☆ 4.5 Review

Neutrophils in triple-negative breast cancer: an underestimated player with increasingly recognized importance

BREAST CANCER RESEARCH (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Oncology

Neutrophil-activating therapy for the treatment of cancer

Ian L. Linde et al.

Summary: Although neutrophils are often used by cancers to promote immunosuppression, tumor growth, and metastasis, this study shows that neutrophils can be harnessed to induce eradication of tumors and reduce metastatic seeding. The combination of tumor necrosis factor, CD40 agonist, and tumor-binding antibody activates human neutrophils in vitro, leading to their lysis of human tumor cells. Mechanistically, this therapy mobilizes neutrophils to infiltrate tumors and activate complement, resulting in the production of leukotriene B4 and subsequent oxidative damage and T cell-independent clearance of multiple tumor types. These findings highlight the potential of using neutrophils as anti-tumor immune mediators.

CANCER CELL (2023)

添加到收藏夹

Article Immunology

CXCL8 is a prognostic biomarker and correlated with TNBC brain metastasis and immune infiltration

Yunzhu Shen et al.

Summary: By analyzing the gene expression profile of brain metastases and primary TNBC, we identified CXCL8 as the only gene associated with prognostic indicators in TNBC brain metastasis. Functional analysis revealed CXCL8's association with immune response and infiltration. In addition, CXCL8 showed a positive correlation with immune-related scores and different types of immune cell infiltration. Our findings suggest that CXCL8 can serve as a prognostic biomarker and is associated with TNBC brain metastasis and immune infiltration.

INTERNATIONAL IMMUNOPHARMACOLOGY (2022)

添加到收藏夹

Review Oncology

Treatment landscape of triple-negative breast cancer - expanded options, evolving needs

Giampaolo Bianchini et al.

Summary: Recent advances in omics technologies have improved our understanding of the heterogeneity and microenvironment of triple-negative breast cancers (TNBCs), supporting a view of this breast cancer subtype as an ecosystem that encompasses both intrinsic and extrinsic features of cancer cells. The authors of this Review describe the current and upcoming therapeutic landscape of TNBC and discuss how an integrated view of the TNBC ecosystem can provide improved opportunities for tailoring treatment.

NATURE REVIEWS CLINICAL ONCOLOGY (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Lin28B-high breast cancer cells promote immune suppression in the lung pre-metastatic niche via exosomes and support cancer progression

Meiyan Qi et al.

Summary: The formation of pre-metastatic niche is a critical step in breast cancer metastasis. Lin28B plays a crucial role in promoting lung metastasis of breast cancer by establishing an immune-suppressive pre-metastatic niche.

NATURE COMMUNICATIONS (2022)

添加到收藏夹

Article Oncology

CXCR2 Mediates Distinct Neutrophil Behavior in Brain Metastatic Breast Tumor

Simrit Safarulla et al.

Summary: This study reveals the mechanisms by which CXCR2 affects neutrophils in brain metastasis of breast cancer. Activation of CXCR2 receptors by brain metastatic tumors promotes neutrophil migration to tumor sites and formation of NETs, thereby facilitating tumor progression. Inhibiting CXCR2 and NETs formation can limit the interaction between neutrophils and tumors, slowing down the development of brain metastatic breast cancer.

CANCERS (2022)

添加到收藏夹

Review Immunology

Neutrophil phenotypes and functions in cancer: A consensus statement

Daniela F. Quail et al.

Summary: This article discusses the functional states and heterogeneity of neutrophils in cancer and provides a consensus statement on the controversies and solutions in neutrophil research. Further research is needed to understand the role of neutrophils in cancer and explore potential novel opportunities for cancer treatment.

JOURNAL OF EXPERIMENTAL MEDICINE (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Enhanced CHOLESTEROL biosynthesis promotes breast cancer metastasis via modulating CCDC25 expression and neutrophil extracellular traps formation

Qiqi Tang et al.

Summary: Our study reveals a novel mechanism for de novo cholesterol biosynthesis in regulating CCDC25 expression, NETs formation, and breast cancer metastasis. Targeting cholesterol biosynthesis may be a promising therapeutic strategy for treating breast cancer metastasis.

SCIENTIFIC REPORTS (2022)

添加到收藏夹

Review Cell Biology

Circulating tumor cell-blood cell crosstalk: Biology and clinical relevance

Thais Pereira-Veiga et al.

