Selenium-enriched peptides identified from selenium-enriched soybean protein hydrolysate: protective effects against heat damage in Caco-2 cells

Article Biochemistry & Molecular Biology

Dietary Selenium Alleviated Mouse Liver Oxidative Stress and NAFLD Induced by Obesity by Regulating the KEAP1/NRF2 Pathway

Yi Wang et al.

Summary: Adequate dietary selenium can effectively resist hepatic injury and insulin resistance during NAFLD development, and regulate the KEAP1/NRF2 pathway to resist oxidative stress by promoting SEPP1 synthesis.

ANTIOXIDANTS (2022)

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Article Agriculture, Multidisciplinary

Selenium-EnrichedPediococcus acidilacticiMRS-7 Alleviates Patulin-Induced Jejunum Injuries in Mice and Its Possible Mechanisms

Hong Chen et al.

Summary: This study investigated the protective effects of a selenium-enriched strain, SeP, on jejunum injuries induced by PAT. The results showed that SeP could alleviate PAT-induced intestinal damage and inflammation, as well as regulate the intestinal microbiota. These findings suggest that SeP may serve as a novel protective agent against the toxicity of PAT.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2022)

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Article Food Science & Technology

Identification, inhibitory mechanism and transepithelial transport of xanthine oxidase inhibitory peptides from whey protein after simulated gastrointestinal digestion and intestinal absorption

Xiaofen Qi et al.

Summary: In this study, peptides that can inhibit xanthine oxidase were identified and their inhibitory mechanism and transportation were investigated. The results suggest that these peptides have the potential to regulate xanthine oxidase activity in vivo.

FOOD RESEARCH INTERNATIONAL (2022)

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Article Nutrition & Dietetics

A Comprehensive Comparison of Different Selenium Supplements: Mitigation of Heat Stress and Exercise Fatigue-Induced Liver Injury

Xinwei Chen et al.

Summary: This study compared the protective effects of different selenium supplements against heat stress and exercise fatigue-induced liver injury. The results showed that selenium-enriched soybean peptides (SePPs) displayed higher antioxidant and anti-inflammatory activity, and could improve antioxidant levels, inhibit lipid peroxidation, reduce liver enzyme levels, promote liver cell repair, and reduce inflammation.

FRONTIERS IN NUTRITION (2022)

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Article Biochemistry & Molecular Biology

(-)-Epigallocatechin-3-gallate Directly Binds Cyclophilin D: A Potential Mechanism for Mitochondrial Protection

Annan Wu et al.

Summary: This study found that EGCG directly binds to CypD and revealed the structural basis and mechanism of EGCG-CypD interaction. This may be a potential mechanism for EGCG to protect mitochondrial functions.

MOLECULES (2022)

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Article Food Science & Technology

Purification, identification, and antioxidative mechanism of three novel selenium-enriched oyster antioxidant peptides

Zhen Xia et al.

Summary: This study identified three novel selenium-enriched antioxidant peptides from selenium-enriched oyster hydrolysate. These peptides exhibited strong cellular antioxidant activity and protected cells from oxidative injury. Furthermore, they enhanced the activity of antioxidant enzymes and inhibited ROS production, potentially through interaction with key proteins involved in cellular protection.

FOOD RESEARCH INTERNATIONAL (2022)

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Review Food Science & Technology

Anti-Inflammatory Function of Plant-Derived Bioactive Peptides: A Review

Wanlu Liu et al.

Summary: Inflammation plays a crucial role in the development of chronic diseases, but traditional anti-inflammatory drugs often have unwanted side effects. Plant-derived bioactive peptides offer gentler alternatives and have shown effectiveness against various chronic diseases. However, a comprehensive and systematic review of the structures and anti-inflammatory activities of these peptides is lacking. This paper provides a review of the latest research on plant-derived anti-inflammatory peptides, including their regulatory mechanisms, structure-activity relationships, and enzymatic processing. Current research problems and potential future directions are also discussed.

FOODS (2022)

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Article Chemistry, Medicinal

Dehydroisohispanolone as a Promising NLRP3 Inhibitor Agent: Bioevaluation and Molecular Docking

Laura Gonzalez-Cofrade et al.

Summary: The study demonstrates that DIH effectively inhibits NLRP3 inflammasome activation in macrophages, showing potential application in treating inflammation-related diseases.

PHARMACEUTICALS (2022)

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Review Biochemistry & Molecular Biology

The adverse effect of heat stress and potential nutritional interventions

Xinwei Chen et al.

