

Summary: This study introduced the concept of Fluorescence Fusion for effectively measuring GSH, which was more efficient than the traditional Logic Gate strategy. The results are significant for future interdisciplinary research in the field of fluorescent probes and image recognition by artificial intelligence.

ANALYTICA CHIMICA ACTA (2021)

添加到收藏夹

Article Chemistry, Analytical

Lipid Droplet-Specific Fluorescent Probe for In Vivo Visualization of Polarity in Fatty Liver, Inflammation, and Cancer Models

Li Fan et al.

Summary: The research team synthesized a sensitive LD-TTP fluorescent probe that can efficiently detect and monitor changes in lipid droplet polarity, holding great potential for clinical diagnosis of lipid droplet polarity-related diseases.

ANALYTICAL CHEMISTRY (2021)

添加到收藏夹

Article Chemistry, Analytical

Low Polarity-Triggered Basic Hydrolysis of Coumarin as an AND Logic Gate for Broad-Spectrum Cancer Diagnosis

Zengqiang Liang et al.

Summary: The probe constructed in this study utilizes mitochondrial microenvironments as inputs to generate fluorescence signals only when high pH and low polarity conditions are met simultaneously, providing a reliable method for cancer detection with reduced false positives. The probe also demonstrates increased affinity for cancer cell mitochondria due to the higher mitochondrial membrane potential in cancer cells, resulting in a high contrast fluorescence diagnosis ability of cancer at cellular and tissue levels exceeding clinic thresholds.

ANALYTICAL CHEMISTRY (2021)

添加到收藏夹

Article Chemistry, Analytical

Evaluation of effectiveness of antiarthritic treatment by in situ ratiometric fluorescence imaging of the endoplasmic reticulum pH

Hui Wang et al.

Summary: Rheumatoid arthritis is a chronic inflammatory disease that causes extreme joint pain, and current therapies cannot provide relief for many patients. The development of novel therapeutic drugs is a major challenge for RA treatment. Research shows that endoplasmic reticulum stress is involved in RA pathogenesis, and ER pH could potentially become a new evaluation parameter.

SENSORS AND ACTUATORS B-CHEMICAL (2021)

添加到收藏夹

Article Chemistry, Analytical

Viscosity sensitive fluorescent dyes with excellent photostability based on hemicyanine dyes for targeting cell membrane

Ya-Nan Wang et al.

Summary: This study obtained three viscosity-sensitive cell membrane fluorescent dyes with excellent optical properties and viscosity response. The dyes showed good location on the cell membrane and low cytotoxicity, making them promising for applications in biosensors and diagnostics.

SENSORS AND ACTUATORS B-CHEMICAL (2021)

添加到收藏夹

Review Chemistry, Multidisciplinary

Fluorescence imaging of pathophysiological microenvironments

Shan Wang et al.

Summary: Abnormal microenvironments play a significant role in various pathophysiological processes such as inflammation, neurodegenerative diseases, and cancer. Fluorescence imaging has emerged as a powerful tool for tracking changes in pathophysiological microenvironments, offering promising prospects for future development and application in fluorescent probes.

CHEMICAL SOCIETY REVIEWS (2021)

添加到收藏夹

Article Materials Science, Biomaterials

The application of amide units in the construction of neutral functional dyes for mitochondrial staining

Wei Ma et al.

Summary: A new class of neutral fluorescent dyes with mitochondrial staining capacity was developed using a series of functional dyes obtained from Nile Red and coumarin via Suzuki coupling reactions. These dyes showed high fluorescence quantum yields and excellent photostability in organic solvents, and exhibited low cytotoxicity. Through confocal fluorescence experiments, it was demonstrated that modified dyes successfully targeted mitochondria in HeLa cancer cells.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

添加到收藏夹

Article Chemistry, Analytical

Solo Smart Fluorogenic Probe for Potential Cancer Diagnosis and Tracking in Vivo Tumorous Lymphatic Systems via Distinct Emission Signals

Soham Samanta et al.

ANALYTICAL CHEMISTRY (2020)

添加到收藏夹

Article Chemistry, Applied

Curcumin-based polarity fluorescent probes: Design strategy and biological applications

Linghao Hu et al.

DYES AND PIGMENTS (2020)

添加到收藏夹

Article Materials Science, Biomaterials

The application of nitrogen heterocycles in mitochondrial-targeting fluorescent markers with neutral skeletons

Yue Wang et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

添加到收藏夹

Article Materials Science, Biomaterials

A unique polarity-sensitive photothermal sensitizer revealing down-regulated mitochondrial polarity during photo-induced cell death

Chuang Liu et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

添加到收藏夹

Article Chemistry, Analytical

Two-photon fluorescence imaging of lipid drops polarity toward cancer diagnosis in living cells and tissue

Junling Yin et al.

SENSORS AND ACTUATORS B-CHEMICAL (2019)

添加到收藏夹

Article Chemistry, Analytical

A mitochondria-targeted and FRET-based ratiometric fluorescent probe for detection of SO2 derivatives in water

Dongsheng Zhang et al.

ANALYTICA CHIMICA ACTA (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

A lysosome-targeting and polarity-specific fluorescent probe for cancer diagnosis

Li Fan et al.