Summary: The interaction between circulating tumor cells (CTCs) and blood cells plays a crucial role in metastatic progression and anti-metastatic therapies.

CELL REPORTS (2022)

添加到收藏夹

Article Oncology

High-resolution single-cell atlas reveals diversity and plasticity of tissue-resident neutrophils in non-small cell lung cancer

Stefan Salcher et al.

Summary: This study investigates the immune cell phenotypes in non-small cell lung cancer (NSCLC) and identifies cellular components associated with tumor histology and genotypes. The study also reveals the plasticity of tissue-resident neutrophils (TRNs) and their association with anti-programmed cell death ligand 1 (PD-L1) treatment failure.

CANCER CELL (2022)

添加到收藏夹

Article Oncology

Autophagy Agents in Clinical Trials for Cancer Therapy: A Brief Review

Samiha Mohsen et al.

Summary: Autophagy has shown effectiveness in Burkitt's lymphoma, and chloroquine and hydroxychloroquine are the only FDA-approved autophagy inhibitors currently available. Although not approved for cancer therapy, ongoing clinical trials are evaluating their safety and efficacy. Pevonedistat, a novel inhibitor through the neddylation pathway, acts as an autophagy activator.

CURRENT ONCOLOGY (2022)

添加到收藏夹

Review Immunology

Neutrophils in cancer: heterogeneous and multifaceted

Catherine C. Hedrick et al.

Summary: Neutrophils have emerged as important regulators of cancer, revealing their diverse and plastic contributions in tumor development and growth, influencing positively and negatively depending on time, place, and disease context. Their functional importance in cancer has been overlooked due to their short-lived, terminally differentiated, and non-proliferative characteristics, but recent studies have led to a paradigm shift in understanding their roles.

NATURE REVIEWS IMMUNOLOGY (2022)

添加到收藏夹

Article Oncology

Prognostic Roles of Neutrophil-to-Lymphocyte Ratio and Stromal Tumor-Infiltrating Lymphocytes and Their Relationship in Locally Advanced Triple-Negative Breast Cancer Treated with Neoadjuvant Chemotherapy

Xue Dong et al.

Summary: The study explored the prognostic roles of NLR and sTILs in TNBC patients treated with NAC, showing that patients with lower NLR1 and higher sTILs scores had a better DFS outcome. Further research is needed to investigate the connection between systemic and local inflammatory/immune markers.

BREAST CARE (2021)

添加到收藏夹

Review Oncology

A clinical calculator to predict disease outcomes in women with triple-negative breast cancer

Mei-Yin C. Polley et al.

Summary: Clinical calculators for predicting recurrence-free survival and overall survival in triple-negative breast cancer patients were constructed and validated, with higher accuracy and predictive ability than base models.

BREAST CANCER RESEARCH AND TREATMENT (2021)

添加到收藏夹

Review Medicine, Research & Experimental

Tumor-associated neutrophils as new players in immunosuppressive process of the tumor microenvironment in breast cancer

Farnaz Hajizadeh et al.

Summary: Neutrophils, traditionally known for their antibacterial properties, have recently gained attention for their role in cancer development and treatment. Tumor-associated neutrophils (TANs) can influence tumor prognosis by exerting pro- or anti-tumoral effects, and have been implicated in promoting tumor growth, genomic instability, and immune suppression in breast cancer. Enhanced neutrophil to lymphocyte ratio may contribute to increased mortality and decreased survival in breast cancer cases.

LIFE SCIENCES (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Nicotine promotes breast cancer metastasis by stimulating N2 neutrophils and generating pre-metastatic niche in lung

Abhishek Tyagi et al.

Summary: Smoking has a profound impact on tumor immunity and tumor progression, with chronic nicotine exposure promoting the formation of a pre-metastatic niche in the lungs by recruiting pro-tumor N2-neutrophils that release lipocalin-2. Salidroside may be used to enhance the anti-tumor activity of neutrophils in breast cancer patients.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

添加到收藏夹

Article Oncology

Relationship Between the Neutrophil to Lymphocyte Ratio, Stromal Tumor-infiltrating Lymphocytes, and the Prognosis and Response to Neoadjuvant Chemotherapy in Triple-negative Breast Cancer

Jian Pang et al.

