期刊
ADVANCED HEALTHCARE MATERIALS
卷 5, 期 18, 页码 2413-2426出版社
WILEY
DOI: 10.1002/adhm.201600359
关键词
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资金
- National Natural Science Foundation of China [31170919, 31370967]
- Science and Technology Planning Project of Guangdong Province [2015A020212033]
- Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme, China
Synthesis of artificial and functional structures for bone tissue engineering has been well recognized but the associated cell senescence issue remains much less concerned so far. In this work, surface-modified polycaprolactone-polylactic acid scaffolds using self-assembled heterojunction carbon nanotubes (sh-CNTs) combined with insulin-like growth factor-1 are synthesized and a series of structural and biological characterizations are carried out, with particular attention to cell senescence mechanism. It is revealed that the modified scaffolds can up-regulate the expressions of alkaline phosphates and bone morphogenetic proteins while down-regulate the expressions of senescence-related proteins in mesenchymal stem cells, demonstrating the highly preferred anti-senescence functionality of the sh-CNTs modified scaffolds in bone tissue engineering. Furthermore, it is also found that with sh-CNTs, scaffolds can accelerate bone healing with extremely low toxicity in vivo.
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