期刊
ADVANCED HEALTHCARE MATERIALS
卷 5, 期 23, 页码 3004-3015出版社
WILEY
DOI: 10.1002/adhm.201600650
关键词
biosensors; cortisol; in vivo; physiologically based pharmacokinetic model
资金
- Simons Foundation for the Social Brain at MIT
- EAGER
- National Science Foundation
- Division Of Behavioral and Cognitive Sci
- Direct For Social, Behav & Economic Scie [1445131] Funding Source: National Science Foundation
Cortisol is an important glucocorticoid hormone whose biochemistry influences numerous physiological and pathological processes. Moreover, it is a biomarker of interest for a number of conditions, including posttraumatic stress disorder, Cushing's syndrome, Addison's disease, and others. An implantable biosensor capable of real time monitoring of cortisol concentrations in adipose tissue may revolutionize the diagnosis and treatment of these disorders, as well as provide an invaluable research tool. Toward this end, a mathematical model, informed by the physiological literature, is developed to predict dynamic cortisol concentrations in adipose, muscle, and brain tissues, where a significant number of important processes with cortisol occur. The pharmacokinetic model is applied to both a prototypical, healthy male patient and a previously studied Cushing's disease patient. The model can also be used to inform the design of an implantable sensor by optimizing the sensor dissociation constant, apparent delay time, and magnitude of the sensor output versus system dynamics. Measurements from such a sensor would help to determine systemic cortisol levels, providing much needed insight for proper medical treatment for various cortisol-related conditions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据