CHEMICAL COMMUNICATIONS (2019)

添加到收藏夹

Article Nanoscience & Nanotechnology

Lipid Nanoparticle-Mediated Induction of Endoplasmic Reticulum Stress in Cancer Cells

Chandramouli Ghosh et al.

ACS APPLIED BIO MATERIALS (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Development of an endoplasmic reticulum-targeting fluorescent probe for the imaging of polarity in living cells and tissues

Wenhui Song et al.

NEW JOURNAL OF CHEMISTRY (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

An Optical Technique for Mapping Microviscosity Dynamics in Cellular Organelles

Joseph E. Chambers et al.

ACS NANO (2018)

添加到收藏夹

Article Engineering, Biomedical

A ratiometric fluorescence probe for lysosomal polarity

Miao Li et al.

BIOMATERIALS (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

Lipid Droplets in Health and Disease

Gizem Onal et al.

LIPIDS IN HEALTH AND DISEASE (2017)

添加到收藏夹

Review Chemistry, Multidisciplinary

Fluorescent chemical probes for accurate tumor diagnosis and targeting therapy

Min Gao et al.

CHEMICAL SOCIETY REVIEWS (2017)

添加到收藏夹

Article Chemistry, Multidisciplinary

A two-photon fluorescent probe for real-time monitoring of autophagy by ultrasensitive detection of the change in lysosomal polarity

Jiacheng Jiang et al.

CHEMICAL COMMUNICATIONS (2017)

添加到收藏夹

Review Chemistry, Multidisciplinary

Solvatochromic and Fluorogenic Dyes as Environment-Sensitive Probes: Design and Biological Applications

Andrey S. Klymchenko

ACCOUNTS OF CHEMICAL RESEARCH (2017)

添加到收藏夹

Article Chemistry, Analytical

Developing Activity Localization Fluorescence Peptide Probe Using Thiol-Ene Click Reaction for Spatially Resolved Imaging of Caspase-8 in Live Cells

Wei Liu et al.

ANALYTICAL CHEMISTRY (2016)

添加到收藏夹

Article Chemistry, Multidisciplinary

An ultrasensitive near-infrared ratiometric fluorescent probe for imaging mitochondrial polarity in live cells and in vivo

Haibin Xiao et al.

CHEMICAL SCIENCE (2016)

添加到收藏夹

Article Materials Science, Multidisciplinary

Quinoxaline-based cross-conjugated luminophores: charge transfer, piezofluorochromic, and sensing properties

Yijing Chen et al.

JOURNAL OF MATERIALS CHEMISTRY C (2016)

添加到收藏夹

Article Chemistry, Multidisciplinary

Ratiometric Fluorescence Imaging of Cellular Polarity: Decrease in Mitochondrial Polarity in Cancer Cells

Na Jiang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)

添加到收藏夹

Review Chemistry, Medicinal

1,8-Naphthyridine Derivatives: A Review of Multiple Biological Activities

Alka Madaan et al.

ARCHIV DER PHARMAZIE (2015)

添加到收藏夹

Article Chemistry, Multidisciplinary

A Nile Red/BODIPY-based bimodal probe sensitive to changes in the micropolarity and microviscosity of the endoplasmic reticulum

Zhigang Yang et al.

CHEMICAL COMMUNICATIONS (2014)

添加到收藏夹

Review Chemistry, Multidisciplinary

Macro-/micro-environment-sensitive chemosensing and biological imaging

Zhigang Yang et al.

CHEMICAL SOCIETY REVIEWS (2014)

添加到收藏夹

Review Medicine, Research & Experimental

Balancing the fat: lipid droplets and human disease

Natalie Krahmer et al.

EMBO MOLECULAR MEDICINE (2013)

添加到收藏夹

Article Multidisciplinary Sciences

Spatial regulation of UBXD8 and p97/VCP controls ATGL-mediated lipid droplet turnover

James A. Olzmann et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

添加到收藏夹

Article Chemistry, Multidisciplinary

A Small Molecule Promotes Mitochondrial Fusion in Mammalian Cells

Danling Wang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2012)

添加到收藏夹

Review Biochemistry & Molecular Biology

Mitochondrial outer membrane permeabilization during apoptosis: The role of mitochondrial fission

Thomas Landes et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2011)

添加到收藏夹

Article Chemistry, Medicinal

Selective labeling and monitoring pH changes of lysosomes in living cells with fluorogenic pH sensors

Lai-Qiang Ying et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2011)

添加到收藏夹

Review Biochemistry & Molecular Biology

ER stress and diseases

Hiderou Yoshida

FEBS JOURNAL (2007)

添加到收藏夹

Review Cell Biology

Cell polarity in development and cancer

Andreas Wodarz et al.

NATURE CELL BIOLOGY (2007)

添加到收藏夹

Review Chemistry, Multidisciplinary

Single-molecule fluorescence studies of protein folding and conformational dynamics

Xavier Michalet et al.

CHEMICAL REVIEWS (2006)

添加到收藏夹

Article Biochemistry & Molecular Biology

Protein sorting upon exit from the endoplasmic reticulum

M Muñiz et al.

CELL (2001)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.