Summary: NLR and sTILs are independent predictors of disease-free survival in patients with triple-negative breast cancer. While they are not directly correlated, low NLR1 and high sTILs are associated with prolonged disease-free survival in TNBC patients.

CLINICAL BREAST CANCER (2021)

添加到收藏夹

Article Oncology

Silencing CTNND1 Mediates Triple-Negative Breast Cancer Bone Metastasis via Upregulating CXCR4/CXCL12 Axis and Neutrophils Infiltration in Bone

Qun Lin et al.

Summary: CTNND1 downregulation plays a critical role in facilitating bone metastasis of TNBC, and may serve as a potential biomarker for predicting the risk of bone metastases in TNBC patients.

CANCERS (2021)

添加到收藏夹

Article Immunology

Triple-Negative Breast Cancer Cells Recruit Neutrophils by Secreting TGF-β and CXCR2 Ligands

Shuvasree SenGupta et al.

Summary: The study found a direct link between the malignant potential of breast cancer cells and their ability to induce neutrophil migration. It also uncovered a novel coordinated function of TGF-beta and GRO chemokines responsible for guiding neutrophil trafficking to the breast tumor.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Article Oncology

CXCR2 Levels Correlate with Immune Infiltration and a Better Prognosis of Triple-Negative Breast Cancers

Florence Boissiere-Michot et al.

Summary: This study focused on the expression of CXCR2 in TNBC and its association with tumor characteristics and immune infiltration. High levels of CXCR2 were found to be correlated with better prognosis in a subgroup of TNBC patients.

CANCERS (2021)

添加到收藏夹

Article Oncology

Unraveling Heterogeneity of Tumor Cells and Microenvironment and Its Clinical Implications for Triple Negative Breast Cancer

Ke Jiang et al.

Summary: This study systematically characterized the tumor heterogeneity of TNBC using single-cell RNA sequencing, revealing the existence of multiple immune cell types and their associations with clinical outcomes in TNBC tissues, particularly highlighting the significance of M2 macrophages and neutrophils.

FRONTIERS IN ONCOLOGY (2021)

添加到收藏夹

Article Oncology

OMO-1 reduces progression and enhances cisplatin efficacy in a 4T1-based non-c-MET addicted intraductal mouse model for triple-negative breast cancer

Jonas Steenbrugge et al.

Summary: c-MET plays a crucial role in cancer progression, and OMO-1, a potent c-MET inhibitor, shows promising therapeutic efficacy in TNBC. OMO-1 not only reduces tumor progression dose dependently but also enhances the effects of cisplatin, providing potential benefits for TNBC patients, even in cases of non-c-MET addicted tumors.

NPJ BREAST CANCER (2021)

添加到收藏夹

Article Oncology

Time-Sequencing of the Neutrophil-to-Lymphocyte Ratio to Predict Prognosis of Triple-Negative Breast Cancer

Joo-Heung Kim et al.

Summary: While the prognosis of triple-negative breast cancer (TNBC) varies, identifying subgroups with particularly poor prognosis is crucial. This study aimed to investigate the association between changes in the neutrophil-to-lymphocyte ratio (NLR) during treatment and poor prognosis in TNBC patients. The findings suggest that an increase in NLR during treatment may indicate a higher risk of recurrence or death, highlighting the need for additional treatment modalities.

CANCERS (2021)

添加到收藏夹

Review Oncology

The Role of Neutrophil Extracellular Traps in Cancer

Bo-Zong Shao et al.

Summary: Neutrophil extracellular traps (NETs) play a vital role in the immune response, combating microbial infections and influencing the pathogenesis of various diseases. This review highlights the biological characteristics of NETs and their mechanisms in cancer, providing insights into potential therapeutic targets.

FRONTIERS IN ONCOLOGY (2021)

添加到收藏夹

Article Oncology

Platelet-to-Lymphocyte Ratio Is Associated With Favorable Response to Neoadjuvant Chemotherapy in Triple Negative Breast Cancer: A Study on 120 Patients

Sejdi Lusho et al.

Summary: In this study, baseline TILs remained predictive of pCR, while PLR was a better predictor of positive outcomes in terms of reduced distant recurrences or longer DRFS. Further investigation of baseline PLR alongside TILs may help identify TNBC patients likely to respond well to NACT when TILs are not available.

FRONTIERS IN ONCOLOGY (2021)

添加到收藏夹

Review Cell Biology

Pre-metastatic Niche Formation in Different Organs Induced by Tumor Extracellular Vesicles

Qi Dong et al.

