期刊
CHEMICAL COMMUNICATIONS
卷 59, 期 64, 页码 9718-9721出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d3cc02792a
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The first example of asymmetric alkene-alkene reductive coupling is demonstrated using visible-light-fueled photoredox/cobalt dual catalysis. The desymmetrization reaction achieves single-step operation with high yields (up to 95%) and excellent control of both relative (>99 : 1 dr) and absolute stereochemistry (up to 98 : 2 er), generating products with up to five chiral centers. Preliminary mechanistic investigations suggest key steps involving light-mediated controlled low-valent cobalt complex generation, oxidative ene-ene cyclization, and protonation.
The first example of asymmetric alkene-alkene reductive coupling is demonstrated via visible-light-fueled photoredox/cobalt dual catalysis. The desymmetrization reaction provided products (>20 examples) with up to five chiral centers in single-step operation in up to 95% yields with very high relative (>99 : 1 dr) and absolute stereochemistry (up to 98 : 2 er) control. The preliminary mechanistic investigations suggested that the critical mechanistic steps involved light-mediated controlled low-valent cobalt complex generation, oxidative ene-ene cyclization, and protonation.
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