期刊
ADVANCED HEALTHCARE MATERIALS
卷 6, 期 1, 页码 -出版社
WILEY
DOI: 10.1002/adhm.201601094
关键词
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资金
- University of Macau [MYRG2014-00093-FHS, MYRG2015-00036-FHS, MYRG2016-00110-FHS]
- Major State Basic Research Development Program of China (973 Program) [2015CB755500]
- Macao government [FDCT 026/2014/A1, FDCT 025/2015/A1]
- Natural Science Foundation of China [81301272, 81401521, 81571745]
Controllable preparation of water-soluble multifunctional nanoprobes is of great significance for cancer early diagnosis. In this study, protein-modified hydrophilic copper sufide (CuS) nanotriangles with tunable absorption in the second near-infrared region are developed in the presence of halide ions. Further, gadolinium ions chelated diethylenetriaminepentaacetic acid is conjugated on it by using the unique characteristics of the protein-protected nanotriangles. Specifically, the as-obtained nanostructures are investigated as contrast agents for enhanced in vivo photoacoustic/magnetic resonance dual-modal tumor imaging. More importantly, in vitro and in vivo toxicity analysis are also performed, which show that the dual-modal nanoprobes are biocompatible for most of the cases. It is demonstrated that the novel as-prepared protein-modified nanotriangles are able to work as a nanoplatform to construct dual-modal nanoprobes, which paves a new avenue for improving the photoacoustic/magnetic resonance imaging contrast in cancer detection. It should be pointed out that other functional blocks may also be linked on it, which makes it a general method to design multifunctional nanoprobes.
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