Summary: Primary tumors modify the microenvironment of distant organs to create a supportive pre-metastatic niche, facilitating metastasis. Extracellular vesicles play a critical role in PMN formation by delivering functional molecules to recipient cells in target organs.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

The Key Role of Exosomes on the Pre-metastatic Niche Formation in Tumors

Xuyang Yang et al.

Summary: Exosomes released from cells transfer bio-information to recipient cells, particularly in the context of tumor pre-metastatic niche (PMN) formation, facilitating tumor cell colonization and metastasis. These exosomes induce epigenetic changes in target cells, contributing to the formation of PMN.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

添加到收藏夹

Article Oncology

Neutrophil to Lymphocyte Ratio after Treatment Completion as a Potential Predictor of Survival in Patients with Triple-Negative Breast Cancer

Kwang-Min Kim et al.

Summary: Post-treatment neutrophil-to-lymphocyte ratio (NLR) is significantly associated with the prognosis of patients with triple-negative breast cancer (TNBC), with the strongest prognostic performance observed at 6 months after treatment completion. Patients with high NLR (>2.47) showed worse overall survival and distant disease-free survival compared to those with low NLR.

JOURNAL OF BREAST CANCER (2021)

添加到收藏夹

Article Cell Biology

Breast Tumor-Derived Exosomal MicroRNA-200b-3p Promotes Specific Organ Metastasis Through Regulating CCL2 Expression in Lung Epithelial Cells

Pengfei Gu et al.

Summary: The study revealed that high expression of CCL2 in the lung can recruit MDSCs and contribute to the establishment of the microenvironment, predicting the development of breast cancer lung metastasis through the regulatory expression of CCL2 in the target organ.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

添加到收藏夹

Article Oncology

Dynamic Neutrophil-to-Lymphocyte Ratio: A Novel Prognosis Measure for Triple-Negative Breast Cancer

Dan Moldoveanu et al.

ANNALS OF SURGICAL ONCOLOGY (2020)

添加到收藏夹

Review Pharmacology & Pharmacy

Rational targeting of immunosuppressive neutrophils in cancer

Yun Zhao et al.

PHARMACOLOGY & THERAPEUTICS (2020)

添加到收藏夹

Article Oncology

Prognostic Value of CXCR2 in Breast Cancer

Florence Boissiere-Michot et al.

CANCERS (2020)

添加到收藏夹

Article Oncology

Tumor-derived HMGB1 induces CD62Ldimneutrophil polarization and promotes lung metastasis in triple-negative breast cancer

Zhen Wang et al.

ONCOGENESIS (2020)

添加到收藏夹

Review Oncology

Pro-Inflammatory Cytokines in the Formation of the Pre-Metastatic Niche

Ru Li et al.

CANCERS (2020)

添加到收藏夹

Article Oncology

Genomic and Transcriptomic Landscape of Triple-Negative Breast Cancers: Subtypes and Treatment Strategies

Yi-Zhou Jiang et al.

CANCER CELL (2019)

添加到收藏夹

Article Oncology

Multi-Omics Profiling Reveals Distinct Microenvironment Characterization and Suggests Immune Escape Mechanisms of Triple-Negative Breast Cancer

Yi Xiao et al.

CLINICAL CANCER RESEARCH (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Neutrophils escort circulating tumour cells to enable cell cycle progression

Barbara Maria Szczerba et al.

NATURE (2019)

添加到收藏夹

Article Cell Biology

Clinical prognostic evaluation of immunocytes in different molecular subtypes of breast cancer

Huang Zenan et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

添加到收藏夹

Review Physiology

THE NEUTROPHIL'S ROLE DURING HEALTH AND DISEASE

Pei Xiong Liew et al.

PHYSIOLOGICAL REVIEWS (2019)

添加到收藏夹

Article Cell Biology

Immature Low-Density Neutrophils Exhibit Metabolic Flexibility that Facilitates Breast Cancer Liver Metastasis

Brian E. Hsu et al.

CELL REPORTS (2019)

添加到收藏夹

Review Immunology

Neutrophil Heterogeneity in Cancer: From Biology to Therapies

Pacome Lecot et al.