Summary: Heat stress can cause tissue damage and metabolic disturbances, which can lead to organ dysfunction and even heatstroke. Nutritional intervention is an effective way to prevent and mitigate the negative effects of heat stress. This article reviews the pathological changes and altered metabolic mechanisms caused by heat stress and discusses the action pathways and mechanisms of various nutrients, providing scientific dietary protocols for special populations.

FOOD & FUNCTION (2022)

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Article Biochemistry & Molecular Biology

Selenium-enriched soybean peptides pretreatment attenuates lung injury in mice induced by fine particulate matters (PM2.5) through inhibition of TLR4/NF-κB/IκBα signaling pathway and inflammasome generation

Jian Zhang et al.

Summary: This study aimed to investigate the inhibitory effect of selenium-enriched soybean peptides (Se-SPep) on lung injury induced by fine particulate matter 2.5 (PM2.5) in mice. The results showed that Se-SPep pretreatment decreased inflammation and inhibited the expression of related proteins, thus protecting the lungs of mice from PM2.5-induced damage.

FOOD & FUNCTION (2022)

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Article Biochemistry & Molecular Biology

Screening and bioavailability evaluation of anti-oxidative selenium-containing peptides from soybeans based on specific structures

Xing Zhang et al.

Summary: Our study evaluated the potential of selenium-containing peptides in terms of antioxidant activity, safety, and bioavailability. We identified the peptide sequence SFQSeM as a promising candidate with strong antioxidant effects, stability in the gastrointestinal tract, and low impact on liver health. SFQSeM has the potential to be an effective selenium nutritional supplement.

FOOD & FUNCTION (2022)

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Article Biochemical Research Methods

Molecular Docking Studies of Bioactive Nicotiflorin against 6W63 Novel Coronavirus 2019 (COVID-19)

Raghvendra Dubey et al.

Summary: This study investigated the inhibitory potential of nicotiflorin against the main protease of COVID-19 using molecular docking approach. The results showed that nicotiflorin exhibited stronger affinity with the viral protein compared to the standard inhibitor X77. Further evaluation of nicotiflorin for safety and efficacy in both preclinical and clinical stages is recommended for effective treatment of COVID-19.

COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING (2021)

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Article Food Science & Technology

Cyanidin-3-O-glucoside and its metabolite protocatechuic acid ameliorate 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) induced cytotoxicity in HepG2 cells by regulating apoptotic and Nrf2/p62 pathways

Lei Zhao et al.

Summary: The study showed that cyanidin-3-O-glucoside (C3G) and its metabolite protocatechuic acid (PCA) can protect against cytotoxic effects induced by heterocyclic aromatic amines. They work by interfering with Nrf2 signaling and apoptotic cascade pathways to minimize cell damage. Additionally, C3G exhibited stronger protective effects compared to PCA.

FOOD AND CHEMICAL TOXICOLOGY (2021)

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Article Chemistry, Applied

Study on the structure-activity relationship of watermelon seed antioxidant peptides by using molecular simulations

Chaoting Wen et al.

Summary: In this study, the antioxidant mechanism of watermelon seed antioxidant peptide P1 was explored using quantum chemistry and molecular docking. The results indicated that P1 can enhance the stability of Keap1 and activate the Keap1-Nrf2 signaling pathway to improve the antioxidant defense system.

FOOD CHEMISTRY (2021)

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Article Chemistry, Applied

Binding mechanism and functional evaluation of quercetin 3-rhamnoside on lipase

Di Wu et al.

Summary: The interaction between lipase and quercetin 3-rhamnoside was studied using fluorescence spectroscopy, enzyme kinetics, and molecular dynamics simulation. Quercetin 3-rhamnoside showed a strong quenching effect on lipase fluorescence and inhibited the enzyme in a dose-dependent manner. Thermodynamic parameters indicated hydrogen bonding and van der Waals forces as the main driving forces for the interaction, causing structural perturbation in the lipase.

FOOD CHEMISTRY (2021)

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Article Biochemistry & Molecular Biology

Investigation of the interaction between Chrysoeriol and xanthine oxidase using computational and in vitro approaches

Yan Liu et al.

Summary: Chrysoeriol (CHE), a natural flavone, shows potent Xanthine oxidase (XO) inhibitory activity through competitive inhibition with hydrogen bonding and hydrophobic interaction. The interaction between CHE and XO was studied through fluorescence quenching and conformational changes, revealing the binding mechanism of CHE towards XO. Molecular docking study enhanced the understanding of CHE's binding affinity towards XO, while molecular dynamic simulation and ADMET prediction showed promising stability and pharmacokinetic properties of CHE.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Biochemistry & Molecular Biology

Crystal Structure of NLRP3 NACHT Domain With an Inhibitor Defines Mechanism of Inflammasome Inhibition

Carien Dekker et al.

