期刊
AGING-US
卷 15, 期 11, 页码 4685-4698出版社
IMPACT JOURNALS LLC
关键词
chaperone-mediated autophagy; autophagy; aging
Chaperone-mediated autophagy (CMA) selectively degrades crucial proteins for glycolysis, fatty acid metabolism, and age-associated diseases. Previous studies suggested a decline in CMA with age due to decreased levels of LAMP2A, the main component of the CMA complex. However, a recent study on genetically heterogeneous mice found no age-related changes in LAMP2A levels or CMA activity, except for sex differences.
Chaperone-mediated autophagy (CMA) selectively degrades proteins that are crucial for glycolysis, fatty acid metabolism, and the progression of several age-associated diseases. Several previous studies, each of which evaluated males of a single inbred mouse or rat strain, have reported that CMA declines with age in many tissues, attributed to an age-related loss of LAMP2A, the primary and indispensable component of the CMA translocation complex. This has led to a paradigm in the field of CMA research, stating that the age-associated decline in LAMP2A in turn decreases CMA, contributing to the pathogenesis of late-life disease. We assessed LAMP2A levels and CMA substrate uptake in both sexes of the genetically heterogeneous UM-HET3 mouse stock, which is the current global standard for the evaluation of anti-aging interventions. We found no evidence for age-related changes in LAMP2A levels, CMA substrate uptake, or whole liver levels of CMA degradation targets, despite identifying sex differences in CMA.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据