FRONTIERS IN IMMUNOLOGY (2019)

添加到收藏夹

Article Immunology

IL-1β Blockade Attenuates Thrombosis in a Neutrophil Extracellular Trap-Dependent Breast Cancer Model

Taina Gomes et al.

FRONTIERS IN IMMUNOLOGY (2019)

添加到收藏夹

Article Oncology

Neutrophil-to-lymphocyte ratio as a predictor of survival in patients with triple-negative breast cancer

Dilan A. Patel et al.

BREAST CANCER RESEARCH AND TREATMENT (2019)

添加到收藏夹

Article Oncology

Tumor-Contacted Neutrophils Promote Metastasis by a CD90-TIMP-1 Juxtacrine-Paracrine Loop

Ying Wang et al.

CLINICAL CANCER RESEARCH (2019)

添加到收藏夹

Review Cell Biology

Getting TANned: How the tumor microenvironment drives neutrophil recruitment

Shuvasree SenGupta et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2019)

添加到收藏夹

Article Oncology

Targeting myeloid-derived suppressor cells in combination with primary mammary tumor resection reduces metastatic growth in the lungs

Momir Bosiljcic et al.

BREAST CANCER RESEARCH (2019)

添加到收藏夹

Review Oncology

Neutrophil extracellular traps in breast cancer and beyond: current perspectives on NET stimuli, thrombosis and metastasis, and clinical utility for diagnosis and treatment

Hunter T. Snoderly et al.

BREAST CANCER RESEARCH (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Neutrophils, G-CSF and their contribution to breast cancer metastasis

Kellie A. Mouchemore et al.

FEBS JOURNAL (2018)

添加到收藏夹

Article Oncology

Blockade of Myeloid-Derived Suppressor Cell Expansion with All-Trans Retinoic Acid Increases the Efficacy of Antiangiogenic Therapy

Raimund Bauer et al.

CANCER RESEARCH (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

LXR/ApoE Activation Restricts Innate Immune Suppression in Cancer

Masoud F. Tavazoie et al.

CELL (2018)

添加到收藏夹

Article Oncology

Neutrophil-lymphocyte ratio predicts response to chemotherapy in triple-negative breast cancer

S. Chae et al.

CURRENT ONCOLOGY (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Increased neutrophil-lymphocyte ratio independently predicts poor survival in non-metastatic triple-negative breast cancer patients

Xiangting Qiu et al.

IUBMB LIFE (2018)

添加到收藏夹

Article Oncology

Entinostat Converts Immune-Resistant Breast and Pancreatic Cancers into CheckpointResponsive Tumors by Reprogramming Tumor-Infiltrating MDSCs

Brian J. Christmas et al.

CANCER IMMUNOLOGY RESEARCH (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice

Jean Albrengues et al.

SCIENCE (2018)

添加到收藏夹

Article Oncology

Circulating tumor cells promote the metastatic colonization of disseminated carcinoma cells by inducing systemic inflammation

Yong-Chao Li et al.

ONCOTARGET (2017)

添加到收藏夹

Review Oncology

The regulation of pre-metastatic niche formation by neutrophils

Jadwiga Jablonska et al.

ONCOTARGET (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Tumor-Derived Exosomes Induce the Formation of Neutrophil Extracellular Traps: Implications For The Establishment of Cancer-Associated Thrombosis

Ana C. Leal et al.

SCIENTIFIC REPORTS (2017)

添加到收藏夹

Article Oncology

Entinostat Neutralizes Myeloid-Derived Suppressor Cells and Enhances the Antitumor Effect of PD-1 Inhibition in Murine Models of Lung and Renal Cell Carcinoma

Ashley Orillion et al.

CLINICAL CANCER RESEARCH (2017)

添加到收藏夹

Article Oncology

Prognostic role of neutrophil-to-lymphocyte ratio in breast cancer: a systematic review and meta-analysis

Josee-Lyne Ethier et al.

BREAST CANCER RESEARCH (2017)

添加到收藏夹

Article Oncology

Type I IFNs induce anti-tumor polarization of tumor associated neutrophils in mice and human

Lisa Andzinski et al.

INTERNATIONAL JOURNAL OF CANCER (2016)

添加到收藏夹

Article Oncology

L-Arginine supplementation inhibits the growth of breast cancer by enhancing innate and adaptive immune responses mediated by suppression of MDSCs in vivo

Yu Cao et al.

