期刊
ADVANCED HEALTHCARE MATERIALS
卷 5, 期 5, 页码 541-547出版社
WILEY
DOI: 10.1002/adhm.201500757
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资金
- NIH [R01 DE013349, R01 EB015498]
- ARO [63846LS]
- HHMI ISRF
Injectable gelatin hydrogels formed with bioorthogonal click chemistry (ClickGel) are cell-responsive ECM mimics for in vitro and in vivo biomaterials applications. Gelatin polymers with pendant norbornene (GelN) or tetrazine (GelT) groups can quickly and spontaneously crosslink upon mixing, allowing for high viability of encapsulated cells, establishment of 3D elongated cell morphologies, and biodegradation when injected in vivo.
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