Summary: The NLRP3 inflammasome responds to various pathogenic and sterile signals, producing interleukin-1 beta and interleukin-18. Understanding the structure of NLRP3 NACHT domain can provide insights into activation mechanisms and aid in the development of inhibitors for inflammatory diseases. Stabilizing the auto-inhibited form of the NACHT domain is an effective strategy to inhibit NLRP3 and could be beneficial in future therapeutic approaches.

JOURNAL OF MOLECULAR BIOLOGY (2021)

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Article Pharmacology & Pharmacy

S-allyl cysteine ameliorates heat stress-induced oxidative stress by activating Nrf2/HO-1 signaling pathway in BMECs

Yue Wang et al.

Summary: Heat stress is harmful to BMECs, and SAC can protect cells from oxidative damage and apoptosis by mediating the Nrf2/HO-1 signaling pathway.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2021)

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Article Food Science & Technology

Dietary supplementation of camel whey protein attenuates heat stress-induced liver injury by inhibiting NLRP3 inflammasome activation through the HMGB1/RAGE signalling pathway

Donghua Du et al.

Summary: The study demonstrates that dietary supplementation of camel whey protein can alleviate heat stress-induced liver injury by inhibiting the HMGB1/RAGE/NLRP3 axis, and the combination of CWP with glycyrrhizic acid can completely prevent hepatocyte apoptosis and injury induced by heat stress.

JOURNAL OF FUNCTIONAL FOODS (2021)

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Article Biochemistry & Molecular Biology

Gintonin-Enriched Fraction Suppresses Heat Stress-Induced Inflammation through LPA Receptor

Sungwoo Chei et al.

MOLECULES (2020)

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Article Food Science & Technology

Milk-derived bioactive peptides exhibit antioxidant activity through the Keapl-Nrf2 signaling pathway

Federica Tonolo et al.

JOURNAL OF FUNCTIONAL FOODS (2020)

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Article Food Science & Technology

Antioxidant and anti-inflammatory activity of peptides from foxtail millet (Setaria italica) prolamins in HaCaT cells and RAW264.7 murine macrophages

Zhongwei Ji et al.

FOOD BIOSCIENCE (2020)

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Review Food Science & Technology

Plant protein-derived antioxidant peptides: Isolation, identification, mechanism of action and application in food systems: A review

Chaoting Wen et al.

TRENDS IN FOOD SCIENCE & TECHNOLOGY (2020)

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Article Chemistry, Multidisciplinary

A Screening of Neuraminidase Inhibition Activities of Isoquinolone Alkaloids in Coptis chinensis Using Molecular Docking and Pharmacophore Analysis

Khanh Le et al.

ACS OMEGA (2020)

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Article Biochemistry & Molecular Biology

Nrf2/ARE pathway activation is involved in negatively regulating heat-induced apoptosis in non-small cell lung cancer cells

Wenyue Xie et al.

ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2020)

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Article Biochemistry & Molecular Biology

Effect of soybean peptides against hydrogen peroxide induced oxidative stress in HepG2 cells via Nrf2 signaling

Guofu Yi et al.

FOOD & FUNCTION (2020)

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Article Cell Biology

Chlorogenic acid isomers directly interact with Keap 1-Nrf2 signaling in Caco-2 cells

Ningjian Liang et al.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2019)

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Article Agriculture, Multidisciplinary

Purification and Characterization of Antioxidant Peptides from Alcalase-Hydrolyzed Soybean (Glycine max L.) Hydrolysate and Their Cytoprotective Effects in Human Intestinal Caco-2 Cells

Qiaozhi Zhang et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2019)

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Article Nutrition & Dietetics

The protective effect of selenium from heat stress-induced porcine small intestinal epithelial cell line (IPEC-J2) injury is associated with regulation expression of selenoproteins

Jiayong Tang et al.

BRITISH JOURNAL OF NUTRITION (2019)

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Article Biochemistry & Molecular Biology

L-Arginine alleviates heat stress-induced intestinal epithelial barrier damage by promoting expression of tight junction proteins via the AMPK pathway

Zhaofei Xia et al.

MOLECULAR BIOLOGY REPORTS (2019)

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Article Biology

Effects of resveratrol on intestinal oxidative status and inflammation in heat-stressed rats

Kang Cheng et al.

JOURNAL OF THERMAL BIOLOGY (2019)

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Article Urology & Nephrology

Selenium effects on antioxidant and inflammatory indices in renal ischemia-reperfusion injury in rats

Hassan Ahmadvand et al.