BMC CANCER (2016)

添加到收藏夹

Article Oncology

Characteristics and Significance of the Pre-metastatic Niche

Yang Liu et al.

CANCER CELL (2016)

添加到收藏夹

Article Oncology

Origin and Role of a Subset of Tumor-Associated Neutrophils with Antigen-Presenting Cell Features in Early-Stage Human Lung Cancer

Sunil Singhal et al.

CANCER CELL (2016)

添加到收藏夹

Editorial Material Gastroenterology & Hepatology

GASTROINTESTINAL CANCER Neutrophils and cancer: guilt by association

Craig N. Jenne et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2016)

添加到收藏夹

Article Cell Biology

Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps

Juwon Park et al.

SCIENCE TRANSLATIONAL MEDICINE (2016)

添加到收藏夹

Article Oncology

Neutrophil to lymphocyte ratio (NLR) for prediction of distant metastasis-free survival (DMFS) in early breast cancer: a propensity score-matched analysis

Michele Orditura et al.

ESMO OPEN (2016)

添加到收藏夹

Review Oncology

Neutrophils in cancer: neutral no more

Seth B. Coffelt et al.

NATURE REVIEWS CANCER (2016)

添加到收藏夹

Article Oncology

Neutrophil Extracellular Traps Accumulate in Peripheral Blood Vessels and Compromise Organ Function in Tumor-Bearing Animals

Jessica Cedervall et al.

CANCER RESEARCH (2015)

添加到收藏夹

Article Multidisciplinary Sciences

Invasive breast cancer reprograms early myeloid differentiation in the bone marrow to generate immunosuppressive neutrophils

Amy-Jo Casbon et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

添加到收藏夹

Article Oncology

Granulocytic immune infiltrates are essential for the efficient formation of breast cancer liver metastases

Sebastien Tabaries et al.

BREAST CANCER RESEARCH (2015)

添加到收藏夹

Article Biochemistry & Molecular Biology

Circulating Tumor Cell Clusters Are Oligoclonal Precursors of Breast Cancer Metastasis

Nicola Aceto et al.

CELL (2014)

添加到收藏夹

Article Oncology

Hydroxychloroquine Inhibits Autophagy to Potentiate Antiestrogen Responsiveness in ER+ Breast Cancer

Katherine L. Cook et al.

CLINICAL CANCER RESEARCH (2014)

添加到收藏夹

Article Multidisciplinary Sciences

Eradication of metastatic mouse cancers resistant to immune checkpoint blockade by suppression of myeloid-derived cells

KiBem Kim et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

添加到收藏夹

Review Immunology

Molecular mechanisms regulating NETosis in infection and disease

Nora Branzk et al.

SEMINARS IN IMMUNOPATHOLOGY (2013)

添加到收藏夹

Article Medicine, General & Internal

Effect of daily aspirin on risk of cancer metastasis: a study of incident cancers during randomised controlled trials

Peter M. Rothwell et al.

LANCET (2012)

添加到收藏夹

Review Cell Biology

Circulating tumor cells: approaches to isolation and characterization

Min Yu et al.

JOURNAL OF CELL BIOLOGY (2011)

添加到收藏夹

Article Oncology

Aspirin Intake and Survival After Breast Cancer

Michelle D. Holmes et al.

JOURNAL OF CLINICAL ONCOLOGY (2010)

添加到收藏夹

Article Biochemistry & Molecular Biology

Neutrophil elastase-mediated degradation of IRS-1 accelerates lung tumor growth

A. McGarry Houghton et al.

NATURE MEDICINE (2010)

添加到收藏夹

Review Medicine, General & Internal

Triple-Negative Breast Cancer

William D. Foulkes et al.

NEW ENGLAND JOURNAL OF MEDICINE (2010)

添加到收藏夹

Article Multidisciplinary Sciences

Granulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6G+Ly6C+ granulocytes

Marcin Kowanetz et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

添加到收藏夹

Article Oncology

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: N1 versus N2 TAN

Zvi G. Fridlender et al.

CANCER CELL (2009)

添加到收藏夹

Review Oncology

The metastatic niche: adapting the foreign soil

Bethan Psaila et al.

NATURE REVIEWS CANCER (2009)

添加到收藏夹

Article Immunology

Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function

Paolo Serafini et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2006)

添加到收藏夹

Article Multidisciplinary Sciences

VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche

RN Kaplan et al.

NATURE (2005)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.