JOURNAL OF RENAL INJURY PREVENTION (2019)

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Article Biochemistry & Molecular Biology

Thermal tolerance and thermal sensitivity of heart mitochondria: Mitochondrial integrity and ROS production

Felix Christen et al.

FREE RADICAL BIOLOGY AND MEDICINE (2018)

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Article Agriculture, Dairy & Animal Science

Glutamine alleviates heat stress-induced impairment of intestinal morphology, intestinal inflammatory response, and barrier integrity in broilers

Q. J. Wu et al.

POULTRY SCIENCE (2018)

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Article Food Science & Technology

Hepatoprotective effects of selenium-biofortified soybean peptides on liver fibrosis induced by tetrachloromethane

Weiwei Liu et al.

JOURNAL OF FUNCTIONAL FOODS (2018)

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Article Biochemistry & Molecular Biology

NLRP3 Phosphorylation Is an Essential Priming Event for Inflammasome Activation

Nan Song et al.

MOLECULAR CELL (2017)

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Article Agriculture, Dairy & Animal Science

Resveratrol alleviates heat stress-induced impairment of intestinal morphology, microflora, and barrier integrity in broilers

C. Zhang et al.

POULTRY SCIENCE (2017)

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Article Biochemistry & Molecular Biology

A Genome-wide CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) Screen Identifies NEK7 as an Essential Component of NLRP3 Inflammasome Activation

Jonathan L. Schmid-Burgk et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

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Article Immunology

NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component

Hexin Shi et al.

NATURE IMMUNOLOGY (2016)

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Article Multidisciplinary Sciences

NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux

Yuan He et al.

NATURE (2016)

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Article Gastroenterology & Hepatology

Heatstroke induces liver injury via IL-1β and HMGB1-induced pyroptosis

Yan Geng et al.

JOURNAL OF HEPATOLOGY (2015)

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Article Food Science & Technology

Galacto-oligosaccharides exert a protective effect against heat stress in a Caco-2 cell model

Soheil Varasteh et al.

JOURNAL OF FUNCTIONAL FOODS (2015)

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Article Nutrition & Dietetics

Glutamine and arginine improve permeability and tight junction protein expression in methotrexate-treated Caco-2 cells

Stephanie Beutheu et al.

CLINICAL NUTRITION (2013)

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Article Multidisciplinary Sciences

Eicosapentaenoic Acid Enhances Heat Stress-Impaired Intestinal Epithelial Barrier Function in Caco-2 Cells

Guizhen Xiao et al.

PLOS ONE (2013)

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Article Multidisciplinary Sciences

Heat Stress Reduces Intestinal Barrier Integrity and Favors Intestinal Glucose Transport in Growing Pigs

Sarah C. Pearce et al.

PLOS ONE (2013)

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Review Food Science & Technology

Food-derived peptidic antioxidants: A review of their production, assessment, and potential applications

Anusha G. P. Samaranayaka et al.

JOURNAL OF FUNCTIONAL FOODS (2011)

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Review Chemistry, Multidisciplinary

Functional Mimics of Glutathione Peroxidase: Bioinspired Synthetic Antioxidants

Krishna P. Bhabak et al.

ACCOUNTS OF CHEMICAL RESEARCH (2010)

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Review Oncology

Selenoproteins-What unique properties can arise with selenocysteine in place of cysteine?

Elias S. J. Arner

EXPERIMENTAL CELL RESEARCH (2010)

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Article Biochemistry & Molecular Biology

Selenium speciation profiles in selenite-enriched soybean (Glycine Max) by HPLC-ICPMS and ESI-ITMS

Qilin Chan et al.

METALLOMICS (2010)

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Article Nutrition & Dietetics

Glutamine Deprivation Alters Intestinal Tight Junctions via a PI3-K/Akt Mediated Pathway in Caco-2 Cells

Nan Li et al.

JOURNAL OF NUTRITION (2009)

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Article Pathology

Cellular and molecular mechanisms of heat stress-induced up-regulation of occludin protein expression - Regulatory role of heat shock factor-1

Karol Dokladny et al.

AMERICAN JOURNAL OF PATHOLOGY (2008)

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Review Biochemistry & Molecular Biology

Adherens and tight junctions: Structure, function and connections to the actin cytoskeleton

Andrea Hartsock et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2008)

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Article Agriculture, Dairy & Animal Science

Superoxide radical production in chicken skeletal muscle induced by acute heat stress

A Mujahid et al.

POULTRY SCIENCE (2005)

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Selenium-enriched peptides identified from selenium-enriched soybean protein hydrolysate: protective effects against heat damage in Caco-2 cells

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